Susnata Pramanik

Verified email at gmail.com

Postdoctoral Fellow
LMU Munich, Dartmouth College



                               

http://researchid.co/susnata_pramanik

RESEARCH INTERESTS

Supramolecular chemistry. molecular switch, organic synthesis, molecular sensor

18

Scopus Publications

742

Scholar Citations

12

Scholar h-index

15

Scholar i10-index

Scopus Publications

  • Remote control of the reversible assembly/disassembly of supramolecular aggregates
    Nikita Mittal, Indrajit Paul, Susnata Pramanik, and Michael Schmittel

    Supramolecular Chemistry, ISSN: 10610278, eISSN: 10290478, Pages: 133-138, Published: 1 February 2020 Informa UK Limited
    A multi-component system is presented in which the actuation of a copper-loaded nanoswitch by zinc(II) ions as an external trigger and the thereby prompted release of copper(I) ions allows self-assembly of 11 parts resulting in the formation of a three-component supramolecular prism. Using the same protocol, a three-component rectangle was made from eight parts. Disassembly of the aggregates was accomplished by selective removal of zinc(II) ions using hexacyclen. In sum, the reversible assembly and disassembly of supramolecular aggregates was controlled in a multi-component mixture through intermolecular communication using a second messenger.

  • Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting
    Sudhakar Gaikwad, Merve Sinem Özer, Susnata Pramanik, and Michael Schmittel

    Organic and Biomolecular Chemistry, ISSN: 14770520, Pages: 7956-7963, Published: 2019 Royal Society of Chemistry (RSC)
    Entangled toggling leads to a rare case of a double-pole change-over switching. Since two connections are cleaved in a correlated manner, it represents an intriguing modus operandi of molecular nanoswitching.

  • Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network
    Abir Goswami, Susnata Pramanik, and Michael Schmittel

    Chemical Communications, ISSN: 13597345, eISSN: 1364548X, Pages: 3955-3958, Published: 2018 Royal Society of Chemistry (RSC)
    As an example of advanced molecular cybernetics eight components work together through chemical signaling reversibly setting up multifunctional nanomachinery.

  • A high-speed network of nanoswitches for on/off control of catalysis
    Sudhakar Gaikwad, Susnata Pramanik, Soumen De, and Michael Schmittel

    Dalton Transactions, ISSN: 14779226, eISSN: 14779234, Pages: 1786-1790, Published: 2018 Royal Society of Chemistry (RSC)
    Copper(i) ion translocation is the key for fast and reliable communication between networked devices in the catalytic machinery.

  • Photochromic Hydrazone Switches with Extremely Long Thermal Half-Lives
    Hai Qian, Susnata Pramanik, and Ivan Aprahamian

    Journal of the American Chemical Society, ISSN: 00027863, eISSN: 15205126, Volume: 139, Pages: 9140-9143, Published: 12 July 2017 American Chemical Society (ACS)
    A family of easily accessible light-activated hydrazone switches has been developed having thermal half-lives of up to 2700 years! Structure-property analysis shows that replacing the rotor pyridyl group of our typical hydrazone switch with a phenyl one leads to the long-lived negative photochromic compounds. The switching properties of the hydrazones in both toluene and DMSO were assessed offering insights into the kinetics and thermodynamics of the switching process.

  • Networking Nanoswitches for ON/OFF Control of Catalysis
    Nikita Mittal, Susnata Pramanik, Indrajit Paul, Soumen De, and Michael Schmittel

    Journal of the American Chemical Society, ISSN: 00027863, eISSN: 15205126, Volume: 139, Pages: 4270-4273, Published: 29 March 2017 American Chemical Society (ACS)
    The nanoswitches 1 and 2 are interdependently linked in so-called network states (NetStates). In NetState I, defined by presence of [Cu(1)]+ and 2, the organocatalyst N-methylpyrrolidine catalyzes a conjugate addition. Addition of iron(II) ions as an external chemical trigger to NetState I discharges Cu+ from [Cu(1)]+. The liberated copper(I) ion acts as a second messenger and changes the toggling state at nanoswitch 2. The resulting nanoswitch [Cu(2)]+ captures the catalytically active species from solution and the conjugate addition is turned OFF. Removal of the original trigger reverses the sequence and turns catalysis ON. The ON/OFF catalytic cycle was run three times in situ.

  • Hydrazone Switch-Based Negative Feedback Loop
    Susnata Pramanik and Ivan Aprahamian

    Journal of the American Chemical Society, ISSN: 00027863, eISSN: 15205126, Volume: 138, Pages: 15142-15145, Published: 23 November 2016 American Chemical Society (ACS)
    A negative feedback loop that relies on the coordination-coupled deprotonation (CCD) of a hydrazone switch has been developed. Above a particular threshold of zinc(II), CCD releases enough protons to the environment to trigger a cascade of reactions that yield an imine. This imine sequesters the excess of zinc(II) from the hydrazone switch, hence lowering the effective amount of protons, and switching the cascade reactions "OFF", thus establishing the negative feedback loop.

  • Redox-dependent self-sorting toggles a rotary nanoswitch
    Michael Schmittel, Soumen De, and Susnata Pramanik

    Organic and Biomolecular Chemistry, ISSN: 14770520, Pages: 8937-8944, Published: 14 July 2015 Royal Society of Chemistry (RSC)
    The pyridine–pyrimidine (py–pym) arm as the moving part of the two-state nanomechanical rotary switch [Cu(1)]+ is toggled reversibly between two stations using one-electron oxidation/reduction.

