Kayode Muiritala Salawu

@unilorin.edu.ng

Lecturer, Faculty of Pharmaceutical Sciences
University of Ilorin

https://researchid.co/kmsalawu

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacy, Cancer Research, Drug Discovery, Chemistry

Scopus Publications

132

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Isolation and Characterization of Cytotoxic Compounds from Detarium microcarpum Guill. and Perr. Stem Bark
Kayode Muritala Salawu, Omonike Oluyemisi Ogbole, Oyindamola Oduola Abiodun, and Yan Wang
Bentham Science Publishers Ltd.
Introduction: Globally, about 8.2 million cancer-related deaths are recorded annually. Sadly, most of the deaths result from the toxicity of most chemotherapeutic agents. Hence, there are growing demands for chemotherapeutic agents with high specificity and selectivity. This study was designed to assess the cytotoxic potential of Detarium microcarpum and isolate cytotoxic compounds with better selectivity profiles. Methods: Detarium microcarpum Stem bark (DMS) was collected and authenticated at the Forest Herbarium Ibadan (FHI), and a voucher (FHI-111954) was issued. Dried DMS was pulverized and extracted into 70% methanol. The extract was partitioned into hexane, dichloromethane, and ethyl acetate fractions. The cytotoxicities of the extract, fractions, and isolated compounds were determined. The cytotoxicity of the isolated compounds was tested against different cell lines, including human breast (AU565 and MDA MB231), oral adenosquamous (CAL27), and cervical (HeLa) cancer cells, as well as healthy (3T3) non-cancer cells. Results: Methyl gallate, eriodictyol, quercetin, quebrachitol, catechin, catechin gallate, and gallic acid, isolated from dichloromethane and ethyl acetate fractions, displayed weak cytotoxicity against breast (AU565 and MDAMD- 231) and cervical (HeLa) cancer cell lines. Interestingly, all the compounds, except gallic acid (48.91±4.51% inhibition), displayed potent cytotoxicity on oral cancer cells. Methyl gallate and quercetin displayed the highest activity, with IC50 values of 89.57±1.98μM and 78.19±1.49μM, respectively. Interestingly, all the compounds were not toxic to healthy non-cancer (3T3) cells. Conclusion: The compounds displayed anticancer activity specific to oral cancer cells and were highly selective for cancer cells without causing significant toxicity to healthy non-cancer cells.

A new sesquiterpene, prosoterpene, from Prosopis africana (Guill. & Perr.) Taub
Raza Ali, Kayode Muritala Salawu, Muhammad Aamer, Humera Jahan, Priya Tufail, Rimsha Irshad, Farooq-Ahmad Khan, Bilge Sener, M. Iqbal Choudhary, and Yan Wang
Informa UK Limited
A new sesquiterpene (Prosoterpene, 1) and eleven reported compounds (2-12) of several classes, such as flavonoids, alkaloids, phenolic acids, and long-chain alcohols, were isolated from the BuOH extract of Prosopis africana (Guill. & Perr.) Taub. Compounds 2-10 were reported for the first time from this plant. Isomers 11 and 12 were separated for the first time. Extensive spectroscopic techniques and literature comparisons were used to characterise their structures. Furthermore, compounds 3, 5-8, and 10-12 were performed for anti-glycation and cytotoxicity activities. Compound 3 (quercetin-3-O-α-L-rhamnoside) exhibited moderate anti-glycation activity. All tested compounds were non-cytotoxic against MCF-7 (breast cancer), NCI-H460 (lung cancer), Hela (cervical cancer), and BJ (normal human fibroblast) cell lines.

A new ent-clerodane diterpene from Detarium microcarpum Guill. & Perr. and its protective potential for osteoporosis
Rimsha Irshad, Ahmed Saeed Ali Kabbashi, Kayode Muritala Salawu, Aziz ur-Rehman, Yan-Gang Cao, Aneela Fayaz, Farooq-Ahmad Khan, Atia tul-Wahab, M. Iqbal Choudhary, and Yan Wang
Elsevier BV

Phytochemical Characterizations of Maranthes polyandra (Benth.) Prance
Nida Ali, Farooq-Ahmad Khan, Kayode Muritala Salawu, Rimsha Irshad, Almas Jabeen, Chun-Lei Zhang, Muhammad Iqbal Choudhary, Xin-Min Liu, and Yan Wang
MDPI AG
Two new ursane-type triterpenoids, named Polyanside A (1) and B (2), along with eleven known compounds (3–13), were isolated and elucidated from Maranthes polyandra (Benth.) Prance. The structures of these compounds were elucidated based on chemical evidence and multiple spectroscopic data. Isolated compounds were evaluated for anti-cancer, anti-inflammatory activities, and cytotoxicity on a normal human cell line (BJ). None of them showed activity and cytotoxicity. The hexane fraction was analyzed by GC-MS, resulting in the identification of forty-one compounds. This is the first comprehensive study on the phytochemistry of M. polyandra.

Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria
Olalere Shittu, Olufunke Adenike Opeyemi, Olumuyiwa Babagbemi Omotesho, Oluwatosin Fakayode, Nnaemeka Asogwa, Opeyemi Margaret Adeniyi, Ifeoluwa Margaret Fatoba, Kayode Muritala Salawu, Olusola Ajibaye, Olarewaju Abdulkareem Babamale,et al.
Charles University in Prague, Karolinum Press
Background: A tremendous level of success has been achieved since the introduction of chloroquine and the combination of amodiaquine and artemisinin for the treatment of both complicated and uncomplicated malaria infections in sub-Saharan Africa. However, the recent discovery of drug resistant strains of Plasmodium falciparum (P.f.) and the ability of the parasite to ingest CYP2C8 into its digestive vacuole is of great public health concern. This study probes the occurrence of CYP2C8*2 allelic mutant amongst malaria patients in North-Central Nigeria. Methods: Three hundred and eighty five (385) unrelated study participants were screened for current malaria episodes using routine microscopy and/or rapid diagnostic test strips (RDTs). Chelex extraction method was used for single nucleotide polymorphisms (SNPs) and identification of CYP2C8*2 (805A > T) variant respectively. Wild-type (A) and the defective allele (T) were differentiated with the use of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The results obtained were further validated with Sanger sequencing of a few samples and thereafter, the genotype data were statistically processed. All alleles obtained were in Hardy Weinberg equilibrium. Results: Out of the 385 participants (45.5% Male and 54.5% Female) genotyped for SNPs, 75 (19.5%) had the autosomal recessive mutant trait. Occurrence of mutant traits was gender and ethnic independent (p > 0.05). Yoruba ethnic group recorded a reduction in proportion of genotypic defective CYP2C8*2 allele (T) (1 in every 8 persons) with a carrier percentage of 13.3% compared with Hausa (26.62%); Igbo (25.37%) and other minority ethnic groups (17.6%). Conclusions: A remarkable inter-ethnic differences in autosomal recessive CYP2C8*2 allele was observed. By implication, there is a gradual incursion of genetic drift for poor CQ and AQ-Artemisinin metabolizers among the inhabitants.

Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth

Antioxidant, Brine Shrimp Lethality, and Antiproliferative Properties of Gel and Leaf Extracts of Aloe schweinfurthii and Aloe vera
Kayode Muritala Salawu, Edith Oriabure Ajaiyeoba, Omonike Oluyemisi Ogbole, Johnson Adekunle Adeniji, Temitope Cephas Faleye, and Abdulkarim Agunu
Informa UK Limited
ABSTRACT Leaf and gel extracts of Aloe schweinfurthii and A. vera were subjected to in vitro antioxidant assay using 2,2-diphennyl-1-picryl hydrazyl (DPPH), brine shrimp lethality bioassay, and cytotoxicity using the MTT assay with two human cancer cell lines: Rd and Hep-2c. Extracts of A. schweinfurthii gel had IC50 values of 44.59; A. vera gel, 41.48, and A. vera leaf, 38.84 µg.mL–1, had similar DPPH radical-scavenging properties and were more active than A. schweinfurthii leaf. Ascorbic acid had an IC50 of 9.26 ± 0.14 µg.mL–1. Aloe vera leaf (LC50 = 325 ± 5.38 µg.mL–1) was more active than the other three extracts in the BSL assay. The gel extracts of A. schweinfurthii (CC50 = 4.06 µg.mL–1on Rd and 9.00 µg.mL–1 on Hep-2c) and A. vera (CC50 = 4.31 µg.mL–1 on Rd, 9.06 µg.mL–1 on Hep-2c) elicited similar and more potent cytotoxicity comparable to cyclophosphamide, with CC50 = 2.2 µg.mL–1 on Rd and 2.66 µg.mL–1 on Hep-2c. Leaf extracts were less active than gel extracts. This study showed that A. schweinfurthii gel, A. vera gel and leaf had weak DPPH activity which were similar. Aloe vera and A. schweinfurthii did not elicit potent cytotoxicity in BSL assay. The gels from both Aloe species displayed antipoliferative activity on Rd and Hep-2c, two human cell cancer lines.

