Structural and mechanistic insights into the constitutive Themis–Grb2 complex in T cell signalling DM Clancy, A Sanz-Sanjuan, E Gilis, P Tougaard, I Velghe, ... Nature Communications , 2026 2026
Improved protein binder design using β-pairing targeted RFdiffusion I Sappington, M Toul, DS Lee, SA Robinson, I Goreshnik, C McCurdy, ... Nature Communications , 2026 2026 Citations: 24
In silico design of stable single-domain antibodies with high affinity Z Zhang, R van der Kant, I Marković, D Vizarraga, T Garcia, K Maragkou, ... Structure , 2026 2026 Citations: 4
Distinct Natural Killer Cell Signature in Still Disease: Insights From a Multinational Immunome Project Consortium for Autoinflammatory Disorders A De Visscher, J Beliën, B Malengier‐Devlies, E Bernaerts, L De Vuyst, ... Arthritis & Rheumatology , 2025 2025
Charcot-Leyden Crystals drive pathology and inflammation in muco-obstructive lung disease H Aegerter, I Janssens, K Verstraete, T Malfait, I Heyndrickx, E Ahmed, ... medRxiv, 2025.11. 26.25341000 , 2025 2025
ACLY inhibition promotes tumour immunity and suppresses liver cancer J Gautam, J Wu, JSV Lally, JD McNicol, R Fayyazi, E Ahmadi, DC Oniciu, ... Nature 645 (8080), 507-517 , 2025 2025 Citations: 31
Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity F Lambert, J Felix, S Wautier, E Dupré, M Jamez, C Michiels, M Gaignage, ... Cell Reports 44 (8) , 2025 2025
Analysis and engineering of KIT. METRNL signalling to boost heart tissue regeneration after myocardial infarction M Toul, K Verstraete, SN Savvides FEBS OPEN BIO 15, 139-140 , 2025 2025
Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses A Matthys, J Felix, JPP Catani, K Roose, W Nerinckx, B Van Buyten, ... Nature Communications 16 (1), 5831 , 2025 2025 Citations: 6
'take 2'On Taok2: Towards the Structure and Mechanism of the Enigmatic Taok2 and Its Interactions with Nuclear Speckle Resident Proteins L Thierens, S Savvides EUROPEAN BIOPHYSICS JOURNAL 54, S100-S100 , 2025 2025
Structural and Functional Insights into the Role of Themis2 and Themis2-protein Complexes AS Sanjuan, D Clancy, S Savvides EUROPEAN BIOPHYSICS JOURNAL 54, S114-S114 , 2025 2025
Themis and Grb2 form a constitutive structural hub in T cell receptor signalling S Savvides, D Clancy, AS Sanjuan, E Gillis, I Velghe, ... 2025
Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2: 1 and 2: 2 stoichiometries J Felix, S De Munck, JF Bazan, SN Savvides PLoS Biology 23 (4), e3003124 , 2025 2025
Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37 J Andries, M Toul, J Felix, DM Clancy, SN Savvides bioRxiv, 2025.02. 22.639629 , 2025 2025 Citations: 1
Themis and Grb2 form a constitutive structural hub in T cell receptor signalling DM Clancy, A Sanz-Sanjuan, E Gilis, P Tougaard, I Velghe, ... bioRxiv, 2025.02. 16.638521 , 2025 2025 Citations: 1
Crystal Structures of ALK and LTK Receptor Tyrosine Kinases and Their Ligands S Savvides, S De Munck US Patent App. 18/577,139 , 2025 2025
Improved protein binder design using beta-pairing targeted RFdiffusion D Baker, I Sappington, M Toul, D Lee, S Robinson, I Goreshnik, ... 2025
Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity A Huard, S Fauteux-Daniel, J Goldstein, P Martin, M Jarlborg, J Andries, ... The Journal of Immunology 214 (1), 180-191 , 2025 2025
Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody S Semwal, M Karamolegkou, S Flament, N Raouraoua, K Verstraete, ... Structural Biology and Crystallization Communications 81 (1), 19-29 , 2025 2025 Citations: 1
The crystal structure of Nictaba reveals its carbohydrate-binding properties and a new lectin dimerization mode Y Bloch, VJS Osterne, SN Savvides, EJM Van Damme Glycobiology 34 (12), cwae087 , 2024 2024 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates Y Dondelinger, W Declercq, S Montessuit, R Roelandt, A Goncalves, ... Cell reports 7 (4), 971-981 , 2014 2014 Citations: 998
