Parthiban S
@tanuvas.ac.in
Assistant profesoor
Tamil Nadu Veterinary and Animal Sciences University
EDUCATION
MVSc, PhD
RESEARCH INTERESTS
Virology, Cell culture, Immunology and Molecular biology
FUTURE PROJECTS
Molecular Virology
Animal viral diseases
Applications Invited
Collaborators
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Duraisamy Thirumeignanam, Mahalingam Chellapandian, Natarajan Arulnathan, Sivamurthy Parthiban, Veluchamy Kumar, M. Panchatcharam Vijayakumar, and Sunil Chauhan
Springer Science and Business Media LLC
Kannan Ganapathy and Sivamurthy Parthiban
American Association of Avian Pathologists (AAAP)
The poultry industry is the largest source of meat and eggs for the growing human population worldwide. Key concerns in poultry farming are nutrition, management, flock health, and biosecurity measures. As part of the flock health, use of live viral vaccines plays a vital role in the prevention of economically important and common viral diseases. This includes diseases and production losses caused by Newcastle disease virus, infectious bronchitis virus, infectious laryngotracheitis virus, infectious bursal disease virus, Marek's disease virus, chicken infectious anemia virus, avian encephalomyelitis virus, fowlpox virus, and avian metapneumovirus. These viruses cause direct and indirect harms, such as financial losses worth millions of dollars, loss of protein sources, and threats to animal welfare. Flock losses vary by type of poultry, age of affected animals, co-infections, immune status, and environmental factors. Losses in broiler birds can consist of high mortality, poor body weight gain, high feed conversion ratio, and increased carcass condemnation. In commercial layers and breeder flocks, losses include higher than normal mortality rate, poor flock uniformity, drops in egg production and quality, poor hatchability, and poor day-old-chick quality. Despite the emergence of technology-based vaccines, such as inactivated, subunit, vector-based, DNA or RNA, and others, the attenuated live vaccines remain as important as before. Live vaccines are preferred in the global veterinary vaccine market, accounting for 24.3% of the global market share in 2022. The remaining 75% includes inactivated, DNA, subunit, conjugate, recombinant, and toxoid vaccines. The main reason for this is that live vaccines can induce innate, mucosal, cellular, and humoral immunities by single or multiple applications. Some live vaccine combinations provide higher and broader protection against several diseases or strains of viruses. This review aimed to explore insights on the pros and cons of attenuated live vaccines commonly used against major viral infections of the global chicken industry, and the future road map for improvement.
Mohammed Al-Rasheed, Christopher Ball, Sivamurthy Parthiban, and Kannan Ganapathy
Elsevier BV
P. Raja, K. Sorna Mallika, V. Yuvachandran Viva, M. Parthiban, G. Sathish, V. Vinitha, S. Parthiban, and G. Dhinakar Raj
Springer Science and Business Media LLC
Thahira parveen S, Parthiban S, Raja P, Parthiban M, and Dhinakar Raj G
Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association
S. Parthiban, A. Ramesh, Anbu Kumar Karuppannan, G. Dhinakar Raj, S. Hemalatha, M. Parthiban, K. Senthilkumar, D. Balasubramaniyam, R. Sumanth Kumar, S. Ranganatha,et al.
Springer Science and Business Media LLC
S. Parthiban, A. Ramesh, G. Dhinakar Raj, Anbu Kumar Karuppannan, S. Hemalatha, M. Parthiban, Chintu Ravishankar, K. Senthilkumar, and D. Balasubramaniyam
Springer Science and Business Media LLC
Parthiban S, Ramesh A, Anbu Kumar Karuppannan, Dhinakar Raj G, Johnson Rajeswar J, Hemalatha S, Jaisree S, Senthilkumar K, Balasubramanyam D, Parthiban M,et al.
Wiley
A total of 200 samples from Porcine circovirus 2 suspected (n=112) and healthy (n=88) swine populations collected from different districts of Tamil Nadu, south India were used in this study. The samples comprising of serum (n=124), swabs from natural orifices (n=52), and postmortem tissues (n=24). All the samples were processed and subjected to the screening and detection of the PCV2 genome by a specific PCR assay. PCV2 genomes from positive samples were further subjected to genotyping with specifically designed primers for the full-length amplification of the ORF2 gene which codes for capsid protein (Cp) and serves as an epidemiological marker. Randomly, thirteen amplified ORF2 genes were sequenced and the aligned sequences were subjected to signature motif analysis and phylogeny in MEGA X. The molecular prevalence of PCV2 infection in Tamil Nadu is 10.5% (n=21). Signature motif and phylogenetic studies of 13 samples revealed 38.5% (n=5) presence of each PCV2b intermediate 1(IM1) and PCV2b genotypes, followed by 15.4% (n=2) PCV2d-2 and 7.7% (n=1) PCV2d genotypes. The PCV2b-IM1 genotype has a 99.43% sequence homology with Vietnam isolate (GenBank Accession No. JX506730). PCV2b genotypes showed 99.72% sequence identity with Chinese isolate (KX068219). PCV2d-2 genotypes reported in this study has 100% sequence identity with Taiwan isolate (MF169721). PCV2d genotype showed 97.87% sequence identity with Thailand isolate (MF314293). Amino acid analysis of all the 13 full-lengths ORF2 gene sequences revealed specific mutations in the immune reactive domains of A, B, C, and D. Capsid protein of three PCV2b and five PCV2b IM1 isolates had extra amino acid residue lysine (K) at 234 position of ORF2 similar to PCV2d. For the first time in south India, PCV2b IM1 and PCV2d-2 genotypes are reported. This study evidences the genetic shifts of PCV2 isolates in India and it is analogs to that of global genotypic shift.
