stephane avril

@emse.fr

Biomedical Engineering / SAINBIOSE
Mines Saint-Etienne



                    

https://researchid.co/stephaneavril

2021-2022: Guest Professor, Technische Universität Graz, Austria.

2020-2022: Guest Professor, Technische Universität Wien, Austria.

2014- 2019: Visiting Professor, Yale University, USA.

EDUCATION

2007: Habilitation à Diriger les Recherches, Université de Technologie de Compiègne, France.

2002: PhD with honors in mechanical and civil engineering, Ecole Nationale Supérieure des Mines, Saint-Etienne, France.

1999: Engineering Graduate School, Ecole Nationale Supérieure des Mines, Saint-Étienne, France.

1999: MSc with honors in mechanical and civil engineering, University of Clermont-Ferrand, France.

1998: Bachelor in mathematics, University of Saint-Etienne, France.

RESEARCH INTERESTS

1. Map quantitatively and non-invasively, with a microscopic resolution, the local mechanical properties (stiffness, resistance, tensile and shear stresses) in the extracellular matrix of biological tissues.
2. Computer modelling for assisting cardiovascular surgical interventions
3. Computer modell

FUTURE PROJECTS

MecOnChip

Recent vascular engineering efforts have focused on two distinct directions: either tissue engineered vessels for implantation as grafts or engineered vascular mimics (vessels-on-a-chip) that serve as platforms for understanding vascular development and disease or for testing the effects of drugs and/or endovascular devices. Our proposal falls in the second category. The state of the art is typically the production of a system that mimics the physiological setting to the extent possible by targeting relevant dimensions, incorporating the pertinent cell types, and attempting to reproduce physiological conditions. Our aim is to go at least one step further and to design and develop a vessel-on-a-chip platform that allows control of the cellular response by modulating the local mechanical environment. Our research hypothesis is that the cross-talk between cells and their biophysical microenvironment regulates the phenotypic endpoint of each single cell.


Applications Invited
8296

Scholar Citations

47

Scholar h-index

138

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • How robust is the virtual fields method with respect to experimental inhomogeneities for bulge inflation testing of hyperelastic materials?
    P Vandemaele, L Maes, H Fehervary, S Avril, N Famaey
    Journal of the mechanical behavior of biomedical materials 167, 106965 2025

  • Machine learning and statistical shape modelling for real-time prediction of stent deployment in realistic anatomies
    B Bisighini, M Aguirre, B Pierrat, S Avril
    Computer Methods and Programs in Biomedicine 260, 108583 2025

  • Machine learning-based pulse wave analysis for classification of circle of Willis topology: An in silico study with 30,618 virtual subjects
    A Sen, M Aguirre, PH Charlton, L Navarro, S Avril, J Alastruey
    Biomedical Signal Processing and Control 100, 106999 2025

  • Machine-learning-based virtual fields method: Application to anisotropic hyperelasticity
    S Meng, AAK Yousefi, S Avril
    Computer Methods in Applied Mechanics and Engineering 434, 117580 2025

  • Aortic Wall Biomechanical Assessment Depends on Ultrasound Probe Pressure: In-Vivo and In-Silico Insights
    MI Bracco, JP Eiberg, US Lorenzen, S Avril, L Rouet
    IEEE Transactions on Biomedical Engineering 2025

  • Deep learning without stress data on the discovery of multi-regional hyperelastic properties
    R Shi, H Yang, J Chen, K Hackl, S Avril, Y He
    Computational Mechanics, 1-30 2025

  • A preliminary ex vivo diffusion tensor imaging study of distinct aortic morphologies
    B Tornifoglio, ST Robinson, RE Levey, AJ Stone, S Campisi, C Kerskens, ...
    Journal of Anatomy 2025

  • Strain Patterns With Ultrasound for Assessment of Abdominal Aortic Aneurysm Vessel Wall Biomechanics
    US Lorenzen, MI Bracco, AH Zielinski, M Broda, S Avril, L Rouet, ...
    Ultrasound in Medicine & Biology 51 (1), 112-119 2025

