Fajar Husen

@stikesbinaciptahusada.ac.id

Medical Laboratory of Technology
College of Health Science of Bina Cipta Husada

Fajar Husen


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https://researchid.co/fajarhusen
Lecturer of Medical Laboratory of Technology

EDUCATION

Bachelor Degree of Biology of Jenderal Soedirman University (UNSOED)
Master of Science of Biology (Microbiology) of Jenderal Soedirman University (UNSOED)

RESEARCH INTERESTS

Microbiology, Immunology, Medical Mycology, Histology

FUTURE PROJECTS

SOYBEAN SELECTION AGAINST CERCOSPORA LEAF BLIGHT DISEASE CAUSED BY CERCOSPORA KIKUCHII BASED ON ANATOMICAL RESISTANCE

Soybean (Glycine max L. Merr.) is the third food crop commodity after rice and maize in Indonesia. This plant is also known as the most important source of vegetable protein, which is relatively inexpensive, but a decrease in soybean productivity can occur due to infection with disease-causing pathogens, one of is Cercospora kikuchii which causes Cercospora leaf blight (CLB). The research objectives were to determine the anatomical resistance and disease severity of soybean cultivars against CLB. The method was an experiment with a completely randomized design (CRD) factorial pattern; factor 1 being soybean cultivars (Dering, Slamet, Grobogan, Wilis) and factor 2, namely pathogen inoculation (0 conidiospores/mL and 105 conidiospores/mL). Anatomical method preparations using paraffin, staining with 1% safranin. Disease criteria are based on the council of scientific and industrial research (CSIR) assessment method. Data were analysis used analysis of variance (p<0.05)


Applications Invited
Anatomical resistance

Ethanol extract of the mushroom Coprinus comatus exhibits anti-diabetic and antioxidant activities in streptozotocininduced diabetic rats

To identify the benefits of ethanol extracts of the C. comatus fruit body in streptozotocin-induced hyperglycemic rats by evaluating their blood glucose, glycosylated hemoglobin (HbA1c), insulin, glucagon-like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DPP-4), and glutathione (GSH) levels, with and without extract administration


Applications Invited
Antidiabetic effect

Antioxidant Activities and Properties of Coprinus comatus Mushroom Both Mycelium and Fruiting Body Extracts In Streptozotocin-Induced Hyperglycemic Rats Model

The study evaluated in vitro and in vivo treatments to evaluate antioxidant effect and activity of C. comatus. The in vivo treatment was conducted using six groups of Wistar rats (n = 24). Group 1 healthy control (HC), groups 2–6 received 45 mg/Kg BW of streptozotocin once, group 2 just streptozotocin-induced (NC), group 3 was given 45 mg/kg BW of metformin (PC), groups 4–6 were given 250 (T1), 500 (T2), and 750 mg (T3) of C. comatus extract for 14 days, and the in vitro was conducted using an antioxidant oxidant assay. Data were analyzed using analysis of variance and Duncan’s multiple-range tests


