Dr. Handayani, dr, MKes

@unusa.ac.id

Faculty of medicine
Universitas Nahdlatul Ulama Surabaya



                    

https://researchid.co/handayanikustyadji

RESEARCH INTERESTS

Pharmacology, Herbal Medicine

12

Scopus Publications

101

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Combination Bitter, Ginger, Turmeric Extract in Mice: Acute and Sub Acute Toxicity Analysis
    Handayani H, Renny Novi P, Andik Ferdiantoro, Afira Febriani S. W, Rifky Dwi Aditya Iryawan, Diaz Syafrie A., Rahadian Zainul, Arif Nur Muhammad Ansori, and Mochammad Aqilah Herdiansyah

    EManuscript Technologies

  • Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
    International Society of Communication and Development Between Universities (ISCDBU)

  • Effect of Bay Leaf (Syzygium polyanthum) Extract on Antioxidant Activity, MDA Levels, and Liver Histopathology Feature of Ethambutol Induced Wistar Rats
    Bambang Edi Suwito, Lea Maera Shanty, Retna Gumilang, Handayani Handayani, and Renata Alya Ulhaq

    Universitas Nahdlatul Ulama Surabaya
    Bay leaf extract (Syzygiun polianthum) is one herbal elemnt that may be used to lessen liver function issues, lessen symptops of nausea, vomiting, discomfort and improve adherence and the effectiveness of tuberculossi treatment. The objective of this study was to determine the effect of bay leaf (Syzygium polyanthum) extract on antioxidant activity, Malondialdehyde (MDA) levels, and liver histopathology of ethambutol-induced Wistar rats. This research is a laboratory experiment. Antioxidant activity of Bay Leaf Extract was evaluated by comparing vitamin C with spectrophotometry methods. White Wistar rats were separated into 6 groups and uset to test the lebel of MDA and livers histopathology. Group 1 serves as the control group and received DMSO (placebo); Group 2 was received ethambutol 50mg/kg BW; Group 3 was received ethambutol and silymarine with dose 50mh/kg BW. Group 4-6 had been given ethambutol and extra ethanol extract of bay leaves of 75,150, dan 300mg/kg BW, respectively. The results of the spectrophotometry showed that the Bay Leaf Extract had antioxidant activity comparable to that of vitamin C, with an IC50 of 11.4 g ± (4.4%). One-Way ANOVA test results obtained p = 0.002 (p<0.05) while the Kruskal-Wallis test results obtained the Asymp. Sig value 0.105> 0.05. There was a significance difference in each group’s MDA levels (p=0.002). Although there was no significant difference in the liver histopathology of treated rats (p>0.05). While bay leaf extract significantly lowers MDA levels in ethambutol-induced Wistar rats, it has no discernible impact on the liver histopathology of ethambutol-induced Wistar rats. Bay leaf extract possesses antioxidant activity comparable to vitamin C.

  • Impact on Medical Education and the Medical Student’s Attitude, Practice, Mental Health, After One Year of the Covid-19 Pandemic in Indonesia
    Yuda Turana, Putu Asih Primatanti, Wawang S. Sukarya, Marwito Wiyanto, Artha Budi Susila Duarsa, Raditya Wratsangka, Donna Adriani, Poppy Kristina Sasmita, Ecie Budiyanti, Dasti Anditiarina,et al.

