Dra. Esp. Maria Angelica Alvarez Paucar

@unmsm.edu.pe

Academic Department of Pediatric Dentistry
Universidad Nacional Mayor de San Marcos (UNMSM)

Dra. Esp. Maria Angelica Alvarez Paucar


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https://researchid.co/ma-angelica

EDUCATION

Universidad Nacional Mayor de San Marcos
Pontificia Universidad Católica del Perú

RESEARCH INTERESTS

Pediatric Dentistry
Public health
Phytotherapeutics
Dental Research
4

Scopus Publications

1467

Scholar Citations

21

Scholar h-index

47

Scholar i10-index

Scopus Publications

  • Development of new experimental dentifrice of peruvian solanum tuberosum (Tocosh ) fermented by water stress: Antibacterial and cytotoxic activity
    Percy Romero-Tapia, Gabriela Sedano-Balbin, Sonia Sacsaquispe-Contreras
    Journal of Contemporary Dental Practice, 2019
    AIM "Tocosh" is a potato that has undergone a process of hydraulic oxidation that enhances its antimicrobial properties so that this natural resource can be used in medical sciences. The aim of this study was to develop and evaluate the antibacterial and cytotoxic activity of a new experimental tooth based on Solanum tuberosum "Tocosh" on the cell lines 3T3 and DU145. MATERIALS AND METHODS To evaluate the cytotoxicity, cell cultures 3T3 and DU145 were used. Cell viability was determined by the MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) in a medium containing 10% calf serum where the cells were preincubated at a concentration of 1 × 106 cells/mL in culture medium for 3 hours at 37°C and 6.5% CO2. Then, the absorbance was measured using a microplate reader where the formazan crystals were diluted with acidic and cold isopropanol, and quantified in an ELISA reader. To evaluate the antibacterial effect, the Kirby Bauer inhibition halos method was used on strains of S. aureus (ATCC 25923), S. mutans (ATCC 25175), and S. mitis (ATCC 49456). RESULTS Solanum tuberosum (tocosh) was not cytotoxic because it only had one CC50 at the concentration of 0.26927 mg/mL and 0.26845 mg/mL for the cell lines 3T3 and DU145, respectively. Tocosh toothpaste (TD) has an antibacterial effect against S. aureus and S. mutans. CONCLUSION The new ecological dentifrice was not cytotoxic since it did not alter cell viability because its CC50 was only 0.268 and 0.269 μg/mL for the 3T3 and DU145 cell lines, respectively; however, it presented an optimal antimicrobial activity against the oral strains evaluated. CLINICAL SIGNIFICANCE This research has great potential for clinical use because this new dentifrice has antimicrobial activity against different oral germs. How to cite this article: Mayta-Tovalino F, Sedano-Balbin G, Romero-Tapia P, et al. Development of New Experimental Dentifrice of Peruvian Solanum tuberosum (Tocosh) Fermented by Water Stress: Antibacterial and Cytotoxic Activity. J Contemp Dent Pract 2019;20(10):1206-1211.
  • Perception of clinical training and future objectives of residents of oral implantology (POCTOIR-30 questionnaire): A pilot study of statistical validation
    G Mendoza-Azpur, María Álvarez-Paucar, Luis Gálvez-Calla, Luz Carbajal
    World Journal of Dentistry, 2019
    Ab s t r Ac t Aim: The aim of the present study was to develop and validate the psychometric properties of the questionnaire (POCTOIR-30) for the evaluation of the perception of clinical training and future goals of residents of oral implantology. Materials and methods: The development of the questionnaire followed the process of five phases: (a) preparation of the instrument, (b) validation of the content, (c) validity of the construct, (d) evaluation of internal consistency and reliability, (e) evaluation of the level of knowledge, for which an instrument on implant training of residency programs was used as a reference. To evaluate the sensitivity and validity of the questionnaire, a pilot sample of 20 residents between 20 years and 50 years of a residency program in oral implantology was used. Results: The factor analysis of the data and the adjustment statistics process resulted in the quality care of 4 factors and 30 questions