Abdul Hafeez
@jsmu.edu.pk
Assistant Professor
Jinnah Sindh Medical University Karachi
Scopus Publications
Scholar Citations
Scholar h-index
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Scopus Publications
Norhafiza Mat Lazim, Abdul Hafeez Kandhro, Anna Menegaldo, Giacomo Spinato, Barbara Verro, and Baharudin Abdullah
MDPI AG
At this juncture, autofluorescence and narrow-band imaging have resurfaced in the medicine arena in parallel with current technology advancement. The emergence of newly developed optical instrumentation in addition to the discovery of new fluorescence biomolecules have contributed to a refined management of diseases and tumors, especially in the management of upper aerodigestive tract tumors. The advancement in multispectral imaging and micro-endoscopy has also escalated the trends further in the setting of the management of this tumor, in order to gain not only the best treatment outcomes but also facilitate early tumor diagnosis. This includes the usage of autofluorescence endoscopy for screening, diagnosis and treatment of this tumor. This is crucial, as microtumoral deposit at the periphery of the gross tumor can be only assessed via an enhanced endoscopy and even more precisely with autofluorescence endoscopic techniques. Overall, with this new technique, optimum management can be achieved for these patients. Hence, the treatment outcomes can be improved and patients are able to attain better prognosis and survival.
Khalid El Bairi, Kanwal Tariq, Imane Himri, Abdeslam Jaafari, Wiam Smaili, Abdul Hafeez Kandhro, Adel Gouri, and Bouchra Ghazi
Elsevier BV
Abdul H. Kandhro, Watshara Shoombuatong, Chanin Nantasenamat, Virapong Prachayasittikul, and Pornlada Nuchnoi
Frontiers Media SA
Background: Dyslipidemia is one of the major forms of lipid disorder, characterized by increased triglycerides (TGs), increased low-density lipoprotein-cholesterol (LDL-C), and decreased high-density lipoprotein-cholesterol (HDL-C) levels in blood. Recently, MicroRNAs (miRNAs) have been reported to involve in various biological processes; their potential usage being a biomarkers and in diagnosis of various diseases. Computational approaches including text mining have been used recently to analyze abstracts from the public databases to observe the relationships/associations between the biological molecules, miRNAs, and disease phenotypes. Materials and Methods: In the present study, significance of text mined extracted pair associations (miRNA-lipid disease) were estimated by one-sided Fisher's exact test. The top 20 significant miRNA-disease associations were visualized on Cytoscape. The CyTargetLinker plug-in tool on Cytoscape was used to extend the network and predicts new miRNA target genes. The Biological Networks Gene Ontology (BiNGO) plug-in tool on Cytoscape was used to retrieve gene ontology (GO) annotations for the targeted genes. Results: We retrieved 227 miRNA-lipid disease associations including 148 miRNAs. The top 20 significant miRNAs analysis on CyTargetLinker provides defined, predicted and validated gene targets, further targeted genes analyzed by BiNGO showed targeted genes were significantly associated with lipid, cholesterol, apolipoprotein, and fatty acids GO terms. Conclusion: We are the first to provide a reliable miRNA-lipid disease association network based on text mining. This could help future experimental studies that aim to validate predicted gene targets.
Abdul Hafeez Kandhro, Watshara Shoombuatong, Virapong Prachayasittikul, and Pornlada Nuchnoi
Oxford University Press (OUP)
Thalassemia traits (TTs) and iron deficiency anemia (IDA) are the most common disorders of hypochromic microcytic anemia (HMA). The present study aimed to differentiate TTs from IDA by analyzing discrimination formulas and provides comprehensive data of hemoglobin disorders prevalent in Pakistan. Among 12 published discrimination formulas, 6 formulas-MI, EF, G&K, RDWI, R, and HHI-were the most reliable to discriminate TTs from IDA. The failure cutoff values were improved by the random forest (RF) decision-tree approach. Moreover, the Shine and Lal (S&L) formula, which completely failed to discriminate IDA from TTs with original cutoff value (<1530), improved with the use of new proposed cutoff value (<1016) and was found to successfully discriminate all cases of TTs from those with IDA. In addition, 2 newly proposed formulas discriminated TTs from IDA more reliably than the original 12 formulas assessed. The proposed formulas could play a crucial role for clinicians to discriminate between TTs and IDA.
