Timothy Omara
@mak.ac.ug
Department of Chemistry
Makerere University
RESEARCH, TEACHING, or OTHER INTERESTS
Analytical Chemistry, Food Science, Environmental Science
Scopus Publications
Scopus Publications
Joseph Wanyama, Justus Kwetegyeka, Hannington Twinomuhwezi, Timothy Omara, and Ivan Kiganda
Elsevier BV
Emmanuel Ebbu, Irene Nalumansi, Ivan Kiganda, Caroline Kiwanuka Nakiguli, Patrick Onen, Simon Ocakacon, Christopher Adaku, Timothy Omara, and Emmanuel Ntambi
MDPI AG
By the time of this study, Kiteezi landfill was Uganda’s largest waste disposal site and received substantial volumes of municipal solid waste. In the present study, water (n = 36), leachates (n = 36), superficial sediments (n = 30), and Colocasia esculenta corms (n = 6) were sampled from Kiteezi landfill in the dry and wet seasons of 2022 before its tragic collapse in 2024. The physicochemical parameters (pH, electrical conductivity, temperature, and oxidation–reduction potential) and concentration of potentially toxic elements (As, Cu, Cr, Pb, and Zn) were analyzed using standard methods and inductively coupled plasma-optical emission spectrometry, respectively. Significant seasonal variations (p < 0.05) were observed for all the physicochemical parameters of water and leachates except temperature. Further, significantly higher concentrations (p < 0.05) of potentially toxic elements (PTXEs) were quantified in environmental matrices sampled during the dry season than the wet season. Arsenic and Pb concentrations in water surpassed their WHO permissible limit of 0.01 mg/L. The concentrations of PTXEs were higher in downstream samples (p < 0.05), indicating that landfill activities led to their enrichment in matrices near the facility. Ecological and pollution risk indices indicated that there is severe enrichment of Cu and Zn in the sediments, with dry season downstream samples having contamination factors and geoaccumulation indices of 539.3 and 74.7 and 8.5 and 5.6, respectively. Although ingestion of water may not cause probable health risks, consumption of Colocasia esculenta corms could lead to non-carcinogenic and cancer health risks in both children and adults (hazard indices = 0.085–189.0 and total cancer risk values of 7.33 × 10−6–4.87 × 10−3). These results emphasize the need that any new replacement for Kiteezi landfill should be properly planned and managed to mitigate potential environmental pollution with xenobiotics.
Gabson Baguma, Gadson Bamanya, Hannington Twinomuhwezi, Allan Gonzaga, Timothy Omara, Patrick Onen, Simon Ocakacon, Christopher Angiro, Wilber Waibale, and Ronald Ntuwa
MDPI AG
Rapid industrialization in peri-urban centers has accelerated the accumulation of potentially toxic elements (PTEs) in agricultural soils, with implications for food safety and public health concerns. This study quantified PTEs (Cu, Cd, Cr, Pb, and Zn) in soils and yam (Colocasia esculenta) tubers from Kampala’s Luzira Industrial Area. Soil contamination levels were evaluated using the geoaccumulation index (Igeo), contamination factor (CF), and pollution load index (PLI), while soil-to-crop transfer of the PTEs was assessed using the biological accumulation factor (BAF). Statistical analyses (One Way Analysis of Variance, Pearson bivariate correlation, and Principal Component Analysis) were applied to identify relationships among PTEs and sampling sites. Soils exhibited marked industrial influence, with PTE concentrations in the order Zn > Pb > Cu > Cr > Cd. The PLI values above unity confirmed cumulative pollution, with hotspots dominated by Zn, Pb, and Cu. Yam tubers contained lower PTE concentrations but reflected a similar contamination pattern as in the soils. The BAF values were <1 for all the PTEs except Zn, pointing to its greater solubility and mobility in the area’s acidic soils. Health risk assessment indicated that yam consumption was the dominant exposure pathway, with hazard indices (HI) for children exceeding the safe threshold at all industrial sites (HI = 1.14–2.06), and total cancer risks (TCR) ranging from 1.27 × 10−4 to 5.83 × 10−4, well above the US EPA limit. For adults, the TCR also surpassed 1 × 10−4 at sampling points SP3 and SP4. These results found potential transfer of the PTEs from soils into yam tubers, with Cd and Cr being the key drivers of dietary risk.
