stephane avril

Biomedical Engineering / SAINBIOSE
Mines Saint-Etienne


2021-2022: Guest Professor, Technische Universität Graz, Austria.

2020-2022: Guest Professor, Technische Universität Wien, Austria.

2014- 2019: Visiting Professor, Yale University, USA.


2007: Habilitation à Diriger les Recherches, Université de Technologie de Compiègne, France.

2002: PhD with honors in mechanical and civil engineering, Ecole Nationale Supérieure des Mines, Saint-Etienne, France.

1999: Engineering Graduate School, Ecole Nationale Supérieure des Mines, Saint-Étienne, France.

1999: MSc with honors in mechanical and civil engineering, University of Clermont-Ferrand, France.

1998: Bachelor in mathematics, University of Saint-Etienne, France.


1. Map quantitatively and non-invasively, with a microscopic resolution, the local mechanical properties (stiffness, resistance, tensile and shear stresses) in the extracellular matrix of biological tissues.
2. Computer modelling for assisting cardiovascular surgical interventions
3. Computer modell



Recent vascular engineering efforts have focused on two distinct directions: either tissue engineered vessels for implantation as grafts or engineered vascular mimics (vessels-on-a-chip) that serve as platforms for understanding vascular development and disease or for testing the effects of drugs and/or endovascular devices. Our proposal falls in the second category. The state of the art is typically the production of a system that mimics the physiological setting to the extent possible by targeting relevant dimensions, incorporating the pertinent cell types, and attempting to reproduce physiological conditions. Our aim is to go at least one step further and to design and develop a vessel-on-a-chip platform that allows control of the cellular response by modulating the local mechanical environment. Our research hypothesis is that the cross-talk between cells and their biophysical microenvironment regulates the phenotypic endpoint of each single cell.

Applications Invited

Scholar Citations


Scholar h-index


Scholar i10-index


  • Patient Specific Numerical Simulation of Endovascular Abdominal Aortic Aneurysm Repair to Predict Type Ia Endoleak
    L Derycke, S Avril, JN Albertini, J Vermunt, S Haulon, A Millon
    European journal of vascular and endovascular surgery: the official journal 2024

  • Experimental validation of auxetic stent designs: three-point bending of 3D printed Titanium prototypes
    R Vellaparambil, WS Han, P Di Giovanni, S Avril
    Frontiers in Medical Technology 6, 1388207 2024

  • 3D Growth and Remodeling Theory Supports the Hypothesis of Staphyloma Formation from Local Scleral Weakening under Normal Intraocular Pressure
    FA Braeu, S Avril, MJA Girard
    arXiv preprint arXiv:2404.03330 2024

  • Non-contact reconstitution of the traction distribution using incomplete deformation measurements: Methodology and experimental validation
    Y Mei, D Zhao, R Kang, X Wang, B Wang, D Song, L Dong, H Jiang, ...
    International Journal of Solids and Structures 289, 112650 2024

  • Computational prediction of proximal sealing in endovascular abdominal aortic aneurysm repair with unfavorable necks
    L Derycke, S Avril, J Vermunt, D Perrin, S El Batti, JM Alsac, JN Albertini, ...
    Computer Methods and Programs in Biomedicine 244, 107993 2024

  • A data-driven computational methodology towards a pre-hospital Acute Ischaemic Stroke screening tool using haemodynamics waveforms
    A Sen, L Navarro, S Avril, M Aguirre
    Computer methods and programs in biomedicine 244, 107982 2024

  • Novel experimental methods to characterize the mechanical properties of the aorta
    B Lane, S Sherifova, VA Santamara, J Molimard, GA Holzapfel, S Avril
    Biomechanics of the Aorta, 91-108 2024

  • Computational modeling of aneurysm growth in mechanobiology
    S Avril, SJ Mousavi
    Biomechanics of the Aorta, 243-264 2024

