Abdul Hafeez

@jsmu.edu.pk

Assistant Professor
Jinnah Sindh Medical University Karachi

Abdul Hafeez


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https://researchid.co/hafeezjaan77
9

Scopus Publications

302

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

Scopus Publications

  • Autofluorescence Image-Guided Endoscopy in the Management of Upper Aerodigestive Tract Tumors
    Norhafiza Mat Lazim, Abdul Hafeez Kandhro, Anna Menegaldo, Giacomo Spinato, Barbara Verro, et al.
    International Journal of Environmental Research and Public Health, 2023
    At this juncture, autofluorescence and narrow-band imaging have resurfaced in the medicine arena in parallel with current technology advancement. The emergence of newly developed optical instrumentation in addition to the discovery of new fluorescence biomolecules have contributed to a refined management of diseases and tumors, especially in the management of upper aerodigestive tract tumors. The advancement in multispectral imaging and micro-endoscopy has also escalated the trends further in the setting of the management of this tumor, in order to gain not only the best treatment outcomes but also facilitate early tumor diagnosis. This includes the usage of autofluorescence endoscopy for screening, diagnosis and treatment of this tumor. This is crucial, as microtumoral deposit at the periphery of the gross tumor can be only assessed via an enhanced endoscopy and even more precisely with autofluorescence endoscopic techniques. Overall, with this new technique, optimum management can be achieved for these patients. Hence, the treatment outcomes can be improved and patients are able to attain better prognosis and survival.
  • Nanotechnology in relevance to dermatology: A perspective review
    Advances in Nanotechnology, 2018
  • Decoding colorectal cancer epigenomics
    Khalid El Bairi, Kanwal Tariq, Imane Himri, Abdeslam Jaafari, Wiam Smaili, et al.
    Cancer Genetics, 2018
  • The MicroRNA interaction network of lipid diseases
    Abdul H. Kandhro, Watshara Shoombuatong, Chanin Nantasenamat, Virapong Prachayasittikul, Pornlada Nuchnoi
    Frontiers in Genetics, 2017
    Background: Dyslipidemia is one of the major forms of lipid disorder, characterized by increased triglycerides (TGs), increased low-density lipoprotein-cholesterol (LDL-C), and decreased high-density lipoprotein-cholesterol (HDL-C) levels in blood. Recently, MicroRNAs (miRNAs) have been reported to involve in various biological processes; their potential usage being a biomarkers and in diagnosis of various diseases. Computational approaches including text mining have been used recently to analyze abstracts from the public databases to observe the relationships/associations between the biological molecules, miRNAs, and disease phenotypes. Materials and Methods: In the present study, significance of text mined extracted pair associations (miRNA-lipid disease) were estimated by one-sided Fisher's exact test. The top 20 significant miRNA-disease associations were visualized on Cytoscape. The CyTargetLinker plug-in tool on Cytoscape was used to extend the network and predicts new miRNA target genes. The Biological Networks Gene Ontology (BiNGO) plug-in tool on Cytoscape was used to retrieve gene ontology (GO) annotations for the targeted genes. Results: We retrieved 227 miRNA-lipid disease associations including 148 miRNAs. The top 20 significant miRNAs analysis on CyTargetLinker provides defined, predicted and validated gene targets, further targeted genes analyzed by BiNGO showed targeted genes were significantly associated with lipid, cholesterol, apolipoprotein, and fatty acids GO terms. Conclusion: We are the first to provide a reliable miRNA-lipid disease association network based on text mining. This could help future experimental studies that aim to validate predicted gene targets.
  • New bioinformatics-based discrimination formulas for differentiation of thalassemiatraits from iron deficiency anemia
    Abdul Hafeez Kandhro, Watshara Shoombuatong, Virapong Prachayasittikul, Pornlada Nuchnoi
    Lab Medicine, 2017
