Raja Prabu Ramachandran

Verified email at gmail.com

Professor & Director (Accreditation & Ranking) - Department of Electrical Engineering
GITAM : Gandhi Institute of Technology And Management, Visakhapatnam, India



                                                           

https://researchid.co/rajaprabur

 Currently Serving as Director (Accreditation & Ranking) and Director (IQAC) at GITAM : A Category – I Deemed to be University

 Published / Presented 100+ Research Articles in Journals / Conferences

 Guided 05 Ph.D Scholars, 01 Scholar submitted Thesis & Guiding 03 other Research Scholars

 Co Authored 1 Book published by Elsevier & Edited 10+ Conference Proceedings

 Successfully Completed 3 Funded Projects

 1 Patent got Published

 Collaborative Research with Purdue University, USA has resulted in 10+ Joint Publications

 Industrial Consultancy to ETA Group, Alstom, Oblum, Apollo Tyres, Garuda VayuSakthi etc.,

 Presented Guest Lectures on “Outdoor Polymeric Insulators” at KOBE University, Japan, University of Missouri, USA and at Chongqing University, China on Invitation

 Countries visited include USA, UK, Japan, China, UAE, Singapore, Malaysia, Hongkong, Thailand, Srilanka, Muscat, Sarawak etc.,

 Member in Professional Societies like IEEE, IE, CIGRE, ISTE, C.Engg.,

EDUCATION

Degree Discipline University Year of Passing

Ph.D. High Voltage Engineering Anna University (CEG) 2006

M.E. Power System Engineering Annamalai University 1990

B.E. Electrical & Electronics Engineering Annamalai University 1988

Training "Electroporation for Effective Cancer
(Post Doctorate) Treatment (Bio Electrics)" Purdue University, USA 2008

P.G.D.B.A. Business Administration Annamalai University 1989

RESEARCH INTERESTS

Bio Electrics
Outdoor Polymeric Insulators
Micro Grid Protection
Pulsed Electric Field

FUTURE PROJECTS

Electro Chemo Therapy for Effective Cancer Treatment

Electrochemotherapy (ECT) is an evolving technique to treat various types of skin, chest wall breast cancer and basal cell carcinoma with minimal side effects. Electrochemotherapy was the only available alternative treatment for patients suffering from lung cancer who are unfit to undergo surgery. This procedure utilizes hydrophilic chemo drugs such as bleomycin and cisplatin which are aided by electroporation to create apoptosis. ECT has an overall response of 80-90% for un-respectable recurrent disease. Typically eight 1200V/cm, 100μs pulses are applied in the clinics.


Applications Invited
Collaborators & Students

Newer Materials for Outdoor Polymeric Insulators

POLYMERIC insulators are being accepted increasingly for use in outdoor applications. The tremendous growth is due to their advantages over the traditional ceramic and glass insulators. It includes lightweight, higher mechanical strength to weight ratio, resistance to vandalism, better performance in the presence of heavy pollution in wet condition, and better withstand voltage than porcelain insulators. However, because polymeric insulators are relatively new, the expected lifetime and their long-term reliability are not known, and therefore are of concern to users.


Applications Invited
Collaborators & Students

Liquid Food Preservation Using Pulsed Electric Field

Pulsed electric field (PEF) treatment has been prevailing for the past two decades as the successful nonthermal food preservation technique due to it’s low energy consumption, retaining of food’s quality attributes such as taste, color, freshness, texture and especially the nutritional qualities when compared with heat treatment methods. The high voltage pulses can be delivered to liquid foods through electrodes where the cell inactivation takes place by means of electroporation phenomenon. The configuration of electrodes and the electric field distribution inside the PEF treatment chamber is supposed to have a greater impact on bacterial inactivation. There are many electrode configurations available where parallel plate electrodes were used in initial studies, and stainless steel was used as the electrode material for most of the PEF applications.


Applications Invited
Collaborators & Students
27

Scopus Publications

Scopus Publications

  • Adaptive relay co-ordination scheme for radial microgrid
    Belwin J. Brearley, R. Raja Prabu, K. Regin Bose, and V. Sankaranarayanan

    International Journal of Ambient Energy, ISSN: 01430750, eISSN: 21628246, Pages: 2180-2193, Published: 2022 Informa UK Limited
    The relay co-ordination is the nerve centre of the microgrid system, as the same is responsible for the reliability of operation and enhanced efficacy. This research work focuses on an ‘adaptive ce...