  • Strain patterns with ultrasound for improved assessment of abdominal aortic aneurysm vessel wall biomechanics
    US Lorenzen, M Bracco, AH Zielinski, M Broda, S Avril, L Rouet, ...
    medRxiv, 2024.05. 27.24307963 2024

  • Computational Comparison of the Mechanical Behavior of Aortic Stent-Grafts Derived from Auxetic Unit Cells
    R Vellaparambil, WS Han, P Di Giovanni, S Avril
    Cardiovascular Engineering and Technology, 1-12 2023

  • Aortic Wall Stiffness Depends on Ultrasound Probe Pressure
    MI Bracco, JP Eiberg, US Lorenzen, S Avril, L Rouet
    arXiv preprint arXiv:2312.07980 2023

  • Cell nucleus elastography with the adjoint-based inverse solver
    Y Mei, X Feng, Y Jin, R Kang, XY Wang, D Zhao, S Ghosh, CP Neu, ...
    Computer Methods and Programs in Biomedicine 242, 107827 2023

  • Patient-specific computational modelling of endovascular treatment for intracranial aneurysms
    B Bisighini, M Aguirre, B Pierrat, S Avril
    Brain Multiphysics 5, 100079 2023

  • Cardiovascular medtech: the grand challenge of computer simulations
    S Avril
    Frontiers in Medical Technology 5, 1304223 2023

  • Effect of foot stato-dynamic disorders on hemodynamics of the lower limb using strain-gauge plethysmography
    L Tsimba, D Rastel, E Dechandon, P Vincent, C Micholet, C Chaigneau, ...
    Journal of Vascular Surgery: Venous and Lymphatic Disorders 11 (6), 1203-1212 2023

  • Rapid, non-invasive, in vivo measurement of tissue mechanical properties using gravitational loading and a nonlinear virtual fields method
    SL Evans, BE Keenan, J Hill, S Zappala, N Bennion, S Avril
    Journal of the Royal Society Interface 20 (207), 20230384 2023

    M Beghi, F Monaco, ASL Salerno, ID Piscitelli, SE Quirk, SE Quirk, ...
    Reviews in psychiatry 2022: Personality disorders, 19 2023

  • Foreword to the special issue entitled “Progress and future directions in soft tissue mechanics” in the Journal Biomechanics and Modeling in Mechanobiology
    S Avril, GA Holzapfel
    Biomechanics and Modeling in Mechanobiology 22 (5), 1461-1464 2023

  • Non-destructive Characterization of Skeletal Muscle Extracellular Matrix Morphology by Combining Optical Coherence Tomography (OCT) Imaging with Tissue Clearing
    M Maillet, M Kammoun, S Avril, MC Ho Ba Tho, O Trabelsi
    Annals of Biomedical Engineering 51 (10), 2323-2336 2023

  • Patient-specific computational simulations of wound healing following midline laparotomy closure
    AA Karkhaneh Yousefi, B Pierrat, A Le Ruyet, S Avril
    Biomechanics and Modeling in Mechanobiology 22 (5), 1589-1605 2023


  • Overview of identification methods of mechanical parameters based on full-field measurements
    S Avril, M Bonnet, AS Bretelle, M Grdiac, F Hild, P Ienny, F Latourte, ...
    Experimental Mechanics 48, 381-402 2008
    Citations: 929

  • The virtual fields method for extracting constitutive parameters from full‐field measurements: a review
    M Grediac, F Pierron, S Avril, E Toussaint
    Strain 42 (4), 233-253 2006
    Citations: 327

  • Sensitivity of the virtual fields method to noisy data
    S Avril, M Grdiac, F Pierron
    Computational Mechanics 34, 439-452 2004
    Citations: 243

  • General framework for the identification of constitutive parameters from full-field measurements in linear elasticity
    S Avril, F Pierron
    International Journal of Solids and Structures 44 (14-15), 4978-5002 2007
    Citations: 219

  • Identification of elasto-visco-plastic parameters and characterization of Lders behavior using digital image correlation and the virtual fields method
    S Avril, F Pierron, MA Sutton, J Yan
    Mechanics of materials 40 (9), 729-742 2008
    Citations: 182

