Elena Petrovna Sokolik

@onmedu.edu.ua

pharmacology and pharmacognosy
Odessa State Medical University

Elena Petrovna Sokolik


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https://researchid.co/sokolikep

EDUCATION

Zaporozhye state medical university: Zaporozhye, Zaporozhye, UA

RESEARCH INTERESTS

neuroprotection, pharmacology, medicine, biochemistry
6

Scopus Publications

197

Scholar Citations

7

Scholar h-index

4

Scholar i10-index

Scopus Publications

  • Analysis of significance of mitochondrial dysfunction in the pathogenesis of diseases of the central nervous system
    Olena Petrivna Sokolik, Galina Olexandrivna Prozorova
    Neuroscience Research Notes, 2022
    One of the promising therapy areas for many diseases of the central nervous system is the search for agents of selective effect on mitochondria. Both the mitochondria themselves and the mitochondrial metabolism of the transformed cell of the central nervous system and activation of energy metabolism by reprogrammed mitochondria give impetus for the development of mitochondrial pharmacology to use the special properties of transformed cells mitochondria as targets for neuroprotective and neuroplastic effects. In this review, we analyse literary sources of domestic and foreign authors about the influence of mitochondrial dysfunction on various links in the pathogenesis of central nervous system diseases. Based on currently available data, scientists divided all signs of mitochondrial dysfunction in schizophrenia into three groups: morphological disorders of mitochondria, signs of a violation of the oxidative phosphorylation system and dysregulation of genes responsible for mitochondrial proteins. The therapeutic effect of drugs for central nervous system disorders should focus on reducing the accumulation of metabolic products and tissue breakdown, restoring mitochondrial functions and synaptic plasticity, and protecting mitochondria from toxic effects, thereby alleviating cognitive disorders with a neuroprotective effect.
  • Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine
    Olena P. Sokolik, Galina O. Prozorova
    Research Results in Pharmacology, 2022
    Introduction: Fibrocystic breast disease, commonly called fibrocystic breasts or fibrocystic change, is a benign (noncancerous) condition, which is the most common pathology in women of reproductive age. Treatment of fibrocystic breast disease and concomitant pathologies can involve using herbs. Materials and Methods: To make an analysis of literary sources on the development of fibrocystic breast disease in the pathogenesis of diseases of the female reproductive system (clinical human (75%) and animal studies (25%)) were published in the period of 2017–2021. Results and discussion: The diversity of plants in the world is a promising ground for therapeutic improvisation, allowing for an individual approach to each patient, but, most importantly, creates possibilities for maneuvering in the event of ineffectiveness of any means. In some situations, herbal medicine is not only possible or permissible, but strictly mandatory, and is essentially the only effective therapeutic method, which is relatively safe provided the correct selection of combinations and control by a doctor who applies a certain method of phytotherapy, especially given a duration of treatment. The need for a deeper study is long overdue for the pharmacological capabilities of various plant raw materials in the treatment of not only this pathology, but others as well. Conclusion: The development of phytotherapy should be based primarily on scientific developments, but this area can not be considered the prerogative of only phytotherapists, as herbal medicines should be in the arsenal of doctors of all specialties.
  • Pharmacological modulation of heat shock protein 70 (hsp70) - Dependent mechanisms of endogenous neuroprotection in conditions of prenatal chronic alcoholism by cerebrocurin and tiocetam
    Igor F. Belenichev, Elena P. Sokolik, Nina V. Bukhtiarova, Sergii V. Levich
    Klinik Psikofarmakoloji Bulteni, 2016
