Adina-Elena Segneanu

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Biomaterials, Bioengineering, Water Science and Technology

Scopus Publications

Wild grown Portulaca oleracea as a novel magnetite based carrier with in vitro antioxidant and cytotoxicity potential
Adina-Elena Segneanu, Gabriela Vlase, Catalin Nicolae Marin, Titus Vlase, Crina Sicoe, Daniel Dumitru Herea, Maria Viorica Ciocîlteu, Ludovic-Everard Bejenaru, Anca Emanuela Minuti, Camelia-Mihaela Zară,et al.
Springer Science and Business Media LLC



Wild-Grown Romanian Eupatorium cannabinum: Advancing Phyto-Nanocarriers via Maltodextrin Micro-Spray Encapsulation—Metabolite Profiling, Antioxidant, Antimicrobial, and Cytotoxicity Insights
Gabriela Vlase, Adina-Elena Segneanu, Ludovic Everard Bejenaru, Ionela Amalia Bradu, Crina Sicoe, Titus Vlase, George Dan Mogoşanu, Gabriela Buema, Dumitru-Daniel Herea, Maria Viorica Ciocîlteu,et al.
MDPI AG
In Romanian ethnopharmacology, Eupatorium cannabinum species is known for its remarkable biological activity. We present an advanced approach to encapsulation using maltodextrin matrices to enhance the stability and efficacy of phytoconstituents and nanoparticles. Two distinct carrier systems were developed: (i) a direct micro-spray encapsulation of E. cannabinum in maltodextrin to produce a maltodextrin-encapsulated carrier (MEC), and (ii) a two-step process involving the preparation of a new phytocarrier system based on gold nanoparticles (EC-AuNPs), followed by micro-spray encapsulation in maltodextrin to create the maltodextrin-encapsulated AuNPs system (MEC-AuNPs system). Comprehensive chemical profiling using GC–MS and ESI–QTOF–MS revealed 80 bioactive molecules, including terpenoids, alkaloids, flavonoids, and phytoecdysteroids. Morpho-structural (XRD, FTIR, Raman spectroscopy, SEM) and thermal analyses confirmed the successful integration of NPs within the matrices. EC-AuNPs and MEC-AuNPs exhibited superior antioxidant activity, significant antimicrobial efficacy against major bacterial pathogens (S. aureus, B. subtilis, B. cereus, P. aeruginosa, S. typhi, and E. coli), and enhanced cytotoxicity against MCF-7 and HT-29 cancer cell lines. This study highlights the potential of combining E. cannabinum with AuNPs and maltodextrin encapsulation to develop multifunctional therapeutic systems. The findings underscore the importance of phytoconstituent stabilization and nanotechnology in addressing global antimicrobial resistance and advancing innovative medical applications.


Phenolic Acid Profile and In Vitro Antioxidant and Anticholinesterase Activities of Romanian Wild-Grown Acer spp. (Sapindaceae)
Cornelia Bejenaru, Adina-Elena Segneanu, Ludovic Everard Bejenaru, Andrei Biţă, Antonia Radu, George Dan Mogoşanu, Maria Viorica Ciocîlteu, and Costel Valentin Manda
MDPI AG
This study investigated, for the first time, the phenolic acid profile along with the in vitro antioxidant and acetylcholinesterase (AChE) inhibitory activities of leaves and fruits from five Romanian wild-grown Acer spp. (Sapindaceae): A. campestre L., A. monspessulanum L., A. platanoides L., A. pseudoplatanus L., and A. tataricum L. High-performance liquid chromatography coupled with ultraviolet and mass spectrometry (HPLC/UV/MS) was employed to identify and quantify key phenolic acids, including gallic, caffeic, protocatechuic, chlorogenic, and p-coumaric acids. Total phenolic content (TPC) ranged from 61.48 ± 3.76 to 512.8 ± 20.54 µg gallic acid equivalents (GAE)/mL. Antioxidant activities, assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, demonstrated the strongest radical scavenging capacities for A. tataricum fruits, with half maximal inhibitory concentration (IC50) values of 10.88 ± 3.39 µg/mL and 10.39 ± 2.86 µg/mL, respectively. The ferric-reducing antioxidant power (FRAP) assay revealed the highest reducing power for A. tataricum fruits (1158 ± 48.98 µmol Fe2+/L) and leaves (1119 ± 164.6 µmol Fe2+/L). AChE inhibition was only found in A. tataricum, with an IC50 of 7.91 ± 7.50 mg/mL for leaves and 15.95 ± 8.52 mg/mL for fruits. These results highlight A. tataricum as a promising source of natural antioxidants and neuroprotective agents.


Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications
Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Ionela Amalia Bradu, Titus Vlase, Dumitru-Daniel Herea, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, Andrei Biţă, Antonia Radu,et al.
MDPI AG
This study investigates the development and comprehensive characterization of innovative thermoresponsive gels incorporating rosemary essential oil (RoEO) encapsulated in poly(lactic-co-glycolic acid) (PLGA) microparticles, with a focus on their potential applications in topical antimicrobial and wound healing therapies. RoEO, renowned for its robust antimicrobial, antioxidant, and wound-healing properties, was subjected to detailed chemical profiling using gas chromatography-mass spectrometry (GC–MS), which identified oxygenated monoterpenes as its dominant constituents. PLGA microparticles were synthesized through an optimized oil-in-water emulsion technique, ensuring high encapsulation efficiency and structural integrity. These microparticles were thoroughly characterized using Fourier-transform infrared (FTIR) spectroscopy to confirm functional group interactions, scanning electron microscopy (SEM) for surface morphology, X-ray diffraction (XRD) for crystalline properties, and thermal analysis for stability assessment. The synthesized microparticles displayed uniform size distribution and efficient encapsulation, demonstrating compatibility with the gel matrix. Two distinct thermoresponsive gel formulations were developed using varying ratios of Poloxamer 407 and Poloxamer 188 to achieve optimal performance. The gels were evaluated for key physicochemical properties, including pH, gelation temperature, viscosity, and rheological behavior. Both formulations exhibited thermoresponsive gelation at skin-compatible temperatures (27.6 °C and 32.9 °C), favorable pH levels (6.63 and 6.40), and shear-thinning behavior suitable for topical application. Antimicrobial efficacy was assessed against common pathogens associated with skin infections, including Staphylococcus aureus, Escherichia coli, and Candida albicans. The RoEO-PLGA-loaded gels demonstrated significant inhibitory effects, confirming their potential as effective carriers for controlled and localized drug delivery. These findings underscore the promising application of RoEO-PLGA-loaded thermoresponsive gels in addressing challenges associated with topical antimicrobial therapies and wound care, offering an innovative approach to enhancing therapeutic outcomes. By integrating the bioactive potential of RoEO with the advanced delivery capabilities of PLGA microparticles and thermoresponsive gels, this study paves the way for the development of next-generation formulations tailored to meet the specific needs of localized drug delivery in skin health management.


Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of Rosmarinus officinalis L. Essential Oil from Southwestern Romania
Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Andrei Biţă, Felicia Tuţulescu, Antonia Radu, Maria Viorica Ciocîlteu, and George Dan Mogoşanu
MDPI AG
Our study reports for the first time, over a 12-month period, the seasonal variations in chemical composition and antibacterial and antioxidant activity of Rosmarinus officinalis L. essential oil (RoEO) from Southwestern Romania (Oltenia region). To analyze the constituents of RoEO, a comprehensive gas chromatography/mass spectrometry (GC/MS) method was employed. The analysis aimed to identify and quantify the various components by comparing their mass spectra with reference spectra from the National Institute of Standards and Technology (NIST) Library 2020. The minimum inhibitory concentration (MIC) values of Staphylococcus aureus minimum were determined using the microdilution method (96-well plates). The antioxidant activity was analyzed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydrogen peroxide (H2O2) radical scavenging assays. This analysis provided a detailed profile of RoEO’s constituents, revealing significant monthly variations. Key compounds, such as camphor, eucalyptol, α-pinene, camphene, and α-myrcene, were quantified, alongside lesser-studied constituents like β-pinene, α-terpinene, linalool, terpinolene, and carvacrol. Comparisons were made with a reference sample from Tunisia. Oxygenated monoterpenes reach the highest concentration (56.82–66.94%), followed by monoterpene hydrocarbons (30.06–40.28%), sesquiterpene hydrocarbons (0.90–2.44%), and oxygenated sesquiterpenes (0.02–0.23%). Camphor was found in high concentrations ranging from 29.41% to 40.03%. 1,8-Cineole was another dominant compound, ranging from 13.07% to 16.16%, significantly lower compared to the Tunisian reference (52.77%). α-Pinene ranged from 11.36% to 19.33%, while α-myrcene ranged from 1.65% to 3.08%. Correlations between specific compounds and their bioactivity were explored to understand their contributions to the overall efficacy of RoEO. This comprehensive analysis provides valuable insights into the potential applications and seasonal variability of RoEO from Romania.


Novel Nanocomposites and Biopolymer-Based Nanocomposites for Hexavalent Chromium Removal from Aqueous Media
Adina-Elena Segneanu, Ionela Amalia Bradu, Mihaela Simona Calinescu (Bocanici), Gabriela Vlase, Titus Vlase, Daniel-Dumitru Herea, Gabriela Buema, Maria Mihailescu, and Ioan Grozescu
MDPI AG
Designing new engineered materials derived from waste is essential for effective environmental remediation and reducing anthropogenic pollution in our economy. This study introduces an innovative method for remediating metal-contaminated water, using two distinct waste types: one biowaste (eggshell) and one industrial waste (fly ash). We synthesized three novel, cost-effective nanoadsorbent types, including two new tertiary composites and two biopolymer-based composites (specifically k-carrageenan and chitosan), which targeted chromium removal from aqueous solutions. SEM analysis reveals that in the first composite, EMZ, zeolite, and magnetite nanoparticles are successfully integrated into the porous structure of the eggshell. In the second composite (FMZ), fly ash and magnetite particles are similarly loaded within the zeolite pores. Each biopolymer-based composite is derived by incorporating the corresponding tertiary composite (FMZ or EMZ) into the biopolymer framework. Structural modifications of the eggshell, zeolite, chitosan, and k-carrageenan resulted in notable increases in specific surface area, as confirmed by BET analysis. These enhancements significantly improve chromium adsorption efficiency for each adsorbent type developed. The adsorption performances achieved are as follows: EMZ (89.76%), FMZ (84.83%), EMZCa (96.64%), FMZCa (94.87%), EMZC (99.64%), and FMZC (97.67%). The findings indicate that chromium adsorption across all adsorbent types occurs via a multimolecular layer mechanism, which is characterized as spontaneous and endothermic. Desorption studies further demonstrate the high reusability of these nanomaterials. Overall, this research underscores the potential of utilizing waste materials for new performant engineered low-cost composites and biocomposites for environmental bioremediation applications.


Spectra Analysis and Plants Research 2.0
Ioan Grozescu, Maria Iorizzi, and Adina-Elena Segneanu
MDPI AG
Medicinal plants have held a crucial position throughout human history, used in ethnomedicine, food preparation, preservation, cosmetics, decoration, disinfection, repelling pests, fabric dyeing, fertility techniques, and spiritual rituals [...]


