Parthiban S

@tanuvas.ac.in

Assistant profesoor
Tamil Nadu Veterinary and Animal Sciences University



              

https://researchid.co/parthis17

EDUCATION

MVSc, PhD

RESEARCH INTERESTS

Virology, Cell culture, Immunology and Molecular biology

FUTURE PROJECTS

Molecular Virology

Animal viral diseases


Applications Invited
Collaborators
18

Scopus Publications

221

Scholar Citations

7

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Complete genome sequence and phylogenetic analysis of feline panleukopenia virus from India
    P. Raja, K. Sorna Mallika, V. Yuvachandran Viva, M. Parthiban, G. Sathish, V. Vinitha, S. Parthiban, and G. Dhinakar Raj

    Springer Science and Business Media LLC

  • Evaluation of Natural Antimicrobial Substances Blend as a Replacement for Antibiotic Growth Promoters in Broiler Chickens: Enhancing Growth and Managing Intestinal Bacterial Diseases
    Duraisamy Thirumeignanam, Mahalingam Chellapandian, Natarajan Arulnathan, Sivamurthy Parthiban, Veluchamy Kumar, M. Panchatcharam Vijayakumar, and Sunil Chauhan

    Springer Science and Business Media LLC

  • Molecular Analysis of Classical Swine Fever Virus Associated Field Infections Evidence Novel CSFV Sub Genotype in Tamil Nadu, Southern India
    S. Parthiban, B. Kowsalya, M. Parthiban, A. Ramesh, P. Raja, K. Gopal, S. Jaisree, R. Thangathurai, and K. Senthilkumar

    Springer Science and Business Media LLC

  • Pros and Cons on Use of Live Viral Vaccines in Commercial Chicken Flocks
    Kannan Ganapathy and Sivamurthy Parthiban

    American Association of Avian Pathologists (AAAP)
    The poultry industry is the largest source of meat and eggs for the growing human population worldwide. Key concerns in poultry farming are nutrition, management, flock health, and biosecurity measures. As part of the flock health, use of live viral vaccines plays a vital role in the prevention of economically important and common viral diseases. This includes diseases and production losses caused by Newcastle disease virus, infectious bronchitis virus, infectious laryngotracheitis virus, infectious bursal disease virus, Marek's disease virus, chicken infectious anemia virus, avian encephalomyelitis virus, fowlpox virus, and avian metapneumovirus. These viruses cause direct and indirect harms, such as financial losses worth millions of dollars, loss of protein sources, and threats to animal welfare. Flock losses vary by type of poultry, age of affected animals, co-infections, immune status, and environmental factors. Losses in broiler birds can consist of high mortality, poor body weight gain, high feed conversion ratio, and increased carcass condemnation. In commercial layers and breeder flocks, losses include higher than normal mortality rate, poor flock uniformity, drops in egg production and quality, poor hatchability, and poor day-old-chick quality. Despite the emergence of technology-based vaccines, such as inactivated, subunit, vector-based, DNA or RNA, and others, the attenuated live vaccines remain as important as before. Live vaccines are preferred in the global veterinary vaccine market, accounting for 24.3% of the global market share in 2022. The remaining 75% includes inactivated, DNA, subunit, conjugate, recombinant, and toxoid vaccines. The main reason for this is that live vaccines can induce innate, mucosal, cellular, and humoral immunities by single or multiple applications. Some live vaccine combinations provide higher and broader protection against several diseases or strains of viruses. This review aimed to explore insights on the pros and cons of attenuated live vaccines commonly used against major viral infections of the global chicken industry, and the future road map for improvement.


  • Tackling African swine fever in India
    S. Parthiban, P. Raja, M. Parthiban, and C. Yamini

    CABI Publishing
    Abstract Globally, African swine fever (ASF) is the most feared swine viral disease, associated with a mortality rate of up to 100%. More than half of the world’s swine population is located in Asia. ASF outbreaks in Asia have a significant impact on the global pig industry. Pig industry’s economic losses have been huge because of ASF outbreaks. Swine husbandry in India is in a flourishing phase to meet food security demands, but the losses associated with ASF greatly hamper its expansion. ASF in India can be controlled and eradicated through strict biosecurity measures and vaccination. Development of penside point-of-care (POC) rapid diagnostics and effective indigenous vaccines are prerequisites to tackle ASF in India. Sensitization of veterinary professionals, researchers, and pig farmers about disease pathogenesis, transmission, and impact are crucial part of ASF control. This review presents the status of ASF in India in comparison to other parts of the world, and current approaches in India to deal with ASF. Further roadmap to combat this calamitous swine infection in India.