    Thalassemia traits (TTs) and iron deficiency anemia (IDA) are the most common disorders of hypochromic microcytic anemia (HMA). The present study aimed to differentiate TTs from IDA by analyzing discrimination formulas and provides comprehensive data of hemoglobin disorders prevalent in Pakistan. Among 12 published discrimination formulas, 6 formulas-MI, EF, G&K, RDWI, R, and HHI-were the most reliable to discriminate TTs from IDA. The failure cutoff values were improved by the random forest (RF) decision-tree approach. Moreover, the Shine and Lal (S&L) formula, which completely failed to discriminate IDA from TTs with original cutoff value (<1530), improved with the use of new proposed cutoff value (<1016) and was found to successfully discriminate all cases of TTs from those with IDA. In addition, 2 newly proposed formulas discriminated TTs from IDA more reliably than the original 12 formulas assessed. The proposed formulas could play a crucial role for clinicians to discriminate between TTs and IDA.
  • Prediction of therapy response in ovarian cancer: Where are we now?
    Khalid El Bairi, Mariam Amrani, Abdul Hafeez Kandhro, Said Afqir
    Critical Reviews in Clinical Laboratory Sciences, 2017
    Therapy resistance is a major challenge in the management of ovarian cancer (OC). Advances in detection and new technology validation have led to the emergence of biomarkers that can predict responses to available therapies. It is important to identify predictive biomarkers to select resistant and sensitive patients in order to reduce important toxicities, to reduce costs and to increase survival. The discovery of predictive and prognostic biomarkers for monitoring therapy is a developing field and provides promising perspectives in the era of personalized medicine. This review article will discuss the biology of OC with a focus on targetable pathways; current therapies; mechanisms of resistance; predictive biomarkers for chemotherapy, antiangiogenic and DNA-targeted therapies, and optimal cytoreductive surgery; and the emergence of liquid biopsy using recent studies from the Medline database and ClinicalTrials.gov.
  • Prevalence of Thalassemia Traits and Iron Deficiency Anemia in Sindh, Pakistan
    Abdul H. Kandhro, Virapong Prachayasittikul, Chartchalerm Isarankura Na-Ayudhya, Pornlada Nuchnoi
    Hemoglobin, 2017
    Among microcytic hypochromic anemias, the most common disorders are iron deficiency anemia and co-pathological conditions such as α- or β-thalassemia (α- or β-thal) traits. The aim of the present study was to determine the frequency and prevalence of iron deficiency anemia and α- or β-thal traits based on clinical laboratory data across different ethnic groups in five districts of Sindh Province, Pakistan. The present retrospective study analyzed 3 years (2012–2015) of encoded and unlinked clinical laboratory data, and identified 3030 microcytic hypochromic anemia cases. The data contained complete blood counts (CBCs) with smear morphology examinations, serum ferritin levels, and hemoglobin (Hb) electrophoreses. After reviewing the data, 994 confirmed subjects (iron deficiency anemia and α- and β-thal traits) were then selected for the present study. The prevalence of α- and β-thal traits was highest in Badin district (35.27%), while the prevalence of iron deficiency anemia was highest in Larkana district (30.73%). According to the ethnic-wise distribution, higher numbers of α- and β-thal trait cases were seen in the Sindhi ethnic group [375 (64.21%) and 283 (69.02%), respectively] than in the other ethnic groups. In addition, a higher distribution of β-thal trait cases was observed in the Sindhi ethnic group [n = 327 (56%)] in α- and β-thal cases overall. Findings from the present study strongly suggested that screening is important not only for β-thal trait but also other traits as well. However, careful monitoring of CBC parameters, including red blood cell (RBC) indices and morphology, along with clinical findings are essential to diagnose carrier cases, especially in high prevalence areas.
  • Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer
    Khalid El Bairi, Abdul Hafeez Kandhro, Adel Gouri, Wafaa Mahfoud, Noureddine Louanjli, et al.
    Cellular Oncology, 2017
  • PepBio: Predicting the bioactivity of host defense peptides
    Saw Simeon, Hao Li, Thet Su Win, Aijaz Ahmad Malik, Abdul Hafeez Kandhro, et al.
    Rsc Advances, 2017
    A large-scale QSAR study of host defense peptides sheds light on the origin of their bioactivities (antibacterial, anticancer, antiviral and antifungal).