that were included in the present questionnaire (POCTOIR), which covers: logistics and infrastructure (five items), training in oral implantology (10 items); information on the postgraduate program (seven items) and accessibility and sustainability of care (ten items) and future goals after postgraduate studies (five items). Content validity was measured using the index that combines the ease of calculation and the evaluation of results at the statistical level (κ 0.833). The reliability of the instrument was evaluated to measure the degree of internal correlation (Cronbach’s α 0.738). Finally, the reliability was evaluated to measure the constancy of the responses repeatedly with the same subjects (intraclass correlation 0.74). Conclusion: This study showed that the POCTOIR-30 instrument has adequate levels of validity and reliability to be used in residents of areas related to oral implantology in new research. Clinical significance: The impact of the academic training of the residents in oral implantology significantly influences their performance at the time of performing the surgical and prosthetic protocols. Therefore, this research validates statistically the perception of academic training and future goals of postgraduate residents in order to quantify and apply improvement strategies during their years of study.
  • Oral health and obesity in the SAYCARE study: reliability and internal validity of diagnostic methods
    M. P. M. Rando-Meirelles, M. L. R. Sousa, G. C. Vale, V. A. Lages, P. P. Vásquez, P. Jimenez, R. S. Villena, M. A. Alvarez-Paucar
    Obesity Science and Practice, 2019
    The aim of this pilot study was to address the reliability, internal validity and viability of oral health methods used in the South American Youth/Child cARdiovascular and Environmental study.
  • An 11-Year Retrospective Research Study of the Predictive Factors of Peri-Implantitis and Implant Failure: Analytic-Multicentric Study of 1279 Implants in Peru
    Frank Mayta-Tovalino, Yens Mendoza-Martiarena, Percy Romero-Tapia, María Álvarez-Paucar, Luis Gálvez-Calla, Juan Calderón-Sánchez, Rodolfo Bolaños-Cardenas, Antonio Diaz-Sarabia
    International Journal of Dentistry, 2019
    Aim. To analyze the risk factors by logistic regression and perform the analysis of the survival rate of osseointegrated dental implants placed in public and private institutions. Methods. An analytic-multicentric study was carried out, where 1279 dental implants that were placed by specialists from January 2006 to October 2017 in public and private institutions (UPCH-SI, HCFAP, CMNAVAL, UPCH-SM, and UPSJB) were evaluated. The variables sex (X1), location (X2), hypertension (X3), antibiotic prophylaxis (X4), diabetes (X5), osteoporosis (X6), bisphosphonates (X7), history of periodontitis (X8), hypercholesterolemia (X9), bone quality (X10), bone quantity (X11), design (X12), smoker (X13), connection (X14), edentulism type (X15), staging (X16), 3D guided surgery (X17), load (X18), bone graft (X19), peri-implantitis (X20), mucositis (X21), and GBR (X22) were collected and analyzed by the Kaplan–Meier survival analysis. The logit analysis was performed among all the variables to choose the best statistical model that explains the true risk factors. The analysis was performed by multivariate logistic regression and the Kaplan–Meier test, at a level of statistical significance of p<0.05. Results. It was found that the failure rate of the 1279 implants evaluated was 17.98% corresponding to only 23 implants lost as they have good longevity over time. When establishing the best multivariate logistic regression model, it was found that the variables that remained stable in relation to their statistically significant value and more stable confidence intervals were age, osteoporosis, bisphosphonates, history of periodontitis, bone quality, bone graft, connection, number of implants, GBR (guided bone regeneration), and follow-up. Conclusions. Dental implants placed by specialists in public and private institutions had a failure rate similar to that in studies previously published in other countries.