    Frontiers Media SA
    IntroductionThe COVID-19 pandemic has caused disruptions in educational institutions across the country, prompting medical schools to adopt online learning systems. This study aims to determine impact on medical education and the medical student’s attitude, practice, mental health after 1 year of the Covid-19 pandemic in Indonesia.MethodsThis study utilized a cross-sectional design. An online questionnaire was distributed digitally to 49 medical schools in Indonesia from February–May 2021. A total of 7,949 medical students participated in this study. Sampling was carried out based on a purposive technique whose inclusion criteria were active college students. This research used questionnaires distributed in online version among 49 medical faculties that belong to The Association of Indonesian Private Medical Faculty. Instruments included demographic database, medical education status, experience with medical tele-education, ownership types of electronic devices, availability of technologies, programs of education methods, career plans, attitudes toward pandemic, and the mental health of respondents. Univariate and bivariate statistical analysis was conducted to determine the association of variables. All statistical analyses using (IBM) SPSS version 22.0.ResultsMost of the respondents were female (69.4%), the mean age was 20.9 ± 2.1 years. More than half of the respondents (58.7%) reported that they have adequate skills in using digital devices. Most of them (74%) agreed that e-learning can be implemented in Indonesia. The infrastructure aspects that require attention are Internet access and the type of supporting devices. The pandemic also has an impact on the sustainability of the education program. It was found that 28.1% were experiencing financial problems, 2.1% postponed their education due to this problems. The delay of the education process was 32.6% and 47.5% delays in the clinical education phase. Around 4% student being sick, self-isolation and taking care sick family. the pandemic was found to affect students’ interests and future career plans (34%). The majority of students (52.2%) are concerned that the pandemic will limit their opportunities to become specialists. Nearly 40% of respondents expressed anxiety symptoms about a variety of issues for several days. About a third of respondents feel sad, depressed, and hopeless for a few days.ConclusionThe infrastructure and competency of its users are required for E-learning to be successful. The majority of medical students believe that e-learning can be adopted in Indonesia and that their capacity to use electronic devices is good. However, access to the internet remains a problem. On the other side, the pandemic has disrupted the education process and mental health, with fears of being infected with SARS-CoV-2, the loss of opportunities to apply for specialty training, and the potential for increased financial difficulties among medical students. Our findings can be used to assess the current educational process in medical schools and maximize e-learning as an alternative means of preparing doctors for the future.

  • Phytochemical screening, antioxidant activity and cytotoxicity assay from noni juice and fermented noni (Morinda citrifolia L.)
    Handayani, Devyana Dyah Wulandari, and Devyani Diah Wulansari

    DiscoverSys, Inc.
    Introduction: Noni fruit is one of the plants that is often used in traditional medicine as a medicine for high blood pressure, beriberi, smooth urination, inflammation of the gallbladder, colitis, dysentery, constipation, spleen pain, liver disease, diabetes and back pain. This study aimed to analyze the content of bioactive compounds, antioxidant properties and cytotoxic activity of fermented noni juice and noni juice. Method: Identification of the content of bioactive compounds was carried out using Gas Chromatography (GC), antioxidant activity testing using the DPPH method (2,2-Diphenyl-1 picrylhydrazine) and cytotoxic testing using the Brine Shrimp Lethality Test (BSLT) method. Results: The results showed that the content of phenolic compounds contained in noni juice and fermented noni juice had strong antioxidant properties with the IC50 value for noni juice of 22.23 ppm and for fermented noni juice of 13.95 ppm. Meanwhile, the results of the cytotoxic test of noni juice and fermented noni showed that the LC50 values of 33.26 ppm and 2.25 ppm respectively. Conclusion: It can be concluded that both of these materials have high antioxidant activity and potential as anticancer.


  • Potential therapy of Sambiloto plant (Andrographis paniculata) using multi-compounds analysis
    Handayani and Wiwik Winarningsih

    Saber CDCH-UCV
    Introduction: Sambiloto plant (Andrographis paniculata) is often used as herbal medicine plant in Indonesia. Previous evidence indicates the use of a whole plant or single-compound approach. Analysis of multi-compounds is needed to determine the therapeutic potential for standardizing herbal medicine to provide a reliable effect. Methods: An exploratory study searching for the active content of A. paniculata was carried out in the Knapsack program. The chemical structure is analyzed computationally using Prediction of Activity Spectra for Substances (PASS) software. The analysis of the mechanism of action of drug molecules was analyzed using the Search Tool for Interacting Chemicals (STITCH) software. Results: The active content of A. paniculata is 46 types, with 5 of them having 6 effects based on chemical bonds and targeting 12 receptor proteins. Five active contents of A. paniculata include andrographidin A, caffeic acid, chlorogenic acid, wogonin 5-glucoside, and cinnamic acid. Analysis of the mechanism of action of A. paniculata based on 12 target proteins from active ingredients using a multi-compound approach shows 6 unique biological processes. Based on the chemical bonds, 5 active contents of A. paniculata have six effects, including anaphylatoxin receptor antagonist, a beta-adrenergic receptor kinase inhibitor, GABA C receptor agonist, G-protein-coupled receptor kinase inhibitor, Aryl hydrocarbon receptor agonist, and Nicotinic alpha6beta3beta4alpha5 receptor antagonist. Conclusion: There is a therapeutic potential of A. paniculata with multi-compounds analysis. A molecular docking analysis is needed to predict the affinity between the ligand (active ingredient) and the target protein.