Applications Invited
Antioxidant supplement
13

Scopus Publications

351

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

Scopus Publications

  • Therapeutic potential of Coprinus comatus nanogels: Antiarthritic and anti-inflammatory effects in rheumatoid arthritis models
    Nuniek Ina Ratnaningtyas, Fajar Husen
    Veterinary World, 2025
    Background and Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation and systemic immune dysregulation. The current pharmacological treatments, primarily synthetic drugs, often present adverse effects and long-term toxicity. This study explores the therapeutic potential of Coprinus comatus nanogels as a novel herbal formulation with antiarthritic and anti-inflammatory properties in a Complete Freund’s Adjuvant (CFA)-induced rat model of RA. The study aims to evaluate the efficacy of C. comatus nanogels in reducing pro-inflammatory cytokine levels, antibody production, paw edema, and arthritis indices and to assess their potential as a safer alternative to conventional RA therapies. Materials and Methods: Twenty-four male Wistar rats were randomized into six groups: Healthy control, negative control (CFA-induced without treatment), positive control (sodium diclofenac 0.012 g/mL), and three treatment groups (TG1, TG2, and TG3) receiving 250, 500, and 750 mg/kg C. comatus nanogels, respectively. Oral treatments were administered for 30 days. Pro-inflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6, IL-1β), antibodies (immunoglobulin [Ig]G, IgE), cyclooxygenase-2 (COX-2) enzyme activity, paw edema, and arthritis indices were measured using enzyme-linked immunosorbent assay and standard methods. Statistical analyses were conducted using one-way analysis of variance. Results: The 750 mg/kg dose of C. comatus nanogels significantly reduced TNF-α (17.71%), IL-1β (19.83%), and IgE (23.91%) levels. The 250 mg/kg dose exhibited the highest reductions in IL-6 (30.88%) and COX-2 (16.54%) levels. TGs demonstrated a 27.75% reduction in paw edema and a 45.45% reduction in arthritis indices. Key bioactive compounds contributing to these effects included flavonoids, polyphenols, triterpenoids, and β-glucans. Conclusion: C. comatus nanogels demonstrated promising anti-inflammatory and antiarthritic properties, suggesting their potential as an alternative herbal treatment for RA. Further studies are recommended to explore the long-term safety and clinical applicability of C. comatus nanogels in human RA management. Keywords: anti-inflammatory, Coprinus comatus, cytokine reduction, herbal medicine, nanogels, rheumatoid arthritis.
  • Anti-Inflammatory Activity of the Shaggy Ink Cap Medicinal Mushroom Coprinus comatus (Agaricomycetes) Nanogel in Complete Freund’s Adjuvant–Induced Rheumatoid Arthritis: In Silico and In Vivo Approach
    Fajar Husen, Nuniek Ina Ratnaningtyas
    International Journal of Medicinal Mushrooms, 2025
    The &lt;i&gt;Coprinus comatus&lt;/i&gt; (O.F. Mull.) Pers. (saggy ink cap) medicinal mushroom is widely found in Indonesia, the utilization and cultivation of this mushroom is still very rare, so further exploration is needed. The potential of bioactive compounds of &lt;i&gt;C. comatus&lt;/i&gt; as a nutraceutical therapeutic is starting to be developed both as antidiabetic, anticancer, antioxidant, and anti-inflammatory. Compounds such as polyphenols, flavonoids, triterpenoids, quercetin and rutin in &lt;i&gt;C. comatus&lt;/i&gt; are known to have biological and pharmacological activities. Many applications of &lt;i&gt;C. comatus &lt;/i&gt;are carried out in the form of extracts, but preparations in the form of nanogels are still not widely applied. This study aimed to determine the effectiveness of &lt;i&gt;C. comatus&lt;/i&gt; nanogels as anti-inflammatory in complete Freund's adjuvant (CFA) induced inflammatory model rats. The research method was a true experiment with a post-test-only approach with a control group design. A total of 24 rats were divided into 6 groups, including healthy control (HGCt), negative control (NGCt) (induced with 0.1 mL CFA), positive control (PGCt) (given sodium diclofenac 0.012 g/kg BW), treatment 1 (TAG1) (given nanogel 250 mg/kg BW), treatment 2 (TAG2) (given nanogel 500 mg/kg BW), and treatment 3 (TAG3) (given nanogel 750 mg/ kg BW). Data were analyzed with SPSS