Adina-Elena Segneanu
@uvt.ro
Institute for Advanced Environmental Research, Department of Chemistry-Biology
West University of Timisoara
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Biomaterials, Bioengineering, Water Science and Technology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Maria-Viorica Ciocalteu, Cornelia Bejenaru, Gabriela Buema, Ludovic Everard Bejenaru, Eugen Radu Boia, Andrei Dumitru, and Simina Boia
MDPI AG
Novel nanotechnology based on herbal products aspires to be a high-performing therapeutic platform. This study reports the development of an original engineering carrier system that jointly combines the pharmacological action of Chelidonium majus and AuNPs, with unique properties that ensure that the limitations imposed by low stability, toxicity, absorption, and targeted and prolonged release can be overcome. The metabolite profile of Romanian wild-grown Chelidonium majus contains a total of seventy-four phytochemicals belonging to eight secondary metabolite categories, including alkaloids, amino acids, phenolic acids, flavonoids, carotenoids, fatty acids, sterols, and miscellaneous others. In this study, various techniques (XRD, FTIR, SEM, DLS, and TG/DTG) were employed to investigate his new carrier system’s morpho-structural and thermal properties. In vitro assays were conducted to evaluate the antioxidant potential and release profile. The results indicate 99.9% and 94.4% dissolution at different pH values for the CG-AuNPs carrier system and 93.5% and 85.26% for greater celandine at pH 4 and pH 7, respectively. Additionally, three in vitro antioxidant assays indicated an increase in antioxidant potential (flavonoid content 3.8%; FRAP assay 24.6%; and DPPH 24.4%) of the CG-AuNPs carrier system compared to the herb sample. The collective results reflect the system’s promising perspective as a new efficient antimicrobial and anti-inflammatory candidate with versatile applications, ranging from target delivery systems, oral inflammation (periodontitis), and anti-age cosmetics to extending the shelf lives of products in the food industry.
Adina-Elena Segneanu, Gabriela Vlase, Titus Vlase, Andrei Bita, Cornelia Bejenaru, Gabriela Buema, Ludovic Everard Bejenaru, Andrei Dumitru, and Eugen Radu Boia
MDPI AG
The cutting-edge field of nanomedicine combines the power of medicinal plants with nanotechnology to create advanced scaffolds that boast improved bioavailability, biodistribution, and controlled release. In an innovative approach to performant herb nanoproducts, Sideritis scardica Griseb and clinoptilolite were used to benefit from the combined action of both components and enhance the phytochemical’s bioavailability, controlled intake, and targeted release. A range of analytical methods, such as SEM-EDX, FT-IR, DLS, and XDR, was employed to examine the morpho-structural features of the nanoproducts. Additionally, thermal stability, antioxidant screening, and in vitro release were investigated. Chemical screening of Sideritis scardica Griseb revealed that it contains a total of ninety-one phytoconstituents from ten chemical categories, including terpenoids, flavonoids, amino acids, phenylethanoid glycosides, phenolic acids, fatty acids, iridoids, sterols, nucleosides, and miscellaneous. The study findings suggest the potential applications as a promising aspirant in neurodegenerative strategy.
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press
Cornelia Bejenaru, Antonia Radu, George Dan Mogoşanu, Ludovic Everard Bejenaru, Andrei Biţă, and Adina-Elena Segneanu
CRC Press