  • Ultrasound Probe Pressure Affects Aortic Wall Stiffness: A Patient-Specific Computational Study in Abdominal Aortic Aneurysms
    MI Bracco, AAK Yousefi, L Rouet, S Avril
    Annals of Biomedical Engineering 53 (1), 71-82 2025

  • Integration of cross-links, discrete fiber distributions and of a non-local theory in the Homogenized Constrained Mixture Model to Simulate Patient-Specific Thoracic Aortic
    F Semprtegui, S Avril
    Journal of Biomechanics 178, 112297 2025

  • Gene expression modulation in human aortic smooth muscle cells under induced physiological mechanical stretch
    A Ben Hassine, C Petit, M Thomas, S Mundweiler, A Guignandon, S Avril
    Scientific Reports 14 (1), 31147 2024

  • Comparative analysis of Zero Pressure Geometry and prestress methods in cardiovascular Fluid-Structure Interaction
    A Mourato, R Valente, J Xavier, M Brito, S Avril, AC Toms, J Fragata
    Computer Methods and Programs in Biomedicine 257, 108475 2024

  • Three-dimensional anisotropic unified continuum model for simulating the healing of damaged soft biological tissues
    D Zuo, M Zhu, D Chen, Q Xue, S Avril, K Hackl, Y He
    Biomechanics and Modeling in Mechanobiology 23 (6), 2193-2212 2024

  • Physics-Informed Graph Neural Networks to solve 1-D equations of blood flow
    A Sen, E Ghajar-Rahimi, M Aguirre, L Navarro, CJ Goergen, S Avril
    Computer methods and programs in biomedicine 257, 108427 2024

  • 3D growth and remodeling theory supports the hypothesis of staphyloma formation from local scleral weakening under normal intraocular pressure
    FA Braeu, S Avril, MJA Girard
    Biomechanics and Modeling in Mechanobiology 23 (6), 2137-2154 2024

  • Computational studies of renal artery hemodynamics induced by breathing in patient-specific models of abdominal aortic aneurysms
    A Corvo, F Chassagne, A Aliseda, S Avril
    APS Division of Fluid Dynamics Meeting Abstracts, C05. 010 2024

  • A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms
    F Bardi, E Gasparotti, E Vignali, MN Antonuccio, E Storto, S Avril, S Celi
    Frontiers in Bioengineering and Biotechnology 12, 1452278 2024

  • Patient Specific Numerical Simulation of Endovascular Abdominal Aortic Aneurysm Repair to Predict Type Ia Endoleak
    L Derycke, S Avril, JN Albertini, J Vermunt, S Haulon, A Millon
    European Journal of Vascular and Endovascular Surgery 68 (3), 412-413 2024

  • Simulation of the Deployment of an Endoprosthesis in Real Time
    A Pionteck, B Pierrat, S Gorges, J Albertini, S Avril
    US Patent 12,070,273 2024

  • Mechanoregulation in Soft Biological Tissues: Application to the Development of Arterial Calcifications
    M MARTIN, C MORIN, S AVRIL
    Mechanics of Living Tissues: Imaging, Characterization and Modeling Towards 2024

MOST CITED SCHOLAR PUBLICATIONS

  • Overview of identification methods of mechanical parameters based on full-field measurements
    S Avril, M Bonnet, AS Bretelle, M Grdiac, F Hild, P Ienny, F Latourte, ...
    Experimental Mechanics 48, 381-402 2008
    Citations: 989

  • The virtual fields method for extracting constitutive parameters from full‐field measurements: a review
    M Grediac, F Pierron, S Avril, E Toussaint
    Strain 42 (4), 233-253 2006
    Citations: 355

  • Sensitivity of the virtual fields method to noisy data
    S Avril, M Grdiac, F Pierron
    Computational Mechanics 34, 439-452 2004
    Citations: 257

  • General framework for the identification of constitutive parameters from full-field measurements in linear elasticity
    S Avril, F Pierron
    International Journal of Solids and Structures 44 (14-15), 4978-5002 2007
    Citations: 229

