Organic Chemistry, Biomaterials, Bioengineering, Water Science and Technology
102
Scopus Publications
1305
Scholar Citations
17
Scholar h-index
34
Scholar i10-index
Scopus Publications
Plant-Derived Nanocarriers for Drug Delivery: A Unified Framework Integrating Extracellular Vesicles, Engineered Phytocarriers, Hybrid Platforms, and Bioinspired Systems Adina-Elena Segneanu, George Dan Mogoşanu, Cornelia Bejenaru, Roxana Kostici, Ludovic Everard Bejenaru Plants, 2026 Plant-derived extracellular vesicles (PDEVs), engineered phytosomes, bioinspired polymeric plant-based nanoparticles (PBNPs), hybrid phyto-inorganic nanocomposites, green-synthesized metal nanoparticles, self-assembled nanoarchitectures, and multifunctional composites represent a rapidly advancing class of sustainable, nature-inspired nanocarriers. These platforms combine exceptional biocompatibility, negligible immunogenicity, and renewable sourcing with tunable drug loading, targeted delivery, and controlled release properties. This review synthesizes translational advances from 2020 to 2026, covering scalable isolation/bioprocessing (bioreactors, elicitation), multi-parametric physicochemical/multi-omics characterization, rational engineering/hybridization, and rigorous in vitro/in vivo assessments of uptake, biodistribution, pharmacokinetic (PK), and efficacy. Phytosomes and PBNPs markedly enhance oral bioavailability and targeted delivery of lipophilic phytochemicals, while PDEVs offer unique immunomodulatory, anti-inflammatory, and gene-regulatory activities. Hybrid and green-synthesized systems provide structural stability, redox modulation, and synergistic effects, and self-assembled/multifunctional composites address solubilization barriers with stimuli-responsive design. Early-phase human studies on grapefruit-, ginger-, turmeric-, and ginseng-derived PDEVs report excellent short-term safety, favorable PK, and preliminary bioactivity signals, with no observed immunogenicity or dose-limiting toxicities; however, these trials remain exploratory, constrained by small sample sizes and safety-focused endpoints. Despite challenges, including methodological heterogeneity, variable yields, long-term safety uncertainties (notably for inorganic hybrids), and regulatory ambiguities, emerging strategies such as clustered regularly interspaced short palindromic repeats (CRISPR)-engineered plant line; artificial-intelligence-driven process optimization; standardized guidelines, and integrated clinical, intellectual property, and commercialization frameworks are progressively addressing these barriers. Collectively, these advances position plant-derived nanocarriers as immunologically privileged, eco-friendly alternatives to synthetic and mammalian platforms, laying the foundation for a sustainable era of precision phytomedicine.
Standardization of Romanian Galeopsis tetrahit Leaf Extract in Verbascoside Using a Validated UHPLC–PDA Method Roxana Maria Golu, Ludovic Everard Bejenaru, Andrei Biţă, Cornelia Bejenaru, Adina-Elena Segneanu, et al. Plants, 2026 Galeopsis tetrahit L. (Lamiaceae) is a traditional European medicinal species rich in phenolic compounds, among which verbascoside is a key bioactive marker with strong antioxidant potential. This study reports the standardization of a G. tetrahit leaf extract in verbascoside using a fully validated UHPLC–PDA method developed according to ICH Q2(R2) requirements. Leaves of wild-grown G. tetrahit collected from southwest Romania flora were extracted with 70% ethanol, yielding 17.28% dry extract. Chromatographic identification of verbascoside was confirmed by retention time, UV–PDA spectra, and QDa mass spectrometry (m/z 623.3 [M–H]−). The method showed excellent performance, including high specificity, linearity over 1.875–60 μg/mL (r = 0.999955), low LOD and LOQ (0.2649 and 0.8028 μg/mL, respectively), and robust precision and accuracy. Dry extract contained 345.8 ± 28.3 mg verbascoside per g (34.6%, w/w), corresponding to approximately 59.8 mg/g in dried leaves. Antioxidant assays (DPPH, ABTS, FRAP), TPC and TFC confirmed notable radical scavenging and reducing activity, with pure verbascoside showing markedly stronger effects, supporting its major contribution to the extract’s antioxidant potential. These results demonstrate a reliable analytical approach and establish a verbascoside-based standardization framework for G. tetrahit extracts of documented Romanian origin.