  • Electric Field Analysis Of Coated Titanium Electrodes On Microbial Inactivation Under Pulsed Electric Field Treatment
    Suranaree Journal of Science and Technology, ISSN: 0858849X, eISSN: 25870009, Pages: 1-10, Published: 2020

  • Electric field analysis of water electrodes for noninvasive pulsed electric field applications
    Ramya Ramaswamy, , Dr. R. Raja Prabu, Dr. V. Gowrisree, , and

    International Journal of Innovative Technology and Exploring Engineering, eISSN: 22783075, Pages: 1210-1214, Published: August 2019 Blue Eyes Intelligence Engineering and Sciences Engineering and Sciences Publication - BEIESP
    Electroporation is an effective phenomenon of inactivating viable pathogens present in the liquid food for pulsed electric field (PEF) applications. It is a technique which depends on applied electric field strength for causing pores on cell plasma membrane. The various parameters which affect the electroporation efficacy are, the electric field intensity, pulse width, number of pulses, pulse interval and the electrode. The electrode provides a contact between the high voltage pulse generator and the liquid food, and it plays an important role in getting the required inactivation outcome. The electric field distribution varies based on electrode designs. Parallel plate electrodes are generally used due to the uniform electric field it delivers in the inactivation area, where high possibility of microbial inactivation will occur. This paper analyses the effectiveness of round edged parallel plate electrodes immersed in water which provides uniform electric field distribution in the inactivation area. Analyses have been performed on electric field distribution through four kinds of materials such as glass, alumina, quartz and plexiglass, which contains these electrodes in the center filled with sterile water. The electrodes are circular, and edge smoothened and hence the field distribution is also analyzed on electrode edges. The distance between the electrodes including the surface material is kept at 5 mm. The diameter of the electrodes are 40 mm and the electric field simulations are implemented in ANSYS MAXWELL v 15.0. Based on results it is reported that alumina required less peak voltage for generating 20 kV/cm field strength (nominal field required for bacterial inactivation) when compared with other materials. Also alumina exhibited less reduction of field travelling through it, and resulted in 82% of field application in the inactivation area which is comparatively higher than other materials. The results indicate that alumina is highly recommended for future noninvasive pulsed electric field applications.

  • Inactivation of Staphylococcus aureus using pulsed electric field treatment under treatment time variation
    Ramya Ramaswamy, Raja Prabu Ramachandran, and V. Gowrisree

    International Journal on Engineering Applications, ISSN: 22812881, eISSN: 25332295, Pages: 197-203, Published: 2019 Praise Worthy Prize
    Pulsed electric field treatment has been successfully applied in various liquid foods in order to inactivate microorganisms through the process of electroporation. The shelf life of liquid foods can be extended using pulsed electric field treatment thereby maintaining the quality attributes of foods with less energy consumption when compared with other heat treatment methods. However, few efforts have been made by using Pulsed electric field technology on electric field application through specific electrode materials focusing on specific type of microorganisms. In this research, Pulsed Electric Field treatment chamber has been modelled using electromagnetic simulation software and has been implemented practically for experimental testing. Titanium electrodes have been used for successful pulsed power applications on culture medium, where Staphylococcus aureus ATCC 25923 was inoculated at 107 colony forming units per ml in sterile water. The impact of Pulsed Electric Field application on microbial colonies has been observed for treatment time variation from one to six minutes. The pulse width has been set to 1 microsecond at a pulse repetition rate of 50 pulses per second. The results have demonstrated that: (i) up to 85% of field reduction could be observed on simulated electrode edges; (ii) under experimentation, the best inactivation efficiency has been obtained at one minute (Continuous) and six minutes (Discrete), with field requirements of 35 kV/cm and 39 kV/cm, resulting in 1.89 and 1.82 of bacterial log reduction respectively.

  • High Voltage Pulsed Electric Field Application Using Titanium Electrodes for Bacterial Inactivation in Unpurified Water
    Ramya RAMASWAMY, Raja PRABU RAMACHANDRAN, and V. GOWRISREE

    Japan Journal of Food Engineering, ISSN: 13457942, Pages: 63-70, Published: 2019 Japan Society for Food Engineering
    Research Scholar, Department of Electrical and Electronics Engineering, BS Abdur Rahman Crescent Institute of Science and Technology, Seethakathi Estate, Vandalur, Chennai 600048, India. Professor, Department of Electrical and Electronics Engineering, BS Abdur Rahman Crescent Institute of Science and Technology, Seethakathi Estate, Vandalur, Chennai 600048, India. Professor, Department of Electrical and Electronics Engineering, College of Engineering, Anna University, Guindy, Chennai 600025, India.