Insight into Romanian Wild-Grown Heracleum sphondylium: Development of a New Phytocarrier Based on Silver Nanoparticles with Antioxidant, Antimicrobial and Cytotoxicity Potential
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Ludovic Everard Bejenaru, George Dan Mogoşanu, Gabriela Buema, Dumitru-Daniel Herea, Maria Viorica Ciocîlteu, and Cornelia Bejenaru
MDPI AG
Background: Heracleum sphondylium, a medicinal plant used in Romanian ethnopharmacology, has been proven to have remarkable biological activity. The escalating concerns surrounding antimicrobial resistance led to a special attention being paid to new efficient antimicrobial agents based on medicinal plants and nanotechnology. We report the preparation of a novel, simple phytocarrier that harnesses the bioactive properties of H. sphondylium and silver nanoparticles (HS-Ag system). Methods: H. sphondylium’s low metabolic profile was determined through gas chromatography–mass spectrometry and electrospray ionization–quadrupole time-of-flight–mass spectrometry. The morphostructural properties of the innovative phytocarrier were analyzed by X-ray diffraction, Fourier-transform infrared spectroscopy, Raman spectroscopy, dynamic light scattering, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The antioxidant activity was evaluated using total phenolic content, ferric reducing antioxidant power, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro assays. The antimicrobial activity screening against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli was conducted using the agar well diffusion method. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay estimated the in vitro potential cytotoxicity on normal human dermal fibroblasts (NHDF) and cervical cancer (HeLa) cells. Results: A total of 88 biomolecules were detected, such as terpenoids, flavonoids, phenolic acids, coumarins, phenylpropanoids, iridoids, amino acids, phytosterols, fatty acids. The HS-Ag phytocarrier heightened efficacy in suppressing the growth of all tested bacterial strains compared to H. sphondylium and exhibited a significant inhibition of HeLa cell viability. Conclusions: The new HS-Ag phytocarrier system holds promise for a wide range of medical applications. The data confirm the capacity to augment the pertinent theoretical understanding in the innovative field of antimicrobial agents.


Gels for Water Remediation: Current Research and Perspectives
Gabriela Buema, Adina-Elena Segneanu, Dumitru-Daniel Herea, and Ioan Grozescu
MDPI AG
The development of cost-effective and high-performance technologies for wastewater treatment is essential for achieving a sustainable economy. Among the various methods available for water remediation, adsorption is widely recognized as an effective and straightforward approach for removing a range of pollutants. Gel materials, particularly hydrogels and aerogels, have attracted significant research interest due to their unique properties. Hydrogels, for instance, are noted for their ability to be regenerated and reused, ease of separation and handling, and suitability for large-scale applications. Additionally, their low cost, high water absorption capacity, and contribution to environmental protection are important advantages. Aerogels, on the other hand, are distinguished by their low thermal conductivity, transparency, flexibility, high porosity, mechanical strength, light weight, large surface area, and ultralow dielectric constant. This review provides a comprehensive analysis of the current literature, highlighting gaps in knowledge regarding the classification, preparation, characterization, and key properties of these materials. The potential application of hydrogels and aerogels in water remediation, particularly in removing contaminants such as dyes, heavy metals, and various organic and inorganic pollutants, is also discussed.


Polyphenols Investigation and Antioxidant and Anticholinesterase Activities of Rosmarinus officinalis L. Species from Southwest Romania Flora
Ludovic Everard Bejenaru, Andrei Biţă, George Dan Mogoşanu, Adina-Elena Segneanu, Antonia Radu, Maria Viorica Ciocîlteu, and Cornelia Bejenaru
MDPI AG
Rosemary is one of the most important medicinal plants for natural therapy due to its multiple pharmacological properties, such as antioxidant, anti-inflammatory, neuroprotective, antiproliferative, antitumor, hepato- and nephroprotective, hypolipidemic, hypocholesterolemic, antihypertensive, anti-ischemic, hypoglycemic, radioprotective, antimicrobial, antiviral, antiallergic, and wound healing properties. Our study reports for the first time, over a 12-month period, the identification and quantification of polyphenols and the investigation of the antioxidant and acetylcholinesterase (AChE) inhibitory activities of the Rosmarinus officinalis L. species harvested at flowering from the flora of southwestern Romania (Oltenia Region). Identification and quantification of polyphenolic acids was made by ultra-high-performance liquid chromatography/mass spectrometry (UHPLC/MS). Total phenolic content was determined using the spectrophotometric method. In situ antioxidant and anticholinesterase activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and AChE inhibitory assay, respectively, on high-performance thin-layer chromatography (HPTLC) plates. DPPH radical scavenging activity was also assessed spectrophotometrically. The results revealed significant correlations between specific polyphenolic compounds and the measured biological activities, understanding the role of seasonal variations and providing insights into the optimal harvesting times and medicinal benefits of rosemary. Our research brings new information on the phytochemical profile of R. officinalis as a natural source of polyphenols with antioxidant and AChE inhibitory properties.