Sumel Ashique, Sourav Mohanto, Mohammed Gulzar Ahmed, Neeraj Mishra, Ashish Garg, Dinesh Kumar Chellappan, Timothy Omara, Shabnoor Iqbal, and Ivan Kahwa
Elsevier BV
Ivan Gumula, Mary Achiro, Sarah Kiwanuka Nanyonga, Denis Akampurira, Patrick Onen, Ronnie Tumwesigye, and Timothy Omara
SAGE Publications
Objective Tuberculosis (TB) is among the major causes of mortality due to a single infectious bacterium. The burden of TB is higher due to multidrug-resistant Mycobacterium tuberculosis strains, which lead to treatment failures. The present study conducted in silico studies of bioactive compounds isolated from Kigelia africana (Lam.) Benth stem bark. Methods Pure compounds were isolated from dichloromethane/methanol stem bark extract of Kigelia africana after repeated column chromatography. The chemical structures of the isolated compounds were established based on 1 H NMR, 13 C NMR and 2D NMR (COSY, HSQC and HMBC) spectroscopy. In silico analyses were performed to assess the drug-likeness, pharmacokinetics and antibacterial potential of the compounds against target proteins (4QIJ and 5HKF, 5L3J and 8GZY, and 2QIL) from M. tuberculosis , Escherichia coli , and Staphylococcus aureus , respectively. Results Four compounds: demethylkigelin, tyrosyl butyrate, stearic acid and stigmasterol were characterized. In molecular docking studies, the compounds showed binding affinities ranging from −4.4 to −9.3 kcal/mol against target proteins 4QIJ, 5HKF, 5L3J, 8GZY and 2QIL. Stigmasterol (L4) had the highest affinity against the highest binding affinity, with a score of −9.3 kcal/mol against S. aureus protein 2QIL. It also showed strong affinities against M. tuberculosis (4QIJ and 5HKF) and E. coli (5L3J and 8GZY) targets. In silico toxicity profiling predicted tyrosyl butyrate and stearic acid to be relatively safe whereas demethylkigelin and stigmasterol showed potential respiratory and cardiotoxic effects that needs further safety evaluation. Conclusion Kigelia africana stem bark possesses bioactive compounds that are potential inhibitors of M. tuberculosis with good to better binding affinities and stable interactions. Future studies should validate the in vitro and in vivo bioactivity as well as toxicity of the compounds.
Ivan Kahwa, Timothy Omara, Innocent Ayesiga, Kamal Shah, Gael Noel Neh Neba Ambe, Zehbanaz Javidbhai Panwala, Rachel Mbabazi, Shabnoor Iqbal, Christine Kyarimpa, Christine Betty Nagawa,et al.
Wiley
AbstractSeaweeds (SWD), macroalgae or sea vegetables are a diverse group of over 9000 macroscopic and multicellular marine algae taxonomically classified (based on morphology and pigmentation) as green, brown and red algae. With microalgae, SWD represents one of the most researched oceanic resources turned to as treasure troves of bioactive compounds with ethnomedicinal, pharmaceutical, cosmeceutical and dietetic end‐uses for millennia. This review compiles the nutraceutical uses of SWD and their bioactive compounds in nutrition and traditional management of diseases, offering future perspectives on using this group of organisms to improve human life. The review reveals that the nutraceutical application of SWD as nutrient‐dense marine foods for treating diseases may be correlated with their inherent biosynthesis and possession of minerals, vitamins, dietary fibres and bioactive compounds. Compounds of algal origin have been validated and found to elicit antimicrobial, anti‐inflammatory, free radical scavenging (antioxidant), antiproliferative and antidiabetic activities, among others. © 2025 Society of Chemical Industry.