  • Electric field analysis of different compact electrodes for pulsed electric field applications in liquid food
    Ramya Ramaswamy and Raja Prabu Ramachandran

    2016 IEEE International Power Modulator and High Voltage Conference, IPMHVC 2016, Pages: 160-165, Published: 17 August 2017 IEEE
    Electromagnetic simulation is performed on two compact electrode designs to obtain higher electric field distribution between high voltage and ground electrode, which ensures high bacterial inactivation in liquid food. Electric field simulations are performed initially for test voltages of 1kV to 5kV to understand the nature of electric field distribution in the inactivation area. Then the applied voltage is gradually increased to induce transmembrane potential on the cell membrane. The microorganism modeled for field analysis is Staphylococcus aureus. For both the round edged and torus tube designs, the transmembrane potential of 0.5V to 1V is achieved with the spherical cell, modeled between the high voltage and the ground electrode, which shows pore formation possibility. Dimensions of the electrodes are maintained in mm and cm suitable for laboratory scale, continuous pulsed electric field treatments. In both the designs, emphasis is on the simulation to achieve higher electric field application in the inactivation area, which can be realized through satisfying electroporation phenomenon. From the observed results, it is understood that greater electric field application is achievable even using small efficient electrode designs, which in turn assures i) A greater bacterial inactivation in the liquid food and ii) A compact pulsed electric field experimental prototype.

  • Design and analysis of grid connected PV generation system
    T. D. Sudhakar, K. N. Srinivas, M. Mohana Krishnan, and R. Raja Prabu

    Advances in Intelligent Systems and Computing, ISSN: 21945357, Volume: 467, Pages: 413-422, Published: 2017 Springer Singapore

  • A review on issues and approaches for microgrid protection
    Belwin J. Brearley and R. Raja Prabu

    Renewable and Sustainable Energy Reviews, ISSN: 13640321, eISSN: 18790690, Pages: 988-997, Published: 1 January 2017 Elsevier BV

  • Design of a grid connected system using proteus software
    T. D. Sudhakar, M. Mohana Krishnan, K. N. Srinivas, and R. Raja Prabu

    2016 3rd International Conference on Electrical Energy Systems, ICEES 2016, Pages: 192-194, Published: 12 July 2016 IEEE
    Nowadays the usage of renewable energy source is being encouraged in developing countries to meet the power shortages. The produced supply must follow the precised guidelines, so that the supply can be connected to the grid system. In this work, a grid connected module is developed using a DC - DC converter and conventional H - bridge inverter. The aim of the proposed methodology is to reduce the size of the filter used across the inverter and it is achieved. This is done by applying SPWM wave to the DC - DC SEPIC converter and the H - bridge inverter is operated at normal power frequency.

  • Modeling and simulation of distribution network with the integration of distribution generator using Matlab
    T. D. Sudhakar, M. Raja Rajan, K. N. Srinivasan, R. Raja Prabu, T.V. Narmadha, and M. Mohana Krishnan

    Indian Journal of Science and Technology, ISSN: 09746846, eISSN: 09745645, Published: 1 March 2016 Indian Society for Education and Environment
    Background: Due to increasing power demand across the country, the usage of renewable systems is being increased. One such efficient and compactly available renewable energy is solar power. In this paper, a clear view of harnessing maximum DC solar power output and converting it to AC is discussed. Methods: A method of grid interconnection of solar powered inverter is presented with IEEE-15 bus system as an example model using Matlab simulation. Findings: A detailed analysis of bus voltage, load current and line current is made with the simulated model. Applications/Improvements: The data obtained could be used for fine optimization of the position in which the distribution generator interconnection is to be made.