Parthiban S, Ramesh A, Anbu Kumar Karuppannan, Dhinakar Raj G, Hemalatha S, John Kirubaharan J, Parthiban M, Senthilkumar K, Balasubramanyam D, Sumanth Kumar R,et al.
Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association
: Porcine circovirus 2 (PCV2) is the emerging viral pathogen in the swine associated with multi-systemic clinical and subclinical outcomes. This study aimed to detect molecular and serological prevalence of PCV2 infection from southern states of India. A total of 434 random samples comprising of serum (n=273), pooled postmortem tissues (n=109) and rectal, vaginal and nasal swabs (n=52) and were collected from PCV2 suspected and healthy swine populations of Tamil Nadu, Kerala, Andhra Pradesh, Telangana and Puducherry states in India during 2019 to 2021 were screened for PCV2 by specific polymerase chain reaction (PCR) assay. Of 434 samples screened, 12.2% (n=53) showed positivity to PCV2 genome. Statistical analysis of molecular prevalence of PCV2 within breed, age, sex and vaccination status revealed no significant (p>0.05) difference but there was a significant (p<0.05) difference in the prevalence of PCV2 among healthy and suspected swine populations. Suspected pigs had significantly higher prevalence of PCV2 in comparison to healthy. ELISA based PCV2 antibody screening in 176 non-vaccinated serum samples revealed sero-positivity of 44.8% (n=79). The molecular and seroprevalence of PCV2 is alarming in southern states of India, which necessitates the need for genotypic characterization and phylogenetic analysis and development of candidate vaccine for implementation of suitable prevention and control measures.
S. Parthiban, J. John Kirubaharan, A. Ramesh, M. Vidhya, S. Rajalakshmi, Ranjani Rajasekaran, and A. Thangavelu
Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association
: Newcastle disease (ND) remains the most significant disease of poultry sector and contributes to huge economic loss. Early detection and pathotyping of Newcastle disease virus associated with field infection are highly crucial. In vivo pathogenicity assaying is sensitive and specific pathotyping tool used for detection and identification of NDV used until the recent past. Genome based sequence analysis yields promising results in virulence determination. Keeping the above facts, the present study was designed to compare the efficacy of conventional and molecular assays in NDV virulence determination. In this study twelve NDV isolates (Isolate numbers 463, 464, 475, 476, 122-17C, 122-17D, 122-17E, 128-17A, 128-17D, 137, 139, 141) available in the Department of Veterinary Microbiology, Madras Veterinary College (MVC), Chennai was subjected for differentiation of virulent and avirulent strains using mean death time (MDT) in specific pathogen-free (SPF) embryonated eggs and TaqMan minor groove binding (MGB) probe real-time PCR assay. Pathotyping based on the MDT revealed two NDV isolates (isolate no. 476 and 128-17D) as velogenic strains and the remaining ten NDV isolates as lentogenic strains. Pathotyping based on TaqMan MGB probe real-time PCR assay revealed six NDV isolates (476, 128-17D, 463, 464, 475, 137) as velogenic/mesogenic strains and remaining six NDV isolates (122-17C, 122-17D, 122-17E 128-17A, 139, 141) as lentogenic strains. Using a TaqMan MGB probe real-time PCR assay, four NDV isolates (463, 464, 475, 137) which were MDT pathotyped as lentogenic strains were re-pathotyped as velogenic/mesogenic strains, which indicates the greater sensitivity of TaqMan MGB probe real-time PCR assay in pathotyping of NDV over conventional MDT.
S. Parthiban, R. K. V. Sowndhraya, P. Raja, M. Parthiban, A. Ramesh, G. Dhinakar Raj, K. Senthilkumar, D. Balasubramanyam, S. Hemalatha, R. Bharathi,et al.
Springer Science and Business Media LLC
S. Parthiban, Hirak Kumar Mukhopadhyay, D. Panneer, P. X. Antony, and R. M. Pillai
Springer Science and Business Media LLC
S. Parthiban, H. K. Mukhopadhyay, P. X. Antony, and R. M. Pillai
Springer Science and Business Media LLC