Shabnoor Iqbal, Timothy Omara, Ivan Kahwa, and Usman Mir Khan
Springer Science and Business Media LLC
AbstractBisphenol S (BPS) is one of the monomers preferred in the manufacturing of polycarbonate plastics. Unfortunately, its estrogenic and genotoxic effects are similar to those of bisphenol A. The protective effects of Sphaeranthus indicus floral extract (SFE) against reprotoxic effects of BPS (50 µg/kg per body weight) in rats exposed to it via drinking water was investigated. Different SFE doses (25, 50, and 100 mg/kg) were administered via oral gavage for 10 weeks. High-performance liquid chromatography (HPLC) results indicated that SFE was rich in polyphenols, with rutin and quercetin being important bioactive molecules modulating BPS-induced necroptosis and apoptosis. Biochemical analyses unveiled that rats administered BPS only exhibited considerable elevation of biomarkers of nitro-oxidative stress, necroptotic (RIPK1/RIPK3 and MLKL), and apoptotic mediators (Fas/FasL and caspase 3/caspase-8). These events caused changes in sperm characteristics (sperm motility, sperm head, and sperm viability), sperm count, and hormonal profile (thyroid stimulating hormone, luteinizing hormone, and follicle-stimulating hormone) of the rats. Histological analysis suggested that there was pronounced sloughing of Sertoli cells, reduced spermatogenic cell density, increased levels of seminiferous tubules, and disorganized morphometric parameters related to seminiferous tubules. The SFE supplementation in rats with BPS-containing water restored nitro-oxidative stress biomarkers, which led to the reduction of necroptosis and apoptosis. Reinstatement of all the biomarkers of oxidative stress, inflammation, necroptosis, and apoptosis after SFE supplementations restored the hormonal profile and normal histoarchitecture of the testes. Virtual screening elucidated that the key regulators of the necroptosis are RIPK3-rutin and RIPK1-quercetin complexes. Further studies are needed to assess its pharmacodynamics, kinetics, and effective concentration for daily use in humans.
Simon Ocakacon, Philip Mayanja Nyenje, Herbert Mpagi Kalibbala, Robinah Nakawunde Kulabako, Christine Betty Nagawa, Timothy Omara, Christine Kyarimpa, Solomon Omwoma Lugasi, and Patrick Ssebugere
MDPI AG
Microplastics (MPs) have been extensively studied in the marine environment, but reliable data on their sources and pathways in freshwater ecosystems, which are the main sources of such pollutants, are still limited. In this study, we investigated the spatiotemporal variations, characteristics, and sources of MPs in Nakivubo catchment, which drains waste and stormwater from Kampala city (Uganda) and empties it into Lake Victoria through the Nakivubo channel. Surface water samples (n = 117) were collected from thirteen sites in the Nakivubo catchment (S1 to S13) during the dry and wet seasons in 2022. The MPs were recovered by wet peroxide oxidation protocol, followed by salinity-based density separation, stereomicroscopy, and micro-attenuated total reflectance Fourier-transform infrared spectroscopy. All the samples had MPs, with mean concentrations ranging from 1568.6 ± 1473.8 particles/m3 during the dry season to 2140.4 ± 3670.1 particles/m3 in the wet season. Nakivubo catchment discharges an estimated 293.957 million particles/day into Lake Victoria. A Two-Way ANOVA revealed significant interactive effects of seasons and sampling sites on MPs abundance (p < 0.05). Spatially, the highest mean concentrations of MPs (5466.67 ± 6441.70 particles/m3) were in samples from site S3, which is characterized by poor solid waste and wastewater management practices. Filaments (79.7%) and fragments (17.9%) made of polyethylene (75.4%) and polyethylene/polypropylene co-polymer (16.0%) were the most common MPs. These are likely from single-use polyethylene and polypropylene packaging bags, water bottles, and filaments shed from textiles during washing. These results highlight the ubiquity of MPs in urban drainage systems feeding into Lake Victoria. To mitigate this pollution, urban authorities need to implement strict waste management policies to prevent plastic debris from entering drainage networks.
Ivan Kahwa, Timothy Omara, Mercy Agaba, Upton Nuwagira, and Clement O. Ajayi
Ilia State University
Christine Betty Nagawa, Isaac Sebuyiira Kitiibwa, Simon Savio Kizito, Agatha Syofuna, Christine Mugumya Kyarimpa, and Timothy Omara
Elsevier BV
Calton Nantinda, Esther Lynnet Kisakye, David Musana, Isaac Ssessanga, Ukashar Ssenabulya, Timothy Omara, Ivan Kahwa, and Florence Nalimu
Elsevier BV
Gerald Kwikiriza, Ivan Abaho, Papius Dias Tibihika, Andrew A. Izaara, Faith Atukwatse, Timothy Omara, Juliet K. Nattabi, Nasser Kasozi, Manuel Curto, Andreas Melcher,et al.
