Dr. Asokan Bagavan

@tvu.edu.in

Arignnar Anna Govt Arts College, Cheyyar. PG & Research Department of Zoology

Interests
Drug Discovery: To take up a challenging research work in Nanotechnology and Bioactive Natural Products Research and contribute significant outcome in connection with animal and human welfare.

EDUCATION

C.Abdul Hakeem College,(Affiliated to Thiruvalluvar University)C.Abdul Hakeem College,(Affiliated to Thiruvalluvar University)
Doctor of Philosophy ( Zoology, ZoologyDoctor of Philosophy ( Zoology, Zoology
2009 - 2014
Activities and societies: Malaria Research and aim to search a new drugActivities and societies: Malaria Research and aim to search a new drug
Screening of medicinal plant extracts for the detection of novel antimalarial compounds against Plasmodium falciparum and Plasmodium berghei

Thiruvalluvar UniversityThiruvalluvar University
Master of Philosophy (MPhil), ZoologyMaster of Philosophy (MPhil), Zoology
2006 - 2007
Grade: 1st Grade
BIOASSAY – GUIDED ISOLATION AND IDENTIFICATION OF MOSQUITO LARVICIDAL COMPOUND FROM INDIGENOUS PLANT EXTRACTS.

Annamalai UniversityAnnamalai University
Bachelor's Degree, B.Ed., Zoology I & IIBachelor's Degree, B.Ed., Zoology I & II
2005 - 2006
Grade: 1st Grade

RESEARCH, TEACHING, or OTHER INTERESTS

Drug Discovery, Animal Science and Zoology, Molecular Biology, Parasitology

Scopus Publications

7442

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Green synthesis of silver and titanium dioxide nanoparticles using Euphorbia prostrata extract shows shift from apoptosis to G<inf>0</inf>/G<inf>1</inf> arrest followed by necrotic cell death in Leishmania donovani
Abdul Abduz Zahir, Indira Singh Chauhan, Asokan Bagavan, Chinnaperumal Kamaraj, Gandhi Elango, Jai Shankar, Nidhi Arjaria, Selvaraj Mohana Roopan, Abdul Abdul Rahuman, and Neeloo Singh
American Society for Microbiology
ABSTRACT The aim of the present study was to synthesize silver (Ag) and titanium dioxide (TiO 2 ) nanoparticles (NPs) using green synthesis from aqueous leaf extract of Euphorbia prostrata as antileishmanial agents and to explore the underlying molecular mechanism of induced cell death. In vitro antileishmanial activity of synthesized NPs was tested against promastigotes of Leishmania donovani by alamarBlue and propidium iodide uptake assays. Antileishmanial activity of synthesized NPs on intracellular amastigotes was assessed by Giemsa staining. The leishmanicidal effect of synthesized Ag NPs was further confirmed by DNA fragmentation assay and by cell cycle progression and transmission electron microscopy (TEM) of the treated parasites. TEM analysis of the synthesized Ag NPs showed a spherical shape with an average size of 12.82 ± 2.50 nm, and in comparison to synthesized TiO 2 NPs, synthesized Ag NPs were found to be most active against Leishmania parasites after 24 h exposure, with 50% inhibitory concentrations (IC 50 ) of 14.94 μg/ml and 3.89 μg/ml in promastigotes and intracellular amastigotes, respectively. A significant increase in G 0 /G 1 phase of the cell cycle with a subsequent decrease in S (synthesis) and G 2 /M phases compared to controls was observed. The growth-inhibitory effect of synthesized Ag NPs was attributed to increased length of S phase. A decreased reactive oxygen species level was also observed, which could be responsible for the caspase-independent shift from apoptosis (G 0 /G 1 arrest) to massive necrosis. High-molecular-weight DNA fragmentation as a positive consequence of necrotic cell death was also visualized. We also report that the unique trypanothione/trypanothione reductase (TR) system of Leishmania cells was significantly inhibited by synthesized Ag NPs. The green-synthesized Ag NPs may provide promising leads for the development of cost-effective and safer alternative treatment against visceral leishmaniasis.