  • MOLECULAR DETECTION AND DIFFERENTIATION OF MYCOPLASMA SPECIES IN SWINE LUNG TISSUES
    Thahira parveen S, Parthiban S, Raja P, Parthiban M, and Dhinakar Raj G

    Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association

  • Isolation and genetic analysis of Porcine circovirus 2 in southern India evidences high circulation of Porcine circovirus 2d genotype
    S. Parthiban, A. Ramesh, Anbu Kumar Karuppannan, G. Dhinakar Raj, S. Hemalatha, M. Parthiban, K. Senthilkumar, D. Balasubramaniyam, R. Sumanth Kumar, S. Ranganatha,et al.

    Springer Science and Business Media LLC

  • Molecular evidence of porcine circovirus 3 infection in swine: first report in southern India
    S. Parthiban, A. Ramesh, G. Dhinakar Raj, Anbu Kumar Karuppannan, S. Hemalatha, M. Parthiban, Chintu Ravishankar, K. Senthilkumar, and D. Balasubramaniyam

    Springer Science and Business Media LLC

  • Emergence of novel Porcine circovirus 2 genotypes in Southern India
    Parthiban S, Ramesh A, Anbu Kumar Karuppannan, Dhinakar Raj G, Johnson Rajeswar J, Hemalatha S, Jaisree S, Senthilkumar K, Balasubramanyam D, Parthiban M,et al.

    Wiley
    A total of 200 samples from Porcine circovirus 2 suspected (n=112) and healthy (n=88) swine populations collected from different districts of Tamil Nadu, south India were used in this study. The samples comprising of serum (n=124), swabs from natural orifices (n=52), and postmortem tissues (n=24). All the samples were processed and subjected to the screening and detection of the PCV2 genome by a specific PCR assay. PCV2 genomes from positive samples were further subjected to genotyping with specifically designed primers for the full-length amplification of the ORF2 gene which codes for capsid protein (Cp) and serves as an epidemiological marker. Randomly, thirteen amplified ORF2 genes were sequenced and the aligned sequences were subjected to signature motif analysis and phylogeny in MEGA X. The molecular prevalence of PCV2 infection in Tamil Nadu is 10.5% (n=21). Signature motif and phylogenetic studies of 13 samples revealed 38.5% (n=5) presence of each PCV2b intermediate 1(IM1) and PCV2b genotypes, followed by 15.4% (n=2) PCV2d-2 and 7.7% (n=1) PCV2d genotypes. The PCV2b-IM1 genotype has a 99.43% sequence homology with Vietnam isolate (GenBank Accession No. JX506730). PCV2b genotypes showed 99.72% sequence identity with Chinese isolate (KX068219). PCV2d-2 genotypes reported in this study has 100% sequence identity with Taiwan isolate (MF169721). PCV2d genotype showed 97.87% sequence identity with Thailand isolate (MF314293). Amino acid analysis of all the 13 full-lengths ORF2 gene sequences revealed specific mutations in the immune reactive domains of A, B, C, and D. Capsid protein of three PCV2b and five PCV2b IM1 isolates had extra amino acid residue lysine (K) at 234 position of ORF2 similar to PCV2d. For the first time in south India, PCV2b IM1 and PCV2d-2 genotypes are reported. This study evidences the genetic shifts of PCV2 isolates in India and it is analogs to that of global genotypic shift.

  • MOLECULAR PREVALENCE OF PORCINE CIRCOVIRUS 2 INFECTION: FOREMOST REPORT IN SOUTHERN STATES OF INDIA
    Parthiban S, Ramesh A, Anbu Kumar Karuppannan, Dhinakar Raj G, Hemalatha S, John Kirubaharan J, Parthiban M, Senthilkumar K, Balasubramanyam D, Sumanth Kumar R,et al.

    Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association
    : Porcine circovirus 2 (PCV2) is the emerging viral pathogen in the swine associated with multi-systemic clinical and subclinical outcomes. This study aimed to detect molecular and serological prevalence of PCV2 infection from southern states of India. A total of 434 random samples comprising of serum (n=273), pooled postmortem tissues (n=109) and rectal, vaginal and nasal swabs (n=52) and were collected from PCV2 suspected and healthy swine populations of Tamil Nadu, Kerala, Andhra Pradesh, Telangana and Puducherry states in India during 2019 to 2021 were screened for PCV2 by specific polymerase chain reaction (PCR) assay. Of 434 samples screened, 12.2% (n=53) showed positivity to PCV2 genome. Statistical analysis of molecular prevalence of PCV2 within breed, age, sex and vaccination status revealed no significant (p>0.05) difference but there was a significant (p<0.05) difference in the prevalence of PCV2 among healthy and suspected swine populations. Suspected pigs had significantly higher prevalence of PCV2 in comparison to healthy. ELISA based PCV2 antibody screening in 176 non-vaccinated serum samples revealed sero-positivity of 44.8% (n=79). The molecular and seroprevalence of PCV2 is alarming in southern states of India, which necessitates the need for genotypic characterization and phylogenetic analysis and development of candidate vaccine for implementation of suitable prevention and control measures.