MDPI AG
Despite the importance of Nile tilapia as a main aquaculture species in Uganda, limited research has been conducted concerning its genetic diversity, particularly in farmed populations. This gap has hindered the development of a systematic breeding program for this species. Successful aquaculture development, especially for genetic improvement, relies on the diversity and purity of wild and farmed populations as germplasm sources for selective breeding. Using microsatellite markers, the current study evaluated the genetic diversity of 480 samples collected from 20 populations of Nile tilapia (Oreochromis niloticus) in Uganda. All the populations exhibited a higher expected heterozygosity (0.50 ± 0.01) than observed heterozygosity (0.42 ± 0.01), although this was not significantly different. Populations from ponds showed lower FST values (<0.001), an indication of lower genetic differentiation. The populations formed four main clusters; the first comprising of mainly cages (Pal and Busana), the second with cages: Katosi and SON in addition to Rocks hatchery, the third comprised of Bawe cage fish farm and Tendo hatchery, and the fourth were populations from ponds and beaches on Lake Victoria. Given the higher genetic diversity and genetic differentiation of Tendo and Rocks populations, these farms would provide potential candidates for the development of local strains in Uganda. These results provide more insights into the management of local Nile tilapia strains towards reduction of inbreeding levels.
Timothy Omara, Solomon Yiga, Florence Nantaba, Christine Betty Nagawa, Ivan Kiganda, Francis Okori, and Emmanuel Ntambi
Elsevier
Hannington Gumisiriza, Eunice Apio Olet, Lydia Mwikali, Racheal Akatuhebwa, Owen Kembabazi, Timothy Omara, and Julius Bunny Lejju
Elsevier BV
Andrew Kaggwa, Denis Byamugisha, Timothy Omara, and Emmanuel Ntambi
MDPI AG
Artisanal and small-scale gold mining (ASCGM) provides a livelihood for many communities worldwide, but it has profound environmental impacts, especially on the quality of nearby water resources. This study assessed the impacts of ASCGM on the physicochemical quality of water and sediments from Kitengure stream, Buhweju Plateau, Western Uganda. Surface water (n = 94) and superficial sediments (n = 36) were sampled between October 2021 and January 2022 from three different sections of Kitengure stream (upstream, midstream around the ASCGM area, and downstream). The samples were analyzed for various physicochemical parameters and selected potentially toxic elements (PTXEs), namely: zinc (Zn), cadmium (Cd), lead (Pb), copper (Cu), and arsenic (As). A health risk assessment was performed using the hazard index and incremental life cancer risk methods. Pearson’s bivariate correlation, geoaccumulation, and pollution indices were used to establish the sources and potential risks that PTXEs in sediments could pose to aquatic organisms. The results indicated that water in Kitengure stream draining the ASCGM site was highly colored (1230.00 ± 134.09 Pt-co units; range = 924.00–1576.00 Pt-co units) and turbid (194.75 ± 23.51 NTU; range = 148–257 NTU). Among the five analyzed PTXEs, only Cd (0.082 ± 0.200–0.092 ± 0.001 mg/L) and Cu (0.022 ± 0.004–0.058 ± 0.005 mg/L) were detected in water, and Cd was above the permissible limit of 0.003 mg/L for potable water. Upon calculating the water quality index (WQI), the water samples were categorized as very poor for upstream samples (WQI = 227) and unfit for use (WQI = 965 and 432) for midstream and downstream samples, respectively. In sediments, the mean concentration ranges of Zn, Cd, Pb, Cu, and As were 0.991 ± 0.038–1.161 ± 0.051, 0.121 ± 0.014–0.145 ± 0.025, 0.260 ± 0.027–0.770 ± 0.037, 0.107 ± 0.017–0.422 ± 0.056, and 0.022 ± 0.002–0.073 ± 0.003 mg/kg, respectively, and they were all below their average shale, toxicity reference, and consensus-based sediment quality guidelines. Geoaccumulation indices suggested that there was no enrichment of the elements in the sedimentary phase and the associated ecological risks were low. However, there were potential non-carcinogenic health risks that maybe experienced by children who drink water from Kitengure stream. No discernable health risks were likely due to dermal contact with water and sediments during dredging or panning activities. It is recommended that further studies should determine the total mercury content of water, sediments, and crops grown along the stream as well as the associated ecological and human health risks.