software version 25.1 and GraphPad Prism version 10.2. &lt;i&gt;In silico&lt;/i&gt; testing of rutin compounds showed high binding affinity values in inhibiting iNOS protein (3E7G) and COX-2 protein (1CX2). Although the administration of &lt;i&gt;C. comatus&lt;/i&gt; nanogels had anti-inflammatory activity by reducing the number of leukocytes 28.36&amp;#37; (TAG2), NOS 23.94&amp;#37; (TAG3), plantar thickness 22.51&amp;#37; (TAG1), increasing eNOS levels by 25.90&amp;#37; (TAG1). This anti-inflammatory activity by suppressing iNOS can potentially prevent the formation of free radicals due to increased iNOS enzyme activity, which can lead to cell lipid peroxidation. These results indicate that &lt;i&gt;C. comatus&lt;/i&gt; can be developed as an anti-inflammatory nutraceutical.
  • Microencapsulation of Abalone Oyster Mushroom Pleurotus cystidiosus (Agaricomycetes): Antidiabetic, and Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic Rat Model
    Nuniek Ina Ratnaningtyas, Fajar Husen, Nur Fitrianto, Juni Safitri Muljowati
    International Journal of Medicinal Mushrooms, 2025
    &lt;i&gt;Pleurotus cystidiosus&lt;/i&gt; (abalone oyster mushroom) is an edible species that belongs to the group of woody mushrooms from the Pleurotaceae family. This mushroom contains bioactive compounds such as alkaloids, flavonoids, polyphenols, rutin, quercetin, and triterpenoids that act as antidiabetics and anti-inflammatory agents. Research on using &lt;i&gt;P. cystidiosus&lt;/i&gt; mushrooms cultivated in Cianjur, West Java, is rare. These mushrooms are only used as daily food; besides that, their activity as antidiabetic and anti-inflammatory has never been reported or investigated. This research aimed to determine and examine the potential of &lt;i&gt;P. cystidiosus &lt;/i&gt;mushroom micro encapsulant as an antidiabetic and anti-inflammatory agent. The research method was an experiment using 30 male white rats of &lt;i&gt;Rattus norvegicus&lt;/i&gt; with 200 g body weight (BW) that induced streptozotocin (STZ) dose of 45 mg/kg BW, and divided into 6 groups: HGCt (healthy control, no treatment), NGCt (negative control, induced STZ only), PGCt (given metformin 45 mg/kg BW), TGM1 (given microencapsulant 150 mg/kg BW), TGM2 (given microencapsulant 200 mg/kg BW), TGM3 (given microencapsulant 250 mg/kg BW) for 15 d. The research approach was post-test-only with the control group and complete randomized design (CRD). The results showed that &lt;i&gt;P. cystidiosus&lt;/i&gt; microencapsulant contained polyphenols (3.61 mg), flavonoids (2.21 mg), alkaloids (5.51 mg), amino acids (3.67), and triglycerides (3.78 mg). Microencapsulant administration was also able to reduce blood glucose levels by &amp;#62; 50&amp;#37;, increase insulin hormone by &amp;#62; 25&amp;#37;, increase GLP-1 hormone levels by &amp;#62; 60&amp;#37;, reduce DPP-4 enzyme levels by &amp;#62; 18&amp;#37;, also reduce inflammatory mediators TNF-&amp;alpha; &amp;#62; 22&amp;#37; and IL-1&amp;beta; &amp;#62; 56&amp;#37;. Based on these results, &lt;i&gt;P. cystidiosus&lt;/i&gt; microencapsulation has the potential to be developed as an anti-diabetic and anti-inflammatory nutraceutical.
  • Effect of Gamma Irradiation on The Microbiological Properties, Phenolic Content, and Antioxidant Activity of Mangosteen (Garcinia mangostana L) Flesh During Storage
    Nur Fitrianto, Siti Samiyarsih, Fajar Husen, Andri Frediansyah, Galang Anahatta Hidayat
    Aip Conference Proceedings, 2024
  • Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in a Complete Freund’s Adjuvant–Induced Rheumatoid Arthritis Rat Model: Anti-Arthritic, Anti-Inflammatory, and Antioxidative Activity
    Nuniek Ina Ratnaningtyas, Fajar Husen, Nur Fitrianto
    International Journal of Medicinal Mushrooms, 2024