  • Fault analysis of multi bus system with three phase solid state circuit breaker
    Journal of Electrical Engineering, ISSN: 15824594, eISSN: 13353632, Pages: 88-93, Published: 2013

  • Understanding treeing phenomena in XLPE cable insulation under composite voltages
    K. G. Shanmuga Priya, R. Raja Prabu, C. L. G. Pavan Kumar, and R. Sarathi

    2013 IEEE 8th International Conference on Industrial and Information Systems, ICIIS 2013 - Conference Proceedings, Pages: 100-104, Published: 2013 IEEE
    Electrical trees were experimentally generated in XLPE cable insulation under AC and composite voltage formed with AC and DC voltages. Bush type and tree like tree structures were generated. Analysis of time to failure due to electrical trees was made by adopting Weibull distribution studies. The life of cable insulation due to electrical tree failure is enhanced in presence of offset voltage. The rate of tree propagation is high under AC voltage with positive offset. Applied voltage and failure time of insulation shows inverse relationship. It is realized that, the frequency content of the UHF signal generated during tree propagation lies in the range 1-3 GHz. The Phase resolved partial discharge (PRPD) analysis indicates that discharges occur in the rising portion of the applied AC voltage. With composite voltages, the discharges occurs near the zero crossing and is predominant with positive DC voltage superposed with AC voltage.

  • Automotive infotainment power management solution by modeling, analysis and control of 42V/14V DC-DC automotive interleaved buck converter
    Anila Thyagarajan, R. Raja Prabu, and G. Uma

    2013 25th Chinese Control and Decision Conference, CCDC 2013, Pages: 4507-4512, Published: 2013 IEEE
    This paper will focus on the Power Management solution of vehicles via Modeling, analysis and simulation of a 42V/14V dc/dc converter based architecture. This architecture is considered to be technically a viable solution for automotive dual-voltage power system for passenger car in the near future. An interleaved dc/dc converter system is chosen for the automotive converter topology due to its advantages regarding filter reduction, dynamic response, reduced ripples and power management. Presented herein, is a model based on one kilowatt interleaved sixphase buck converter designed to operate in a Discontinuous Conduction Mode (DCM). The control strategy of the converter is based on a voltagemode-controlled Pulse Width Modulation (PWM) with a Proportional-Integral-Derivative (PID). The effectiveness of the interleaved step-down converter is verified through simulation results using Matlab/Simulink.

  • Improvement of transient stability of power system using solid state circuit breaker
    Amirthalingam

    American Journal of Applied Sciences, ISSN: 15469239, eISSN: 15543641, Pages: 563-569, Published: 7 June 2013 Science Publications
    The aim of this study is to use a solid state circuit breaker for the improvement of transient stability margin. Long distance AC transmission is often subject to stability problems, which limits the transmission capability. Interconnected power systems suffer from weakly damped swings between synchronous generator and sub systems. The development of modern power system has lead to an increasing complexity in the study of power system and also presents new challenges to power system stability and in particular to the aspects of transient stability and small signal stability. Transient stability control plays a significant role in ensuring the stable operation of power systems in the event of large disturbances and faults and is thus a significant area of research. This study investigates the improvement of transient stability of a two area system, using Solid State Circuit Breaker which is capable of fast switching in case of faults and thus controlling the real and reactive power flows in a faulted transmission line. Simulations are carried out in Matlab/Simulink environment for two area system model with Solid State Circuit Breaker to analyze the effects of SSCB on transient stability performance of the system. From the simulation results, swing curves of the three phase faulted power system without SSCB gets increases monotonically and thus the system can be considered as unstable whereas the swing curves of the system with an SSCB reaches to a steady state.

  • Modeling and simulation of thirty bus system employing solid state circuit breaker
    A. Kalai Murugan and R. Raja Prabu

    Proceedings - ICETEEEM 2012, International Conference on Emerging Trends in Electrical Engineering and Energy Management, Pages: 98-103, Published: 2012 IEEE
    This work deals with protection of thirty bus system using Solid State Circuit Breaker. The Solid State Circuit Breakers (SSCBs) based on high power semiconductors, offer considerable advantages when compared to mechanical circuit breakers with respect to speed and life. The distortions caused by the three phase short circuit can be reduced to 100 μs, in contrast to 100 ms achieved by the present technology. The Solid State Circuit Breaker uses high power anti parallel switches to carry bidirectional current. During normal operation the solid state circuit breaker is "on". During faults, the gate of the SSCB is pulse modulated to prevent the circuit current from exceeding a predetermined limit. The load voltage is sensed and it is used to turn on and turn off the SSCB. The thirty bus system with SSCB is modeled and simulated using Matlab/Simulink. The circuit model and results of simulation for thirty bus system employing SSCB are presented in this paper. Simulations demonstrate that the protection circuit provides a fast and maintenance free protection solution for multi bus system.