Hepatoprotective, antioxidant and phytochemical properties of leaf extracts of Newbouldia laevies

RECENT SCHOLAR PUBLICATIONS

Isolation and Characterization of Cytotoxic Compounds from Detarium microcarpum Guill. and Perr. Stem Bark
KM Salawu, OO Ogbole, OO Abiodun, Y Wang
Anti-cancer agents in medicinal chemistry 24 (17) 2024

Phytochemical and Anticonvulsant Activity of the Ethanol Root Bark Extract of Mimosa pigra L. (Fabaceae) in Laboratory Animals
M Aiyelero, O., Olatunde, K., Salawu, M., Eniayewu, O., Ojuade, F., Akinpelu ...
Nigerian Journal of Pharmaceutical Research 20 (1), 49-55 2024

A new sesquiterpene, prosoterpene, from Prosopis africana (Guill. & Perr.) Taub
R Ali, KM Salawu, M Aamer, H Jahan, P Tufail, R Irshad, FA Khan, ...
Natural Product Research 37 (19), 3220-3227 2023

African Journal of Pharmaceutical Research & Development
ELEOFA DJALONENSIS, OM AIYELERO, MA SALAHUDEEN, ...
2023

EVALUATION OF PHYTOCHEMICAL CONSTITUENTS AND ANTICONVULSANT ACTIVITY OF ETHANOL LEAF EXTRACT OF ANTHOCLEISTA DJALONENSIS (LOGANIACEAE) IN MICE
OM Aiyelero, MA Salahudeen, KM Salawu, FI Ojuade, NS Njinga, ...
Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka. 2023

A new ent-clerodane diterpene from Detarium microcarpum Guill. & Perr. and its protective potential for osteoporosis
R Irshad, ASA Kabbashi, KM Salawu, YG Cao, A Fayaz, FA Khan, ...
Fitoterapia 160, 105226 2022

Phytochemical Characterizations of Maranthes polyandra (Benth.) Prance
XMLYW Nida Ali, Farooq-Ahmad Khan, Kayode Muritala Salawu, Rimsha Irshad ...
Molecules 27 (4), 1316 2022

Evaluation of heavy metal impurities in metformin tablet brands marketed in Ilorin, Nigeria
OD Bamidelea, OI Eniayewua, AJ Adegbolab, KM Salawuc, NS Njingaa, ...
Faculty of Pharmaceutical Sciences, University of Ilorin 2022

Antiproliferative and Antimicrobial Activities of Citrus limon (L.) Burm. f. Stem Bark Extract
AAORHB K.M. Salawu
Nigerian Journal of Basic and Applied Science 29 (1), 49-54 2021

Alterations in histological, biochemical and hematological parameters in Plasmodium berghei NK-65 infected balb/c mice treated with Bridelia ferruginea stem
O Shittu, OA Opeyemi, MK Salawu, AA Ashiru, SA Medaiyese, N Asogwa, ...
Journal of Complementary and Integrative Medicine 18 (1), 93-105 2021

Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae)
NN Stanislaus, SM Ibrahim, PU Usman, HH Sa’adiya, MM Garba, ...
Pak. J. Pharm. Sci 34 (2), 629-634 2021

Ethnobotanical survey, phytochemical screening, growth inhibitory effects and cytotoxicity evaluation of medicinal plants used for cancer management in ilorin metropolis, Nigeria
KM Salawu, OO Ogbole, OO Abiodun, EO Ajaiyeoba
Archives of Basic and Applied Medicine 9 (2), 168-175 2021

Assessment of Antiviral Activity of Curcuma longa on Two RNA Viruses
KMS Juliet A. Shenge, Robert K Obi
Nigerian Journal of Pure and Applied Sciences 34 (1), 3915-3928 2021

Antibacterial screening and isolation of compounds from Detarium microcarpum stem bark against methicillin resistant Staphylococcus aureus
KM Salawu, Y Wang, R Maharjan, EO Ajaiyeoba
J. Sci. Pract. Pharm 7 (1), 400-405 2020

Clinical probe of Cyp2C8* 2 mutants in a malaria hyperendemic zone: evidence from North-Central, Nigeria
O Shittu, OA Opeyemi, OB Omotesho, O Fakayode, N Asogwa, ...
Acta Medica 63 (3), 119-123 2020

PHYTOCHEMICAL, ANTIOXIDANT, CYTOTOXICITY, ANTIPROLIFERATIVE AND ANTIMICROBIAL STUDIES OF SECURINEGA VIROSA AERIAL PARTS EXTRACT.
KM Salawu, AA Oyerinde, EO Ajaiyeoba
Journal of Pharmaceutical & Allied Sciences 17 (3) 2020

Cytotoxicity and Anti-Proliferative Studies of Crinum jagus L.(Amaryllidaceae) Bulb Extract
KM Salawu, SA Atunwa, IO ENIAYEWU
BIMA JOURNAL OF SCIENCE AND TECHNOLOGY (2536-6041) 4 (01), 131-140 2020

Phytochemical screening and in vivo antidiabetic evaluation of 1: 1 combination of the leaf extracts of Heliotropium indicum L.(Boraginaceae) and Anthocleista djalonensis A
BA Lawal, RO Ayanniyi, FI Ojuade, SO Usman, HA Olumoh-Abdul, ...
West African Journal of Pharmacy 31 (1), 16-25 2020