  • PATHOTYPING OF NEWCASTLE DISEASE VIRUS BY MEAN DEATH TIME AND REAL-TIME PCR ASSAY: AN EMPIRICAL COMPARISON
    S. Parthiban, J. John Kirubaharan, A. Ramesh, M. Vidhya, S. Rajalakshmi, Ranjani Rajasekaran, and A. Thangavelu

    Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association
    : Newcastle disease (ND) remains the most significant disease of poultry sector and contributes to huge economic loss. Early detection and pathotyping of Newcastle disease virus associated with field infection are highly crucial. In vivo pathogenicity assaying is sensitive and specific pathotyping tool used for detection and identification of NDV used until the recent past. Genome based sequence analysis yields promising results in virulence determination. Keeping the above facts, the present study was designed to compare the efficacy of conventional and molecular assays in NDV virulence determination. In this study twelve NDV isolates (Isolate numbers 463, 464, 475, 476, 122-17C, 122-17D, 122-17E, 128-17A, 128-17D, 137, 139, 141) available in the Department of Veterinary Microbiology, Madras Veterinary College (MVC), Chennai was subjected for differentiation of virulent and avirulent strains using mean death time (MDT) in specific pathogen-free (SPF) embryonated eggs and TaqMan minor groove binding (MGB) probe real-time PCR assay. Pathotyping based on the MDT revealed two NDV isolates (isolate no. 476 and 128-17D) as velogenic strains and the remaining ten NDV isolates as lentogenic strains. Pathotyping based on TaqMan MGB probe real-time PCR assay revealed six NDV isolates (476, 128-17D, 463, 464, 475, 137) as velogenic/mesogenic strains and remaining six NDV isolates (122-17C, 122-17D, 122-17E 128-17A, 139, 141) as lentogenic strains. Using a TaqMan MGB probe real-time PCR assay, four NDV isolates (463, 464, 475, 137) which were MDT pathotyped as lentogenic strains were re-pathotyped as velogenic/mesogenic strains, which indicates the greater sensitivity of TaqMan MGB probe real-time PCR assay in pathotyping of NDV over conventional MDT.

  • Molecular detection of porcine parvovirus 1–associated reproductive failure in southern India
    S. Parthiban, R. K. V. Sowndhraya, P. Raja, M. Parthiban, A. Ramesh, G. Dhinakar Raj, K. Senthilkumar, D. Balasubramanyam, S. Hemalatha, R. Bharathi,et al.

    Springer Science and Business Media LLC

  • Serum based screening and molecular detection of brucellosis in ruminants


  • Hematological and therapeutic aspects of canine parvovirus infection in non descript pups


  • Canine Parvovirus


  • Isolation and Typing of Canine Parvovirus in CRFK Cell Line in Puducherry, South India
    S. Parthiban, Hirak Kumar Mukhopadhyay, D. Panneer, P. X. Antony, and R. M. Pillai

    Springer Science and Business Media LLC

  • Molecular typing of canine parvovirus occurring in pondicherry by multiplex PCR and PCR-RFLP
    S. Parthiban, H. K. Mukhopadhyay, P. X. Antony, and R. M. Pillai

    Springer Science and Business Media LLC

RECENT SCHOLAR PUBLICATIONS

  • Molecular Analysis of Classical Swine Fever Virus Associated Field Infections Evidence Novel CSFV Sub Genotype in Tamil Nadu, Southern India
    S Parthiban, B Kowsalya, M Parthiban, A Ramesh, P Raja, K Gopal, ...
    Indian Journal of Microbiology 64 (3), 1347-1354 2024

  • Formulation and Evaluation of Drumstick Leaves Tablet as An Immunomodulator
    VR Ravikkumar, BD Patel, S Rathi, S Parthiban, MC Upadhye, AM Shah, ...
    Chinese Journal of Applied Physiology, e20240004 2024

  • Complete genome sequence and phylogenetic analysis of feline panleukopenia virus from India
    P Raja, KS Mallika, VY Viva, M Parthiban, G Sathish, V Vinitha, ...
    VirusDisease 35 (1), 34-40 2024