Innovative Strategies for Upcycling Agricultural Residues and Their Various Pharmaceutical Applications
Ludovic Everard Bejenaru, Antonia Radu, Adina-Elena Segneanu, Andrei Biţă, Costel-Valentin Manda, George Dan Mogoşanu, and Cornelia Bejenaru
MDPI AG
This review investigates innovative strategies for upcycling agricultural residues into valuable pharmaceutical compounds. The improper disposal of agricultural residues contributes to significant environmental issues, including increased greenhouse gas emissions and ecosystem degradation. Upcycling offers a sustainable solution, transforming these residues into high-value bioproducts (antioxidants, antitumor agents, antidiabetic compounds, anti-inflammatory agents, and antiviral drugs). Nanotechnology and microbial biotechnology have a crucial role in enhancing bioavailability and targeted delivery of bioactive compounds. Advanced techniques like enzymatic hydrolysis, green solvents, microwave processing, pyrolysis, ultrasonic processing, acid and alkaline hydrolysis, ozonolysis, and organosolv processes are explored for their effectiveness in breaking down agricultural waste and extracting valuable compounds. Despite the promising potential, challenges such as variability in residue composition, scalability, and high costs persist. The review emphasizes the need for future research on cost-effective extraction techniques and robust regulatory frameworks to ensure the safety, efficacy, and quality of bioproducts. The upcycling of agricultural residues represents a viable path towards sustainable waste management and production of pharmaceutical compounds, contributing to environmental conservation and public health improvements. This review provides an analysis of the current literature and identifies knowledge gaps, offering recommendations for future studies to optimize the use of agricultural residues in the drug industry.


Resveratrol: A Review on the Biological Activity and Applications
Ludovic Everard Bejenaru, Andrei Biţă, Ionela Belu, Adina-Elena Segneanu, Antonia Radu, Andrei Dumitru, Maria Viorica Ciocîlteu, George Dan Mogoşanu, and Cornelia Bejenaru
MDPI AG
Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.


Pharmaceutical Applications of Biomass Polymers: Review of Current Research and Perspectives
Cornelia Bejenaru, Antonia Radu, Adina-Elena Segneanu, Andrei Biţă, Maria Viorica Ciocîlteu, George Dan Mogoşanu, Ionela Amalia Bradu, Titus Vlase, Gabriela Vlase, and Ludovic Everard Bejenaru
MDPI AG
Polymers derived from natural biomass have emerged as a valuable resource in the field of biomedicine due to their versatility. Polysaccharides, peptides, proteins, and lignin have demonstrated promising results in various applications, including drug delivery design. However, several challenges need to be addressed to realize the full potential of these polymers. The current paper provides a comprehensive overview of the latest research and perspectives in this area, with a particular focus on developing effective methods and efficient drug delivery systems. This review aims to offer insights into the opportunities and challenges associated with the use of natural polymers in biomedicine and to provide a roadmap for future research in this field.


Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Maria-Viorica Ciocalteu, Cornelia Bejenaru, Gabriela Buema, Ludovic Everard Bejenaru, Eugen Radu Boia, Andrei Dumitru, and Simina Boia
MDPI AG
Novel nanotechnology based on herbal products aspires to be a high-performing therapeutic platform. This study reports the development of an original engineering carrier system that jointly combines the pharmacological action of Chelidonium majus and AuNPs, with unique properties that ensure that the limitations imposed by low stability, toxicity, absorption, and targeted and prolonged release can be overcome. The metabolite profile of Romanian wild-grown Chelidonium majus contains a total of seventy-four phytochemicals belonging to eight secondary metabolite categories, including alkaloids, amino acids, phenolic acids, flavonoids, carotenoids, fatty acids, sterols, and miscellaneous others. In this study, various techniques (XRD, FTIR, SEM, DLS, and TG/DTG) were employed to investigate his new carrier system’s morpho-structural and thermal properties. In vitro assays were conducted to evaluate the antioxidant potential and release profile. The results indicate 99.9% and 94.4% dissolution at different pH values for the CG-AuNPs carrier system and 93.5% and 85.26% for greater celandine at pH 4 and pH 7, respectively. Additionally, three in vitro antioxidant assays indicated an increase in antioxidant potential (flavonoid content 3.8%; FRAP assay 24.6%; and DPPH 24.4%) of the CG-AuNPs carrier system compared to the herb sample. The collective results reflect the system’s promising perspective as a new efficient antimicrobial and anti-inflammatory candidate with versatile applications, ranging from target delivery systems, oral inflammation (periodontitis), and anti-age cosmetics to extending the shelf lives of products in the food industry.


An Innovative Approach to a Potential Neuroprotective Sideritis scardica-Clinoptilolite Phyto-Nanocarrier: In Vitro Investigation and Evaluation
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Andrei Bita, Cornelia Bejenaru, Gabriela Buema, Ludovic Everard Bejenaru, Andrei Dumitru, and Eugen Radu Boia
MDPI AG
The cutting-edge field of nanomedicine combines the power of medicinal plants with nanotechnology to create advanced scaffolds that boast improved bioavailability, biodistribution, and controlled release. In an innovative approach to performant herb nanoproducts, Sideritis scardica Griseb and clinoptilolite were used to benefit from the combined action of both components and enhance the phytochemical’s bioavailability, controlled intake, and targeted release. A range of analytical methods, such as SEM-EDX, FT-IR, DLS, and XDR, was employed to examine the morpho-structural features of the nanoproducts. Additionally, thermal stability, antioxidant screening, and in vitro release were investigated. Chemical screening of Sideritis scardica Griseb revealed that it contains a total of ninety-one phytoconstituents from ten chemical categories, including terpenoids, flavonoids, amino acids, phenylethanoid glycosides, phenolic acids, fatty acids, iridoids, sterols, nucleosides, and miscellaneous. The study findings suggest the potential applications as a promising aspirant in neurodegenerative strategy.


Phyto-carrier Systems Based on Nanoparticles
Adina-Elena Segneanu
CRC Press



Gentianaceae Juss. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Cistaceae Adans. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Lycopodiaceae Pal. ex Mirb. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Alliaceae J.G. Agardh Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Boraginaceae Adans. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Solanaceae Adans. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Ranunculaceae Adans. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Papaveraceae Adans. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press



Elaeagnaceae Adans. Family
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press

RECENT SCHOLAR PUBLICATIONS

Phenolic Acids Investigation and In Vitro Antioxidant and Antiacetylcholinesterase Potential of Galeopsis spp. (Lamiaceae) from Romania Flora
RM Golu, C Bejenaru, LE Bejenaru, AE Segneanu, A Biţă, A Radu, ...
Preprints 2025



Wild grown Portulaca oleracea as a novel magnetite based carrier with in vitro antioxidant and cytotoxicity potential
AE Segneanu, G Vlase, CN Marin, T Vlase, C Sicoe, DD Herea, ...
Scientific Reports 15 (1), 8694 2025



Wild-Grown Romanian Eupatorium cannabinum: Advancing Phyto-Nanocarriers via Maltodextrin Micro-Spray Encapsulation—Metabolite Profiling, Antioxidant
G Vlase, AE Segneanu, LE Bejenaru, IA Bradu, C Sicoe, T Vlase, ...
Polymers 17 (4), 482 2025



Phenolic Acid Profile and In Vitro Antioxidant and Anticholinesterase Activities of Romanian Wild-Grown Acer spp.(Sapindaceae).
C Bejenaru, AE Segneanu, LE Bejenaru, A Biţă, A Radu, GD Mogoşanu, ...
Applied Sciences (2076-3417) 15 (3) 2025



Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications
LE Bejenaru, AE Segneanu, C Bejenaru, IA Bradu, T Vlase, DD Herea, ...
Gels 11 (1), 61 2025



Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of Rosmarinus officinalis L. Essential Oil from Southwestern Romania
LE Bejenaru, AE Segneanu, C Bejenaru, A Biţă, F Tuţulescu, A Radu, ...
Applied Sciences 15 (2), 681 2025



Novel Nanocomposites and Biopolymer-Based Nanocomposites for Hexavalent Chromium Removal from Aqueous Media
AE Segneanu, IA Bradu, MS Calinescu, G Vlase, T Vlase, DD Herea, ...
Polymers 16 (24), 3469 2024



Spectra Analysis and Plants Research 2.0
I Grozescu, M Iorizzi, AE Segneanu
Plants 13 (20), 2941 2024



Insight into Romanian Wild-Grown Heracleum sphondylium: Development of a New Phytocarrier Based on Silver Nanoparticles with Antioxidant, Antimicrobial and
AE Segneanu, G Vlase, T Vlase, LE Bejenaru, GD Mogoşanu, G Buema, ...
Antibiotics 13 (9), 911 2024



Polyphenols Investigation and Antioxidant and Anticholinesterase Activities of Rosmarinus officinalis L. Species from Southwest Romania Flora
LE Bejenaru, A Biţă, GD Mogoşanu, AE Segneanu, A Radu, MV Cioclteu, ...
Molecules 29 (18), 4438 2024



Gels for Water Remediation: Current Research and Perspectives
G Buema, AE Segneanu, DD Herea, I Grozescu
Gels 10 (9), 585 2024



Innovative Strategies for Upcycling Agricultural Residues and Their Various Pharmaceutical Applications
LE Bejenaru, A Radu, AE Segneanu, A Biţă, CV Manda, GD Mogoşanu, ...
Plants 13 (15), 2133 2024



Resveratrol: A review on the biological activity and applications
LE Bejenaru, A Biţă, I Belu, AE Segneanu, A Radu, A Dumitru, ...
Applied Sciences 14 (11), 4534 2024



Natural Products and Medicinal Properties of Carpathian (Romanian) Plants
AE Segneanu
CRC Press 2024



Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro
AE Segneanu, G Vlase, T Vlase, MV Ciocalteu, C Bejenaru, G Buema, ...
Plants 13 (5), 734 2024



11 Phyto-carrier Based on Nanoparticles Systems
AE Segneanu
Advanced Nanotechnology in Plants: Methods and Applications 8, 170 2024



Pharmaceutical applications of biomass polymers: Review of current research and perspectives
C Bejenaru, A Radu, AE Segneanu, A Biţă, MV Cioclteu, GD Mogoşanu, ...
Polymers 16 (9), 1182 2024



Scrophulariaceae Juss. Family
C Bejenaru, A Radu, GD Mogoşanu, LE Bejenaru, A Biţă, AE Segneanu
Natural Products and Medicinal Properties of Carpathian (Romanian) Plants 2024



An innovative approach to a potential neuroprotective Sideritis scardica-Clinoptilolite phyto-nanocarrier: in vitro investigation and evaluation
AE Segneanu, G Vlase, T Vlase, A Bita, C Bejenaru, G Buema, ...
International Journal of Molecular Sciences 25 (3), 1712 2024



Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties
AE Segneanu, G Vlase, T Vlase, CA Sicoe, MV Ciocalteu, DD Herea, ...
Plants 12 (19), 3479 2023

MOST CITED SCHOLAR PUBLICATIONS

Organic compounds FT-IR spectroscopy
AE Segneanu, I Gozescu, A Dabici, P Sfirloaga, Z Szabadai
Macro to nano spectroscopy 145 2012
Citations: 118



Waste water treatment methods
AE Segneanu, C Orbeci, C Lazau, P Sfirloaga, P Vlazan, C Bandas, ...
Water treatment 2013
Citations: 95