  • Electrical field analysis of pentagonal needle array electrode for electrochemotherapy applications
    Sadasivam Pachamuthu, Vishveswaran Jothi, Mohamed I Neamathulla, P. S. S. Samu Safwan, Arun Kuppan, Rajaprabu Ramachandran, Raji Sundararajan, and Kavitha Sankaranarayanan

    Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP, ISSN: 00849162, Pages: 263-266, Published: 2012 IEEE
    Electrochemotherapy is an effective palliative way of treating inoperable chemo-resistant cancers. It is a therapeutic technique for treating tumors with nonpermeant drugs using electroporation of cells. The cells are electroporated to form temporary hydrophilic pores. The various parameters which affect the electroporation efficacy are, the voltage (electric field intensity), pulse length, number of pulses, pulse interval and the electrode. The electrode provides a contact between the high voltage pulse generator and the patient, and as such it plays a vital role in the treatment outcome. In general, needle array electrodes are used in many cases, including treating of deep seated tumors. The electric field distribution varies according to the electrode design. This paper explores the effectiveness of a pentagonal array electrode with a centre electrode for obtaining uniform electric field distribution in the treated area. This model is symmetrical in which surrounding electrodes are displaced by 4 mm from the centre electrode. The diameter of the needle is 1 mm. The electric field simulations were implemented in 2D in ANSYS 13.0. The electric field considered for the analysis is 1200 V/cm, same as what is currently used in the clinics. The results indicate that the electric field distribution is uniform at a value of 1200 V/cm.

  • Modelling and simulation of thirty bus system using multiple statcom & TCTC
    European Journal of Scientific Research, ISSN: 1450216X, eISSN: 1450202X, Pages: 285-297, Published: July 2012

  • Effect of irreversible electroporation on cancer cells
    Raji Sundararajan, Ramya Rajendran, Sajan S. Shahid, D. K. Santosh, Snehalatha Radhakrishnan, K. Priyadarshan, S. Varsha, U. Vimal Kumar, Rajaprabu Ramachandran, and Kavitha Sankaranarayanan

    Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP, ISSN: 00849162, Pages: 164-167, Published: 2011 IEEE
    Cancer remains responsible for several million deaths each year, occurring worldwide. The conventional treatment strategies for cancer cause a plethora of side effects along with an exorbitant treatment cost per sitting. The focus now is on the development of new modalities of treatments which could minimize the side effects and prove to be an affordable treatment option to the patients. Usage of electrical pulses along with drugs - Electrochemotherapy (ECT) is a fast rising option for the treatment of chemo-refractive cancers. This has proven to be more efficient and effective than other existing methods of treatment and there is a growing evidence of research and clinical trials on the same. The major advantage that this mode of treatment offers is the massive reduction in the dosage of drug that is administered, thus significantly reducing the intensity of undesired side effects. The applied electrical pulses can be of two types - that for reversible and irreversible electroporation of cells. While reversible electroporation is primarily used as a means for delivery of molecules into the cell, irreversible electroporation is a mode which could be applied as such in the absence of a chemodrug to kill the cancerous cells. This would be of immense significance in the clinical scenario since it could be targeted treatment while totally eliminating the necessity of any chemodrug. In this paper we give a detailed report on the effect of such high voltage pulses on cancer cells. The variables tested out in the pulse parameters used include intensity of electric field applied, pulse duration, number of pulses and time interval between each train. The electric field applied is varied between 500V/cm to 2500V/cm with a pulse duration ranging from microseconds to milliseconds to keep the energy delivery constant. The effect of the parameters individually and effect of combination of all these parameters on the cells is studied and discussed in this paper. This study could be of clinical relevance in the translation of these findings to application at the patient-level.

  • Efficient, electrically-enhanced proliferation control of adult human mesenchymal stem cells
    R. Sundararajan, R. P. Ramachandran, and K. Sankaranarayanan

    Proceedings - International Symposium on Electrets, Pages: 47-48, Published: 2011 IEEE
    Our study indicates that indeed it is possible to control the proliferation of adult hMScs. These results could be used to arrest cancer stem cells from proliferation and thus pave the way for a physical cancer therapy that can be out-patient-based using reduced doses of highly toxic chemo drugs, thus enhancing quality of life by reducing cost and side effects.