  • Respiratory allergy with concentration ability in young adults
    Handayani and Evi Sylvia Awwalia

    Saber CDCH-UCV
    Introduction: Respiratory allergies prevalence in Indonesia, Asia, and the world ranges from 4-10%. Patients with respiratory allergies and other chronic respiratory diseases often experienced deterioration of productivity and concentration ability. This study aims to observe the correlation between respiratory allergy and concentration ability in adults.

  • Correlation of pre-operating antibiotic types with surgical site infection in post-appendectomy patients
    Fitria Romadoni, Handayani, and Aditya Bhayusakti

    Saber CDCH-UCV
    Introduction: Prophylactic antibiotics are antibiotics given to patients undergoing surgery to prevent infection due to surgery. Surgical site infection (SSI) is an infection that occurs when microorganisms from the skin, other body parts, or the environment enter the postoperative incision. This study aimed to analyze the relationship between preoperative antibiotics and the occurrence of SSI.

  • Analysis of self-empowerment of pregnant women during Covid-19 pandemic


  • Apoptotic effect of Physalis minima Linn ethanol extract on breast cancer cells via p53 wild-type and Apaf-1 protein
    Handayani Handayani, Retno Handajani, Imam Susilo, Achmad Basori, and Hotimah Masdan Salim

    African Journals Online (AJOL)
    Purpose: To produce an anti-cancer agent from Physalis minima ethanol extract as well as prevent the growth of NMU-induced breast cancer and MCF-7 cell line.Methods: This research used an animal model (Wistar-Furth rats), and cell line used in this study was normal breast-cell line MCF-7. The rats were administered with the ethanol extract of Physalis minima Linn (100, 250 and 400 mg/kg/day) by gavage, once a day for 4 weeks. Meanwhile, MCF-7 cell lines were cultured in medium and incubated in 100 μg/mL of ethanol extract of Physalis minima for 48 h. The samples were analyzed using histology and immunohistochemistry techniques for expression of p53 antibody DO-1 and APAF-1.Results: The results of immunohistological analysis in the breast organ showed that Physalis minima Linn extract significantly (p < 0.05) increased the tumor suppressor protein p53 at doses of 100, 250 and 400 mg/kg/day. In addition, the extract also significantly (p < 0.05) increased APAF-1, which is a gene determining cell death, at doses of 100, 200 and 400 mg/day.Conclusion: Ethanol extract of Physalis minima Linn inhibits the cytotoxic activity of NMU-induced breast cancer by increasing the tumor suppressor protein p53 and APAF-1. Thus, Physalis minima Linn extract can potentially be used as a complementary treatment for inhibiting the growth of breast cancer cells in patients.
 Keywords: Apoptosis protease-activating factor-1, Breast cancer, MCF-7 cell line, Physalis minima, p53

  • Why does de-radicalization seem a utopia? Evaluation on “children of the country” program
    Hafid Algristian, Dian Dakwatul Choiriya, Diaz Syafrie Abdillah, Athiyatul Ulya, Hafizh Auliyan Sodali, Akbar Reza Muhammad, and Handayani Handayani

    PAGEPress Publications
    Children and adolescents are groups that are vulnerable to the radicalism influence. Curiosity and trial-error behaviour make them tend to do risk-taking behaviours. If it is not accompanied by good self-control ability, it will encourage them to do actions without thinking about the impact of these actions (impulsivity). If it is not accompanied by empathy, then it tends to be behaviour that opposes and disrupts the interests of others (aggressive behaviour). This study aimed to assess the “Children of the Country” program as an effort to de-radicalize children and adolescents. Quasi experimental study was used on 30 children and adolescents in a shelter of street children in Surabaya with a pretest/ post-test design. In order to measure the outcome of the program, a Radical Personality Test (RPT) was developed using big five personality construct. The increase of nationalism and positive behaviour score is not much to compensate the increase of negative radicalism score. This evaluation brings awareness to form a novel de-radicalization strategy for children and adolescents in the future.