    Lingzhi or reishi mushroom, Ganoderma lucidum, is a medicinal mushroom quite widely developed as herbal medicine because it has acted as an anticancer, antitumor, antioxidant, and anti-inflammatory. The active mycochemical compounds of G. lucidum mushrooms, such as flavonoids and polysaccharides, can suppress the release of pro-inflammatory cytokines and prevent lipid peroxidation due to oxidative stress. Rheumatoid arthritis (RA) is an autoimmune disease where the exact cause is unknown, and RA prevalence continues to increase yearly. In patients with RA, joint damage and inflammation occur. This study aims to evaluate the effectiveness of G. lucidum nanogels as anti-arthritis, anti-inflammatory, and antioxidative. The research method was a true experiment using a control group and treatment group that randomly assigned, using 24 male Wistar rats (Rattus norvegicus) induced with complete Freund's adjuvant (CFA) 0.1 mL. The rats were divided into six groups; healthy control/HCt (did not receive the treatment), negative control/NCt (induced by CFA), and positive control/PCt (given 0.012 diclofenac sodium). TG1 (given 250 mg G. lucidum nanogels), TG2 (given 500 mg G. lucidum nanogels), TG3 (given 750 mg G. lucidum nanogels). IgG, eNOS, IL-1β, COX-2, NOS, TNF-α, and IL-6 parameters were measured using ELISA, and the data obtained were analyzed by one-way ANOVA using SPSS (P < 0.05). The results showed that administering G. lucidum nanogels significantly reduced IgG, NOS, TNF-α, COX-2, IL-1β, and IL-6 and increased eNOS levels. The anti-inflammatory and antioxidative activities in suppressing pro-inflammatory cytokines and increasing eNOS levels prove that the nanogel extract G. lucidum have the potential to be developed as anti-arthritis natural therapeutic.
  • Tea Fungus Beverages from Torch Ginger (Etlingera elatior): Total microbial, Physicochemical, and Antioxidant Activity
    Biosaintifika, 2023
  • Antidiabetic Effects and Enzymatic Antioxidant Activity of Chicken Drumstick Mushroom (Coprinus comatus) Extract in Diabetic Rats Model
    Nuniek Ina Ratnaningtyas, Fajar Husen, Dalia Sukmawati, Eko Setio Wibowo, Arif Rahman Hikam, et al.
    Journal of Pure and Applied Microbiology, 2022
    Coprinus comatus (O.F. Mull.) Pers. is a medicinal and edible mushroom containing bioactive compounds known as antidiabetic and antioxidant agents. The pancreatic β-cells were sensitive to reactive oxygen species (ROS) attacks, which can cause necrosis and disrupt insulin production. Therefore, this research aimed to evaluate the C. comatus ethyl acetate extract for antidiabetic and antioxidant to decrease fasting blood glucose, dipeptidyl peptidase-4 enzyme (DPP-4) levels, and increase glutathione peroxidase (GPx). Subsequently, 24 male Wistar rats were divided into six groups, namely 2-5 streptozotocin (STZ)-induced 45 mg/kg, 1/HC (without any treatment), 2/NC (negative control), 3/PC (administered metformin 45 mg/kg Body weight (BW), 4-6 (T1: administered 250 mg, T2: administered 500 mg, and T3: administered 750 mg/kg BW extract). The parameters were analyzed using ANOVA, followed by Duncan’s multiple range test. According to the results, the extract significantly decreased DPP-4 levels, blood glucose and increased GPx (p ≤ 0.05). The 500 mg extract effectively reduced blood glucose levels and DPP-4 enzyme as well as increased levels of GPx.
  • Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats of Rattus norvegicus
    Nuniek Ina Ratnaningtyas, Fajar Husen, Hernayanti Hernayanti, Nuraeni Ekowati, Bambang Heru Budianto
    Molekul, 2022
    &#x0D; &#x0D; &#x0D; oprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant compounds. This is a true experiment conducted using a Completely Randomized Design (CRD) with a post-test and a control group. The rats were divided into 6 categories, which include 1 healthy and 5 groups induced with 1% carrageenan. Out of the treatment groups, 3 were treated with ethanol extract of C. comatus fruiting body at doses of 250 (T1), 500 (T2), and 750 mg/kg BW (T3), 1 received diclofenac sodium (PC) and the other as a negative control (NC), were given extract for 14 days and induced with 0.5 mL carrageenan in paw of rats at day 15. The qualitative identification showed the extracts contains flavonoid, polyphenol, alkaloid, triterpenoid, steroids and saponins, and GC-MS analysis showed 10 putative metabolites compound. T2 group significantly decreased the levels of IL-1β (70.63%), IgE (59.04%), total leukocyte count (31.24%), plantar thickness (12.5%), edema volume (33.3%), and increased endothelial NO levels (48.2%).&#x0D; &#x0D; &#x0D;
  • Soybean Selection Against Cercospora Leaf Blight Disease Caused By Cercospora kikuchii Based on Anatomical Resistance
    Fajar Husen, Nuniek Ina Ratnaningtyas, Siti Samiyarsih, Juni Safitri Muljowati, Nur Fitrianto