RECENT SCHOLAR PUBLICATIONS

  • Bombardment of Mysterious Environmental Factors in Overpopulated Cities Of Pakistan: Unveiling Hidden Influences and Associated Diseases
    DAH Kandhro
    Journal of Gandhara Nursing and Allied Health Sciences (JGNAHS) 4 (1), 1-2 , 2024
    2024
  • Medical Technology Education — Current Trends and Future Perspectives
    AH Kandhro
    Annals of Jinnah Sindh Medical University (AJSMU) 9 (01), 1-2 , 2023
    2023
  • Autofluorescence Image-Guided Endoscopy in the Management of Upper Aerodigestive Tract Tumors
    NM Lazim, AH Kandhro, A Menegaldo, G Spinato, B Verro, B Abdullah
    International Journal of Environmental Research and Public Health 20 (1) , 2022
    2022
    Citations: 10
  • Screening of depression in chronic kidney disease patients undergoing haemodialysis
    SWK Muhammad Fahad, Abdul Hafeez Kandhro
    International Journal of Endorsing Health Science Research (IJEHSR) 9 (3 … , 2021
    2021
  • Lymphocytopenia in COVID-19 patients, where are we now?
    AH Kandhro, S Khatoon, DR Seelro
    Hematology & Transfusion International Journal 8 (3), 59-60 , 2020
    2020
    Citations: 1
  • Decoding colorectal cancer epigenomics. Cancer Genet 220: 49–76
    K El Bairi, K Tariq, I Himri, A Jaafari, W Smaili, AH Kandhro, A Gouri, ...
    2018
    Citations: 5
  • Chapter 3. Nanotechnology in Relevance to Dermatology: A Perspective Review
    AEM El-Kenawy, BL Tan, SMA Hassan, HS Rahman, AH Kandhro, ...
    Advances in Nanotechnology 21 , 2018
    2018
  • Resistance Patterns among Multidrug - Resistant Tuberculosis Patients: A Multi - Center Study from Pakistan
    R Batool, M Imran, AH Kandhro, Z Barry, N Salahuddin, MKH Uddin
    International Journal of Endorsing Health Science Research 5 (4), 7-11 , 2017
    2017
    Citations: 4
  • Decoding colorectal cancer epigenomics
    KE Bairi, K Tariq, I Himri, A Jaafari, W Smaili, AH Kandhro, A Gouri, ...
    Cancer Genetics , 2017
    2017
    Citations: 52
  • New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia
    AH Kandhro, W Shoombuatong, V Prachayasittikul, P Nuchnoi
    Lab Medicine 48 (3), 230-237 , 2017
    2017
    Citations: 31
  • The MicroRNA interaction network of lipid diseases
    AH Kandhro, W Shoombuatong, C Nantasenamat, V Prachayasittikul, ...
    Frontiers in Genetics , 2017
    2017
    Citations: 21
  • Prevalence of Thalassemia Traits and Iron Deficiency Anemia in Sindh, Pakistan
    AH Kandhro, V Prachayasittikul, CI Na- Ayudhya, P Nuchnoi
    Hemoglobin, 1-7 , 2017
    2017
    Citations: 15
  • PepBio: predicting the bioactivity of host defense peptides
    S Simeon, H Li, TS Win, AA Malik, AH Kandhro, T Piacham, ...
    RSC Advances, 35119-35134 , 2017
    2017
    Citations: 12
  • The Management of Glycemic Control in Associated Disorders
    M Imran, S Begum, AH Kandhro, N Ahmed, R Qasim
    International Journal of Endorsing Health Science Research 5 (2), 37-42 , 2017
    2017
    Citations: 10
  • Demographic, Dietary and Biochemical Risk Factors Associated with the causation of Goiter in Plain Areas o Sindh province
    TU Khan, F Khand, AH Kandhro, MY Memon
    Annals of LUMHS 1 (1), 5-8 , 2017
    2017
    Citations: 1
  • Prediction of therapy response in ovarian cancer: Where are we now?
    KE Bairi, M Amrani, AH Kandhro, S Afqir
    Critical Reviews in Clinical Laboratory Scinces, 1-34 , 2017
    2017
    Citations: 34
  • In Silico approach for differentiation of hypochromic microcytic anemia and dyslipidemia
    AH Kandhro
    Mahidol University. Mahidol University Library and Knowledge Center , 2017
    2017
  • Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer
    KE Bairi, AH Kandhro, A Gouri, W Mahfoud, N Louanjli, B Saadani, S Afqir, ...
    Cellular Oncology, 1-14 , 2016
    2016
    Citations: 70
  • MicroRNAs from Diagnosis to Therapy: Future Perspective
    AH Kandhro
    Translational Biomedicine 7 (4) , 2016
    2016
    Citations: 5
  • Hematological Parameters in Transgender Persons
    AH Kandhro
    Hematology & Transfusion International Journal 2 (4) , 2016
    2016
    Citations: 4

