Lazaro Hiram Betancourt Nunez

RESEARCH, TEACHING, or OTHER INTERESTS

Cancer Research, Molecular Medicine, Multidisciplinary, Biotechnology

RECENT SCHOLAR PUBLICATIONS

Proteogenomic Profiling of Treatment-Nave Metastatic Malignant Melanoma
M Kuras, LH Betancourt, R Hong, L Szadai, J Rodriguez, P Horvatovich, ...
Cancers 17 (5), 832 2025



Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes
I Pla, BL Szabolcs, PN Pter, Z Ujfaludi, Y Kim, P Horvatovich, A Sanchez, ...
International journal of dermatology 2024



In Vivo Photopolymerization: Achieving Detailed Conducting Patterns for Bioelectronics
F Ek, T Abrahamsson, M Savvakis, S Bormann, AH Mousa, MA Shameem, ...
Advanced Science 11 (48), 2408628 2024



Proteogenomics reveals varying levels of intra-patient heterogeneity in melanoma metastases
B Szeitz, Y Hagemeijer, Z Pahi, Z Ujfaludi, V Doma, J Gil, R Appelqvist, ...
VIRCHOWS ARCHIV 485, S430-S430 2024



Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts
L Szadai, A Bartha, IP Parada, AIT Lakatos, DMP Pl, AS Lengyel, ...
Frontiers in Oncology 14, 1428182 2024



Mitochondrial dysfunction and immune suppression in BRAF V600E‐mutated metastatic melanoma
N Pinto de Almeida, J Jnosi, R Hong, A Rajeh, F Nogueira, L Szadai, ...
Clinical and Translational Medicine 14 (7), e1773 2024



Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction
I Pla, BL Szabolcs, PN Pter, Z Ujfaludi, Y Kim, P Horvatovich, A Sanchez, ...
bioRxiv, 2024.02. 08.579424 2024



A time-efficient workflow to purify a library of alanine mutants of surface-exposed residues of the domain III of the envelope protein of dengue virus serotype 1.
MD AM, LG Gonzlez-Lodeiro, C Gonzlez, L Betancourt
Micropublication Biology 2023 2023



A time-efficient workflow to purify a library of alanine mutants of surface-exposed residues of the domain III of the envelope protein of dengue virus serotype 1
DM Prieto, AMM Dunn, AE Llumbet, LG Gonzlez-Lodeiro, MS Nez, ...
microPublication Biology 2023, 10.17912/micropub. biology. 001012 2023



Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases
M Kuras, LH Betancourt, R Hong, L Szadai, J Rodriguez, P Horvatovich, ...
bioRxiv, 2023.09. 29.559755 2023



Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma
J Gil, Y Kim, V Doma, U akır, M Kuras, LH Betancourt, IP Parada, ...
bioRxiv, 2022.10. 24.513481 2022



Method Matters: Exploring Alkoxysulfonate-Functionalized Poly(3,4-ethylenedioxythiophene) and Its Unintentional Self-Aggregating Copolymer toward Injectable Bioelectronics
RO Abdelrazek H Mousa, David Bliman, Lazaro Hiram Betancourt, Karin Hellman ...
Chem Mater. 34 (6), 2752-2763 2022



Mapping the melanoma plasma proteome (MPP) using single-shot proteomics interfaced with the WiMT database
N Almeida, J Rodriguez, I Pla Parada, Y Perez-Riverol, N Woldmar, Y Kim, ...
Cancers 13 (24), 6224 2021



Deep proteomic analysis on biobanked paraffine-archived melanoma with prognostic/predictive biomarker read-out
L Szadai, E Velasquez, B Szeitz, NP Almeida, G Domont, LH Betancourt, ...
Cancers 13 (23), 6105 2021



A biobanking turning‐point in the use of formalin‐fixed, paraffin tumor blocks to unveil kinase signaling in melanoma
E Velasquez, L Szadai, Q Zhou, Y Kim, I Pla, A Sanchez, R Appelqvist, ...
Clinical and Translational Medicine 11 (8), e466 2021



The Human Melanoma Proteome Atlas—Complementing the melanoma transcriptome
K Pawłowski, P Horvath, J Tmr, BS Knudsen, T Miliotis, H Lindberg, ...
Clinical and Translational Medicine 11 2021



The human melanoma proteome atlas—Complementing the melanoma transcriptome
LH Betancourt, J Gil, A Sanchez, V Doma, M Kuras, JR Murillo, ...
Clinical and Translational Medicine 11 (7), e451 2021



The human melanoma proteome atlas—Defining the molecular pathology
LH Betancourt, J Gil, Y Kim, V Doma, U akır, A Sanchez, JR Murillo, ...
Clinical and Translational Medicine 11 (7), e473 2021



Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion
J Gil, Y Kim, B Szeitz, V Doma, U akır, NP de Almeida, YP Hagemeijer, ...
bioRxiv, 2021.04. 10.439245 2021



Mapping the melanoma plasma proteome (MPP) using single-shot proteomics interfaced with the WiMT database. Cancers 2021 13 6224
N Almeida, J Rodriguez, I Pla Parada, Y Perez-Riverol, N Woldmar, Y Kim, ...
s Note: MDPI stays neutral with regard to jurisdictional claims in published 2021

MOST CITED SCHOLAR PUBLICATIONS

Activation of Rho through a cross‐link with polyamines catalyzed by Bordetella dermonecrotizing toxin
M Masuda, L Betancourt, T Matsuzawa, T Kashimoto, T Takao, ...
The EMBO Journal 2000
Citations: 138



CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo
SE Perea, O Reyes, I Baladron, Y Perera, H Farina, J Gil, A Rodriguez, ...
Molecular and cellular biochemistry 316, 163-167 2008
Citations: 125



Primary structure of two cytolysin isoforms from Stichodactyla helianthus differing in their hemolytic activity.
V Huerta, V Morera, Y Guanche, G Chinea, LJ Gonzlez, L Betancourt, ...
Toxicon 39 (8), 1253-1256 2001
Citations: 95



Differentiating α‐and β‐aspartic acids by electrospray ionization and low‐energy tandem mass spectrometry
LJ Gonzlez, T Shimizu, Y Satomi, L Betancourt, V Besada, G Padrn, ...
Rapid Communications in Mass Spectrometry 14 (22), 2092-2102 2000
Citations: 95



Automated interpretation of low‐energy collision‐induced dissociation spectra by SeqMS, a software aid for de novo sequencing by tandem mass spectrometry
J Fernandez‐de‐Cossio, J Gonzalez, Y Satomi, T Shima, N Okumura, ...
ELECTROPHORESIS: An International Journal 21 (9), 1694-1699 2000
Citations: 93



Outer membrane vesicles of the VA‐MENGOC‐BC vaccine against serogroup B of Neisseria meningitidis: Analysis of protein components by two‐dimensional
L Uli, L Castellanos‐Serra, L Betancourt, F Domnguez, R Barber, ...
Proteomics 6 (11), 3389-3399 2006
Citations: 87



A novel fusion protein domain III-capsid from dengue-2, in a highly aggregated form, induces a functional immune response and protection in mice
I Valds, L Bernardo, L Gil, A Pavn, L Lazo, C Lpez, Y Romero, ...
Virology 394 (2), 249-258 2009
Citations: 86



Automated interpretation of high‐energy collision‐induced dissociation spectra of singly protonated peptides by ‘seqms', a software aid for de novo sequencing by
J Fernandez‐de‐Cossio, J Gonzalez, L Betancourt, V Besada, G Padron, ...
Rapid communications in mass spectrometry 12 (23), 1867-1878 1998
Citations: 68



Proteome analysis of Leishmania (Viannia) braziliensis by two-dimensional gel electrophoresis and mass spectrometry
P Cuervo, JB de Jesus, M Junqueira, L Mendona-Lima, LJ Gonzlez, ...
Molecular and biochemical parasitology 154 (1), 6-21 2007
Citations: 62



CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research
SE Perea, I Baladron, Y Garcia, Y Perera, A Lopez, JL Soriano, N Batista, ...
Molecular and cellular biochemistry 356, 45-50 2011
Citations: 54



Quantitative assessment of urea in-solution Lys-C/trypsin digestions reveals superior performance at room temperature over traditional proteolysis at 37 C
LH Betancourt, A Sanchez, I Pla, M Kuras, Q Zhou, R Andersson, ...
Journal of proteome research 17 (7), 2556-2561 2018
Citations: 53



Automated interpretation of mass spectra of complex mixtures by matching of isotope peak distributions
J Fernndez‐de‐Cossio, LJ Gonzalez, Y Satomi, L Betancourt, Y Ramos, ...
Rapid Communications in Mass Spectrometry 18 (20), 2465-2472 2004
Citations: 48



Isoelectric point optimization using peptide descriptors and support vector machines
Y Perez-Riverol, E Audain, A Millan, Y Ramos, A Sanchez, JA Vizcano, ...
Journal of proteomics 75 (7), 2269-2274 2012
Citations: 46



Isotopica: a tool for the calculation and viewing of complex isotopic envelopes
J Fernandez-de-Cossio, LJ Gonzalez, Y Satomi, L Betancourt, Y Ramos, ...
Nucleic acids research 32 (suppl_2), W674-W678 2004
Citations: 43



Clinical protein science in translational medicine targeting malignant melanoma
J Gil, LH Betancourt, I Pla, A Sanchez, R Appelqvist, T Miliotis, M Kuras, ...
Cell biology and toxicology 35, 293-332 2019
Citations: 40



Levansucrase from Acetobacter diazotrophicus SRT4 Is Secreted via Periplasm by a Signal-Peptide-Dependent Pathway
L Hernndez, J Arrieta, L Betancourt, V Falcn, J Madrazo, A Coego, ...
Current microbiology 39, 146-152 1999
Citations: 40



Identification of vimentin as a potential therapeutic target against HIV infection
C Fernndez-Ortega, A Ramrez, D Casillas, T Paneque, R Ubieta, ...
Viruses 8 (6), 98 2016
Citations: 39



In silico analysis of accurate proteomics, complemented by selective isolation of peptides
Y Perez-Riverol, A Snchez, Y Ramos, A Schmidt, M Mller, L Betancourt, ...
Journal of proteomics 74 (10), 2071-2082 2011
Citations: 38



Development and validation of a bioanalytical LC–MS method for the quantification of GHRP-6 in human plasma
J Gil, A Cabrales, O Reyes, V Morera, L Betancourt, A Snchez, G Garca, ...
Journal of pharmaceutical and biomedical analysis 60, 19-25 2012
Citations: 34



SCX charge state selective separation of tryptic peptides combined with 2D-RP-HPLC allows for detailed proteome mapping
LH Betancourt, PJ De Bock, A Staes, E Timmerman, Y Perez-Riverol, ...
Journal of proteomics 91, 164-171 2013
Citations: 33