RECENT SCHOLAR PUBLICATIONS

  • Anti-Inflammatory Effects of the Herbal Combination SambilotoGinger-Turmeric (SIJAKUN)
    RZ Handayani Handayani1 , Ardyarini Dyah Savitri1 , Afira Febriani Surya ...
    Journal of Medicinal and chemical Sciences 7 (Journal homepage: http://www 2024

  • Combination Bitter, Ginger, Turmeric Extract in Mice: Acute and Sub Acute Toxicity Analysis
    MAH Handayani H., Renny Novi P., Andik Ferdiantoro, Afira Febriani S. W ...
    Pharmacognosy Journal, Vol 16, Issue 3, May-June, 2024 16 ( 2024 Phcogj.Com 2024

  • Archive of SID. ir
    H Handayani, AD Savitri, AFS Wijaya, H Satriawan, V Jakhmola, ...
    in vitro 26, 27 2024

  • PEMANFAATAN MINUMAN HERBAL SIJAKUN UNTUK MENINGKATKAN IMUNITAS PADA KOMUNITAS IMIGRAN DI PUSPA AGRO SIDOARJO
    H Handayani, RS Munir, RN Puspitasari, EBP Putri, BM Oktaviana, ...
    Community Development Journal: Jurnal Pengabdian Masyarakat, Lembaga 2023

  • The Relationship Of Anti-Inflammation Non Steroid Use PatternsWith Side EffectsIn Patients PostAppendectomy At JemursariIslamic Hospital
    AAA Shafira Nur Lailia1,Handayani1*, Aditya Bhayusakti1
    International Islamic Medical Journal 5 (Universitas Nahdlatul Ulama 2023

  • Hepatoprotective effect of ethanolic extract of Syzygium polyanthum in rats induced by rifampicin and isoniazid
    DDW Handayani, Renny Novi Puspitasari, Lysa Veterini
    Bali Medical Journal, http://www.balimedicaljournal.org/; DOI http://dx.doi 2023

  • Antioxidant potential effect combination of the bitter, red ginger, and turmeric extract with the DPPH method
    H Handayani, AD Savitri, RN Puspitasari, AZZA Hajiri, RDA Iryawan, ...
    Bali Medical Journal (Bali MedJ) 2022, Volume 11, Number 3: 2071-2074 P-ISSN 2022

  • The Use of Antibiotics withoutaPrescription: a Literature Review
    AFSW Arie Kusumo Dewi, Handayani H*
    International Islamic Medical Journal 4 (Universitas Nahdlatul Ulama 2022

  • Drug Interactions in Coronary Heart Disease Patients: a Literature Review
    AF Elok Tamarah, Handayani H*
    International Islamic Medical Journal DOI : 10.33086/iimj.v4i1.3855 ; https 2022

  • Effect of bay leaf (Syzygium polyanthum) extract on antioxidant activity, MDA levels, and liver histopathology feature of ethambutol induced wistar rats
    BE Suwito, LM Shanty, R Gumilang, H Handayani, RA Ulhaq
    Indonesian Journal of Medical Laboratory Science and Technology 4 (2), 148-156 2022

  • Phytochemical screening, antioxidant activity and cytotoxicity assay from noni juice and fermented noni (Morinda citrifolia L.)
    H Handayani*, DD Wulandari, DD Wulansari
    Bali Medical Journal (Bali MedJ) 11 (2022, Volume 11, Number 3: 1168-1171 2022

  • Edukasi Pembuatan Yogurt Susu Kambing Sebagai Upaya Peningkatan Minat Berwirausaha Pada Ibu PKK Kalidami, Mojo, Gubeng, Surabaya
    HH Endah Budi Permana Putri, Rizki Nurmalya Kardina, Youwan Tobing Lukiyono
    Wisanggeni: Jurnal Pengabdian Masyarakat 2 (Volume 2, Nomor 1, Juni 2022), 1-7 2022

  • Impact on Medical Education and the Medical Student’s Attitude, Practice, Mental Health, After One Year of the Covid-19 Pandemic in Indonesia
    YT all
    Frontiers in Education 7 (https://www.frontiersin.org/), 8439-98 2022

  • Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet
    M Salim, H.M. , Kurnia, L.F. , Bintarti, T.W. , Handayani, H. , Shimabukuro
    Tropical Journal of Natural Product Research 2092 (Tropical Journal of 2022

  • Community Service About the Risk of Degenerative Diseases and Infections in Aru Surabaya Student Association (HIMAS) Dorms
    R Anggraini, H H, E Setiyowati, EJ Selly, M Malae
    Journal of Health Community Service 2 (1), 1-11 2022

  • Pencegahan stunting di Kabupaten Pasuruan dengan pelatihan pengolahan ikan gabus
    H H, W Wiwik, FK Muhammad
    Journal of Dedicator Community 6 (1), 59-66 2022

  • Potential therapy of Sambiloto plant (Andrographis paniculata) using multi-compounds analysis
    WW Handayani H*
    Gaceta Mdica de Caracas 129 (2021;129(4):814-822), 814-822 2021

  • Minuman Jahe Berpengaruh terhadap Penurunan Mual dan Muntah pada Pasien Kanker Payudara yang Menjalani Kemoterapi dengan Pendekatan Comfort Theory
    FU Sri Wahyu Wilujeng, Handayani H
    Jurnal Keperawatan Stikes Kendal 13 (No 3), https://doi.org/10.32583 2021

  • Respiratory allergy, concentration ability; Krawietz concentration scale questionnaire; respiratory allergy prediction test questionnaire.
    H Handayani, ES Awwalia
    Gaceta Mdica de Caracas 129 (Gac Md Caracas 2021;129(Supl 2):S469-S4 2021

  • Correlation of pre-operating antibiotic types with surgical site infection in post-appendectomy patients
    AB Fitria Romadoni, Handayani H
    Gaceta Mdica de Caracas 129 (Md Caracas 2021;129(Supl 2):S463-S468), S463-S468 2021

MOST CITED SCHOLAR PUBLICATIONS

  • THE EFFECTS OF HIGH-FAT DIET ON HISTOLOGICAL CHANGES OF KIDNEYS IN RATS
    HH Hotimah Masdan Salim, Lintan Farizqi Kurnia, Tri Wahyu Bintarti
    Biomolecular and Health Sience Journal 2 (2), 109-112 2018
    Citations: 26

  • Impact on Medical Education and the Medical Student’s Attitude, Practice, Mental Health, After One Year of the Covid-19 Pandemic in Indonesia
    YT all
    Frontiers in Education 7 (https://www.frontiersin.org/), 8439-98 2022
    Citations: 22

  • Pencegahan stunting di Kabupaten Pasuruan dengan pelatihan pengolahan ikan gabus
    H H, W Wiwik, FK Muhammad
    Journal of Dedicator Community 6 (1), 59-66 2022
    Citations: 12

  • Apoptotic effect of Physalis minima Linn ethanol extract on breast cancer cells via p53 wild-type and Apaf-1 protein
    H Handayani, R Handajani, I Susilo, A Basori, HM Salim
    Tropical Journal of Pharmaceutical Research 19 (10), 2085-2089 2020
    Citations: 7

  • Effect of bay leaf (Syzygium polyanthum) extract on antioxidant activity, MDA levels, and liver histopathology feature of ethambutol induced wistar rats
    BE Suwito, LM Shanty, R Gumilang, H Handayani, RA Ulhaq
    Indonesian Journal of Medical Laboratory Science and Technology 4 (2), 148-156 2022
    Citations: 5

  • “PERUBAHAN KEMAMPUAN KOMUNIKASI VERBAL PASIEN STROKE ISKEMIK DENGAN DISARTRIA PASCA LSVT LOUD DI RSI JEMURSARI SURABAYA
    YK Yuliastuti, Retno Ayu, Handayani Handayani
    Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) 2 (https://doi.org 2018
    Citations: 5

  • Phytochemical screening, antioxidant activity and cytotoxicity assay from noni juice and fermented noni (Morinda citrifolia L.)
    H Handayani*, DD Wulandari, DD Wulansari
    Bali Medical Journal (Bali MedJ) 11 (2022, Volume 11, Number 3: 1168-1171 2022
    Citations: 3

