Alaaeldin Ahmed Hamza

@nodcar.eg.net

Biology , Department of Hormones
National Organization for Drug control and Researc

Alaaeldin Ahmed Hamza


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Dr. Alaaeldin Ahmed Hamza, who earned his PhD from Cairo University in Animal Physiology, is currently working as an Emeritus professor of physiology at the National Organization for Drug Control and Research (NODCAR) in Egypt. He is an established scientist in the fields of liver toxicity, reproductive toxicity, and liver cancer. He was awarded the best individual non-funded research project award at the 9th Annual Research Conference, U.A.E. University, Al-Ain April 21–23, 2008. Based on his highly cited publications, he has been ranked among the top scientists in United Arab Emirates institutions according to GSC public profiles from 2017 to 2024 and among the top 2% of the world's scientists by Stanford University from 2020 to 2023. He has published more than 52 papers in different fields of pharmacology and toxicology in many prestigious journals, such as Hepatology, Biomedicine & Pharmacotherapy, Frontiers in Pharmacology Scientific Report, Toxicology Letters, Toxicology, Food and

EDUCATION

Cairo University, Cairo, Egypt 2004
Ph.D., Animal Physiology, Zoology Department, Faculty of Science

Cairo University,Cairo, Egypt 1995
M.Sc., Animal Physiology, Zoology Department, Faculty of Science

Ain –Shams University, Cairo, Egypt 1987
Institut of Environmental Studies and Research
Diploma, In Enviromental Biological Sciences

Cairo University, Cairo, Egypt 1983
B.Sc., Zoology Department, Faculty of Science

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Cancer Research, Physiology (medical), Hepatology

FUTURE PROJECTS

Biosynthesis and Characterization of Gold and Copper Nanoparticles from Salvadora persica Fruit Extracts and Their Biological Properties

Introduction: Metal nanoparticle synthesis using plant has emerged as an eco-friendly, clean, and viable strategy alternative to chemical and physical approaches. Methods: The fruit extract of Salvadora persica (SP) was utilized as a reducing and stabilizing agent in the synthesis of gold (AuNPs) and copper (CuNPs) nanoparticles. Results: UV–Vis spectra of the AuNPs and CuNPs showed peaks at the wavelengths of 530 nm and 440 nm, respectively. Transmission electron microscopy showed that nanoparticles exhibited a mainly spherical form, with a distribution range of 100 to 113 nm in diameter for AuNPs and of 130 to 135 nm in diameter for CuNPs. While energy-dispersive X-ray spectroscopy was able to confirm the existence of AuNPs and CuNPs. The alcoholic extract of the fruit SP was analyzed by GC-MS in order to identify whether or not it contained any active phytochemicals. Fourier-transform infrared spectra confirmed the presence capping functional biomolecules of SP on the surface of nan


Applications Invited
International Journal of Nanomedicine 2022, 17:6095-10.2147/ijn.s385543

Withania somnifera Ameliorates Doxorubicin-Induced Nephrotoxicity and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2, Oxidative Stress, Inflammation, and Apoptosis

Doxorubicin (DOX) is a potent chemotherapy drug, but its severe toxicity and potential for resistance limit its use. *Withania somnifera* L. Dunal (WIT) possesses therapeutic properties, including anti-inflammatory, antioxidant, and anticancer activities. This study aims to examine the preventive effects of a standardized WIT extract against DOX-induced kidney damage in vivo. Additionally, it explores the synergistic effects of combining WIT with DOX to enhance therapeutic efficacy in drug-resistant breast cancer cells (MCF7-ADR).In this study, an animal model was used, where rats were administered 300 mg/kg/day of WIT orally for 14 days. DOX was injected at a dose of 5 mg/kg, totaling 15 mg, on days 6, 8, and 10.The results showed that WIT significantly reduced the DOX-induced increase in blood urea and creatinine levels, as well as the activity of kidney injury molecule-1 (KIM-1). WIT also alleviated kidney tissue damage, oxidative stress, and levels of pro-inflammatory markers. It m


Applications Invited
Pharmaceuticals 2025, Volume 18, Issue 2, 248
42

Scopus Publications

Scopus Publications

Publications

Withania somnifera Ameliorates Doxorubicin-Induced Nephrotoxicity
and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2,
Oxidative Stress, Inflammation, and Apoptosis
Amany Mohammed Mohmmed Hegab; Soha Osama Hassanin; Reham Hassan Mekky; Samah
Sulaiman Abuzahrah; Alaaeldin Ahmed Hamza; Iman M. Talaat; Amr Amin
Pharmaceuticals 2025, Volume 18, Issue 2, 248, doi:

GRANT DETAILS

• Bioavailability of Itraconazole-β-cyclodextrin Complex. (2003).
• Establish post natal mammalian neuronal system from different regions of the brain for isolation and identification of serotonin receptor (2003)(UAEU Grant # 01-14-2-11/03).
• Control the Diminution of antioxidants in diabetes using UAE Herbal Medicine. (2004),
Project number :07-04-2-11-04
• Ghrelin and recovery after antineoplastic and cytotoxic therapy (2004).
• Amin, A., Hamza, A. (2006). Examining the protective role of the unicellular green algae (Chlorella sp.) against breast cancer. UAEU GRANT; ~$8,000
• Introducing Cichorium Pumilum as a Potential Therapeutical Agent Against Drug-Induced Breast Tumor in Rats, 2006, Project number : 08-02-2-11/06.
• Screening of estrogenic and anti-estrogenic activities of traditional medicinal plants (2008). ~$8,000
• Amin, A., Hamza, A (2006). Potential of local plants to protect against drug induced liver fibrosis in rats (2007), ~$8,000
• Amin, A., Mahmoud-Ghoneim, D., Alaaeldin A. Hamza. Evaluation of the saffron-based chemoprevention against liver cancer (2009), Emirates Foundation grant (2009-2011). . ~$60,000
• Amin, A., Marzouk, S., Hamza, A. Potentiating the platinum-based cancer chemotherapy with herbal extracts: Fertility restoration approach (2010). Project number :1170-02-02-10~$60,000
• Khasawna, M., Hamza A. The isolation and identification of the chemical components of come UAE plants and their use as potential anti canc