    Objective: One of the primary reactions of the genome in response to stress is different genesis induction of heat shock proteins – HSP. The purpose of this study was to investigate the concentration of heat shock protein (HSP70) and hypoxia-inducible factor (HIF-1) in the brain of rats undergoing chronic prenatal alcoholism in different periods of ischemia and define the role of these proteins in the implementation of neuroprotective effect of Cerebrocurin and Tiocetam. Methods: Experiments were carried out on female rats weighing 150-180 g. All animals were on standard food ration of vivarium, with natural alteration of day and night. Rats were recieved from nursery of «Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine». All experimental procedures and operative interventions were done in accordance with WMA Statement on Animal Use in Biomedical Research. Rats from the 5th to the 20th day of gestation received ethanol in a dose of 6-8 g/kg/day, control rats – isocalorific sucrose solution. Offspring of alcoholized rats immediately after birth during 25 days were injected intraperitoneally Tiocetam (125 mg/kg), Piracetam (125 mg/kg) and Cerebrocurin (0.06 mg/kg), control rats received saline solution. There were 20 infants in each group. Biochemical studies carried out on brain on 26 days of the experiment, for this purpose the animals were decapitated under anesthesia using Thiopental (30 mg/kg, intraperitoneally). Concentration in the brain tissue and HIF proteins and HSP proteins were determined by Western blot analysis. Results: Study of concentration in brain tissue HIF proteins and HSP-proteins showed that after undergoing prenatal chronic alcoholism there was an observed decrease in concentration of HSP, so HIF-proteins. Course treatment by Cerebrocurin and Tiocetam resulted in statistically significant increased content of HIF and HSP proteins in the brain in comparison with a group of untreated animals. Neuroprotective activity of Cerebrocurin and Tiocetam was observed in reduction of neurological deficit, as evidenced by the statistically significant decrease in the average score on a scale of C.P. McGrow. Cerebrocurin and Tiocetam directly or indirectly can modulate the expression of early response c-fos genes and thus the “run” software adaptation protein synthesis (including HSP and HIF) in neurons with acute cerebral ischemia. Conclusion: Implementation of the neuroprotective effect of Cerebrocurin and Tiocetam revealed apparently their ability to increase the concentration in the brain tissues of HSP-protein.
  • Malate-aspartate shunt in neuronal adaptation to ischemic conditions: Molecular-biochemical mechanisms of activation and regulation
    I. F. Belenichev, Yu. M. Kolesnik, S. V. Pavlov, E. P. Sokolik, N. V. Bukhtiyarova
    Neurochemical Journal, 2012
    Acute or chronic brain ischemia induces a cascade of pathobiochemical reactions that finally result in the development of focal neurological deficit, dyscirculatory encephalopathy, or the death of a patient. We studied the effects of ischemia at different time points, including 1, 6, 24, 48, 72, and 120 h, and 21 days. During the period of the strongest ischemia-induced disturbances (24–72 h), we found lactate over-production associated with inhibition of hexokinase, an enzyme that catalyzes the first “trigger” reaction of glycolysis. An increase in the malate content associated with increasing activities of mitochondrial and cytosolic malate dehydrogenases within the first hours of cerebral ischemia indicates the activation of the malateaspartate shuttle, which is responsible for the transportation of reduced equivalents to mitochondria. The inhibition of malate production and activity of NAD-dependent malate dehydrogenase correlates with a decrease in the contents of ATP, HSP70, and hypoxia-induced factor-1a (HIF-1a) and the severity of neurological disturbances. We believe that in response to brain ischemia, HIF-1a is expressed, which induces compensatory mechanisms of energy production.
  • Pharmacological modulation of nitrogen oxide system in experimental chronic alcoholic intoxication in rats
    Eksperimental Naya I Klinicheskaya Farmakologiya, 2011
  • Disturbance of HSP70 chaperone activity is a possible mechanism of mitochondrial dysfunction
    I. F. Belenichev, Yu. M. Kolesnik, S. V. Pavlov, E. P. Sokolik, N. V. Bukhtiyarova
    Neurochemical Journal, 2011
    We studied the involvement of HSP70 and Hif1b genes in the development of pathological changes in the brains of experimental animals during ischemia. We found neuro- and mitoprotective characteristics of heat shock protein HSP70 and Hif1b in vitro and under cerebral ischemia due to stabilization of molecules damaged by oxidation, inhibition of nitrosative and oxidative stress and mitoprotective action directed to amelioration of mitochondrial dysfuction. The protective role of these proteins provides a new direction for the development of novel neuroprotective drugs that protect or modulate the genes that encode these proteins.