Polyphenols Investigation and In Vitro Antioxidant Capacity of Romanian Wild-Grown Geranium spp. (Geraniaceae) Cornelia Bejenaru, Adina-Elena Segneanu, Andrei Biţă, Ludovic Everard Bejenaru, Marilena-Viorica Hovaneţ, et al. Plants, 2025 Geranium spp. are recognized as rich sources of phenolic metabolites, with potential health benefits, yet comparative evaluations remain limited. We assessed four wild-grown Geranium spp. (G. dissectum—G1, G. lucidum—G2, G. pusillum—G3, and G. robertianum—G4), from southwestern Romanian flora, using complementary antioxidant (DPPH, ABTS, and FRAP) and phytochemical (TPC and TFC) assays. Targeted UHPLC/UV with MS confirmation quantified eight phenolic acids. FRAP provided the strongest discrimination between species, and mirrored TPC, with the highest values in G4 sample. ABTS and DPPH supported the same ranking, and TFC varied only modestly, but differences were narrower and not significant between species. Caffeic acid was highest in G1 sample, and chlorogenic acid was selectively elevated in G3 sample. Gallic and protocatechuic acids were highest in G4 sample, both tracking the FRAP/TPC gradient. Syringic acid and vanillic acid were enriched in weaker antioxidant species. Distinctive signatures included high p-coumaric acid in G4 sample and chlorogenic and ferulic acids in G3 sample. Antioxidant potential among Geranium spp. is best explained by TPC, particularly hydroxybenzoic acids, with FRAP emerging as the most sensitive discriminator. These findings provide a comparative benchmark for Geranium spp. phytochemistry and a framework for future pharmacological studies.
Portulaca oleracea Extract Modulates Diet-Dependent Neuroplasticity in a Murine Model of MCD-Induced NAFLD and Depression Smaranda Ioana Mitran, Mădălina Iuliana Muşat, Cornelia Bejenaru, George Dan Mogoşanu, Ianis Kevyn Ştefan Boboc, et al. International Journal of Molecular Sciences, 2025 Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a systemic condition with neuropsychiatric comorbidities, including depression. Growing evidence for the neuroprotective, antidepressant, and anxiolytic potential of Portulaca oleracea (PO) extract, provides a compelling rationale for investigating its effects in the interaction between dietary models of NAFLD and vulnerability to stress-related disorders. Fifty-four 14- to 18-week-old male and female C57BL/6N mice were distributed in two equal groups and fed either a methionine- and choline-deficient diet (MCD) or a methionine- and choline-controlled diet (MC). Subsequently, half of each group was subjected to chronic unpredictable mild stress (CUMS) and PO treatment. MCD caused significant weight loss, whereas MC promoted weight gain. Behaviorally, MCD induced anhedonia- and anxiety-like behaviors, worsened by CUMS. MC diet reduced CUMS-induced anhedonia, though anxiety-like behavior emerged only under stress. Recognition memory was impaired in stressed MCD-fed mice, while MC-fed mice showed enhanced novel object preference. At the cellular level, MCD suppressed hippocampal microglia and caused cortical astrocyte dysfunction, whereas the MC diet promoted cortical neurogenesis potentiated through PO, abolished by chronic stress. These findings underscore the impact of dietary composition on PO’s systemic effects under chronic stress and support a mechanistic link between NAFLD-related dysfunction and depression-like phenotypes.