Hannington Gumisiriza, Eunice Apio Olet, Lydia Mwikali, Racheal Akatuhebwa, Timothy Omara, Julius Bunny Lejju, and Duncan Crispin Sesaazi
MDPI AG
The leaves of Gouania longispicata Engl. (GLE) have been traditionally used to treat more than forty ailments in Uganda, including stomachache, lung and skin cancers, syphilis, toothache, and allergies. In this study, pure compounds were isolated from the methanolic extract of GLE leaves and their structures elucidated using ultraviolet visible spectroscopy, liquid chromatography–tandem mass spectrometry, high performance liquid chromatography, and 1D and 2D NMR techniques. The antibacterial and antioxidant activities of the compounds were assessed using the broth dilution and DPPH assays, respectively. Two known flavonoid glycosides (kaempferol-3-O-α-rhamnopyranoside and rutin), a phenolic glycoside (4,6-dihydroxy-3-methylacetophenone-2-O-β-D-glucopyranoside), and flavonoids (kaempferol and quercetin) were characterized. This is the first time that the kaempferol derivative, the acetophenone as well as free forms of quercetin, kaempferol, and rutin, are being reported in GLE and the Gouania genus. The compounds exhibited antibacterial activity against Streptococcus pneumoniae and Escherichia coli with minimum inhibitory concentrations between 16 µg/mL and 125 µg/mL. The radical scavenging activities recorded half-minimum inhibitory concentrations (IC50) ranging from 18.6 ± 1.30 µg/mL to 28.1 ± 0.09 µg/mL. The IC50 of kaempferol and quercetin were not significantly different from that of ascorbic acid (p > 0.05), highlighting their potential as natural antioxidant agents. These results lend credence to the use of GLE leaves in herbal treatment of microbial infections and oxidative stress-mediated ailments.
Stephen Super Barasa, Fidele Ntie-Kang, , Enos W. Wambu, Jonathan Metuge, Philippe Belle Ebanda Kedi, Richard Amewu, Daniel M. Shadrack, Daniel Tevin Barasa, Timothy Omara,et al.
Springer Science and Business Media LLC
Shabnoor Iqbal, Timothy Omara, Ivan Kahwa, and Usman Mir Khan
Springer Science and Business Media LLC
AbstractAnthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plants and vegetables. One of the important anthocyanidin components of red wine and berries is delphinidin (DP). This review provides an update on the potential of DP in cancer therapy, with a further understanding of the mechanisms involved. Delphinidin has been shown to elicit inhibitory effects on catabolizing enzymes of human granulocytes and parasites, TNF-induced COX-2 expression in mouse epidermal cells, and reduce oxidative stress. It also inhibited anchorage-independent growth and caused cell death in breast cancer cell lines. Delphinidin increased Nrf2 expression, increased HO-1 production, and promoted mRNA expression of mitochondrial biogenesis-related factors. Further, DP has anti-proliferative and pro-apoptotic effects in various cancer cell lines such as lung, breast, and ovarian cancer cells. The mTOR-related pathway is the most important signaling pathway in the activation of autophagy, and DP has been shown to exert its cytotoxic effects on cancer cell lines via activating protein kinases. Among DP derivatives, delphinidin-3-O-glucoside has the best anticancer activity because it is easily absorbed. However, the metabolism of DP and its bioavailability in biological systems need to be explored to fully understand its benefits.
Ronald Tenywa, Timothy Omara, Gerald Kwikiriza, Christopher Angiro, and Emmanuel Ntambi
MDPI AG
For millennia, springs have provided water for drinking, domestic use, balneological treatment, liminality rites as well as tourist attractions. Amidst these uses, anthropogenic activities, especially urbanization and agriculture, continue to impair the functionality of springs. With the looming decadal climate change, freshwater springs could be a sustainable source of clean water for the realisation of Sustainable Development Goal 6. This paper presents the results of the sanitary inspection and assessment of limnochemical characteristics and quality of water samples (n = 64) from four freshwater springs (coded SPR1, SPR2, SPR3, and SPR4) in Kansanga, a flash flood-prone area in the African Great Lakes region of Uganda. Each sample was analysed for 17 parameters (temperature, pH, electrical conductivity, turbidity, fluorides, sulphates, chlorides, nitrates, orthophosphates, total dissolved solids, dissolved oxygen, total alkalinity, potassium, sodium, total, magnesium and calcium hardness) following the standard methods. Water quality index (WQI) was calculated to establish the quality of the water samples based on the physicochemical parameters measured. Based on the sanitary risk assessment results, the springs had medium- to high-risk scores, but most water parameters were within the WHO guidelines for potable water, except for nitrates (in SPR1 and SPR2), hardness levels (in SPR2), and dissolved oxygen (in all the samples). Sampling season and location had significant effects on the limnochemistry of the freshwater springs (p < 0.05). The water quality indices calculated indicated that the water from the springs was of good quality (WQI = 50–57), but there was a reduction in water quality during the wet season. The best water quality was recorded in samples from SPR4, followed by those for SPR3, SPR1, and SPR2. These results provide insights into the contribution of floods and poor sanitation facilities to the deterioration of spring water quality in Kansanga, and the need to leverage additional conservation strategies to support vulnerable communities in the area. Further studies are required to establish the risk posed by trace metals and microbes that may contaminate freshwater in the studied springs, especially following flood events.