RECENT SCHOLAR PUBLICATIONS

  • Features of lipid metabolism in membranes of rat cells atexperimental traumatic brain injury on the background of chronic alcohol intoxication
    V Kresyun, V Godovan, E Sokolik, N Kresyun
    Revista de Ştiinţe ale Sănătăţii din Moldova 29 (3), 13-20 , 2022
    2022
  • Analysis of significance of mitochondrial dysfunction in the pathogenesis of diseases of the central nervous system
    OP Sokolik, GO Prozorova
    Neuroscience Research Notes 5 (3), 151-151 , 2022
    2022
    Citations: 2
  • Аналіз та узагальнення ключових методів екстракції, виділення та характеристики біологічно активних сполук, отриманих з екстрактів рослин
    G Prozorova, O Sokolik
    Annals of Mechnikov's Institute, 77-84 , 2022
    2022
  • Features of lipid metabolism in membranes of rat cells at experimental traumatic brain injury on the background of chronic alcohol intoxication
    V Kresyun, V Godovan, E Sokolik, N Kresyun
    Revista de Științe ale Sănătății din Moldova= Moldovan Journal of Health … , 2022
    2022
  • Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine
    OP Sokolik, GO Prozorova
    Research Results in Pharmacology 8 (2), 77-86 , 2022
    2022
    Citations: 5
  • Current research opportunities for potential phytotherapeutic agents for the treatment of pathologies of the female reproductive system
    OP Sokolik, GO Prozorova
    Wydawnictwo Uniwersytetu Rzeszowskiego , 2022
    2022
    Citations: 6
  • Профилактическое влияние нейропептидных препаратов на обучаемость и память при алкогольной энцефалопатии
    ЕП Соколик, ИФ Беленичев
    2019
  • Вплив черепно-мозкової травми на тлі хронічної алкогольної інтоксикації в експерименті на активність Na+/K+-АТФази еритроцитів і можливість її корекції
    ВЙ Кресюн, ОП Соколик, ВИ Кресюн, ЕП Соколик
    2019
  • Особливості профілактичного застосування нейропептидних препаратів при хронічній алкогольній інтоксикації з метою корекції неврологічних порушень
    ОП Соколик
    Реєстраційне посвідчення УкрІНТЕІ № 609 від 11.10. 2017 р. Механізми … , 2018
    2018
  • Особенности морфо-функциональных изменений миокарда, печени и мозга при хронической алкогольной интоксикации у крыс и пути их фармакокоррекции
    ЕП Соколик
    Молодёжь и медицинская наука, 412-416 , 2018
    2018
    Citations: 1