Sprayable Hybrid Gel with Cannabidiol, Hyaluronic Acid, and Colloidal Silver: A Multifunctional Approach for Skin Lesion Therapy Geta-Simona Cîrloiu (Boboc), Adina-Elena Segneanu, Ludovic Everard Bejenaru, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, et al. Pharmaceutics, 2025 Background/Objectives: This study presents the development and characterization of a novel thermoresponsive hydrogel composed of hyaluronic acid (HA), poloxamer 407, cannabidiol (CBD), and colloidal silver (Ag), designed for topical antimicrobial therapy. Methods: The Ag-CBD complex was first synthesized and subsequently incorporated into a HA–poloxamer gel matrix to produce a stable, sprayable formulation with suitable physicochemical properties for dermal applications. Results: The HA-Ag-CBD hybrid gel exhibited a physiological pH, a gelation temperature compatible with skin surface conditions, and favorable rheological behavior, including thixotropy and shear thinning—critical for uniform application and retention under dynamic conditions. Release studies confirmed a sustained delivery profile, supporting prolonged local activity of CBD and colloidal Ag. Antimicrobial assays demonstrated that the HA-Ag-CBD hybrid gel retained potent activity against Staphylococcus aureus and Candida albicans, with minimum inhibitory and bactericidal concentrations (MIC/MBC) statistically comparable to those of the unencapsulated Ag-CBD complex. Against E. coli, the HA-Ag-CBD hydrogel exhibited primarily bacteriostatic activity, with a low MIC (9.24 μg/mL) but a substantially higher MBC (387.35 μg/mL), consistent with the intrinsic structural resistance of Gram-negative bacteria. In contrast, bactericidal activity was more pronounced against Gram-positive strains, reflecting differential susceptibility related to bacterial envelope properties. CBD consistently demonstrated superior antimicrobial efficacy to colloidal Ag, while the Ag-CBD combination produced slightly enhanced, mainly additive effects, likely due to complementary membrane disruption and intracellular Ag+ ion activity. Cytotoxicity assays on normal human dermal fibroblasts confirmed that the HA-Ag-CBD hybrid gel maintained >70% cell viability at therapeutically relevant concentrations, in accordance with ISO 10993-5:2009 guidelines, and effectively mitigated the inherent cytotoxicity of the Ag-CBD complex. Conclusions: The HA-Ag-CBD hybrid gel demonstrates strong potential as a biocompatible, multifunctional topical formulation for the treatment of infected wounds and skin lesions. Future work will focus on in vivo evaluation, assessment of skin permeation, and further development to support translational applications.
Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications Adina-Elena Segneanu, Ludovic Everard Bejenaru, Cornelia Bejenaru, Antonia Blendea, George Dan Mogoşanu, et al. Polymers, 2025 In the rapidly evolving field of biomedical engineering, hydrogels have emerged as highly versatile biomaterials that bridge biology and technology through their high water content, exceptional biocompatibility, and tunable mechanical properties. This review provides an integrated overview of both natural and synthetic hydrogels, examining their structural properties, fabrication methods, and broad biomedical applications, including drug delivery systems, tissue engineering, wound healing, and regenerative medicine. Natural hydrogels derived from sources such as alginate, gelatin, and chitosan are highlighted for their biodegradability and biocompatibility, though often limited by poor mechanical strength and batch variability. Conversely, synthetic hydrogels offer precise control over physical and chemical characteristics via advanced polymer chemistry, enabling customization for specific biomedical functions, yet may present challenges related to bioactivity and degradability. The review also explores intelligent hydrogel systems with stimuli-responsive and bioactive functionalities, emphasizing their role in next-generation healthcare solutions. In modern medicine, temperature-, pH-, enzyme-, light-, electric field-, magnetic field-, and glucose-responsive hydrogels are among the most promising “smart materials”. Their ability to respond to biological signals makes them uniquely suited for next-generation therapeutics, from responsive drug systems to adaptive tissue scaffolds. Key challenges such as scalability, clinical translation, and regulatory approval are discussed, underscoring the need for interdisciplinary collaboration and continued innovation. Overall, this review fosters a comprehensive understanding of hydrogel technologies and their transformative potential in enhancing patient care through advanced, adaptable, and responsive biomaterial systems.
Design and Evaluation of a Inonotus obliquus–AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential Ana-Maria Stanoiu, Cornelia Bejenaru, Adina-Elena Segneanu, Gabriela Vlase, Ionela Amalia Bradu, et al. Polymers, 2025 Inonotus obliquus, a medicinal mushroom valued for its bioactive compounds, has not been previously characterized from Romanian sources. This study presents the first comprehensive chemical and biological screening of I. obliquus, introducing novel polymer-based encapsulation systems to enhance the stability and bioavailability of its bioactive constituents. Two distinct delivery systems were designed to enhance the functionality of I. obliquus extracts: (i) microencapsulation in maltodextrin (MIO) and (ii) a sequential approach involving preparation of silver nanoparticle-loaded I. obliquus (IO–AgNPs), followed by microencapsulation to yield the hybrid MIO–AgNP system. Comprehensive metabolite profiling using GC–MS and ESI–QTOF–MS revealed 142 bioactive constituents, including terpenoids, flavonoids, phenolic acids, amino acids, coumarins, styrylpyrones, fatty acids, and phytosterols. Structural integrity and successful encapsulation were confirmed by XRD, FTIR, and SEM analyses. Both IO–AgNPs and MIO–AgNPs demonstrated potent antioxidant activity, significant acetylcholinesterase inhibition, and robust antimicrobial effects against Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Escherichia coli. Cytotoxicity assays revealed pronounced activity against MCF-7, HCT116, and HeLa cell lines, with MIO–AgNPs exhibiting superior efficacy. The synergistic integration of maltodextrin and AgNPs enhanced compound stability and bioactivity. As the first report on Romanian I. obliquus, this study highlights its therapeutic potential and establishes polymer-based nanoencapsulation as an effective strategy for optimizing its applications in combating microbial resistance and cancer.