    Biosaintifika, 2022
    Soybean (Glycine max L. Merr.) is the third food crop commodity after rice and maize in Indonesia. This plant is also known as the most important source of vegetable protein, which is relatively inexpensive, but a decrease in soybean productivity can occur due to infection with disease-causing pathogens, one of is Cercospora kikuchii which causes Cercospora leaf blight (CLB). The research objectives were to determine the anatomical resistance and disease severity of soybean cultivars against CLB. The method was an experiment with a completely randomized design (CRD) factorial pattern; factor 1 being soybean cultivars (Dering, Slamet, Grobogan, Wilis) and factor 2, namely pathogen inoculation (0 conidiospores/mL and 105 conidiospores/mL). Anatomical method preparations using paraffin, staining with 1% safranin. Disease criteria are based on the council of scientific and industrial research (CSIR) assessment method. Data were analysis used analysis of variance (p0.05) and the least significance difference (LSD). The results showed that Dering and Slamet cultivars had the largest cuticle, epidermis, and palisade ratios and the smallest stomata length and width with the largest number of stomata and trichomes compared to Grobogan and Wilis. The disease severity (DS) of the cultivars Dering 14.6%, Slamet 24.64%, Grobogan 24.80% (classified as a resistant with low infection), while Wilis cultivar was 31.08% as a moderately susceptible cultivar with moderate infection. The novelty of soybean cultivar selection against CLB is important and its effectiveness for increasing soybean productivity. Dering, Slamet and Grobogan are likely to be further developed with their resistance to CLB disease.
  • Antioxidant Activities and Properties of Coprinus comatus Mushroom Both Mycelium and Fruiting Body Extracts In Streptozotocin-Induced Hyperglycemic Rats Model
    Nuniek Ina Ratnaningtyas, Hernayanti Hernayanti, Nuraeni Ekowati, Fajar Husen, Isnaini Maulida, et al.
    Biosaintifika, 2022
    Coprinus comatus, well-known as Shaggy Ink Cap mushroom, is potential herbal medicine. Synthetic medicines sometimes cause side effects; therefore, it is necessary to innovate with herbal medications with minimal side effects. The study evaluated in vitro and in vivo treatments to evaluate the antioxidant effect and activity of C. comatus. The in vivo treatment was conducted using six groups of Wistar rats (n = 24). Group 1 healthy control (HC), groups 2–6 received 45 mg/Kg BW of streptozotocin once, group 2 just streptozotocin-induced (NC), group 3 was given 45 mg/kg BW of metformin (PC), groups 4–6 were given 250 (T1), 500 (T2), and 750 mg (T3) of C. comatus extract for 14 days, and the in vitro was conducted using an antioxidant oxidant assay. Data were analyzed using analysis of variance and Duncan's multiple range tests. Based on qualitative analysis, C. comatus mycelium extract contained polyphenol, flavonoids, terpenoids, and fruiting body extract had flavonoids, alkaloids, and saponins. The in vitro analysis showed that the mycelium extract had an antioxidant activity by inhibiting free radicals up to 58.51% with an IC50 value of 72.77 mg/L. The in vivo treatment using C. comatus fruiting body extract showed that it could increase the endogenous antioxidant levels of GPx, SOD, catalase and reduce MDA levels (p 0.05). The most effective dose of C. comatus extract is 500 mg. This research has shown the potential of mycelium and C. comatus fruitbody extract as an antioxidant supplement in a diabetic rat model.
  • Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats
    N. I. Ratnaningtyas, Hernayanti Hernayanti, Nuraeni Ekowati, F. Husen
    Pharmaceutical Biology, 2022
  • Nephroprotective and antioxidant effects of ethanol extract of Coprinus comatus mushroom fruit-bodies on streptozotocin-induced diabetic rat models
    N. I. Ratnaningtyas, Hernayanti, N. Ekowati, F. Husen
    Iop Conference Series Earth and Environmental Science, 2021
  • Antidiabetic effects and antioxidant properties of the saggy ink cap medicinal mushroom, coprinus comatus (Agaricomycetes), in streptozotocin-induced hyperglycemic rats
    Fajar Husen, Hernayanti Hernayanti, Nuraeni Ekowati, Dalia Sukmawati, Nuniek Ina Ratnaningtyas
    International Journal of Medicinal Mushrooms, 2021