  • Effective electro-chemo-therapy for proliferation control of adult human mesenchymal stem cells
    Sankaranarayanan Kavitha, Ramachandran Raja Prabhu, Kumar Raghavan, Muralitharen Sinthu, S. Mansoor Usman, M. Sriram Kumar, V. Madan Kumar, S. Vignesh, V. Malini, K.M. Cherian, S. Madhivanan, Sankaranarayanan Karthik, Natarajan Arutselvan, and Sundararajan Raji

    Journal of Electrostatics, ISSN: 03043886, Pages: 267-274, Published: August 2011 Elsevier BV

  • Viability of cancerous cell lines as a function of energy delivered
    K Sankaranarayanan, R P Ramachandran, M Sriram Kumar, V Madan Kumar, S Vignesh, P Sadasivam, G Gency Ponrose, T Chandana, S Prithika, S Guhathakurta, K M Cherian, S Madhivanan, and R Sundararajan

    Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP, ISSN: 00849162, Published: 2010 IEEE
    Electroporation is an elegant technique used for proliferation control in Cancer cells. This budding mode of therapy called electrochemotherapy uses electrical pulses and chemodrugs to trigger cell death in cancerous cells. The efficacy of this technique depends on a variety of factors including electric field intensity, pulse duration and the number of pulses. In this study, Human cervical (ME180), Human Acute Myeloid Leukemia (KG1) and Human Promyelocytic leukemia (HL60) cancerous cell lines were subjected to electroporation in the presence of 1µM Bleomycin at 1200 V/cm, 100µs; 450 V/cm, 25ms; and 200 V/cm, 40ms. The energy applied and charge delivered with each pulse are also calculated. The results indicate that with increase in energy delivered, there in increase in cell death. This promises to be a very useful tool in for the treatment of patients suffering from chemo-refractive tumors.

  • Power quality improvement of eight bus system using TCTC
    S. D. Sundarsingh Jebaseelan and R. Raja Prabu

    International Conference on "Emerging Trends in Robotics and Communication Technologies", INTERACT-2010, Pages: 161-163, Published: 2010 IEEE
    If the reactive power of the load is changing rapidly, a suitable fast response compensator is needed. SVC and TCTC (Thyristor controlled tap changer) are two such compensators belonging to FACTS devices. A model for the Thyristor tap changer has been designed to improve the voltage level at the load end. Smooth reactive power control is achieved by varying the firing angle of TCTC system. The simulation results of eight bus TCTC system are presented.

  • Efficient and economical electro-drug delivery
    Raji Sundararajan, Funian Xiao, Nick Lenarduzzi, Ignacio G. Camarillo, Jim Leary, Lisa Reese, Raghavan Kumar, Sinthu Muralitharen, Syed Mansoor Usman, Raja Prabhu Ramachandran, K.M. Cherian, Sheerin Begam, Soma Guhathakurta, and Kavitha Sankaranarayanan

    TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity, Pages: 843-848, Published: 2009 IEEE
    Presented in this paper are our investigations on the application of short duration (milli and micro seconds) electrical voltage pulses for the treatment of breast carcinoma cells and also for delivering molecules into adult mesenchymal stem cells. Since current therapies do not work effectively for many patients, there is a need for alternative, affordable, yet effective treatments for various cancers and other diseases. For this purpose, electroporation, a pulse power technology was used as a tool to investigate its effect on viability and proliferation on human breast cancer cell lines and adult stem cells using various voltages and pulse durations. The results indicate that electrical pulses could be used effectively and economically to enhance drug transport across the normally impermeable plasma cell membranes as well as to reduce proliferation.

  • Electrically-enhanced proliferation control in adult human mesenchymal stem cells
    Raghavan Kuma, Sinthu Muralitharen, S. Mansoor Usman, Raja Prabhu Ramachandran, Raji Sundararajan, S. Madhivanan, K.M. Cherian, Sheerin Begam, Soma Guhathakurta, and Kavitha Sankaranarayanan

    Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP, ISSN: 00849162, Pages: 474-477, Published: 2009 IEEE
    This paper represents a study on the effect of electrical pulses on adult stem cells, especially on proliferation control and also as a method of delivering molecules inside the cytoplasm. Mesenchymal stem cells have been targeted for this study primarily because of their ability to home towards tumor cells, making the possibility to generate targeted tumor therapy more realistic. Human adult bone marrow stem cells were subjected to high intensity, short duration (1200V/cm, 100μs) and low intensity, long duration (200V/cm, 500V/cm, 10 and 20 ms) pulses. The effect of these voltages on the viability and proliferation ability of these cells in the presence and absence of Bleomycin (a chemodrug used in the treatment of various types of tumors) hint at the possibility of extrapolation of this technique to effective electrochemotherapy using the mesenchymal stem cells as a 'Trojan horse' and to control the proliferation ability of cancer cells.