Design and Evaluation of a Zingiber officinale–Kaolinite–Maltodextrin Delivery System: Antioxidant, Antimicrobial, and Cytotoxic Activity Assessment Adina-Elena Segneanu, Ionela Amalia Bradu, Gabriela Vlase, Titus Vlase, Cornelia Bejenaru, et al. Pharmaceutics, 2025 Background/Objectives: Zingiber officinale Roscoe (Zingiberaceae) is widely recognized for its diverse biological activities; however, the stability and bioavailability of its bioactive compounds remain significant challenges. This study aimed to investigate an innovative approach to enhance the stability and efficacy of Z. officinale phytoconstituents through advanced encapsulation techniques. Methods: Two novel carrier systems were developed: (i) direct micro-spray encapsulation of Z. officinale in maltodextrin (MZO) and (ii) a two-step process involving the creation of a kaolinite-based phytocarrier system (ZO–kaolinite), followed by micro-spray encapsulation in maltodextrin to form the MZO–kaolinite system. Results: Comprehensive chemical profiling using GC–MS and ESI–QTOF–MS identified 105 phytochemicals, including terpenoids, gingerols, shogaols, flavonoids, and phenolic acids. Morphostructural analyses (XRD, FTIR, Raman, SEM) confirmed the successful development of the newly engineered kaolinite carrier systems (ZO–kaolinite and MZO–kaolinite systems). Both the ZO–kaolinite and MZO–kaolinite systems exhibited superior antioxidant activity, potent antimicrobial efficacy against major bacterial pathogens (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli), and enhanced cytotoxicity against MCF-7, HCT-116, and HeLa cancer cell lines. Conclusions: This study underscores the synergistic action of kaolinite and maltodextrin in developing multifunctional therapeutic systems, emphasizing the importance of phytoconstituent stabilization and nanotechnology in addressing antimicrobial resistance and advancing innovative medical applications.
Advanced materials for wastewater treatment Adina-Elena Segneanu, Gabriela Buema, Ioan Grozescu, Dumitru Daniel Herea Advanced Composite Materials for Wastewater Treatment, 2025
Scrophulariaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Papaveraceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Asteraceae Martinov (Compositae Adans.) Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Hypericaceae Juss. Family Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Caryophyllaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Lamiaceae Martinov (Labiatae Adans.) Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Ranunculaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Rhamnaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Lycopodiaceae Pal. ex Mirb. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Elaeagnaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Polypodiaceae Bercht. et J. Presl Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Thymelaeaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Equisetaceae Michx. ex DC. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Rosaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Euphorbiaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Gentianaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Cistaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Cupressaceae Gray Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Alliaceae J.G. Agardh Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Plantaginaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Saxifragaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Corylaceae Mirb. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Boraginaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Liliaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Dipsacaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Caprifoliaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Apiaceae (Lindl.) (Umbelliferae Juss.) Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Rubiaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Solanaceae Adans. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Ericaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Violaceae Batsch Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Amaryllidaceae Juss. Family Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, et al. Natural Products and Medicinal Properties of Carpathian Romanian Plants, 2024