Synthesis and larvicidal activity of low-temperature stable silver nanoparticles from psychrotolerant Pseudomonas mandelii
Anbazhagan Mageswari, Parthiban Subramanian, Vini Ravindran, Sreelekha Yesodharan, Asokan Bagavan, Abdul Abdul Rahuman, Sivashanmugam Karthikeyan, and Kodiveri Muthukaliannan Gothandam
Springer Science and Business Media LLC

Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats
Naveen K Kaushik, Asokan Bagavan, Abdul A Rahuman, Abdul A Zahir, Chinnaperumal Kamaraj, Gandhi Elango, Chidambaram Jayaseelan, Arivarasan V Kirthi, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu,et al.
Springer Science and Business Media LLC

Solanum trilobatum extract-mediated synthesis of titanium dioxide nanoparticles to control Pediculus humanus capitis, Hyalomma anatolicum anatolicum and Anopheles subpictus
Govindasamy Rajakumar, Abdul Abdul Rahuman, Chidambaram Jayaseelan, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu, Chinnaperumal Kamaraj, Asokan Bagavan, Abdul Abduz Zahir, Arivarasan Vishnu Kirthi, Gandhi Elango,et al.
Springer Science and Business Media LLC

Bioassay-guided isolation and characterization of active antiplasmodial compounds from Murraya koenigii extracts against Plasmodium falciparum and Plasmodium berghei
Chinnaperumal Kamaraj, Abdul Abdul Rahuman, Selvaraj Mohana Roopan, Asokan Bagavan, Gandhi Elango, Abdul Abduz Zahir, Govindasamy Rajakumar, Chidambaram Jayaseelan, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu,et al.
Springer Science and Business Media LLC

Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa
Sampath Marimuthu, Abdul Abdul Rahuman, Chidambaram Jayaseelan, Arivarasan Vishnu Kirthi, Thirunavukkarasu Santhoshkumar, Kanayairam Velayutham, Asokan Bagavan, Chinnaperumal Kamaraj, Gandhi Elango, Moorthy Iyappan,et al.
Medknow

Antiplasmodial potential of selected medicinal plants from Eastern Ghats of South India
Naveen Kumar Kaushik, Asokan Bagavan, Abdul Abdul Rahuman, Dinesh Mohanakrishnan, Chinnaperumal Kamaraj, Gandhi Elango, Abdul Abduz Zahir, and Dinkar Sahal
Elsevier BV

Novel and simple approach using synthesized nickel nanoparticles to control blood-sucking parasites
Govindasamy Rajakumar, Abdul Abdul Rahuman, Kanayairam Velayutham, Jeyaraman Ramyadevi, Kadarkaraithangam Jeyasubramanian, Arumugam Marikani, Gandhi Elango, Chinnaperumal Kamaraj, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu,et al.
Elsevier BV

Feeding deterrent activity of synthesized silver nanoparticles using Manilkara zapota leaf extract against the house fly, Musca domestica (Diptera: Muscidae)
Chinnaperumal Kamaraj, Govindasamy Rajakumar, Abdul Abdul Rahuman, Kanayairam Velayutham, Asokan Bagavan, Abdul Abduz Zahir, and Gandhi Elango
Springer Science and Business Media LLC

Evaluation of Catharanthus roseus leaf extract-mediated biosynthesis of titanium dioxide nanoparticles against Hippobosca maculata and Bovicola ovis
Kanayairam Velayutham, Abdul Abdul Rahuman, Govindasamy Rajakumar, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu, Chidambaram Jayaseelan, Asokan Bagavan, Arivarasan Vishnu Kirthi, Chinnaperumal Kamaraj, Abdul Abduz Zahir,et al.
Springer Science and Business Media LLC

Lousicidal activity of synthesized silver nanoparticles using Lawsonia inermis leaf aqueous extract against Pediculus humanus capitis and Bovicola ovis
Sampath Marimuthu, Abdul Abdul Rahuman, Thirunavukkarasu Santhoshkumar, Chidambaram Jayaseelan, Arivarasan Vishnu Kirthi, Asokan Bagavan, Chinnaperumal Kamaraj, Gandhi Elango, Abdul Abduz Zahir, Govindasamy Rajakumar,et al.
Springer Science and Business Media LLC

Evaluation of medicinal plant extracts and isolated compound epicatechin from Ricinus communis against Paramphistomum cervi
Abdul Abduz Zahir, Abdul Abdul Rahuman, Asokan Bagavan, Kannappan Geetha, Chinnaperumal Kamaraj, and Gandhi Elango
Springer Science and Business Media LLC

Efficacy of adulticidal and larvicidal properties of botanical extracts against haemaphysalis bispinosa, hippobosca maculata, and anopheles subpictus
Thirunavukkarasu Santhoshkumar, Abdul Abdul Rahuman, Asokan Bagavan, Arivarasan Vishnu Kirthi, Sampath Marimuthu, Chidambaram Jayaseelan, Chinnaperumal Kamaraj, Abdul Abduz Zahir, Gandhi Elango, Govindasamy Rajakumar,et al.
Springer Science and Business Media LLC