  • ОСОБЕННОСТИ ПРОФИЛАКТИЧЕСКОГО ВВЕДЕНИЯ НЕЙРОПЕПТИДНЫХ ПРЕПАРАТОВ ПРИ АЛКОГОЛЬНОЙ ИНТОКСИКАЦИИ
    ЕП Соколик
    Научный медицинский вестник Югры, 65-66 , 2018
    2018
  • Особенности дисфункции глутатионовой системы на фоне хронической алкогольной интоксикации: нейропротекция пептидными препаратами
    ЕП Соколик
    2017
  • Psychobiotics: the potential therapeutic promise of microbes in psychiatry
    GH Sayar, M Cetin
    Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 26 … , 2016
    2016
    Citations: 9
  • Pharmacological Modulation of Heat Shock Protein 70 (HSP70)—Dependent Mechanisms of Endogenous Neuroprotection in Conditions of Prenatal Chronic Alcoholism by Cerebrocurin and …
    IF Belenichev, EP Sokolik, NV Bukhtiarova, SV Levich
    Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 26 … , 2016
    2016
    Citations: 6
  • Hizli-Sayar G, Cetin M.
    IF Belenichev, EP Sokolik, NV Bukhtiarova, SV Levich, G Umut, MI Atagun, ...
    Klinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology 26 … , 2016
    2016
  • Pharmacological modulation of HSP70-dependent mechanisms of endogenous neuroprotection in conditions of prenatal chronic alcoholism by Cerebrocurin and Tiocetam
    IF Belenichev, EP Sokolik, NV Buchtiarova, SV Levich
    Turkiye: Istanbul , 2016
    2016
  • СРАВНИТЕЛЬНАЯ ОЦЕНКА ЭНЕРГОМОДУЛИРУЮЩЕГО ДЕЙСТВИЯ ЦЕРЕБРОКУРИНА, КОРТЕКСИНА ИЦЕРЕБРОЛИЗИНА ПРИ ХРОНИЧЕСКОЙ АЛКОГОЛЬНОЙ ИНТОКСИКАЦИИ
    ЕП Соколик
    МОЛОДЕЖЬ, НАУКА, МЕДИЦИНА, 454-457 , 2016
    2016
  • ВЛИЯНИЕ НЕЙРОТРОФИЧЕСКОЙ ЦЕРЕБРОПРОТЕКЦИИ НА ЭКСПРЕССИЮ БЕЛКА ТЕПЛОВОГОТ ШОКА HSP70 В ГОЛОВНОМ МОЗГЕ ПРЕНАТАЛЬНО АЛКОГОЛИЗИРОВАННЫХ КРЫС
    ЕП Соколик
    Медико-биологические аспекты мультифакториальной патологии, 96-96 , 2016
    2016
  • ГИСТОМОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ НЕЙРОНОВ В ЗОНЕ СА1-ГИППОКАМПА КРЫС С ХРОНИЧЕСКОЙ АЛКОГОЛЬНОЙ ИНТОКСИКАЦИЕЙ НА ФОНЕ ПРОФИЛАКТИЧЕСКОЙ ФАРМАКОКОРРЕКЦИИ НЕЙРОПЕПТИДАМИ
    ЕП Соколик
    Университетская наука: взгляд в будущее, 345 , 2016
    2016
  • Особенности воздействия нейропептидных препаратов на содержание маркеров окислительной модификации и нитрозилирования белков в головном мозге на фоне алкогольной интоксикации
    ЕП Соколик
    Фармацевтическое образование, наука и практика: горизонты развития, 599 , 2016
    2016