Magnetic cobalt ferrite nanoparticles: Synthesis and surface functionalization with naturally small peptide Digest Journal of Nanomaterials and Biostructures, 2014
The influence of extraction process parameters of some biomaterials precursors from Helianthus annuus Digest Journal of Nanomaterials and Biostructures, 2013
Aspects regarding the economic study of the bioethanol obtained by development of a new environmentally friendly pretreated method Revista De Chimie, 2013
Comparative study on enzymatic hydrolysis of cellulose Digest Journal of Nanomaterials and Biostructures, 2013
New series of asymmetrical carbonates used in peptide synthesis Optoelectronics and Advanced Materials Rapid Communications, 2012
Synthesis of a new symmetric carbonate with leaving group Optoelectronics and Advanced Materials Rapid Communications, 2012
Phtalimidyl derivates used at peptide bonds formation Digest Journal of Nanomaterials and Biostructures, 2012
Use of alkaline lyophilization process for lignocellulosic biomass pretreatment Digest Journal of Nanomaterials and Biostructures, 2012
Comparative analytical study of active compounds from zingiber officinale Optoelectronics and Advanced Materials Rapid Communications, 2012
Antioxidant capacity of Camellia sinensis extracts Digest Journal of Nanomaterials and Biostructures, 2012
Anticorrosive protection system based on nanocomposites Ionel Balcu, Adina-Elena Segneanu, Marius Constantin Mirica, Mirela Ioana Iorga, Corina Amalia Macarie, et al. Environmental Engineering and Management Journal, 2009
Microwaves effect over biomass hydrolysis Adina-Elena Segneanu, Ionel Balcu, Marius Constantin Mirica, Mirela Ioana Iorga, Corina Macarie, et al. Environmental Engineering and Management Journal, 2009
N,N′-diphtalimidylcarbonate used in synthesis of unsymmetrical organic carbonates with applications in peptide synthesis Revista De Chimie, 2008
Unsymetrical organic carbonates synthesis from N,N′- succinimidilcarbonat and alcohols Revista De Chimie, 2007
Using of N-succinimidil mixed carbonates to protect amino groups from amin and amino-acids Revista De Chimie, 2007
N,N′-disuccinimidylcarbonate, a potential reagent in fine organic synthesis of reactive asymmetrical carbonates, used to protect amino groups from aminoacids for peptides synthesis Revista De Chimie, 2006
RECENT SCHOLAR PUBLICATIONS
Plant-Derived Nanocarriers for Drug Delivery: A Unified Framework Integrating Extracellular Vesicles, Engineered Phytocarriers, Hybrid Platforms, and Bioinspired Systems AE Segneanu, GD Mogoşanu, C Bejenaru, R Kostici, LE Bejenaru Plants 15 (6), 908 , 2026 2026 Citations: 1
Standardization of Romanian Galeopsis tetrahit Leaf Extract in Verbascoside Using a Validated UHPLC–PDA Method RM Golu, LE Bejenaru, A Biţă, C Bejenaru, AE Segneanu, MV Ciocîlteu, ... Plants 15 (3), 461 , 2026 2026 Citations: 1
Polyphenols Investigation and In Vitro Antioxidant Capacity of Romanian Wild-Grown Geranium spp. ( Geraniaceae ) C Bejenaru, AE Segneanu, A Biţă, LE Bejenaru, MV Hovaneţ, ... Plants 14 (20), 3190 , 2025 2025 Citations: 2
Portulaca oleracea Extract Modulates Diet-Dependent Neuroplasticity in a Murine Model of MCD-Induced NAFLD and Depression SI Mitran, MI Muşat, C Bejenaru, GD Mogoşanu, IKŞ Boboc, RI Tudoraşcu, ... International Journal of Molecular Sciences 26 (20), 10050 , 2025 2025