  • Theoretical correlations amongst electrical and mechanical characteristics of polymeric housing materials for outdoor insulators
    R. Prabu, S. Usa, K. Udayakumar, M. Khan, and S.S.M. Majeed

    IEEE Transactions on Dielectrics and Electrical Insulation, ISSN: 10709878, Pages: 771-782, Published: June 2008 Institute of Electrical and Electronics Engineers (IEEE)
    In this paper, theoretical correlation amongst various electrical characteristics of a housing / weather shed material is attempted. Also, a correlation relating tensile strength (a mechanical property) to insulation characteristics is proposed. The housing material used, is made of polymeric blends (Silicone/EPDM) with and without fillers (silica and alumina trihydrate).The proposed correlation is obtained through Dimensional Analysis technique. An attempt is also made to provide qualitative interpretations for these relationships, based on the fundamental physical quantities. Multivariate regression analysis of experimental values of the dependent and independent variables, that figure in these correlations is carried out. It yielded almost the same values for the exponents as those in the correlations developed using dimensional analysis. This confirmed similar quantitative and qualitative influences of various insulation parameters on tracking resistance and tensile strength, as predicted by the dimensional analysis approach.

RECENT SCHOLAR PUBLICATIONS

    Publications

    International / National Journals : 34
    International / National Conferences : 70
    Total Publications : 104

    GRANT DETAILS

    Principal Investigator

     AICTE, GOI, under R&D scheme
     Project worth of Rs. 6 Lakhs
     Duration – 3 years (2001 – 04)
     Performance Study of Outdoor Polymeric Insulators.
     Project completed successfully and completion report is submitted.
     Developed high voltage test facilities with the help of AICTE grant at Crescent Campus.
     Test facilities are as per IEC / ASTM standards


    Principal Investigator

     AICTE, GOI, under MODROB scheme
     “Modernization of Power Electronics Lab”
     Project worth of Rs. 8 Lakhs
     Duration – 2 years (2006 – 08)
     Project completed successfully and completion report is submitted.
     Developed Power Electronics Lab facilities with the help of AICTE grant.



    Co-Investigator

     Project from DRDO, GOI
     “Low Magnetic Field Sensors”
     Project worth of Rs. 8.9 Lakhs
     Duration – 3 years (2010 – 13)
     Project completed successfully and completion report is submitted.

    RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

    Title : Silicone / EPDM Polymeric blend compound with ATH & Silica fillers for High Voltage Outdoor Insulators

    Application No. : 201641026589

    Publication Date : 19.08.2016

    Journal No. : 34.2016

    Patent Office : IPR, Chennai

    CONSULTANCY

     Consultancy to M/s. Oblum Industries, Hyderabad in the “Outdoor Polymeric Insulators”
     Consultancy to M/s. Alstom Unit, Pondy, in the “Outdoor Polymeric Insulators”
     Industrial Training Programme to ETA-STAR-ASCON Group Industries
     Industrial Training Programme to Apollo Tyres
     Regular Consultancy to University Estate Office (Campus Electrical Maintenance & HT Sub Station)
     Industrial Consultancy to M/s. Garuda Vayu Sakthi Ltd.,
     Consultancy to several academic institutions on NAAC Accreditation & NBA Accreditation
     Consultancy to several academic institutions on implementation of Outcome Based Education

    Industry, Institute, or Organisation Collaboration

     Purdue University, USA
     University of Missouri, Columbia, USA
     PPKS, Sarawak, Malaysia
     UNIMAS, Sarawak, Malaysia
     UITM, Sarawak, Malaysia
     ETA-ASCON-STAR, Dubai
     AU-KBC, Chennai, India
     Apollo Tyres, Chennai, India
     Frontier Lifeline Research Institute, Chennai, India
     Chennai Power Desalination Training (CPDT), Chennai, India
     Mando Automotives India Pvt. Limited

    STARTUP

    Will be Updated..

    SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

    Will be Updated..