stephane avril

Biomedical Engineering / SAINBIOSE
Mines Saint-Etienne


2021-2022: Guest Professor, Technische Universität Graz, Austria.

2020-2022: Guest Professor, Technische Universität Wien, Austria.

2014- 2019: Visiting Professor, Yale University, USA.


2007: Habilitation à Diriger les Recherches, Université de Technologie de Compiègne, France.

2002: PhD with honors in mechanical and civil engineering, Ecole Nationale Supérieure des Mines, Saint-Etienne, France.

1999: Engineering Graduate School, Ecole Nationale Supérieure des Mines, Saint-Étienne, France.

1999: MSc with honors in mechanical and civil engineering, University of Clermont-Ferrand, France.

1998: Bachelor in mathematics, University of Saint-Etienne, France.


1. Map quantitatively and non-invasively, with a microscopic resolution, the local mechanical properties (stiffness, resistance, tensile and shear stresses) in the extracellular matrix of biological tissues.
2. Computer modelling for assisting cardiovascular surgical interventions
3. Computer modell



Recent vascular engineering efforts have focused on two distinct directions: either tissue engineered vessels for implantation as grafts or engineered vascular mimics (vessels-on-a-chip) that serve as platforms for understanding vascular development and disease or for testing the effects of drugs and/or endovascular devices. Our proposal falls in the second category. The state of the art is typically the production of a system that mimics the physiological setting to the extent possible by targeting relevant dimensions, incorporating the pertinent cell types, and attempting to reproduce physiological conditions. Our aim is to go at least one step further and to design and develop a vessel-on-a-chip platform that allows control of the cellular response by modulating the local mechanical environment. Our research hypothesis is that the cross-talk between cells and their biophysical microenvironment regulates the phenotypic endpoint of each single cell.

Applications Invited

Scholar Citations


Scholar h-index


Scholar i10-index


  • Patient-specific computational modelling of endovascular treatment for intracranial aneurysms
    B Bisighini, M Aguirre, B Pierrat, S Avril
    Brain Multiphysics 5, 100079 2023

    A Ariel, T Van Der Sluis, G Schlecht-Louf, C et Immunopathologie, ...
    Immunity, Cancer and the Microenvironment: Resolving a 3-Way Standoff, 96 2023

  • Effect of foot stato-dynamic disorders on hemodynamics of the lower limb using strain-gauge plethysmography
    L Tsimba, D Rastel, E Dechandon, P Vincent, C Micholet, C Chaigneau, ...
    Journal of Vascular Surgery: Venous and Lymphatic Disorders 2023

  • Re-interpretation of the Homogenized Constrained Mixture Theory within the plasticity framework and application to soft tissue growth and remodeling
    F Semprtegui, S Avril
    Computer Methods in Applied Mechanics and Engineering 412, 116059 2023

  • Stiffness sensing by smooth muscle cells: Continuum mechanics modeling of the acto-myosin role
    AAK Yousefi, C Petit, AB Hassine, S Avril
    Journal of the Mechanical Behavior of Biomedical Materials, 105990 2023

  • Non-destructive Characterization of Skeletal Muscle Extracellular Matrix Morphology by Combining Optical Coherence Tomography (OCT) Imaging with Tissue Clearing
    M Maillet, M Kammoun, S Avril, MC Ho Ba Tho, O Trabelsi
    Annals of Biomedical Engineering, 1-14 2023

  • Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns
    MI Bracco, M Broda, US Lorenzen, MC Florkow, O Somphone, S Avril, ...
    Frontiers in Physiology 14, 1163204 2023

  • Adaptation of the virtual fields method for the identification of biphasic hyperelastic model parameters in soft biological tissues with osmotic swelling
    R Shi, S Avril, H Yang, V Acosta Santamara, Y Mei, Y He
    Strain 59 (3), e12435 2023

  • Effect of dysmorphic plantar arch on venous hemodynamics of the lower limb
    L Tsimba, D Rastel, E Dechandon, P Vincent, C Micholet, C Chaigneau, ...
    Phlebology, 02683555231176940 2023

  • Stiffness Sensing by Smooth Muscle Cells: Continuum Mechanics Modeling of the Acto-Myosin Role
    C Petit, B Hassine, S Avril

  • Patient-specific computational simulations of wound healing following midline laparotomy closure
    AA Karkhaneh Yousefi, B Pierrat, A Le Ruyet, S Avril
    Biomechanics and Modeling in Mechanobiology, 1-17 2023

  • Machine learning and reduced order modelling for the simulation of braided stent deployment
    B Bisighini, M Aguirre, ME Biancolini, F Trovalusci, D Perrin, S Avril, ...
    Frontiers in physiology 14, 508 2023

  • How does mechanical stress affect gene expression in human aortic smooth muscle cells?
    MC Petit, AB Hassine, M Thomas, A Guignandon, S Avril
    Artery Research 29 (1) 2023

  • Computational modeling of multiple myeloma interactions with resident bone marrow cells
    P Urdeitx, SJ Mousavi, S Avril, MH Doweidar
    Computers in Biology and Medicine 153, 106458 2023

  • Potential of auxetic designs in endovascular aortic repair: A computational study of their mechanical performance
    R Vellaparambil, WS Han, P Di Giovanni, S Avril
    Journal of the Mechanical Behavior of Biomedical Materials 138, 105644 2023

  • Patient-Specific Numerical Simulations of Endovascular Procedures in Complex Aortic Pathologies: Review and Clinical Perspectives
    L Derycke, S Avril, A Millon
    Journal of Clinical Medicine 12 (3), 766 2023

  • Inverse problems in the characterization of soft connective tissue: perspective for reproduction system
    S Avril
    Biomechanics of the Female Reproductive System: Breast and Pelvic Organs 2023