  • Analisis Status Gizi Terhadap Tingkat Kelelahan Kerja Pada Pekerja Divisi Kapal Perang Pt. Pal Indonesia (Persero)
    AA Adriansyah, TA Imanniyah, H Handayani
    Medical Technology and Public Health Journal 2 (2), 101-108 2018
    Citations: 3

  • THE EFFECT OF COMBINATION SPHERICAL GRIP AND KINESIO TAPING EXERCISE TO ENHANCE OF MUSCLE STRENGTH IN ISCHEMIC STROKE PATIENTS IN JEMURSARI ISLAMIC HOSPITAL SURABAYA
    WH Qori Mariyanto, Handayani
    Jurnal Ners dan Kebidanan Indonesia 6 (DOI: http://dx.doi.org/10.21927/jnki 2018
    Citations: 3

  • TRADITIONAL TO RATIONAL AND MODERN PHYTOPHARMACA HANDAYANI
    H Handayani
    Proceeding Surabaya International Health Conference 2017 1 (1) 2017
    Citations: 3

  • SKRINING HIV PADA REMAJA DI SURABAYA DENGAN MENGGUNAKAN RAPID TEST
    MYA Thomas S, Rahayu A, Handayani Handayani
    Medical and Health Science Journal 1 (2) 2017
    Citations: 3

  • Drug Interactions in Coronary Heart Disease Patients: a Literature Review
    AF Elok Tamarah, Handayani H*
    International Islamic Medical Journal DOI : 10.33086/iimj.v4i1.3855 ; https 2022
    Citations: 1

  • Community Service About the Risk of Degenerative Diseases and Infections in Aru Surabaya Student Association (HIMAS) Dorms
    R Anggraini, H H, E Setiyowati, EJ Selly, M Malae
    Journal of Health Community Service 2 (1), 1-11 2022
    Citations: 1

  • The Effects of Turmeric Infusion and Turmeric Juice (Curcuma Domestica) on The Staphylococcus Aureus Growth in Vitro
    H Handayani, RN Puspitasari, R Sofaria
    International Islamic Medical Journal 2 (2), 54-60 2021
    Citations: 1

  • Why Does de-Radicalizayion Seem A Utopia? Evaluation on "Chlidren of The Country" Program
    H ALGRISTIAN, HANDAYANI H
    Journal of Public Health in Africa 10 (1), https://www.publichealthinafrica 2020
    Citations: 1

  • Edukasi Kebersihan Diri Dan Kesehatan Lingkungan Pada Program Kemitraan Masyarakat Pembentukan Poskestren Di Pondok Pesantren Al Hikam Bangkalan Madura
    TW Bintarti, H Handayani, RPN Budiarti
    Community Development Journal 3 (2), 89-94 2019
    Citations: 1

  • Determination of Lead Level (Pb) in Garage Worker’s Hair Using Atomic Absorption Spectroscopy (AAS)
    DD Wulandari, AYUM PUTRI, H Handayani
    Surabaya Internasional Health Conference 1 (1), 388-392 2019
    Citations: 1

  • Meningkatkan Nasionalisme dan Spiritualitas Anak Jalanan dengan Program Pembelajaran Anak Negeri
    DS Abdillah, AR Muhammad, A ULYA, HA Sodali, DD Choiriya, ...
    Jurnal Al-Insyiroh: Jurnal Studi Keislaman 2 (1) 2018
    Citations: 1

  • SKRINING MALARIA PADA REMAJA DI SURABAYA DENGAN MENGGUNAKAN METODE HAPUSAN DARAH
    MYA Firdaus ., Handayani Handayani.
    Medical and Health Science Journal 2 (1) 2018
    Citations: 1

  • HUBUNGAN POLA MAKAN DAN KEBIASAAN OLAHRAGA YANG BAIK DENGAN KADAR GULA DARAH PENDERITA DIABETES MELLITUS TIPE II DI RSI JEMURSARI Marlia Alief Rachmawati, Handayani ., Adyan
    AD Marlia Alief Rachmawati, Handayani .
    Medical and Health Science Journal 2 (1), 40-50 2018
    Citations: 1