Portulaca oleracea Extract Modulates Diet-Dependent Neuroplasticity in a Murine Model of NAFLD and Depression SI Mitran, MI Muşat, C Bejenaru, GD Mogoşanu, IKŞ Boboc, R Tudoraşcu, ... 2025
Sprayable Hybrid Gel with Cannabidiol, Hyaluronic Acid, and Colloidal Silver: A Multifunctional Approach for Skin Lesion Therapy GS Cîrloiu, AE Segneanu, LE Bejenaru, MC Văruţ, RM Bălăşoiu, D Călina, ... Pharmaceutics 17 (9), 1189 , 2025 2025 Citations: 2
Composite Nanomaterials with Carbon Nanotubes for Biomedical Applications AE Segneanu, I Grozescu, C Bejenaru, A Radu, LE Bejenaru, ... Carbon Nanotubes and Biomedicine, 22-45 , 2025 2025
Design and Evaluation of a Inonotus obliquus –AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential AM Stanoiu, C Bejenaru, AE Segneanu, G Vlase, IA Bradu, T Vlase, ... Polymers 17 (15), 2163 , 2025 2025 Citations: 4
Advancements in hydrogels: a comprehensive review of natural and synthetic innovations for biomedical applications AE Segneanu, LE Bejenaru, C Bejenaru, A Blendea, GD Mogoşanu, ... Polymers 17 (15), 2026 , 2025 2025 Citations: 180
Design and Evaluation of a Zingiber officinale –Kaolinite–Maltodextrin Delivery System: Antioxidant, Antimicrobial, and Cytotoxic Activity Assessment AE Segneanu, IA Bradu, G Vlase, T Vlase, C Bejenaru, LE Bejenaru, ... Pharmaceutics 17 (6), 751 , 2025 2025 Citations: 4
Phenolic Acid Investigation and In Vitro Antioxidant and Antiacetylcholinesterase Potentials of Galeopsis spp. ( Lamiaceae ) from Romanian Flora RM Golu, C Bejenaru, LE Bejenaru, AE Segneanu, A Biţă, A Radu, ... Pharmaceuticals 18 (4), 599 , 2025 2025 Citations: 4
Advanced aerogels for water remediation: unraveling their potential in fats, oils, and grease sorption—a comprehensive review AE Segneanu, DD Herea, G Buema, IA Bradu, M Cepan, I Grozescu Gels 11 (4), 268 , 2025 2025 Citations: 14
Wild grown Portulaca oleracea as a novel magnetite based carrier with in vitro antioxidant and cytotoxicity potential AE Segneanu, G Vlase, CN Marin, T Vlase, C Sicoe, DD Herea, ... Scientific Reports 15 (1), 8694 , 2025 2025 Citations: 8
Wild-Grown Romanian Eupatorium cannabinum : Advancing Phyto-Nanocarriers via Maltodextrin Micro-Spray Encapsulation—Metabolite Profiling, Antioxidant … G Vlase, AE Segneanu, LE Bejenaru, IA Bradu, C Sicoe, T Vlase, ... Polymers 17 (4), 482 , 2025 2025 Citations: 4
Phenolic Acid Profile and In Vitro Antioxidant and Anticholinesterase Activities of Romanian Wild-Grown Acer spp. ( Sapindaceae ) C Bejenaru, AE Segneanu, LE Bejenaru, A Biţă, A Radu, GD Mogoşanu, ... Applied Sciences 15 (3), 1235 , 2025 2025 Citations: 5
Thermoresponsive gels with rosemary essential oil: a novel topical carrier for antimicrobial therapy and drug delivery applications LE Bejenaru, AE Segneanu, C Bejenaru, IA Bradu, T Vlase, DD Herea, ... Gels 11 (1), 61 , 2025 2025 Citations: 11
Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of Rosmarinus officinalis L. Essential Oil from Southwestern Romania LE Bejenaru, AE Segneanu, C Bejenaru, A Biţă, F Tuţulescu, A Radu, ... Applied Sciences 15 (2), 681 , 2025 2025 Citations: 13
Polyphenols Profile, and In Vitro Antioxidant and Anticholinesterase Activities of Romanian Wild-Grown Acer spp.(Sapindaceae) C Bejenaru, AE Segneanu, LE Bejenaru, A Biţă, A Radu, GD Mogoşanu, ... Preprints , 2025 2025 Citations: 1
Advanced materials for wastewater treatment AE Segneanu, G Buema, I Grozescu, DD Herea Advanced Composite Materials for Wastewater Treatment, 1-26 , 2025 2025
Novel nanocomposites and Biopolymer-Based nanocomposites for hexavalent chromium removal from aqueous media AE Segneanu, IA Bradu, MS Calinescu, G Vlase, T Vlase, DD Herea, ... Polymers 16 (24), 3469 , 2024 2024 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Advancements in hydrogels: a comprehensive review of natural and synthetic innovations for biomedical applications AE Segneanu, LE Bejenaru, C Bejenaru, A Blendea, GD Mogoşanu, ... Polymers 17 (15), 2026 , 2025 2025 Citations: 180
