MOST CITED SCHOLAR PUBLICATIONS
- MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphatesY Dondelinger, W Declercq, S Montessuit, R Roelandt, A Goncalves, ...Cell reports 7 (4), 971-981 2014Citations: 855
- Design of protein-binding proteins from the target structure aloneL Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ...Nature 605 (7910), 551-560 2022Citations: 318
- Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion systemHJ Yeo, SN Savvides, AB Herr, E Lanka, G WaksmanMolecular cell 6 (6), 1461-1472 2000Citations: 275
- Protein crystallization promotes type 2 immunity and is reversible by antibody treatmentEK Persson, K Verstraete, I Heyndrickx, E Gevaert, H Aegerter, JM Percier, ...Science 364 (6442), eaaw4295 2019Citations: 259
- Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactionsM Szaruga, B Munteanu, S Lismont, S Veugelen, K Horr, M Mercken, ...Cell 170 (3), 443-456. e14 2017Citations: 252
- VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretionSN Savvides, HJ Yeo, MR Beck, F Blaesing, R Lurz, E Lanka, R Buhrdorf, ...The EMBO journal 2003Citations: 231
- Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriersK Becker, SN Savvides, M Keese, RH Schirmer, PA KarplusNature Structural Biology 5 (4), 267-271 1998Citations: 191
- Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor developmentGN Sarma, SN Savvides, K Becker, M Schirmer, RH Schirmer, PA KarplusJournal of molecular biology 328 (4), 893-907 2003Citations: 179
- Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthmaK Verstraete, F Peelman, H Braun, J Lopez, D Van Rompaey, ...Nature communications 8 (1), 14937 2017Citations: 166
- Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasmsBH Durham, E Lopez Rodrigo, J Picarsic, D Abramson, V Rotemberg, ...Nature medicine 25 (12), 1839-1842 2019Citations: 165
- Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitriteSN Savvides, M Scheiwein, CC Bohme, GE Arteel, PA Karplus, K Becker, ...Journal of Biological Chemistry 277 (4), 2779-2784 2002Citations: 163
- The C‐terminal domain of full‐length E. coli SSB is disordered even when bound to DNASN Savvides, S Raghunathan, K Ftterer, AG Kozlov, TM Lohman, ...Protein Science 13 (7), 1942-1947 2004Citations: 160
- Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammationY Dondelinger, T Delanghe, D Priem, MA Wynosky-Dolfi, D Sorobetea, ...Nature communications 10 (1), 1729 2019Citations: 156
- Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycleKHG Verschueren, C Blanchet, J Felix, A Dansercoer, D De Vos, Y Bloch, ...Nature 568 (7753), 571-575 2019Citations: 155
- Improving de novo protein binder design with deep learningNR Bennett, B Coventry, I Goreshnik, B Huang, A Allen, D Vafeados, ...Nature Communications 14 (1), 2625 2023Citations: 147
- Catalytic cycle of human glutathione reductase near 1 resolutionDS Berkholz, HR Faber, SN Savvides, PA KarplusJournal of molecular biology 382 (2), 371-384 2008Citations: 146
- Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cellsS Linart, R Merceron, C Vanderaa, F Lambert, D Colau, J Stockis, ...Science 362 (6417), 952-956 2018Citations: 144
- Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1Y Bloch, L Bouchareychas, R Merceron, K Składanowska, ...Immunity 48 (1), 45-58. e6 2018Citations: 116
- Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complexK Verstraete, G Vandriessche, M Januar, J Elegheert, AV Shkumatov, ...Blood, The Journal of the American Society of Hematology 118 (1), 60-68 2011Citations: 108
- Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitorSN Savvides, PA KarplusJournal of Biological Chemistry 271 (14), 8101-8107 1996Citations: 107
