Teemu Ihalainen

RESEARCH, TEACHING, or OTHER INTERESTS

Biophysics, Biochemistry, Genetics and Molecular Biology, Cell Biology, Biomedical Engineering

RECENT SCHOLAR PUBLICATIONS

Mitochondrial temperature homeostasis resists external metabolic stresses
M Terzioglu, K Veeroja, T Montonen, TO Ihalainen, TS Salminen, P Bnit, ...
Elife 12, RP89232 2023



The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales
A Tervonen, S Korpela, S Nymark, J Hyttinen, TO Ihalainen
Cellular and Molecular Bioengineering 16 (5), 475-495 2023



Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular Ca2+ Increase via Mechanosensitive Cation Channels
H Peussa, C Fedele, H Tran, M Marttinen, J Fadjukov, E Mntyl, ...
Advanced Science 10 (35) 2023



Toward Corneal Limbus In Vitro Model: Regulation of hPSC‐LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process
M Kauppila, A Mr, JJ Valle‐Delgado, T Ihalainen, L Sukki, P Puistola, ...
Advanced Healthcare Materials 12 (29), 2301396 2023



Substrate microtopographies induce cellular alignment and affect nuclear force transduction
B Belay, E Mntyl, C Maibohm, OF Silvestre, J Hyttinen, JB Nieder, ...
Journal of the Mechanical Behavior of Biomedical Materials 146, 106069 2023



Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina
E Mntyl, T Montonen, L Azzari, S Mattola, M Hannula, M Vihinen-Ranta, ...
Molecular Biology of the Cell 34 (9), br13 2023



Nuclear lamina strain states revealed by intermolecular force biosensor
BE Danielsson, B George Abraham, E Mntyl, JI Cabe, CR Mayer, ...
Nature Communications 14 (1), 3867 2023



CDK5 activity in retinal pigment epithelium contributes to gap junction dynamics during phagocytosis
J Fadjukov, S Wienbar, N Milićević, S Hakanen, M Vihinen-Ranta, ...
bioRxiv, 2023.02. 09.527850 2023



Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms
L Azizi, L Varela, P Turkki, VV Mykuliak, S Korpela, TO Ihalainen, ...
Human Molecular Genetics 31 (24), 4159-4172 2022



G2/M checkpoint regulation and apoptosis facilitate the nuclear egress of parvoviral capsids
S Mattola, E Mntyl, V Aho, S Salminen, S Leclerc, M Oittinen, K Salokas, ...
Frontiers in cell and developmental biology 10, 1070599 2022



Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology
H Peussa, J Kreutzer, E Mntyl, AJ Mki, S Nymark, P Kallio, ...
PloS one 17 (6), e0268570 2022



Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins
S Mattola, K Salokas, V Aho, E Mntyl, S Salminen, S Hakanen, ...
PLoS pathogens 18 (4), e1010353 2022



Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium
J Fadjukov, S Wienbar, S Hakanen, V Aho, M Vihinen-Ranta, ...
Journal of General Physiology 154 (4), e202112916 2022



Light‐Responsive Bilayer Cell Culture Platform for Reversible Cell Guidance
M Isomki, C Fedele, L Kriinen, E Mntyl, S Nymark, TO Ihalainen, ...
Small Science 2 (3), 2100099 2022



Toward Xeno-Free Differentiation of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells
J Saari, F Siddique, S Korpela, E Mntyl, TO Ihalainen, K Kaukinen, ...
International Journal of Molecular Sciences 23 (3), 1312 2022



Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells
E Mntyl, TO Ihalainen
Scientific Reports 11 (1), 18520 2021



Concepts to Reveal Parvovirus–Nucleus Interactions
S Mattola, S Hakanen, S Salminen, V Aho, E Mntyl, TO Ihalainen, ...
Viruses 13 (7), 1306 2021



Surface-shaving proteomics of Mycobacterium marinum identifies biofilm subtype-specific changes affecting virulence, tolerance, and persistence
K Savijoki, H Myllymki, H Luukinen, L Paulamki, LM Vanha-Aho, ...
Msystems 6 (3), 10.1128/msystems. 00500-21 2021



Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE
T Viheril, J Sorvari, TO Ihalainen, A Mr, P Grnroos, S Schlie-Wolter, ...
Scientific reports 11 (1), 933 2021



A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples
I Tamminen, K Lehto, M Hannula, M Ojansivu, L Johansson, M Kellomki, ...
Communications biology 3 (1), 548 2020

MOST CITED SCHOLAR PUBLICATIONS

Protein diffusion in mammalian cell cytoplasm
T Khn, TO Ihalainen, J Hyvluoma, N Dross, SF Willman, J Langowski, ...
PLoS One 6 (8), e22962 2011
Citations: 213



Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension
TO Ihalainen, L Aires, FA Herzog, R Schwartlander, J Moeller, V Vogel
Nature materials 14 (12), 1252-1261 2015
Citations: 186



Transdifferentiation and proliferation in two distinct hemocyte lineages in Drosophila melanogaster larvae after wasp infection
I Anderl, L Vesala, TO Ihalainen, LM Vanha-aho, I And, M Rmet, ...
PLoS pathogens 12 (7), e1005746 2016
Citations: 155



Carbon nanotubes as electrodes for dielectrophoresis of DNA
S Tuukkanen, JJ Toppari, A Kuzyk, L Hirviniemi, VP Hytnen, T Ihalainen, ...
Nano letters 6 (7), 1339-1343 2006
Citations: 128



Dielectrophoresis of nanoscale double-stranded DNA and humidity effects on its electrical conductivity
S Tuukkanen, A Kuzyk, JJ Toppari, VP Hytnen, T Ihalainen, P Trm
Applied Physics Letters 87 (18) 2005
Citations: 104



Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studies
J Karvinen, TO Ihalainen, MT Calejo, I Jnkkri, M Kellomki
Materials Science and Engineering: C 94, 1056-1066 2019
Citations: 92



Internalization of novel non-viral vector TAT-streptavidin into human cells
J Rinne, B Albarran, J Jylhv, TO Ihalainen, P Kankaanp, VP Hytnen, ...
BMC biotechnology 7, 1-14 2007
Citations: 90



Bioamine-crosslinked gellan gum hydrogel for neural tissue engineering
JT Koivisto, T Joki, JE Parraga, R Pkknen, L Yl-Outinen, L Salonen, ...
Biomedical Materials 12 (2), 025014 2017
Citations: 88



Magnetic resonance imaging of viral particle biodistribution in vivo
JK Rty, T Liimatainen, T Wirth, KJ Airenne, TO Ihalainen, T Huhtala, ...
Gene therapy 13 (20), 1440 2006
Citations: 71



Mechanical stability of talin rod controls cell migration and substrate sensing.
R Rahikainen, M von Essen, M Schaefer, L Qi, L Azizi, C Kelly, ...
Scientific reports 7 (1), 3571 2017
Citations: 64



His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display
T Koho, TO Ihalainen, M Stark, H Uusi-Kerttula, R Wieneke, R Rahikainen, ...
European Journal of Pharmaceutics and Biopharmaceutics 96, 22-31 2015
Citations: 61



Regulation of Human Mesenchymal Stem Cell Osteogenesis by Specific Surface Density of Fibronectin: a Gradient Study
AB Faia-Torres, T Goren, TO Ihalainen, S Guimond-Lischer, M Charnley, ...
ACS applied materials & interfaces 7 (4), 2367-2375 2015
Citations: 51



Effect of ATP binding and hydrolysis on dynamics of canine parvovirus NS1
EA Niskanen, TO Ihalainen, O Kalliolinna, MM Hakkinen, ...
Journal of virology 84 (10), 5391-5403 2010
Citations: 46



Parvovirus induced alterations in nuclear architecture and dynamics
TO Ihalainen, EA Niskanen, J Jylhv, O Paloheimo, N Dross, ...
PLoS One 4 (6), e5948 2009
Citations: 46



Baculovirus‐mediated immediate‐early gene expression and nuclear reorganization in human cells
JP Laakkonen, MU Kaikkonen, PHA Ronkainen, TO Ihalainen, ...
Cellular microbiology 10 (3), 667-681 2008
Citations: 45



Switchavidin: reversible biotin-avidin-biotin bridges with high affinity and specificity
B Taskinen, D Zauner, SI Lehtonen, M Koskinen, C Thomson, ...
Bioconjugate Chemistry 2014
Citations: 44



Direct laser writing of tubular microtowers for 3D culture of human pluripotent stem cell-derived neuronal cells
S Turunen, T Joki, ML Hiltunen, TO Ihalainen, S Narkilahti, M Kellomaki
ACS applied materials & interfaces 9 (31), 25717-25730 2017
Citations: 42



Structural dynamics of tight junctions modulate the properties of the epithelial barrier
A Tervonen, TO Ihalainen, S Nymark, J Hyttinen
PloS one 14 (4), e0214876 2019
Citations: 38



Coxsackievirus B3-induced cellular protrusions: structural characteristics and functional competence
O Paloheimo, TO Ihalainen, S Tauriainen, O Vlilehto, S Kirjavainen, ...
Journal of virology 85 (13), 6714-6724 2011
Citations: 33



Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells
C Fedele, E Mntyl, B Belardi, T Hamkins-Indik, S Cavalli, PA Netti, ...
Scientific reports 10 (1), 15329 2020
Citations: 32