RECENT SCHOLAR PUBLICATIONS

  • Molecular Docking Analysis of Bioactive Constituents Identified by GC-MS from Coprinus comatus as α-Amylase and α-Glucosidase Inhibitors
    F Husen, NI Ratnaningtyas, JH Situmorang, S Widiyanto, RS Kasiamdari
    International Conference on Multidisciplinary Engagement (IN-COME) 2026 1 (1 … , 2026
    2026
  • Anti-Cancer Activity of Gallic Acid and Flavonoid Compounds of Ganoderma lucidum Mushrooms Against the Oxidoreductase and Transferase Enzymes of Breast Cancer In Silico Study
    NI Ratnaningtyas, F Husen
    Jurnal Biologi Babasal, 94-110 , 2025
    2025
  • Doking molekuler in silico senyawa bioaktif ekstrak etanol abalone oyster mushrooms (Pleurotus cystidiosus) sebagai inhibitor enzim α-glukosidase
    NI Ratnaningtyas, F Husen
    Jurnal Penelitian Dan Pengabdian Kepada Masyarakat UNSIQ 12 (3), 149-161 , 2025
    2025
  • Beban Tugas Dosen Kian Menumpuk dan Mencekik tapi Kesejahteraan Semakin Sempit?
    F Husen
    Tribunnews.com , 2025
    2025
  • Belajar Hal Sederhana Dari Negara Maju, Belanda
    F Husen
    Kumparan.com , 2025
    2025
  • Pengabdian Masyarakat, Cara Dosen Dan Mahasiswa Berkontribusi Nyata
    F Husen
    Kumparan.com , 2025
    2025
  • Sosialisasi Dan Pemeriksaan Tekanan Darah Dan Asam Urat Sebagai Upaya Monitoring Kesehatan Lanjut Usia (LANSIA)
    F Husen
    Jurnal Pengabdian Masyarakat Ilmu-Ilmu Kesehatan Dan Terapan 1 (1), 50-57 , 2025
    2025
  • Aktivitas Hesperidin dan Quercetin Ekstrak Ganoderma lucidum Sebagai Inhibitor Poly (ADP-ribose) Polymerase (PARP) Dalam Mencegah DNA Repair Pada Breast Cancer: In Silico (4UND)
    F Husen, NI Ratnaningtyas, NAH Khasanah
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 21 (2), 22-35 , 2025
    2025
    Citations: 1
  • Perbandingan Aktivitas Antibakteri Kloramfenikol Terhadap Bakteri Gram Positif Dan Gram Negatif Secara In Silico Dan In Vitro
    D Islamiyati, F Husen
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 21 (2), 1-8 , 2025
    2025
  • Novel Tamarillo-Red Ginger Kombucha: Impact of Carbon Source Variations on Physicochemical Characteristics, Antioxidant Potential, and Sensory Acceptance
    N Fitrianto, S Mutmainah, MZ Zaman, LS Palindung, E Damayanti, ...
    Carpathian Journal of Food Science and Technology 17 (1), 137-153 , 2025
    2025
    Citations: 2
  • Therapeutic potential of Coprinus comatus nanogels: Antiarthritic and anti-inflammatory effects in rheumatoid arthritis models
    NI Ratnaningtyas, F Husen
    Veterinary World 18 (3), 582 , 2025
    2025
    Citations: 3
  • Patofisiologi 1
    G Saputra, Nurhilaliyah, F Husen, Herman, SI Budiarti, D Nurmansyah, ...
    PT. Media Pustaka Indo 1, xii - 169 , 2025
    2025
  • Aktivitas rutin dan α-tokoferol medicinal mushroom coprinus comatus sebagai anti-inflamasi dan antidiabetes terhadap beberapa enzim secara in silico
    F Husen
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 21 (1), 114-126 , 2025
    2025
    Citations: 3
  • FROZEN GRANULATION OF ETHANOL EXTRACT OF BROWN OYSTER MUSHROOM (Pleurotus cystidiosus): MYCOCHEMICAL PROFILE BASED ON FOURIER TRANSFORM INFRARED (FTIR) AND ANTIBACTERIAL ACTIVITY
    NI Ratnaningtyas, F Husen, N Fitrianto, JS Muljowati
    Proceeding ICMA-SURE, 686-695 , 2025
    2025
    Citations: 2
  • Aktivitas Hepatoprotektif Madu Terhadap Hepar Dan Perubahan Berat Badan Mencit Yang Diinduksi Alkohol
    NAH Khasanah, F Husen
    Ensiklopedia of Journal 8 (2), 127-135 , 2025
    2025
  • Anti-Inflammatory Activity of the Shaggy Ink Cap Medicinal Mushroom Coprinus comatus (Agaricomycetes) Nanogel in Complete Freund's Adjuvant− Induced Rheumatoid Arthritis: In …
    F Husen, NI Ratnaningtyas
    International Journal of Medicinal Mushrooms 27 (8) , 2025
    2025
    Citations: 3
  • Microencapsulation of Abalone Oyster Mushroom Pleurotus cystidiosus (Agaricomycetes): Antidiabetic, and Anti-Inflammatory Activity in Streptozotocin-Induced …
    NI Ratnaningtyas, F Husen, N Fitrianto, JS Muljowati
    International Journal of Medicinal Mushrooms 27 (7) , 2025
    2025
    Citations: 6
  • Evaluasi Struktur Histologi Hati dan Paru-Paru Mencit yang Diinduksi Karbon Tertraklorida (CCl4)
    NAH Khasanah, F Husen
    BioEksakta : Jurnal Ilmiah Biologi Unsoed 6 (4), 263-270 , 2024
    2024
    Citations: 3
  • Imunologi Sistem Pertahanan Tubuh
    YF Tandjungbulu, AR Virgiawan, YES Sari, D Rakhmina, FAQ Wasdili, ...
    2024
  • Profil Sedimen Urin Pasien Suspek Infeksi Saluran Kemih Di Puskesmas Purwokerto Selatan
    NAH Khasanah, F Husen, NI Yuniati
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 20 (2), 51-59 , 2024
    2024
    Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

  • Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats
    NI Ratnaningtyas, H Hernayanti, N Ekowati, F Husen
    Pharmaceutical Biology 60 (1), 1126-1136 , 2022
    2022
    Citations: 53
  • Antidiabetic Effects and Antioxidant Properties of the Saggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), in Streptozotocin-Induced Hyperglycemic Rats
    F Husen, H Hernayanti, N Ekowati, D Sukmawati, NI Ratnaningtyas
    International Journal of Medicinal Mushrooms 23 (10), 9-21 , 2021
    2021
    Citations: 35
  • Peningkatan kadar kolesterol dan usia pada ibu rumah tangga
    F Husen, NI Ratnaningtyas, NA Hidayah Khasanah, NI Yuniati
    Jurnal Ilmiah Kesehatan Sandi Husada 11 (2), 351-59 , 2022
    2022
    Citations: 29
  • Nephroprotective and antioxidant effects of ethanol extract of Coprinus comatus mushroom fruit-bodies on streptozotocin-induced diabetic rat models
    NI Ratnaningtyas, Hernayanti, N Ekowati, F Husen
    IOP Conference Series: Earth and Environmental Science 948 (1), 012078 , 2021
    2021
    Citations: 19
  • Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in a Complete Freund's Adjuvant-Induced Rheumatoid Arthritis Rat Model …
    NI Ratnaningtyas, F Husen, N Fitrianto
    International journal of medicinal mushrooms 26 (8) , 2024
    2024
    Citations: 16
  • Karakteristik, Profil Dan Diganosa Pasien Hipertensi Rawat Inap Di Rsu Aghisna Sidareja Kabupaten Cilacap
    F Husen, R Basuki
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 18 (2), 59-73 , 2022
    2022
    Citations: 13
  • Antioxidant Activities and Properties of Coprinus comatus Mushroom Both Mycelium and Fruiting Body Extracts In Streptozotocin-Induced Hyperglycemic Rats Model
    NI Ratnaningtyas, H Hernayanti, N Ekowati, F Husen, I Maulida, ...
    Biosaintifika: Journal of Biology & Biology Education 14 (1), 9-21 , 2022
    2022
    Citations: 13
  • Inhibitory test of gentamicin antibiotics against Escherichia coli and Staphylococcus aureus bacteria using disc method
    F Husen
    Biotropika: Journal of Tropical Biology , 2022
    2022
    Citations: 12
  • Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus)
    NI Ratnaningtyas, F Husen, H Hernayanti, N Ekowati, BH Budianto
    Molekul 17 (3), 335-345 , 2022
    2022
    Citations: 11
  • Antidiabetic Effects and Enzymatic Antioxidant Activity of Chicken Drumstick Mushroom (Coprinus comatus) Extract in Diabetic Rats Model
    NI Ratnaningtyas, F Husen, D Sukmawati, ES Wibowo, AR Hikam, ...
    Journal of Pure and Applied Microbiology 16 (4), 1-11 , 2022
    2022
    Citations: 10
  • Pewarnaan Sediaan Apusan Darah Tepi (SADT) Menggunakan Infusa Bunga Telang (Clitorea ternatea)