Bioactive molecules profile from natural compounds
AE Segneanu, SM Velciov, S Olariu, F Cziple, D Damian, I Grozescu
Amino Acid—New Insights and Roles in Plant and Animal; Asao, T., Ed, 209-228 2017
Citations: 47



Effect of a modified photo-Fenton procedure on the oxidative degradation of antibiotics in aqueous solutions
C Orbeci, I Untea, G Nechifor, AE Segneanu, ME Craciun
Separation and Purification Technology 122, 290-296 2014
Citations: 33



Highly efficient engineered waste eggshell-fly ash for cadmium removal from aqueous solution
AE Segneanu, CN Marin, G Vlase, C Cepan, M Mihailescu, C Muntean, ...
Scientific Reports 12 (1), 9676 2022
Citations: 27



Biomass extraction methods
AE Segneanu, F Cziple, P Vlazan, P Sfirloaga, I Grozescu, VD Gherman
Biomass now-sustainable growth and use, 390-399 2013
Citations: 26



Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds
AE Segneanu, I Grozescu, F Cziple, D Berki, D Damian, CM Niculite, ...
Molecules 20 (12), 22170-22187 2015
Citations: 22



Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly
AE Segneanu, CN Marin, DD Herea, I Stanusoiu, C Muntean, I Grozescu
Plants 11 (14), 1820 2022
Citations: 20



Assessment of the different type of materials used for removing phosphorus from wastewater
C Cepan, AE Segneanu, O Grad, M Mihailescu, M Cepan, I Grozescu
Materials 14 (16), 4371 2021
Citations: 20



Food security into a circular economy
AE Segneanu, I Grozescu, C Cepan, F Cziple, V Lazar, S Velciov
J. Food Sci. Nutr 4, 1-3 2018
Citations: 18



Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles
AE Segneanu, G Vlase, AT Lukinich-Gruia, DD Herea, I Grozescu
Antioxidants 11 (11), 2261 2022
Citations: 16



THE INFLUENCE OF EXTRACTION PROCESS PARAMETERS OF SOME BIOMATERIALS PRECURSORS FROM HELIANTHUS ANNUUS.
AE Segneanu, I Grozescu, P Sfirloaga
Digest Journal of Nanomaterials & Biostructures (DJNB) 8 (4) 2013
Citations: 15



Organic compounds FT-IR spectroscopy, macro to nano spectroscopy
AE Segneanu, I Gozescu, A Dabici, P Sfirloaga, Z Szabadai
Dr. Jamal Uddin (Ed.) 2012
Citations: 15



Artemisia annua Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
AE Segneanu, CN Marin, IOF Ghirlea, CVI Feier, C Muntean, I Grozescu
Plants 10 (11), 2245 2021
Citations: 14



A simple and rapid method for calixarene-based selective extraction of bioactive molecules from natural products
AE Segneanu, D Damian, I Hulka, I Grozescu, A Salifoglou
Amino Acids 48, 849-858 2016
Citations: 14



Combined microwave-acid pretreatment of the biomass
I Balcu, CA Macarie, AE Segneanu, RO Pop
Progress in biomass and bioenergy production 2011
Citations: 14



Therapeutic use of some Romanian medicinal plants
AE Segneanu, C Cepan, I Grozescu, F Cziple, S Olariu, S Ratiu, V Lazar, ...
Pharmacognosy-Medicinal Plants 2019
Citations: 13



Resveratrol: A review on the biological activity and applications
LE Bejenaru, A Biţă, I Belu, AE Segneanu, A Radu, A Dumitru, ...
Applied Sciences 14 (11), 4534 2024
Citations: 12



Chemical Screening of Metabolites Profile from Romanian Tuber spp.
AE Segneanu, M Cepan, A Bobica, I Stanusoiu, IC Dragomir, A Parau, ...
Plants 10 (3), 540 2021
Citations: 11



Characterisation of truffles using electrochemical and analytical methods
A Segneanu, P Sfirloaga, I David, I Balcu, I Grozescu
Digest J. Nanomater Biostruct 7, 199-205 2012
Citations: 11