MOST CITED SCHOLAR PUBLICATIONS

  • Malate-aspartate shunt in neuronal adaptation to ischemic conditions: Molecular-biochemical mechanisms of activation and regulation
    IF Belenichev, YM Kolesnik, SV Pavlov, EP Sokolik, NV Bukhtiyarova
    Neurochemical Journal 6 (1), 22-28 , 2012
    2012
    Citations: 30
  • Disturbance of HSP70 chaperone activity is a possible mechanism of mitochondrial dysfunction
    IF Belenichev, YM Kolesnik, SV Pavlov, EP Sokolik, NV Bukhtiyarova
    Neurochemical Journal 5 (4), 251-256 , 2011
    2011
    Citations: 27
  • Новые возможности лечения алкогольной болезни. Перспективы применения Цереброкурина®
    ИФ Беленичев, СВ Павлов, ЕП Соколик, НВ Бухтиярова
    Международный неврологический журнал, 105-119 , 2009
    2009
    Citations: 17
  • Effect of the Spin Trapping Compound PBN and Thiotriazoline on the Outcome from Experimental Middle Cerebral Artery Occlusion in Rats
    IF Belenichev, SV Pavlov, E Sokolik, I Mazur, N Buhtiyarova, ...
    2010
    Citations: 11
  • Psychobiotics: the potential therapeutic promise of microbes in psychiatry
    GH Sayar, M Cetin
    Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 26 … , 2016
    2016
    Citations: 9
  • Содержание маркеров окислительной модификации и нитрозилирования белков в головном мозге при введении цереброкурина, кортексина и церебролизина на фоне алкогольной интоксикации
    ИФ Беленичев, ЕП Соколик
    Запорожский медицинский журнал, 5-7 , 2011
    2011
    Citations: 9
  • Reduction of apoptotic death of neurons-1 zone of hippocampus of rats in the condition of prenatal chronic alcoholisation by cerebrocurin and tiocetam
    IF Belenichev, EP Sokolik, AN Egorov
    2013
    Citations: 7
  • Фармакологическая модуляция системы окиси азота при моделировании хронической алкогольной интоксикации у крыс
    ИФ Беленичев, ЕП Соколик
    Экспериментальная и клиническая фармакология 74 (10), 43-45 , 2011
    2011
    Citations: 7
  • Pharmacological modulation of apoptosis signaling in neurons of CA1-zone of hippocampus of rats with chronic alcohol intoxication
    IF Belenichev, E Sokolik, A Abramov
    India: Innovative Journal , 2011
    2011
    Citations: 7
  • Current research opportunities for potential phytotherapeutic agents for the treatment of pathologies of the female reproductive system
    OP Sokolik, GO Prozorova
    Wydawnictwo Uniwersytetu Rzeszowskiego , 2022
    2022
    Citations: 6
  • Pharmacological Modulation of Heat Shock Protein 70 (HSP70)—Dependent Mechanisms of Endogenous Neuroprotection in Conditions of Prenatal Chronic Alcoholism by Cerebrocurin and …
    IF Belenichev, EP Sokolik, NV Bukhtiarova, SV Levich
    Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 26 … , 2016
    2016
    Citations: 6
  • Фармакологическая модуляция компенсаторных механизмов энергетического метаболизма в головном мозге пренатально алкоголизированных животных
    ИФ Беленичев, ЕП Соколик, АН Егоров
    Вестник новых медицинских технологий 21 (3), 54-57 , 2014
    2014
    Citations: 6
  • Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine
    OP Sokolik, GO Prozorova
    Research Results in Pharmacology 8 (2), 77-86 , 2022
    2022
    Citations: 5
  • Фармакологічна модуляція сигналінгу апоптозу нейронів СА1-зони гіпокампа щурів з хронічною алкогольною інтоксикацією
    ІФ Бєленічев, ОП Соколик, АВ Абрамов
    2011
    Citations: 5
  • Сравнительная оценка энергомодулирующего действия цереброкурина, кортексина и церебролизина при хронической алкогольной интоксикации
    ИФ Беленичев, ЕП Соколик
    Патологiя. 7 (2), 50 , 2010
    2010
    Citations: 5
  • Nitrozine Stress and Neurological Disorders in Experimental Alcohol Intoxication and Their Pharmacological Correction by Neuropeptides
    IF Belenichev, E Sokolik
    2011
    Citations: 4
  • Роль нитрозирующего стресса в механизмах нейродеструкции в условиях пренатальной алкогольной интоксикации и пути фармакокоррекции возникающих нарушений
    АН Егоров, ИФ Беленичев, ЕП Соколик, ЛИ Кучеренко
    Запорожский медицинский журнал, 25-28 , 2012
    2012
    Citations: 3
  • Малат-аспартатный шунт в реакциях адаптации нейронов к условиям ишемии: молекулярно-биохимические механизмы активации и регуляции
    ИФ Беленичев, ЮМ Колесник, СВ Павлов, ЕП Соколик, НВ Бухтиярова
    Нейрохимия 29 (1), 28-28 , 2012
    2012
    Citations: 3
  • Pharmacological modulation of nitrogen oxide system in experimental chronic alcoholic intoxication in rats
    IF Belenichev, EP Sokolik
    Eksperimental'naia i Klinicheskaia Farmakologiia 74 (10), 43-45 , 2011
    2011
    Citations: 3
  • Analysis of significance of mitochondrial dysfunction in the pathogenesis of diseases of the central nervous system
    OP Sokolik, GO Prozorova
    Neuroscience Research Notes 5 (3), 151-151 , 2022
    2022
    Citations: 2