Organic compounds FT-IR spectroscopy AE Segneanu, I Gozescu, A Dabici, P Sfirloaga, Z Szabadai Macro to nano spectroscopy 145 , 2012 2012 Citations: 137
Waste water treatment methods AE Segneanu, C Orbeci, C Lazau, P Sfirloaga, P Vlazan, C Bandas, ... Water treatment , 2013 2013 Citations: 100
Resveratrol: A review on the biological activity and applications LE Bejenaru, A Biţă, I Belu, AE Segneanu, A Radu, A Dumitru, ... Applied Sciences 14 (11), 4534 , 2024 2024 Citations: 84
Bioactive molecules profile from natural compounds AE Segneanu, SM Velciov, S Olariu, F Cziple, D Damian, I Grozescu Amino acid—new insights and roles in plant and animal, 209-228 , 2017 2017 Citations: 57
Highly efficient engineered waste eggshell-fly ash for cadmium removal from aqueous solution AE Segneanu, CN Marin, G Vlase, C Cepan, M Mihailescu, C Muntean, ... Scientific Reports 12 (1), 9676 , 2022 2022 Citations: 42
Effect of a modified photo-Fenton procedure on the oxidative degradation of antibiotics in aqueous solutions C Orbeci, I Untea, G Nechifor, AE Segneanu, ME Craciun Separation and Purification Technology 122, 290-296 , 2014 2014 Citations: 34
Biomass extraction methods AE Segneanu, F Cziple, P Vlazan, P Sfirloaga, I Grozescu, VD Gherman Biomass now-sustainable growth and use, 390-399 , 2013 2013 Citations: 33
Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles AE Segneanu, G Vlase, AT Lukinich-Gruia, DD Herea, I Grozescu Antioxidants 11 (11), 2261 , 2022 2022 Citations: 31
Assessment of the different type of materials used for removing phosphorus from wastewater C Cepan, AE Segneanu, O Grad, M Mihailescu, M Cepan, I Grozescu Materials 14 (16), 4371 , 2021 2021 Citations: 28
Innovative strategies for upcycling agricultural residues and their various pharmaceutical applications LE Bejenaru, A Radu, AE Segneanu, A Biţă, CV Manda, GD Mogoşanu, ... Plants 13 (15), 2133 , 2024 2024 Citations: 26
Pharmaceutical applications of biomass polymers: review of current research and perspectives C Bejenaru, A Radu, AE Segneanu, A Biţă, MV Ciocîlteu, GD Mogoşanu, ... Polymers 16 (9), 1182 , 2024 2024 Citations: 26
Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly AE Segneanu, CN Marin, DD Herea, I Stanusoiu, C Muntean, I Grozescu Plants 11 (14), 1820 , 2022 2022 Citations: 26
Helleborus purpurascens —Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds AE Segneanu, I Grozescu, F Cziple, D Berki, D Damian, CM Niculite, ... Molecules 20 (12), 22170-22187 , 2015 2015 Citations: 26
Artemisia annua Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles AE Segneanu, CN Marin, IOF Ghirlea, CVI Feier, C Muntean, I Grozescu Plants 10 (11), 2245 , 2021 2021 Citations: 23
Food security into a circular economy AE Segneanu, I Grozescu, C Cepan, F Cziple, V Lazar, S Velciov J. Food Sci. Nutr 4, 1-3 , 2018 2018 Citations: 23
Polyphenols Investigation and Antioxidant and Anticholinesterase Activities of Rosmarinus officinalis L. Species from Southwest Romania Flora LE Bejenaru, A Biţă, GD Mogoşanu, AE Segneanu, A Radu, MV Ciocîlteu, ... Molecules 29 (18), 4438 , 2024 2024 Citations: 21
Organic Compounds FT-IR Spectroscopy: Macro to Nano Spectroscopy AE Segneanu, I Gozescu, A Dabici, P Sfirloaga, Z Szabadai Fourier Transform-Materials Analysis; InTechOpen, 15-30 , 2012 2012 Citations: 16
Therapeutic use of some Romanian medicinal plants AE Segneanu, C Cepan, I Grozescu, F Cziple, S Olariu, S Ratiu, V Lazar, ... Pharmacognosy-Medicinal Plants , 2019 2019 Citations: 15
A simple and rapid method for calixarene-based selective extraction of bioactive molecules from natural products AE Segneanu, D Damian, I Hulka, I Grozescu, A Salifoglou Amino Acids 48 (3), 849-858 , 2016 2016 Citations: 15