    NAH Khasanah, F Husen, NI Yuniati
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 19 (1), 67-76 , 2023
    2023
    Citations: 9
  • Soybean selection against cercospora leaf blight disease caused by Cercospora kikuchii based on anatomical resistance
    F Husen, NI Ratnaningtyas, S Samiyarsih, JS Muljowati, N Fitrianto
    Biosaintifika: Journal of Biology & Biology Education 14 (1), 90-102 , 2022
    2022
    Citations: 8
  • HUBUNGAN DAN PROFIL TEKANAN DARAH DENGAN PENINGKATAN KADAR GLUKOSA DARAH PEDAGANG DI DESA MANDIRAJA WETAN
    F Husen, NI Ratnaningtyas
    Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ 9 (3), 209-306 , 2022
    2022
    Citations: 7
  • Analisis Faktor Risiko Personal Hygiene terhadap Pediculosis capitis pada Santriwati Ponpes Miftahul Huda: Personal Hygiene Risk Factor Analysis of Pediculosis capitis in …
    NAHK Khasanah, NI Yuniati, F Husen, UF Rudatiningtyas
    Journal of Holistics and Health Sciences 4 (2), 282-291 , 2022
    2022
    Citations: 7
  • Microencapsulation of Abalone Oyster Mushroom Pleurotus cystidiosus (Agaricomycetes): Antidiabetic, and Anti-Inflammatory Activity in Streptozotocin-Induced …
    NI Ratnaningtyas, F Husen, N Fitrianto, JS Muljowati
    International Journal of Medicinal Mushrooms 27 (7) , 2025
    2025
    Citations: 6
  • Effect of gamma irradiation on the microbiological properties, phenolic content, and antioxidant activity of mangosteen ( Garcinia mangostana L) flesh during storage
    N Fitrianto, S Samiyarsih, F Husen, A Frediansyah, GA Hidayat
    AIP Conference Proceedings 2967 (1), 040001 , 2024
    2024
    Citations: 6
  • Buku Ajar Imunologi
    D Luthfianto, C Indriputri, ST AK, M Imun, DRPS Kp, IA Faizal, ST AK, ...
    Science Techno Direct , 2023
    2023
    Citations: 6
  • Potensi aktivitas antibakteri ekstrak moringa oleifera (Lamk.) terhadap bakteri escherichia coli secara in silico dan in vitro
    D Islamiyati, F Husen, NI Ratnaningtyas
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 19 (2), 80-90 , 2023
    2023
    Citations: 5
  • Hubungan kadar asam urat dan glukosa darah pada wanita usia dewasa-tua di desa mandiraja wetan
    F Husen, NI Ratnaningtyas
    Jurnal Penelitian Dan Pengabdian Kepada Masyarakat UNSIQ 10 (3), 177-185 , 2023
    2023
    Citations: 5
  • Karakteristik Dan Gambaran Diagnosa Komplikasi Pasien Diabetes Di Rumah Sakit Umum Aghisna Sidareja
    R Basuki, F Husen
    Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science 18 (2), 1-15 , 2022
    2022
    Citations: 5

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Effervescent of Mushroom Extracts