Growth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract
KM Salawu, AA Oyerinde, A Aliyu, OI Obajemihi
Journal of Pharmacy & Bioresources 17 (2), 174-179 2020

Phytochemical, antioxidant, brine shrimp lethality and antiproliferative analyses of Solanum dasyphyllum schum. & thonn. leaf and fruit extracts [Solanaceae]
OA Sodeinde, KM Salawu, OO Ogbole, EO Ajaiyeoba
Savannah Veterinary Journal 2 (2), 13-17 2019

MOST CITED SCHOLAR PUBLICATIONS

Antioxidant, Brine Shrimp Lethality, and Antiproliferative Properties of Gel and Leaf Extracts of Aloe schweinfurthii and Aloe vera
KM Salawu, EO Ajaiyeoba, OO Ogbole, JA Adeniji, TC Faleye, A Agunu
Journal of herbs, spices & medicinal plants 23 (4), 263-271 2017
Citations: 31

Phytochemical screening and acute toxicity studies of crude ethanolic extract and flavonoid fraction of Carissa edulis leaves
H Ibrahim, FE Williams, KM Salawu, AM Usman
Biokemistri 27 (1), 39-43 2015
Citations: 13

Safety and toxicity of aqueous leaf extracts of Camellia sinensis, Parquetina nigrescens and Telfairia occidentalis in mice
OL Olayinka, EAG Khalil, SA Atunwa, AA Abdullaahi, MK Salawu, ...
African Journal of Pharmacy and Pharmacology 12 (18), 208-220 2018
Citations: 10

Phytochemical and anti-inflammatory studies of ethanol extract of Terminalia macroptera Guill. & Perr.(Combretaceae) stem bark in rats and mice
S Usman, A Agunu, S Atunwa, S Hassan, A Sowemimo, K Salawu
Nigerian Journal of Pharmaceutical Research 13 (2), 147-156 2017
Citations: 8

Assessment of Antiviral Activity of Curcuma longa on Two RNA Viruses
KMS Juliet A. Shenge, Robert K Obi
Nigerian Journal of Pure and Applied Sciences 34 (1), 3915-3928 2021
Citations: 7

Radical scavenging and cytotoxicity evaluation of eight extracts of Citrus limon and Citrus aurantifolia
EO Ajaiyeoba, KM Salawu, OO Ogbole, JA Adeniji
Nigerian Journal of Natural Products and Medicine 20 (1), 121-127 2016
Citations: 7

Phytochemical Characterizations of Maranthes polyandra (Benth.) Prance
XMLYW Nida Ali, Farooq-Ahmad Khan, Kayode Muritala Salawu, Rimsha Irshad ...
Molecules 27 (4), 1316 2022
Citations: 6

Cytotoxicity and Anti-Proliferative Studies of Crinum jagus L.(Amaryllidaceae) Bulb Extract
KM Salawu, SA Atunwa, IO ENIAYEWU
BIMA JOURNAL OF SCIENCE AND TECHNOLOGY (2536-6041) 4 (01), 131-140 2020
Citations: 4

Response surface methodology assessment of osmotic pre-drying and convective dehydration processes on the anti-oxidant property of Hausa variety of tomato
OI OBAJEMIHI, JO OLAOYE, MS SANUSI, TD AKPENPUUN, ...
Croatian Journal of Food Science and Technology 11 (2) 2019
Citations: 4

Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth.
RO Ayanniyi, FI Ojuade, H Olumoh-Abdul, KM Salawu, H Olufadi-Ahmed, ...
Pakistan Journal of Pharmaceutical Sciences 32 2019
Citations: 4

MOLECULAR IDENTIFICATION AND ANTIMICROBIAL ACTIVITY OF ENDOPHYTIC FUNGI ASPERGILLUS TAMARII (TRICHOMACEAE)
OO Ogbole, BC Adebayo-Tayo, KM Salawu, VC Okoli
Nigerian Journal of Pharmaceutical Sciences 16 (1), 41-48 2017
Citations: 4

Phytochemical, Analgesic and Anti-inflammatory Analysis of the Ethyl acetate Fraction of Paullinia pinata Leaf L.(Sapindaceae).
OM Aiyelero, KM Salawu, AH Yaro, OJ Enape, SO Usman
Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin. 2018
Citations: 3

Antiproliferative and Antimicrobial Activities of Citrus limon (L.) Burm. f. Stem Bark Extract
AAORHB K.M. Salawu
Nigerian Journal of Basic and Applied Science 29 (1), 49-54 2021
Citations: 2

Clinical probe of Cyp2C8* 2 mutants in a malaria hyperendemic zone: evidence from North-Central, Nigeria
O Shittu, OA Opeyemi, OB Omotesho, O Fakayode, N Asogwa, ...
Acta Medica 63 (3), 119-123 2020
Citations: 2