RECENT SCHOLAR PUBLICATIONS

  • Carbene‐Induced Reversible and Complete Decoordination of Tridentate Trispyrazolylborate Ligands in Copper Complexes
    M Casciotti, M Álvarez, G Sciortino, A Lledós, TR Belderrain, PJ Pérez
    ChemistryEurope 4 (5), e70296 , 2026
    2026
  • Methane Catalytic Amidation via a Plausible Copper-Nitrene Intermediate
    J Martínez-Laguna, A Cholewinska, E Borrego, M Besora, M Álvarez, ...
    Journal of the American Chemical Society 148 (8), 9057-9065 , 2026
    2026
  • A copper-masked monosubstituted carbene as a general transmetalating agent toward stable carbene complexes
    M Álvarez, F Villalba, M Casciotti, F Molina, G Sciortino, A Lledós, ...
    Chem 10 (5), 1576-1592 , 2024
    2024
    Citations: 9
  • Copper‐Catalyzed Sulfimidation in Aqueous Media: a Fast, Chemoselective and Biomolecule‐Compatible Reaction
    EJ Meeus, M Álvarez, E Koelman, PJ Pérez, JNH Reek, B de Bruin
    Chemistry–A European Journal 30 (14), e202303939 , 2024
    2024
    Citations: 4
  • Predictive factors of non-pharmacological measures to prevent SARS-CoV-2 contagion: Results of a large adult Spanish sample from the PSY-COVID study
    C Mateo-Canedo, JP Sanabria-Mazo, JB Navarro, I Cigarroa, M Álvarez, ...
    medRxiv, 2023.10. 30.23297748 , 2023
    2023
  • The catalytic nitrene-oxo transfer battle in water as solvent
    M Álvarez, PJ Pérez
    Chem Catalysis 3 (8) , 2023
    2023
  • Oncoguía de melanoma cutáneo 2023
    H Martínez, M Vega, M Cuéllar, V Villavicencio, D García, F Aldaco, ...
    Latin American Journal of Clinical Sciences and Medical Technology 5, 155-167 , 2023
    2023
    Citations: 5
  • Intramolecular Interception of the Remote Position of Vinylcarbene Silver Complex Intermediates by C(sp 3 )−H Bond Insertion
    À Díaz‐Jiménez, R Monreal‐Corona, A Poater, M Álvarez, E Borrego, ...
    Angewandte Chemie 135 (5), e202215163 , 2023
    2023
    Citations: 14
  • Carbene-controlled regioselective functionalization of linear alkanes under silver catalysis
    M Alvarez, F Molina, PJ Perez
    Journal of the American Chemical Society 144 (51), 23275-23279 , 2022
    2022
    Citations: 26
  • Predictive factors of non-pharmacological measures to prevent SARS-CoV-2 contagion: A cross-sectional study in a large Spanish sample
    C Mateo-Canedo, JP Sanabria-Mazo, JB Navarro, I Cigarroa, ...
    2022
  • Environmental Dissemination of Carbapenem Resistant Enterobacteria in the Rio Grande River: A Public Health Concern?
    MD Fuentes, G Sepulveda, M Flores, J Mendoza, M Alvarez, ...
    Texas Public Health Journal 74 (4) , 2022
    2022
  • Pulmonary telerehabilitation in patients with chronic respiratory diseases during the pandemic by COVID-19 in Argentina. A multicenter observational study.
    S Larrateguy, G Mazzucco, S Dell, R Torres-Castro, N De Carlo, G Turon, ...
    European Respiratory Journal 60 (suppl 66) , 2022
    2022
  • Alkane Functionalization by Metal‐Catalyzed Carbene Insertion from Diazo Reagents
    M Álvarez, A Caballero, PJ Pérez
    Transition Metal‐Catalyzed Carbene Transformations, 1-24 , 2022
    2022
    Citations: 3
  • Gold (I) complexes bearing a PNP-type pincer ligand: photophysical properties and catalytic investigations
    M Casciotti, G Romo-Islas, M Álvarez, F Molina, JM Muñoz-Molina, ...
    Dalton Transactions 51 (45), 17162-17169 , 2022
    2022
    Citations: 10
  • Locus of Control and the Acknowledgment of Effort
    F Aguiar, M Álvarez, L Miller
    American Behavioral Scientist 65 (11), 1480-1496 , 2021
    2021
    Citations: 12
  • Indicadores de salud oral en niños y adolescentes con parálisis cerebral de centros especializados de Lima-Perú, periodo 2012-2013.
    MA Alvarez-Páucar, MRLC Say, R Revoredo-Morote
    Odontología sanmarquina 24 (3), 225-234 , 2021
    2021
    Citations: 1
  • Two copper-carbenes from one diazo compound
    M Alvarez, M Besora, F Molina, F Maseras, TR Belderrain, PJ Perez
    Journal of the American Chemical Society 143 (12), 4837-4843 , 2021
    2021
    Citations: 40
  • Actividad antioxidante del gel a base de extracto de Origanum vulgare¿ Importante para la salud bucal? Estudio preliminar
    L Galvez-Calla, MA Alvarez-Páucar, O Alcázar-Aguilar, F Mayta-Tovalino, ...
    Revista Estomatológica Herediana 31 (1), 6-16 , 2021
    2021
    Citations: 6
  • PGI7 Budget IMPACT of Capsule Endoscopy for Crohn's Disease Management in Spain
    RT Torrejon, JFM Nuñez, L Menchén, IE Martín, M Alvarez, R Saunders
    Value in Health 23, S534 , 2020
    2020
  • BUDGET IMPACT OF CAPSULE ENDOSCOPY FOR CROHN'S DISEASE MANAGEMENT IN SPAIN
    TR Torrejon, JF Munoz Nunez, L Menchen, I Elias Martin, N Van Ient, ...
    VALUE IN HEALTH 23, S533-S533 , 2020