Evaluation of stem aqueous extract and synthesized silver nanoparticles using Cissus quadrangularis against Hippobosca maculata and Rhipicephalus (Boophilus) microplus
Thirunavukkarasu Santhoshkumar, Abdul Abdul Rahuman, Asokan Bagavan, Sampath Marimuthu, Chidambaram Jayaseelan, Arivarasan Vishnu Kirthi, Chinnaperumal Kamaraj, Govindasamy Rajakumar, Abdul Abduz Zahir, Gandhi Elango,et al.
Elsevier BV

Evaluation of antileishmanial activity of South Indian medicinal plants against Leishmania donovani
Abdul Abduz Zahir, Abdul Abdul Rahuman, Sourav Pakrashi, Debopam Ghosh, Asokan Bagavan, Chinnaperumal Kamaraj, Gandhi Elango, and Mitali Chatterjee
Elsevier BV

Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India
Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan, Gandhi Elango, Asokan Bagavan, Abdul Abduz Zahir, Abdul Abdul Rahuman, and Dinkar Sahal
Springer Science and Business Media LLC

Efficacy of plant-mediated synthesized silver nanoparticles against hematophagous parasites
Chidambaram Jayaseelan, Abdul Abdul Rahuman, Govindasamy Rajakumar, Thirunavukkarasu Santhoshkumar, Arivarasan Vishnu Kirthi, Sampath Marimuthu, Asokan Bagavan, Chinnaperumal Kamaraj, Abdul Abduz Zahir, Gandhi Elango,et al.
Springer Science and Business Media LLC

Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India
Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Abdul Abdul Rahuman, Dinesh Mohanakrishnan, Asokan Bagavan, Gandhi Elango, Abdul Abduz Zahir, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu, Chidambaram Jayaseelan,et al.
Elsevier BV

Efficacy of plant-mediated synthesized silver nanoparticles against Sitophilus oryzae

Novel microbial route to synthesize ZnO nanoparticles using Aeromonas hydrophila and their activity against pathogenic bacteria and fungi
C. Jayaseelan, A. Abdul Rahuman, A. Vishnu Kirthi, S. Marimuthu, T. Santhoshkumar, A. Bagavan, K. Gaurav, L. Karthik, and K.V. Bhaskara Rao
Elsevier BV

Efficacy of medicinal plant extracts against Formosan subterranean termite, Coptotermes formosanus
G. Elango, A. Abdul Rahuman, C. Kamaraj, A. Bagavan, A. Abduz Zahir, T. Santhoshkumar, S. Marimuthu, K. Velayutham, C. Jayaseelan, A. Vishnu Kirthi,et al.
Elsevier BV

Adult emergence inhibition and adulticidal activity of leaf crude extracts against Japanese encephalitis vector, Culex tritaeniorhynchus
G. Elango, A. Abdul Rahuman, C. Kamaraj, A. Bagavan, and A. Abduz Zahir
Elsevier BV

Contact and fumigant toxicity of hexane flower bud extract of Syzygium aromaticum and its compounds against Pediculus humanus capitis (Phthiraptera: Pediculidae)
Asokan Bagavan, Abdul Abdul Rahuman, Chinnaperumal Kamaraj, Gandhi Elango, Abdul Abduz Zahir, Chidambaram Jayaseelan, Thirunavukkarasu Santhoshkumar, and Sampath Marimuthu
Springer Science and Business Media LLC

Efficacy of indigenous plant extracts on the malaria vector anopheles subpictus grassi (diptera: Culicidae)

Larvicidal and repellent activity of medicinal plant extracts from Eastern Ghats of South India against malaria and filariasis vectors
Chinnaperumal Kamaraj, Abdul Abdul Rahuman, Asokan Bagavan, Gandhi Elango, Abdul Abduz Zahir, and Thirunavukkarasu Santhoshkumar
Medknow

RECENT SCHOLAR PUBLICATIONS

Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats
NK Kaushik, A Bagavan, AA Rahuman, AA Zahir, C Kamaraj, G Elango, ...
Malaria journal 14, 1-8 2015

Green Synthesis of Silver and Titanium Dioxide Nanoparticles Using Euphorbia prostrata Extract Shows Shift from Apoptosis to G₀/G₁ Arrest followed by Necrotic
AA Zahir, IS Chauhan, A Bagavan, C Kamaraj, G Elango, J Shankar, ...
Antimicrobial agents and chemotherapy 59 (8), 4782-4799 2015

