Phytochemical characterisation, antioxidant and anti-microbial efficacy of allspice Pimenta dioica K. Nagalakshmi, R Monica Angeline, G. Sriram Prasath Research Journal of Pharmacy and Technology, 2023 Pimenta dioica (L.) Merr (also known as Pimenta Officinalis) belongs to the family Myrtaceae is globally as valuable spices. This is commonly known as allspice, Jamaica pepper and Pimento. This spice possesses the characteristic flavor and aroma of clove, nutmeg, cinnamon and black pepper, all combined in this one spice, hence named allspice. Allspice is used for treating indigestion which might be due to the abundance of the common polyphenol Eugenol , known to stimulate digestive enzymes. The present study was aimed in analysing the bioactive compounds present in P.diocia. Additionally, the antibacterial efficacy of P.diocia was determined. GC-MS Pattern of the ethanolic extract confirms the presence of eugenol a potent bioactive compound and qualitative analysis revealed the presence of various phytoconstituents. The ethanolic extract of plant proved to have anti-microbial effect on disease causing microbes such as Pseudomonas aeruginosa ,Bacillus anthracis, Klebsiella pneumoniae and Streptococcus pneumoniae with MIC of 5mg of the ethanolic extract which may be due to the different phytocontituents in the plant extract and partly due to eugenol a potent anti-microbial compound. The results of the present study indicate that Pimenta dioica is a good source of bioactive compounds and possess antibacterial activity which might be due to presence of eugenol.
Targeting nuclear factor kappa b with chelated zinc compounds towards anticancer drug design NAGALAKSHMI K., SHILA S., INBATHAMIZH L., THENMOZHI A., RASAPPAN P., et al. International Journal of Applied Pharmaceutics, 2021 Objective: The objective of the study was to analyse the target-ligand interactions between nuclear factor-κB (NF-κB) and chelated Zinc compounds and to explore the anticancer drug potential of these ligands by a bio computational approach.
 Methods: Bioinformatics databases and tools were applied for the study. Three dimensional structure of the target NF-κB was retrieved from Protein Data Bank (PDB). The optimized structures of two chelated Zinc compounds, Zinc acetate and Zinc orotate were taken for docking studies with the target using docking tool AutoDock 4.2. Drug properties of the ligands were further assessed by Molinspiration server.
 Results: Docking results as predicted by AutoDock and as visualized by PyMol viewer were effective for both the ligands. Comparatively, Zinc orotate showed minimum energy and more interactions with the target. Both the ligands satisfied the Lipinski’s rule of five with zero violations.
 Conclusion: The findings emphasized the promising role of chelated Zinc compounds as potent drug candidates in anti-cancer drug design against NF-κB.
Biochemical characterization, clinical diagnosis and hepatic complication of weil's disease and other co-infections Asian Journal of Pharmaceutical and Clinical Research, 2012