  • Evaluation of natural antimicrobial substances blend as a replacement for antibiotic growth promoters in broiler chickens: Enhancing growth and managing intestinal bacterial
    D Thirumeignanam, M Chellapandian, N Arulnathan, S Parthiban, ...
    Current Microbiology 81 (2), 55 2024

  • Detection of dermatophytes through multiplex PCR and loop-mediated isothermal amplification (LAMP)
    AP Surendar, M Vijayabharathi, NR Senthil, S Sureshkannan, S Parthiban
    2024

  • Isolation and identification of dermatophytes from dogs and cats in Chennai by conventional and UniPlex PCR assay
    AP Surendar, M Vijayabharathi, NR Senthil, S Sureshkannan, S Parthiban
    2024

  • Pros and Cons on Use of Live Viral Vaccines in Commercial Chicken Flocks
    K Ganapathy, S Parthiban
    Avian Diseases 67 (4), 410-420 2024

  • Tackling African swine fever in India
    S Parthiban, P Raja, M Parthiban, C Yamini
    CABI Reviews 2023

  • Evaluation of protection and immunity induced by infectious bronchitis vaccines administered by oculonasal, spray or gel routes in commercial broiler chicks
    M Al-Rasheed, C Ball, S Parthiban, K Ganapathy
    Vaccine 41 (31), 4508-4524 2023

  • Genomic Sequence and Phylogenetic Analysis of Canine Parvovirus New 2a Variant Strain in Indian Dogs
    YV Vimalan, R Paramasivam, P Manoharan, MP Ramalingam, ...
    Indian Journal of Veterinary Sciences and Biotechnology 19 (2), 47-53 2023

  • MOLECULAR DETECTION AND DIFFERENTIATION OF MYCOPLASMA SPECIES IN SWINE LUNG TISSUES
    S Parthiban, P Raja, M Parthiban
    Exploratory Animal and Medical Research 13 (1), 98-104 2023

  • Isolation and genetic analysis of Porcine circovirus 2 in southern India evidences high circulation of Porcine circovirus 2d genotype
    S Parthiban, A Ramesh, AK Karuppannan, G Dhinakar Raj, S Hemalatha, ...
    Molecular Biology Reports 49 (12), 11829-11846 2022

  • Molecular evidence of porcine circovirus 3 infection in swine: first report in southern India
    S Parthiban, A Ramesh, G Dhinakar Raj, AK Karuppannan, S Hemalatha, ...
    VirusDisease 33 (3), 284-290 2022

  • Molecular detection of porcine parvovirus 1–associated reproductive failure in southern India
    S Parthiban, RKV Sowndhraya, P Raja, M Parthiban, A Ramesh, GD Raj, ...
    Tropical Animal Health and Production 54 (3), 195 2022

  • Prevalence of canine enteritis parvovirus by hemagglutination and PCR tests.
    S Parthiban, HK Mukhopadhyay, K Ravikumar, PX Antony, RM Pillai
    2022

  • Molecular prevalence of Porcine circovirus 2 infection: foremost report in southern states of India.
    S Parthiban, A Ramesh, AK Karuppannan, RG Dhinakar, S Hemalatha, ...
    2022

  • MOLECULAR CHARACTERIZATION OF CIRCULATING PORCINE CIRCOVIRUS 2 (PCV2) AND DEVELOPMENT OF INACTIVATED VACCINE
    S Parthiban
    2022

  • Transboundary Swine Infections in India: An Overview
    S Parthiban, A Ramesh, AK Karuppannan, P Raja, M Parthiban, GD Raj
    Society for Immunology and Immunopathology 24 (1), 1-8 2022

  • Pathotyping of Newcastle disease virus by mean death time and real-time PCR assay: an empirical comparison.
    S Parthiban, JJ Kirubaharan, A Ramesh, M Vidhya, S Rajalakshmi, ...
    2022

  • Incidence of canine parvovirus by hemagglutination, hemagglutination inhibition and PCR tests.
    S Parthiban, HK Mukhopadhyay, K Ravikumar, PX Antony, RM Pillai
    2021

MOST CITED SCHOLAR PUBLICATIONS

  • Review on emerging and reemerging microbial causes in bovine abortion
    S Parthiban, S Malmarugan, MS Murugan, J Rajeswar, P Pothiappan
    International Journal of Nutrition and Food Sciences 4 (4-1), 1-6 2015
    Citations: 35

  • Isolation and typing of canine parvovirus in CRFK cell line in Puducherry, South India
    S Parthiban, HK Mukhopadhyay, D Panneer, PX Antony, RM Pillai
    Indian journal of microbiology 51, 456-460 2011
    Citations: 28