Synthesis and larvicidal activity of low-temperature stable silver nanoparticles from psychrotolerant Pseudomonas mandelii
A Mageswari, P Subramanian, V Ravindran, S Yesodharan, A Bagavan, ...
Environmental Science and Pollution Research 22, 5383-5394 2015

Bioassay-guided isolation and characterization of active antiplasmodial compounds from Murraya koenigii extracts against Plasmodium falciparum and Plasmodium berghei
C Kamaraj, AA Rahuman, SM Roopan, A Bagavan, G Elango, AA Zahir, ...
Parasitology research 113, 1657-1672 2014

Synthesis of Nanoparticles Using Euphorbia prostrata Extract Reveals a Shift from Apoptosis to G0/G1 Arrest in Leishmania donovani. J Nanomed Nanotechnol 5: 213. doi: 10.4172
AA Zahir, IS Chauhan, A Bagavan, C Kamaraj, G Elango
Euphorbia prostrata 2014

Synthesis of nanoparticles using Euphorbia prostrata extract reveals a shift from apoptosis to G0/G1 arrest in Leishmania donovani
AA Zahir, IS Chauhan, A Bagavan, C Kamaraj, G Elango, J Shankar, ...
2014

Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa
S Marimuthu, AA Rahuman, C Jayaseelan, AV Kirthi, T Santhoshkumar, ...
Asian Pacific Journal of Tropical Medicine 6 (9), 682-688 2013

Antiplasmodial potential of selected medicinal plants from eastern Ghats of South India
NK Kaushik, A Bagavan, AA Rahuman, D Mohanakrishnan, C Kamaraj, ...
Experimental Parasitology 134 (1), 26-32 2013

Novel and simple approach using synthesized nickel nanoparticles to control blood-sucking parasites
G Rajakumar, AA Rahuman, K Velayutham, J Ramyadevi, ...
Veterinary Parasitology 191 (3-4), 332-339 2013

Feeding deterrent activity of synthesized silver nanoparticles using Manilkara zapota leaf extract against the house fly, Musca domestica (Diptera: Muscidae)
C Kamaraj, G Rajakumar, AA Rahuman, K Velayutham, A Bagavan, ...
Parasitology research 111, 2439-2448 2012

Evaluation of Catharanthus roseus leaf extract-mediated biosynthesis of titanium dioxide nanoparticles against Hippobosca maculata and Bovicola ovis
K Velayutham, AA Rahuman, G Rajakumar, T Santhoshkumar, ...
Parasitology research 111, 2329-2337 2012

Lousicidal activity of synthesized silver nanoparticles using Lawsonia inermis leaf aqueous extract against Pediculus humanus capitis and Bovicola ovis
S Marimuthu, AA Rahuman, T Santhoshkumar, C Jayaseelan, AV Kirthi, ...
Parasitology research 111, 2023-2033 2012

Efficacy of adulticidal and larvicidal properties of botanical extracts against Haemaphysalis bispinosa, Hippobosca maculata, and Anopheles subpictus
T Santhoshkumar, AA Rahuman, A Bagavan, AV Kirthi, S Marimuthu, ...
Parasitology research 111, 1833-1840 2012

Evaluation of antileishmanial activity of South Indian medicinal plants against Leishmania donovani
AA Zahir, AA Rahuman, S Pakrashi, D Ghosh, A Bagavan, C Kamaraj, ...
Experimental parasitology 132 (2), 180-184 2012

Evaluation of stem aqueous extract and synthesized silver nanoparticles using Cissus quadrangularis against Hippobosca maculata and Rhipicephalus (Boophilus) microplus
T Santhoshkumar, AA Rahuman, A Bagavan, S Marimuthu, C Jayaseelan, ...
Experimental Parasitology 132 (2), 156-165 2012

Evaluation of medicinal plant extracts and isolated compound epicatechin from Ricinus communis against Paramphistomum cervi
AA Zahir, AA Rahuman, A Bagavan, K Geetha, C Kamaraj, G Elango
Parasitology research 111, 1629-1635 2012

Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India
C Kamaraj, NK Kaushik, D Mohanakrishnan, G Elango, A Bagavan, ...
Parasitology research 111, 703-715 2012

Efficacy of plant-mediated synthesized silver nanoparticles against hematophagous parasites
C Jayaseelan, AA Rahuman, G Rajakumar, T Santhoshkumar, AV Kirthi, ...
Parasitology research 111, 921-933 2012

Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India
C Kamaraj, NK Kaushik, AA Rahuman, D Mohanakrishnan, A Bagavan, ...
Journal of Ethnopharmacology 141 (3), 796-802 2012

MOST CITED SCHOLAR PUBLICATIONS

Novel microbial route to synthesize ZnO nanoparticles using Aeromonas hydrophila and their activity against pathogenic bacteria and fungi
C Jayaseelan, AA Rahuman, AV Kirthi, S Marimuthu, T Santhoshkumar, ...
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 90, 78-84 2012
Citations: 825

Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors
T Santhoshkumar, AA Rahuman, G Rajakumar, S Marimuthu, A Bagavan, ...
Parasitology research 108, 693-702 2011
Citations: 543

Evaluation of green synthesized silver nanoparticles against parasites
S Marimuthu, AA Rahuman, G Rajakumar, T Santhoshkumar, AV Kirthi, ...
Parasitology research 108, 1541-1549 2011
Citations: 370

Synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, Tinospora cordifolia Miers
C Jayaseelan, AA Rahuman, G Rajakumar, A Vishnu Kirthi, ...
Parasitology research 109, 185-194 2011
Citations: 300

Larvicidal potential of medicinal plant extracts against Anopheles subpictus Grassi and Culex tritaeniorhynchus Giles (Diptera: Culicidae)
C Kamaraj, A Bagavan, AA Rahuman, AA Zahir, G Elango, G Pandiyan
Parasitology research 104, 1163-1171 2009
Citations: 248

Larvicidal activity of saponin from Achyranthes aspera against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae)
A Bagavan, AA Rahuman, C Kamaraj, K Geetha
Parasitology research 103, 223-229 2008
Citations: 236

Biosynthesis of titanium dioxide nanoparticles using bacterium Bacillus subtilis
AV Kirthi, AA Rahuman, G Rajakumar, S Marimuthu, T Santhoshkumar, ...
Materials Letters 65 (17-18), 2745-2747 2011
Citations: 200

Larvicidal activity of medicinal plant extracts against Anopheles subpictus & Culex tritaeniorhynchus
C Kamaraj, A Bagavan, G Elango, AA Zahir, G Rajakumar, S Marimuthu, ...
Indian Journal of Medical Research 134 (1), 101-106 2011
Citations: 195

Antifeedant and larvicidal effects of plant extracts against Spodoptera litura (F.), Aedes aegypti L. and Culex quinquefasciatus Say
C Kamaraj, AA Rahuman, A Bagavan
Parasitology research 103, 325-331 2008
Citations: 189

Efficacy of larvicidal botanical extracts against Culex quinquefasciatus Say (Diptera: Culicidae)
AA Rahuman, A Bagavan, C Kamaraj, E Saravanan, AA Zahir, G Elango
Parasitology Research 104, 1365-1372 2009
Citations: 186

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum
A Bagavan, AA Rahuman, NK Kaushik, D Sahal
Parasitology research 108, 15-22 2011
Citations: 176

Efficacy of plant-mediated synthesized silver nanoparticles against Sitophilus oryzae
AA Zahir, A Bagavan, C Kamaraj, G Elango, AA Rahuman
Journal of Biopesticides 5, 95 2012
Citations: 172

Oviposition-deterrent, ovicidal, and repellent activities of indigenous plant extracts against Anopheles subpictus Grassi (Diptera: Culicidae)
G Elango, A Bagavan, C Kamaraj, A Abduz Zahir, A Abdul Rahuman
Parasitology research 105, 1567-1576 2009
Citations: 153

Laboratory determination of efficacy of indigenous plant extracts for parasites control
AA Zahir, AA Rahuman, C Kamaraj, A Bagavan, G Elango, A Sangaran, ...
Parasitology research 105, 453-461 2009
Citations: 151

Laboratory study on larvicidal activity of indigenous plant extracts against Anopheles subpictus and Culex tritaeniorhynchus
G Elango, AA Rahuman, A Bagavan, C Kamaraj, AA Zahir, C Venkatesan
Parasitology Research 104, 1381-1388 2009
Citations: 136

Evaluation of indigenous plant extracts against larvae of Culex quinquefasciatus Say (Diptera: Culicidae)
AA Rahuman, A Bagavan, C Kamaraj, M Vadivelu, AA Zahir, G Elango, ...
Parasitology Research 104, 637-643 2009
Citations: 136

Insecticidal and larvicidal activities of medicinal plant extracts against mosquitoes
C Kamaraj, AA Rahuman, A Mahapatra, A Bagavan, G Elango
Parasitology research 107, 1337-1349 2010
Citations: 124