Khalid El Bairi, Mariam Amrani, Abdul Hafeez Kandhro, and Said Afqir
Informa UK Limited
Abstract Therapy resistance is a major challenge in the management of ovarian cancer (OC). Advances in detection and new technology validation have led to the emergence of biomarkers that can predict responses to available therapies. It is important to identify predictive biomarkers to select resistant and sensitive patients in order to reduce important toxicities, to reduce costs and to increase survival. The discovery of predictive and prognostic biomarkers for monitoring therapy is a developing field and provides promising perspectives in the era of personalized medicine. This review article will discuss the biology of OC with a focus on targetable pathways; current therapies; mechanisms of resistance; predictive biomarkers for chemotherapy, antiangiogenic and DNA-targeted therapies, and optimal cytoreductive surgery; and the emergence of liquid biopsy using recent studies from the Medline database and ClinicalTrials.gov.
Abdul H. Kandhro, Virapong Prachayasittikul, Chartchalerm Isarankura Na-Ayudhya, and Pornlada Nuchnoi
Informa UK Limited
Abstract Among microcytic hypochromic anemias, the most common disorders are iron deficiency anemia and co-pathological conditions such as α- or β-thalassemia (α- or β-thal) traits. The aim of the present study was to determine the frequency and prevalence of iron deficiency anemia and α- or β-thal traits based on clinical laboratory data across different ethnic groups in five districts of Sindh Province, Pakistan. The present retrospective study analyzed 3 years (2012–2015) of encoded and unlinked clinical laboratory data, and identified 3030 microcytic hypochromic anemia cases. The data contained complete blood counts (CBCs) with smear morphology examinations, serum ferritin levels, and hemoglobin (Hb) electrophoreses. After reviewing the data, 994 confirmed subjects (iron deficiency anemia and α- and β-thal traits) were then selected for the present study. The prevalence of α- and β-thal traits was highest in Badin district (35.27%), while the prevalence of iron deficiency anemia was highest in Larkana district (30.73%). According to the ethnic-wise distribution, higher numbers of α- and β-thal trait cases were seen in the Sindhi ethnic group [375 (64.21%) and 283 (69.02%), respectively] than in the other ethnic groups. In addition, a higher distribution of β-thal trait cases was observed in the Sindhi ethnic group [n = 327 (56%)] in α- and β-thal cases overall. Findings from the present study strongly suggested that screening is important not only for β-thal trait but also other traits as well. However, careful monitoring of CBC parameters, including red blood cell (RBC) indices and morphology, along with clinical findings are essential to diagnose carrier cases, especially in high prevalence areas.
Khalid El Bairi, Abdul Hafeez Kandhro, Adel Gouri, Wafaa Mahfoud, Noureddine Louanjli, Brahim Saadani, Said Afqir, and Mariam Amrani
Springer Science and Business Media LLC
Saw Simeon, Hao Li, Thet Su Win, Aijaz Ahmad Malik, Abdul Hafeez Kandhro, Theeraphon Piacham, Watshara Shoombuatong, Pornlada Nuchnoi, Jarl E. S. Wikberg, M. Paul Gleeson,et al.
Royal Society of Chemistry (RSC)
A large-scale QSAR study of host defense peptides sheds light on the origin of their bioactivities (antibacterial, anticancer, antiviral and antifungal).
RECENT SCHOLAR PUBLICATIONS
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1. Chanin Nantasenamat, Saw Simeon, Abdul Hafeez, Veda Prachayasittikul, Apilak Worachartcheewan, Napat Songtawee, Kakanand Srungboonmee, Chartchalerm Isarankura-Na-Ayudhya, Supaluk Prachayasittikul, Virapong Prachayasittikul: Chapter 2. Elucidating the Structure-Activity Relationship of Curcumin and Its Biological Activities. Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications, Edited by Daniel Loïc Pouliquen, 08/2014: chapter Elucidating the Structure-Activity Relationship of Curcumin and Its Biological Activities: pages 49-86; Nova Science Publishers, USA, ISBN: 978-1-63321-319-7 Google Scholar Citations 12
2. Ayman EL-Kenawy, Bee Tan, Snur Hassan, Heshu Rahman, Abdul Hafeez Kandhro, Mohd Norhaizan, and Azad Saeed, “Nanotechnology in relevance to dermatology: A Perspective review" , in Nova Science Publishers, USA, ISBN: 978-1-53613-202-1