  • Hyperelastic and damage properties of the hypoxic aorta treated with Cinaciguat
    JD Laubrie, A Bezmalinovic, CM Garca-Herrera, DJ Celentano, ...
    Journal of Biomechanics 147, 111457 2023

  • FEniCS implementation of the Virtual Fields Method (VFM) for nonhomogeneous hyperelastic identification
    J Deng, X Guo, Y Mei, S Avril
    Advances in Engineering Software 175, 103343 2023

  • A hybrid mock circulatory loop for fluid dynamic characterization of 3D anatomical phantoms
    F Bardi, E Gasparotti, E Vignali, S Avril, S Celi
    IEEE Transactions on Biomedical Engineering 70 (5), 1651-1661 2022


  • Overview of identification methods of mechanical parameters based on full-field measurements
    S Avril, M Bonnet, AS Bretelle, M Grdiac, F Hild, P Ienny, F Latourte, ...
    Experimental Mechanics 48, 381-402 2008
    Citations: 875

  • The virtual fields method for extracting constitutive parameters from full‐field measurements: a review
    M Grediac, F Pierron, S Avril, E Toussaint
    Strain 42 (4), 233-253 2006
    Citations: 312

  • Sensitivity of the virtual fields method to noisy data
    S Avril, M Grdiac, F Pierron
    Computational Mechanics 34, 439-452 2004
    Citations: 228

  • General framework for the identification of constitutive parameters from full-field measurements in linear elasticity
    S Avril, F Pierron
    International Journal of Solids and Structures 44 (14-15), 4978-5002 2007
    Citations: 208

  • Identification of elasto-visco-plastic parameters and characterization of Lders behavior using digital image correlation and the virtual fields method
    S Avril, F Pierron, MA Sutton, J Yan
    Mechanics of materials 40 (9), 729-742 2008
    Citations: 176

  • Anisotropic and hyperelastic identification of in vitro human arteries from full-field optical measurements
    S Avril, P Badel, A Duprey
    Journal of biomechanics 43 (15), 2978-2985 2010
    Citations: 166

  • In vitro characterisation of physiological and maximum elastic modulus of ascending thoracic aortic aneurysms using uniaxial tensile testing
    A Duprey, K Khanafer, M Schlicht, S Avril, D Williams, R Berguer
    European Journal of Vascular and Endovascular Surgery 39 (6), 700-707 2010
    Citations: 158

  • Biaxial rupture properties of ascending thoracic aortic aneurysms
    A Duprey, O Trabelsi, M Vola, JP Favre, S Avril
    Acta biomaterialia 42, 273-285 2016
    Citations: 129

  • Stress reconstruction and constitutive parameter identification in plane-stress elasto-plastic problems using surface measurements of deformation fields
    S Avril, F Pierron, Y Pannier, R Rotinat
    Experimental Mechanics 48, 403-419 2008
    Citations: 114

  • Experimental identification of a nonlinear model for composites using the grid technique coupled to the virtual fields method
    H Chalal, S Avril, F Pierron, F Meraghni
    Composites Part A: Applied Science and Manufacturing 37 (2), 315-325 2006
    Citations: 108

  • Identification of the orthotropic elastic stiffnesses of composites with the virtual fields method: sensitivity study and experimental validation
    F Pierron, G Vert, R Burguete, S Avril, R Rotinat, MR Wisnom
    Strain 43 (3), 250-259 2007
    Citations: 105

  • Identification of elasto-plastic constitutive parameters from statically undetermined tests using the virtual fields method
    Y Pannier, S Avril, R Rotinat, F Pierron
    Experimental Mechanics 46, 735-755 2006
    Citations: 102

  • Computational comparison of the bending behavior of aortic stent-grafts
    N Demanget, S Avril, P Badel, L Orgas, C Geindreau, JN Albertini, ...
    Journal of the mechanical behavior of biomedical materials 5 (1), 272-282 2012
    Citations: 97

  • Experimental characterization of rupture in human aortic aneurysms using a full-field measurement technique
    JH Kim, S Avril, A Duprey, JP Favre
    Biomechanics and modeling in mechanobiology 11, 841-853 2012
    Citations: 96

  • In vitro analysis of localized aneurysm rupture
    A Romo, P Badel, A Duprey, JP Favre, S Avril
    Journal of Biomechanics 47 (3), 607-616 2014
    Citations: 94

  • Extension of the virtual fields method to elasto-plastic material identification with cyclic loads and kinematic hardening
    F Pierron, S Avril, VT Tran
    International Journal of Solids and Structures 47 (22-23), 2993-3010 2010
    Citations: 94

  • Finite element analysis of the mechanical performances of 8 marketed aortic stent-grafts
    N Demanget, A Duprey, P Badel, L Orgas, S Avril, C Geindreau, ...
    Journal of endovascular therapy 20 (4), 523-535 2013
    Citations: 91

  • Patient-specific numerical simulation of stent-graft deployment: Validation on three clinical cases
    D Perrin, P Badel, L Orgas, C Geindreau, A Dumenil, JN Albertini, S Avril
    Journal of Biomechanics 48 (10), 1868-1875 2015
    Citations: 87

  • Identification of heterogeneous constitutive parameters in a welded specimen: uniform stress and virtual fields methods for material property estimation
    MA Sutton, JH Yan, S Avril, F Pierron, SM Adeeb
    Experimental Mechanics 48, 451-464 2008
    Citations: 87

  • Novel methodology for characterizing regional variations in the material properties of murine aortas
    MR Bersi, C Bellini, P Di Achille, JD Humphrey, K Genovese, S Avril
    Journal of biomechanical engineering 138 (7), 071005 2016
    Citations: 86