Design of protein-binding proteins from the target structure alone L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ... Nature 605 (7910), 551-560 , 2022 2022 Citations: 680
Improving de novo protein binder design with deep learning NR Bennett, B Coventry, I Goreshnik, B Huang, A Allen, D Vafeados, ... Nature Communications 14 (1), 2625 , 2023 2023 Citations: 472
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment EK Persson, K Verstraete, I Heyndrickx, E Gevaert, H Aegerter, JM Percier, ... Science 364 (6442), eaaw4295 , 2019 2019 Citations: 343
Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions M Szaruga, B Munteanu, S Lismont, S Veugelen, K Horré, M Mercken, ... Cell 170 (3), 443-456. e14 , 2017 2017 Citations: 299
Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system HJ Yeo, SN Savvides, AB Herr, E Lanka, G Waksman Molecular cell 6 (6), 1461-1472 , 2000 2000 Citations: 280
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms BH Durham, E Lopez Rodrigo, J Picarsic, D Abramson, V Rotemberg, ... Nature medicine 25 (12), 1839-1842 , 2019 2019 Citations: 240
VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion SN Savvides, HJ Yeo, MR Beck, F Blaesing, R Lurz, E Lanka, R Buhrdorf, ... The EMBO journal 22 (9), 1969-1980 , 2003 2003 Citations: 239
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma K Verstraete, F Peelman, H Braun, J Lopez, D Van Rompaey, ... Nature Communications 8 (1), 14937 , 2017 2017 Citations: 228
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle KHG Verschueren, C Blanchet, J Felix, A Dansercoer, D De Vos, Y Bloch, ... Nature 568 (7753), 571-575 , 2019 2019 Citations: 209
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways P Vandenabeele, G Bultynck, SN Savvides Nature reviews Molecular cell biology 24 (5), 312-333 , 2023 2023 Citations: 206
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation Y Dondelinger, T Delanghe, D Priem, MA Wynosky-Dolfi, D Sorobetea, ... Nature communications 10 (1), 1729 , 2019 2019 Citations: 205
Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers K Becker, SN Savvides, M Keese, RH Schirmer, PA Karplus Nature Structural Biology 5 (4), 267-271 , 1998 1998 Citations: 193
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development GN Sarma, SN Savvides, K Becker, M Schirmer, RH Schirmer, PA Karplus Journal of molecular biology 328 (4), 893-907 , 2003 2003 Citations: 185
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells S Liénart, R Merceron, C Vanderaa, F Lambert, D Colau, J Stockis, ... Science 362 (6417), 952-956 , 2018 2018 Citations: 176
Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite SN Savvides, M Scheiwein, CC Bohme, GE Arteel, PA Karplus, K Becker, ... Journal of Biological Chemistry 277 (4), 2779-2784 , 2002 2002 Citations: 172
The C‐terminal domain of full‐length E. coli SSB is disordered even when bound to DNA SN Savvides, S Raghunathan, K Fütterer, AG Kozlov, TM Lohman, ... Protein Science 13 (7), 1942-1947 , 2004 2004 Citations: 164
Catalytic cycle of human glutathione reductase near 1 Å resolution DS Berkholz, HR Faber, SN Savvides, PA Karplus Journal of molecular biology 382 (2), 371-384 , 2008 2008 Citations: 163
Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1 Y Bloch, L Bouchareychas, R Merceron, K Składanowska, ... Immunity 48 (1), 45-58. e6 , 2018 2018 Citations: 150
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function W Dejonghe, I Sharma, B Denoo, S De Munck, Q Lu, K Mishev, H Bulut, ... Nature chemical biology 15 (6), 641-649 , 2019 2019 Citations: 127