Onani Makeo, Amito Patricia Okot, Isaac Isabirye, Timothy Omara, and Joel Walugembe
Springer Science and Business Media LLC
Ivan Gumula, Christine Kyarimpa, Sarah Kiwanuka Nanyonga, George Kwesiga, George Busulwa, Boniface Opio, Mathias Heydenreich, and Timothy Omara
SAGE Publications
Objective The leaves of Alstonia boonei and aerial parts of Ipomoea cairica are used for treatment of microbial infections among other ailments in African traditional medicine. The aim of this study was to investigate the antimicrobial phytochemicals in A. boonei leaves and Ipomoea cairica aerial parts to validate their traditional use in Ugandan herbal medicine. Methods The plant materials were separately extracted using a dichloromethane/methanol (1:1) solvent system and subjected to repeated chromatographic separation to isolate pure compounds. The chemical structures of the isolated compounds were determined through 1H NMR, 13C NMR and 2D NMR (COSY, HSQC and HMBC). The antibacterial activity of the extracts and pure compounds were assessed using the agar well diffusion method. Results Chromatographic fractionation of the extracts yielded trans-fagaramide and a pentacyclic lupane-type triterpenoid, lupeol, from A. boonei, and friedelin from I. cairica. Trans-fagaramide was identified for the first time in the Alstonia genus while friedelin was identified for the first time in I. cairica. The isolated compounds demonstrated antibacterial activity, with trans-fagaramide showing a minimum inhibitory concentration (MIC) of 125 μg/mL against Pseudomonas aeruginosa and 250 μg/mL against Staphylococcus aureus, Salmonella typhi and Escherichia coli. Friedelin exhibited a MIC of 125 μg/mL against Escherichia coli and 250 μg/mL against Pseudomonas aeruginosa, Staphylococcus aureus and Salmonella typhi. Conclusion The antibacterial activities observed in this study support the traditional use of A. boonei and I. cairica by indigenous communities in Uganda for treating microbial infections.
Shabnoor Iqbal and Timothy Omara
Springer Science and Business Media LLC
AbstractCarbamazepine is a first-choice anticonvulsant, and its medication is typically well tolerated when compared to lithium and valproic acid. Patients of Alzheimer’s Disease who are administered carbamazepine tend to develop acute tubulointerstitial nephritis. In this study, we established an Alzheimer’s model using scopolamine in Sprague Dawley rats to find out the nephroprotective effect of matricin (a bioactive sesquiterpene isolated from chamomile flowers) against carbamazepine-induced acute tubulointerstitial nephritis and its underlying mechanism of action. Scopolamine (16 mg/kg) was intraperitoneally injected for induction of Alzheimer’s disease on the 28th day whereas carbamazepine (25 mg/kg) was given daily to induce acute tubulointerstitial nephritis. Treatment with matricin inhibited carbamazepine-induced mRNA expressions of RAS-ERK-MEK-JAK2-STAT3, cytokines (IL-1β, TNF-α, and IL-6), and restored the optimal levels of biomarkers of oxidative stress (MDA, SOD and CAT). Further, matricin treatments reinstated biomarkers of kidney function (creatinine, uric acid, and blood urea nitrogen), and refurbished the levels of MDA, SOD, and CAT. Histopathological analyses indicated that there was systemic dilation, tubular necrosis, interstitial edema, and glomerulus nephritis in the medulla region of the kidneys in rats with Alzheimer’s disease that received carbamazepine only. Treatment with matricin reconsolidated histopathology, and only mild glomerulus nephritis were observed in rats with Alzheimer’s disease. These results suggest that matricin could be utilized as a co-supplement with carbamazepine for the treatment of patients with Alzheimer’s disease to minimize the risk of kidney damage.
Samuel Baker Obakiro, Timothy Omara, Ambrose Kiprop, Lydia Bunalema, Isaac Kowino, and Elizabeth Kigondu
Springer Science and Business Media LLC