MOST CITED SCHOLAR PUBLICATIONS

  • Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer
    KE Bairi, AH Kandhro, A Gouri, W Mahfoud, N Louanjli, B Saadani, S Afqir, ...
    Cellular Oncology, 1-14 , 2016
    2016
    Citations: 70
  • Decoding colorectal cancer epigenomics
    KE Bairi, K Tariq, I Himri, A Jaafari, W Smaili, AH Kandhro, A Gouri, ...
    Cancer Genetics , 2017
    2017
    Citations: 52
  • Prediction of therapy response in ovarian cancer: Where are we now?
    KE Bairi, M Amrani, AH Kandhro, S Afqir
    Critical Reviews in Clinical Laboratory Scinces, 1-34 , 2017
    2017
    Citations: 34
  • New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia
    AH Kandhro, W Shoombuatong, V Prachayasittikul, P Nuchnoi
    Lab Medicine 48 (3), 230-237 , 2017
    2017
    Citations: 31
  • The MicroRNA interaction network of lipid diseases
    AH Kandhro, W Shoombuatong, C Nantasenamat, V Prachayasittikul, ...
    Frontiers in Genetics , 2017
    2017
    Citations: 21
  • Chapter: Elucidating the Structure-Activity Relationship of Curcumin and Its Biological Activities
    SPVP Chanin Nantasenamat, Saw Simeon, Abdul Hafeez, Veda Prachayasittikul ...
    Curcumin: Synthesis, Emerging Role in Pain Management and Health … , 2014
    2014
    Citations: 18
  • Prevalence of Thalassemia Traits and Iron Deficiency Anemia in Sindh, Pakistan
    AH Kandhro, V Prachayasittikul, CI Na- Ayudhya, P Nuchnoi
    Hemoglobin, 1-7 , 2017
    2017
    Citations: 15
  • PepBio: predicting the bioactivity of host defense peptides
    S Simeon, H Li, TS Win, AA Malik, AH Kandhro, T Piacham, ...
    RSC Advances, 35119-35134 , 2017
    2017
    Citations: 12
  • Autofluorescence Image-Guided Endoscopy in the Management of Upper Aerodigestive Tract Tumors
    NM Lazim, AH Kandhro, A Menegaldo, G Spinato, B Verro, B Abdullah
    International Journal of Environmental Research and Public Health 20 (1) , 2022
    2022
    Citations: 10
  • The Management of Glycemic Control in Associated Disorders
    M Imran, S Begum, AH Kandhro, N Ahmed, R Qasim
    International Journal of Endorsing Health Science Research 5 (2), 37-42 , 2017
    2017
    Citations: 10
  • Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications
    C Nantasenamat, S Simeon, A Hafeez, V Prachayasittikul, ...
    Curcumin: Synthesis, Emerging Role in Pain Management and Health … , 2014
    2014
    Citations: 6
  • Decoding colorectal cancer epigenomics. Cancer Genet 220: 49–76
    K El Bairi, K Tariq, I Himri, A Jaafari, W Smaili, AH Kandhro, A Gouri, ...
    2018
    Citations: 5
  • MicroRNAs from Diagnosis to Therapy: Future Perspective
    AH Kandhro
    Translational Biomedicine 7 (4) , 2016
    2016
    Citations: 5
  • Resistance Patterns among Multidrug - Resistant Tuberculosis Patients: A Multi - Center Study from Pakistan
    R Batool, M Imran, AH Kandhro, Z Barry, N Salahuddin, MKH Uddin
    International Journal of Endorsing Health Science Research 5 (4), 7-11 , 2017
    2017
    Citations: 4
  • Hematological Parameters in Transgender Persons
    AH Kandhro
    Hematology & Transfusion International Journal 2 (4) , 2016
    2016
    Citations: 4
  • Study of biochemical risk factors involved in the pathogenesis of goiter in adults in Sindh
    AH Kandhro, F Khand
    J Clin Exp Pathol 3 (138), 2161-0681.1000 , 2013
    2013
    Citations: 2
  • Lymphocytopenia in COVID-19 patients, where are we now?
    AH Kandhro, S Khatoon, DR Seelro
    Hematology & Transfusion International Journal 8 (3), 59-60 , 2020
    2020
    Citations: 1
  • Demographic, Dietary and Biochemical Risk Factors Associated with the causation of Goiter in Plain Areas o Sindh province
    TU Khan, F Khand, AH Kandhro, MY Memon
    Annals of LUMHS 1 (1), 5-8 , 2017
    2017
    Citations: 1
  • Interplay between Cholesterol, SREBPs, MicroRNA-33 in Dyslipidemia
    AH Kandhro
    International Journal of Endorsing Health Science Research (IJEHSR) 4 (2), 5-10 , 2016
    2016
    Citations: 1
  • Bombardment of Mysterious Environmental Factors in Overpopulated Cities Of Pakistan: Unveiling Hidden Influences and Associated Diseases
    DAH Kandhro
    Journal of Gandhara Nursing and Allied Health Sciences (JGNAHS) 4 (1), 1-2 , 2024
    2024

Publications

Book Chapters
1. Chanin Nantasenamat, Saw Simeon, Abdul Hafeez, Veda Prachayasittikul, Apilak Worachartcheewan, Napat Songtawee, Kakanand Srungboonmee, Chartchalerm Isarankura-Na-Ayudhya, Supaluk Prachayasittikul, Virapong Prachayasittikul: Chapter 2. Elucidating the Structure-Activity Relationship of Curcumin and Its Biological Activities. Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications, Edited by Daniel Loïc Pouliquen, 08/2014: chapter Elucidating the Structure-Activity Relationship of Curcumin and Its Biological Activities: pages 49-86; Nova Science Publishers, USA, ISBN: 978-1-63321-319-7 Google Scholar Citations 12
2. Ayman EL-Kenawy, Bee Tan, Snur Hassan, Heshu Rahman, Abdul Hafeez Kandhro, Mohd Norhaizan, and Azad Saeed, “Nanotechnology in relevance to dermatology: A Perspective review" , in Nova Science Publishers, USA, ISBN: 978-1-53613-202-1