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Nivel de conocimientos en salud bucal de las madres y su relación con el estado de salud bucal del niño menor de cinco años de edad.
    LAB Lipa, SAC Vlllacampa, CHC Reátegui, EP Alva, MSV Huasupoma, ...
    Odontología sanmarquina 15 (1), 14-19 , 2012
    2012
    Citations: 135
  • Effectiveness of primary healthcare educational interventions undertaken by nurses to improve chronic disease management in patients with diabetes mellitus, hypertension and …
    M Gorina, JT Limonero, M Alvarez
    International journal of nursing studies 86, 139-150 , 2018
    2018
    Citations: 85
  • Lightweight insulating concretes with rice husk
    J Salas, M Alvarez, J Veras
    International Journal of Cement Composites and Lightweight Concrete 8 (3 … , 1986
    1986
    Citations: 60
  • Educación y familia: La educación familiar en un mundo de cambio
    M Álvarez, A Berástegui
    Madrid. Universidad pontificia Comillas , 2006
    2006
    Citations: 59
  • An unforgettable event: a qualitative study of the 1997–98 El Niño in northern Peru
    AM Bayer, HE Danysh, M Garvich, G Gonzálvez, W Checkley, M Álvarez, ...
    Disasters 38 (2), 351-374 , 2014
    2014
    Citations: 49
  • El Niño adversely affected childhood stature and lean mass in northern Peru
    HE Danysh, RH Gilman, JC Wells, WK Pan, B Zaitchik, G Gonzálvez, ...
    Climate Change Responses 1 (1), 7 , 2014
    2014
    Citations: 47
  • An 11‐year retrospective research study of the predictive factors of peri‐Implantitis and implant failure: analytic‐multicentric study of 1279 implants in Peru
    F Mayta-Tovalino, Y Mendoza-Martiarena, P Romero-Tapia, ...
    International journal of dentistry 2019 (1), 3527872 , 2019
    2019
    Citations: 43
  • Two copper-carbenes from one diazo compound
    M Alvarez, M Besora, F Molina, F Maseras, TR Belderrain, PJ Perez
    Journal of the American Chemical Society 143 (12), 4837-4843 , 2021
    2021
    Citations: 40
  • Validation of a new portable metabolic system during an incremental running test
    V Díaz, PJ Benito, AB Peinado, M Álvarez, C Martín, V Di Salvo, F Pigozzi, ...
    Journal of sports science & medicine 7 (4), 532 , 2008
    2008
    Citations: 40
  • AIDS prevention training for pharmacy workers in Mexico City
    S Pick, J Reyes, M Alvarez, S Cohen, J Craige, A Troya
    AIDS care 8 (1), 55-70 , 1996
    1996
    Citations: 33
  • Educational diagnosis of self‐management behaviours in patients with diabetes mellitus, hypertension and hypercholesterolaemia based on the PRECEDE model: Qualitative study
    M Gorina, JT Limonero, M Álvarez
    Journal of clinical nursing 28 (9-10), 1745-1759 , 2019
    2019
    Citations: 31
  • Could white coat ocular hypertension affect to the accuracy of the diagnosis of glaucoma? Relationships between anxiety and intraocular pressure in a simulated clinical setting
    JL Méndez-Ulrich, A Sanz, A Feliu-Soler, M Álvarez, X Borràs
    Applied Psychophysiology and Biofeedback 43 (1), 49-56 , 2018
    2018
    Citations: 31
  • Assessment of antibiotic levels, multi-drug resistant bacteria and genetic biomarkers in the waters of the Rio Grande River between the United States-Mexico border
    MD Fuentes, S Gutierrez, D Sahagun, J Gomez, J Mendoza, CC Ellis, ...
    Journal of health & pollution 9 (23), 190912 , 2019
    2019
    Citations: 27
  • Properties of concrete made with fly ash
    M Alvarez, J Salas, J Veras
    International Journal of Cement Composites and Lightweight Concrete 10 (2 … , 1988
    1988
    Citations: 27
  • Carbene-controlled regioselective functionalization of linear alkanes under silver catalysis
    M Alvarez, F Molina, PJ Perez
    Journal of the American Chemical Society 144 (51), 23275-23279 , 2022
    2022
    Citations: 26
  • La familia ante la enfermedad
    M Álvarez, F Montalvo
    Madrid: Ormag , 2010
    2010
    Citations: 25
  • Development of new experimental dentifrice of Peruvian Solanum tuberosum (Tocosh) fermented by water stress: Antibacterial and cytotoxic activity
    S Sacsaquispe-Contreras
    The journal of contemporary dental practice 20 (10), 1206-1211 , 2018
    2018
    Citations: 24
  • Terapias artísticas y creativas en la mejora del malestar psicológico en mujeres con cáncer de mama. Revisión sistemática
    MR Álvarez
    Psicooncología , 2017
    2017
    Citations: 24
  • Modelos sociocognitivos en promoción de la salud: un análisis conceptual.
    F Villamarín, M Álvarez
    Psicologemas 12 (24), 161-204 , 1998
    1998
    Citations: 24
  • El perfil de salud-enfermedad bucal y las necesidades de tratamiento de los adultos mayores de Lima urbana 2012
    CHC Reátegui, S Chein-Villacampa, LB Lipa, RV Goñi, JRD Avila, ...
    Odontología sanmarquina 16 (2), 29-33 , 2013
    2013
    Citations: 23