  • Identification of elasto-visco-plastic parameters and characterization of Lders behavior using digital image correlation and the virtual fields method
    S Avril, F Pierron, MA Sutton, J Yan
    Mechanics of materials 40 (9), 729-742 2008
    Citations: 186

  • Anisotropic and hyperelastic identification of in vitro human arteries from full-field optical measurements
    S Avril, P Badel, A Duprey
    Journal of biomechanics 43 (15), 2978-2985 2010
    Citations: 182

  • In vitro characterisation of physiological and maximum elastic modulus of ascending thoracic aortic aneurysms using uniaxial tensile testing
    A Duprey, K Khanafer, M Schlicht, S Avril, D Williams, R Berguer
    European Journal of Vascular and Endovascular Surgery 39 (6), 700-707 2010
    Citations: 173

  • Biaxial rupture properties of ascending thoracic aortic aneurysms
    A Duprey, O Trabelsi, M Vola, JP Favre, S Avril
    Acta biomaterialia 42, 273-285 2016
    Citations: 160

  • Stress reconstruction and constitutive parameter identification in plane-stress elasto-plastic problems using surface measurements of deformation fields
    S Avril, F Pierron, Y Pannier, R Rotinat
    Experimental Mechanics 48, 403-419 2008
    Citations: 121

  • In vitro analysis of localized aneurysm rupture
    A Romo, P Badel, A Duprey, JP Favre, S Avril
    Journal of Biomechanics 47 (3), 607-616 2014
    Citations: 117

  • Experimental characterization of rupture in human aortic aneurysms using a full-field measurement technique
    JH Kim, S Avril, A Duprey, JP Favre
    Biomechanics and modeling in mechanobiology 11, 841-853 2012
    Citations: 116

  • Experimental identification of a nonlinear model for composites using the grid technique coupled to the virtual fields method
    H Chalal, S Avril, F Pierron, F Meraghni
    Composites Part A: Applied Science and Manufacturing 37 (2), 315-325 2006
    Citations: 115

  • Identification of the orthotropic elastic stiffnesses of composites with the virtual fields method: sensitivity study and experimental validation
    F Pierron, G Vert, R Burguete, S Avril, R Rotinat, MR Wisnom
    Strain 43 (3), 250-259 2007
    Citations: 114

  • Patient-specific numerical simulation of stent-graft deployment: validation on three clinical cases
    D Perrin, P Badel, L Orgas, C Geindreau, A Dumenil, JN Albertini, S Avril
    Journal of Biomechanics 48 (10), 1868-1875 2015
    Citations: 113

  • Identification of elasto-plastic constitutive parameters from statically undetermined tests using the virtual fields method
    Y Pannier, S Avril, R Rotinat, F Pierron
    Experimental Mechanics 46, 735-755 2006
    Citations: 112

  • Finite element analysis of the mechanical performances of 8 marketed aortic stent-grafts
    N Demanget, A Duprey, P Badel, L Orgas, S Avril, C Geindreau, ...
    Journal of endovascular therapy 20 (4), 523-535 2013
    Citations: 109

  • Novel methodology for characterizing regional variations in the material properties of murine aortas
    MR Bersi, C Bellini, P Di Achille, JD Humphrey, K Genovese, S Avril
    Journal of biomechanical engineering 138 (7), 071005 2016
    Citations: 107

  • Extension of the virtual fields method to elasto-plastic material identification with cyclic loads and kinematic hardening
    F Pierron, S Avril, VT Tran
    International Journal of Solids and Structures 47 (22-23), 2993-3010 2010
    Citations: 105

  • Identification of heterogeneous constitutive parameters in a welded specimen: uniform stress and virtual fields methods for material property estimation
    MA Sutton, JH Yan, S Avril, F Pierron, SM Adeeb
    Experimental Mechanics 48, 451-464 2008
    Citations: 102

  • Computational comparison of the bending behavior of aortic stent-grafts
    N Demanget, S Avril, P Badel, L Orgas, C Geindreau, JN Albertini, ...
    Journal of the mechanical behavior of biomedical materials 5 (1), 272-282 2012
    Citations: 101