  • Molecular Typing of Canine parvovirus Occurring in Pondicherry by Multiplex PCR and PCR–RFLP
    S Parthiban, HK Mukhopadhyay, PX Antony, RM Pillai
    Indian Journal of Virology 21, 86-89 2010
    Citations: 28

  • Surgical management of cherry eye in a dog
    A Thamizharasan, MS Murugan, S Parthiban
    Intas Polivet 17 (2), 420-421 2016
    Citations: 12

  • Emergence of novel Porcine circovirus 2 genotypes in Southern India.
    S Parthiban
    Transboundary and Emerging Diseases 69 (4), 1804-1812 2021
    Citations: 10

  • Molecular detection of porcine parvovirus 1–associated reproductive failure in southern India
    S Parthiban, RKV Sowndhraya, P Raja, M Parthiban, A Ramesh, GD Raj, ...
    Tropical Animal Health and Production 54 (3), 195 2022
    Citations: 8

  • Schistosomus reflexus with cyclopia related foetal dystocia in a Tellicherry doe-case report.
    L Sivasudharsan, S Parthiban, P Pothiappan, B Karthikeyan, ...
    2010
    Citations: 8

  • Antibiogram and therapeutic management of bacterial otitis externa-a clinical study of 81 dogs
    MS Murugan, S Parthiban, S Malmarugan, JJ Rajeshwar
    Intas Polivet 17 (2), 292-294 2016
    Citations: 7

  • Epidemiology of canine parvovirus enteritis in pet dogs in Puducherry (India).
    S Parthiban, HK Mukhopadhyay, PX Antony, RM Pillai
    2010
    Citations: 7

  • Serum based screening and molecular detection of brucellosis in ruminants
    S Parthiban, M Prabhu, NS Anne, S Malmarugan, JJ Rajeswar
    NISCAIR-CSIR, India 2019
    Citations: 6

  • Anthrax: A re-emerging livestock disease
    S Parthiban, S Malmarugan, MS Murugan, JJ Rajeswar, P Pothiappan
    Int J Nutr Food Sci 4 (4), 7 2015
    Citations: 6

  • Evaluation of natural antimicrobial substances blend as a replacement for antibiotic growth promoters in broiler chickens: Enhancing growth and managing intestinal bacterial
    D Thirumeignanam, M Chellapandian, N Arulnathan, S Parthiban, ...
    Current Microbiology 81 (2), 55 2024
    Citations: 5

  • Diagnosis and therapeutic management of goat pox in ovines
    S Malmarugan, S Parthiban, JJ Rajeswar
    Intas Polivet 16 (2), 438-440 2015
    Citations: 5

  • Management of Dystocia due to Hydrocephalus Fetus in a Cow
    MS Murugan, S Parthiban, S Malmarugan, JJ Raheswar
    Intas polivet 15 (2), 338-340 2014
    Citations: 5

  • Isolation and genetic analysis of Porcine circovirus 2 in southern India evidences high circulation of Porcine circovirus 2d genotype
    S Parthiban, A Ramesh, AK Karuppannan, G Dhinakar Raj, S Hemalatha, ...
    Molecular Biology Reports 49 (12), 11829-11846 2022
    Citations: 4

  • Detection of Mycoplasma gallisepticum infection in Turkey and chicken farms of Tamilnadu, India
    M Prabhu, S Malmarugan, N Sweetline Anne, S Parthiban, ...
    Int. J. Curr. Microbiol. App. Sci 10 (01), 3151-3158 2021
    Citations: 4

  • Evaluation of protection and immunity induced by infectious bronchitis vaccines administered by oculonasal, spray or gel routes in commercial broiler chicks
    M Al-Rasheed, C Ball, S Parthiban, K Ganapathy
    Vaccine 41 (31), 4508-4524 2023
    Citations: 3

  • Molecular evidence of porcine circovirus 3 infection in swine: first report in southern India
    S Parthiban, A Ramesh, G Dhinakar Raj, AK Karuppannan, S Hemalatha, ...
    VirusDisease 33 (3), 284-290 2022
    Citations: 3

  • Molecular prevalence of Porcine circovirus 2 infection: foremost report in southern states of India.
    S Parthiban, A Ramesh, AK Karuppannan, RG Dhinakar, S Hemalatha, ...
    2022
    Citations: 3

  • Effect of Calcium, Boron and Micronutrient Formulations on Berry Cracking in Grapes var. Muscat Hamburg.
    S Parthiban, R Indirani, A Subbiah, S Saraswathy, N Nireshkumar
    Madras Agricultural Journal 108 2021
    Citations: 3