Yuan Su

Verified email at purdue.edu

Post-Doctoral Research Associate
Purdue University



                          

http://researchid.co/yuansu
1

Scopus Publications

104

Scholar Citations

4

Scholar h-index

4

Scholar i10-index

Scopus Publications

  • The minor matrix protein VP24 from ebola virus lacks direct lipid-binding properties
    Yuan Su and Robert V. Stahelin

    Viruses, eISSN: 19994915, Published: August 2020 MDPI AG
    Viral protein 24 (VP24) from Ebola virus (EBOV) was first recognized as a minor matrix protein that associates with cellular membranes. However, more recent studies shed light on its roles in inhibiting viral genome transcription and replication, facilitating nucleocapsid assembly and transport, and interfering with immune responses in host cells through downregulation of interferon (IFN)-activated genes. Thus, whether VP24 is a peripheral protein with lipid-binding ability for matrix layer recruitment has not been explored. Here, we examined the lipid-binding ability of VP24 with a number of lipid-binding assays. The results indicated that VP24 lacked the ability to associate with lipids tested regardless of VP24 posttranslational modifications. We further demonstrate that the presence of the EBOV major matrix protein VP40 did not promote VP24 membrane association in vitro or in cells. Further, no protein–protein interactions between VP24 and VP40 were detected by co-immunoprecipitation. Confocal imaging and cellular membrane fractionation analyses in human cells suggested VP24 did not specifically localize at the plasma membrane inner leaflet. Overall, we provide evidence that EBOV VP24 is not a lipid-binding protein and its presence in the viral matrix layer is likely not dependent on direct lipid interactions.

RECENT SCHOLAR PUBLICATIONS

  • Different effects of phospholipase Dζ2 and non‐specific phospholipase C4 on lipid remodeling and root hair growth in Arabidopsis response to phosphate deficiency
    Y Su, M Li, L Guo, X Wang
    The Plant Journal 94 (2), 315-326 2018

  • Roles of Phospholipases and Ribosomal S6 Kinase in Lipid Remodeling and Growth in Arabidopsis Response to Phosphate Deprivation
    Y Su
    2018

  • Non‐specific phospholipase C1 affects silicon distribution and mechanical strength in stem nodes of rice
    H Cao, L Zhuo, Y Su, L Sun, X Wang
    The Plant Journal 86 (4), 308-321 2016

  • Phosphatidic acid as lipid messenger and growth regulators in plants
    X Wang, Y Su, Y Liu, SC Kim, B Fanella
    Phospholipases in Plant Signaling, 69-92 2014

  • Phosphatidic acid-mediated signaling
    Y Liu, Y Su, X Wang
    Lipid-mediated Protein Signaling, 159-176 2013

MOST CITED SCHOLAR PUBLICATIONS

  • Phosphatidic acid-mediated signaling
    Y Liu, Y Su, X Wang
    Lipid-mediated Protein Signaling, 159-176 2013
    Citations: 71

  • Phosphatidic acid as lipid messenger and growth regulators in plants
    X Wang, Y Su, Y Liu, SC Kim, B Fanella
    Phospholipases in Plant Signaling, 69-92 2014
    Citations: 12

  • Non‐specific phospholipase C1 affects silicon distribution and mechanical strength in stem nodes of rice
    H Cao, L Zhuo, Y Su, L Sun, X Wang
    The Plant Journal 86 (4), 308-321 2016
    Citations: 11

  • Different effects of phospholipase Dζ2 and non‐specific phospholipase C4 on lipid remodeling and root hair growth in Arabidopsis response to phosphate deficiency
    Y Su, M Li, L Guo, X Wang
    The Plant Journal 94 (2), 315-326 2018
    Citations: 10