  • Anisotropic and hyperelastic identification of in vitro human arteries from full-field optical measurements
    S Avril, P Badel, A Duprey
    Journal of biomechanics 43 (15), 2978-2985 2010
    Citations: 175

  • In vitro characterisation of physiological and maximum elastic modulus of ascending thoracic aortic aneurysms using uniaxial tensile testing
    A Duprey, K Khanafer, M Schlicht, S Avril, D Williams, R Berguer
    European Journal of Vascular and Endovascular Surgery 39 (6), 700-707 2010
    Citations: 169

  • Biaxial rupture properties of ascending thoracic aortic aneurysms
    A Duprey, O Trabelsi, M Vola, JP Favre, S Avril
    Acta biomaterialia 42, 273-285 2016
    Citations: 140

  • Experimental identification of a nonlinear model for composites using the grid technique coupled to the virtual fields method
    H Chalal, S Avril, F Pierron, F Meraghni
    Composites Part A: Applied Science and Manufacturing 37 (2), 315-325 2006
    Citations: 112

  • Stress reconstruction and constitutive parameter identification in plane-stress elasto-plastic problems using surface measurements of deformation fields
    S Avril, F Pierron, Y Pannier, R Rotinat
    Experimental Mechanics 48, 403-419 2008
    Citations: 111

  • Identification of the orthotropic elastic stiffnesses of composites with the virtual fields method: sensitivity study and experimental validation
    F Pierron, G Vert, R Burguete, S Avril, R Rotinat, MR Wisnom
    Strain 43 (3), 250-259 2007
    Citations: 111

  • Identification of elasto-plastic constitutive parameters from statically undetermined tests using the virtual fields method
    Y Pannier, S Avril, R Rotinat, F Pierron
    Experimental Mechanics 46, 735-755 2006
    Citations: 109

  • In vitro analysis of localized aneurysm rupture
    A Romo, P Badel, A Duprey, JP Favre, S Avril
    Journal of Biomechanics 47 (3), 607-616 2014
    Citations: 106

  • Experimental characterization of rupture in human aortic aneurysms using a full-field measurement technique
    JH Kim, S Avril, A Duprey, JP Favre
    Biomechanics and modeling in mechanobiology 11, 841-853 2012
    Citations: 106

  • Extension of the virtual fields method to elasto-plastic material identification with cyclic loads and kinematic hardening
    F Pierron, S Avril, VT Tran
    International Journal of Solids and Structures 47 (22-23), 2993-3010 2010
    Citations: 103

  • Finite element analysis of the mechanical performances of 8 marketed aortic stent-grafts
    N Demanget, A Duprey, P Badel, L Orgas, S Avril, C Geindreau, ...
    Journal of endovascular therapy 20 (4), 523-535 2013
    Citations: 101

  • Patient-specific numerical simulation of stent-graft deployment: validation on three clinical cases
    D Perrin, P Badel, L Orgas, C Geindreau, A Dumenil, JN Albertini, S Avril
    Journal of Biomechanics 48 (10), 1868-1875 2015
    Citations: 99

  • Computational comparison of the bending behavior of aortic stent-grafts
    N Demanget, S Avril, P Badel, L Orgas, C Geindreau, JN Albertini, ...
    Journal of the mechanical behavior of biomedical materials 5 (1), 272-282 2012
    Citations: 98

  • Identification of heterogeneous constitutive parameters in a welded specimen: uniform stress and virtual fields methods for material property estimation
    MA Sutton, JH Yan, S Avril, F Pierron, SM Adeeb
    Experimental Mechanics 48, 451-464 2008
    Citations: 98

  • Novel methodology for characterizing regional variations in the material properties of murine aortas
    MR Bersi, C Bellini, P Di Achille, JD Humphrey, K Genovese, S Avril
    Journal of biomechanical engineering 138 (7), 071005 2016
    Citations: 93