  • A toggle nanoswitch alternately controlling two catalytic reactions
    Soumen De, Susnata Pramanik, and Michael Schmittel

    Angewandte Chemie - International Edition, ISSN: 14337851, eISSN: 15213773, Pages: 14255-14259, Published: 15 December 2014 Wiley
    Reversible switching between two states of the triangular nanoswitch [Cu(1)](+) was accomplished by alternate addition of 2-ferrocenyl-1,10-phenanthroline (2) and copper(I) ions. The two switching states regulate the binding and release of two distinct catalysts, piperidine and [Cu(2)](+), in a fully interference-free manner and allow alternating on/off switching of two orthogonal catalytic processes. In switching state I, piperidine is released from the nanoswitch and catalyzes a Knoevenagel addition between 4-nitrobenzaldehyde and diethyl malonate (ON-1 and OFF-2), while in state II the released [Cu(2)](+) catalyzes a click reaction between 4-nitrophenylacetylene and benzylazide (OFF-1 and ON-2). Upon addition of one equivalent of 2 to the (OFF-1 and ON-2)-state, both catalytically active processes are shut down (OFF-1 and OFF-2).

  • A trio of nanoswitches in redox-potential controlled communication
    Susnata Pramanik, Soumen De, and Michael Schmittel

    Chemical Communications, ISSN: 13597345, eISSN: 1364548X, Pages: 13254-13257, Published: 11 November 2014 Royal Society of Chemistry (RSC)
    A potential-controlled two-step bidirectional communication protocol between the nanoswitches [Cu(1)](+), 2 and 3 is set up, in which ligand followed by metal-ion oxidation drives two subsequent metal ion translocations (self-sorting) changing the switching state at each switch. The communication is reset to its starting point by a two-electron reduction.

  • A monomer-dimer nanoswitch that mimics the working principle of the SARS-CoV 3CLpro enzyme controls copper-catalysed cyclopropanation
    Soumen De, Susnata Pramanik, and Michael Schmittel

    Dalton Transactions, ISSN: 14779226, eISSN: 14779234, Pages: 10977-10982, Published: 28 July 2014 Royal Society of Chemistry (RSC)
    A triangular framework with a terpyridine and shielded phenanthroline at its termini constitutes an open/close nanoswitch that is toggled by chemical inputs. In the presence of copper(I) ions, the open triangular framework (OPEN-I) firmly closes to a catalytically inactive heteroleptic [Cu(phen)(terpy)](+) complex (CLOSE). Reversible switching between CLOSE and OPEN-I states was demonstrated by successive addition and removal of Cu(+). In contrast, after addition of iron(II) ions to the CLOSE state a bishomoleptic dimeric [Fe(terpy)2](2+) complex is formed with the copper(I) ions placed in the phenanthroline cavities (OPEN-II). Due to its coordinatively unsaturated [Cu(Phen)](+) sites the dimeric iron complex is able to serve as a catalyst in the cyclopropanation of Z-cyclooctene using ethyl diazoacetate.

  • Bidirectional chemical communication between nanomechanical switches
    Susnata Pramanik, Soumen De, and Michael Schmittel

    Angewandte Chemie - International Edition, ISSN: 14337851, eISSN: 15213773, Pages: 4709-4713, Published: 25 April 2014 Wiley
    The interplay of biological machines depends critically on the bidirectionality of chemical information exchange. The implementation of such a communication procedure for abiological systems is achieved using two nanoswitches that both operate as transmitters and receivers by transfering copper ions in oxidation states +I and +II. Even at micromolar concentrations, communication in both directions is remarkably fast, occurring at t1/2 =2-3 min. Metal ion translocation triggers a 20 Å relocation of the toggle at both nanoswitches, entailing major geometric and electronic changes.

  • Dual coordination in ditopic azabipyridines and azaterpyridines as a key for reversible switching
    Soumen De, Susnata Pramanik, and Michael Schmittel

    Dalton Transactions, ISSN: 14779226, eISSN: 14779234, Pages: 15391-15398, Published: 21 November 2013 Royal Society of Chemistry (RSC)
    Dual coordination at two distinct nitrogen binding sites in various ditopic azabipyridines and azaterpyridines was evaluated by preparing 3- and 4-component complexes. The 4-aza-2,2'-bipyridine unit was implemented into a nanoswitch and used for reversible switching between open and closed forms.

  • Orthogonality in discrete self-assembly – survey of current concepts
    Manik Lal Saha, Soumen De, Susnata Pramanik, and Michael Schmittel

    Chemical Society Reviews, ISSN: 03060012, eISSN: 14604744, Pages: 6860-6909, Published: 22 July 2013 Royal Society of Chemistry (RSC)
    Over years, mathematicians, biologists and chemists have capitalised on the highly useful concept of orthogonality for developing sophisticated complex systems. The use of orthogonal pairs ensures that any modification made on one pair does not propagate any effect onto the other. While the concept equally pertains to dynamic supramolecular interactions, interference-free self-assembly built on multiple orthogonal interactions is still limited and the underlying notions are not yet firmly established. Herein, we identify, classify and evaluate dynamic interactions in various orthogonal settings in order to distill out general recommendations for reliable dynamic orthogonality. Our classification has to exclude templating, allosteric and/or cooperative effects as the latter are specific for individual cases only.

  • A reversible nanoswitch as an ON–OFF photocatalyst
    Michael Schmittel, Susnata Pramanik, and Soumen De

    Chemical Communications, ISSN: 13597345, eISSN: 1364548X, Pages: 11730-11732, Published: 7 November 2012 Royal Society of Chemistry (RSC)
    The two states of a new nanomechanical switch were quantitatively and reversibly populated in several subsequent switching cycles using either Cu(+) or cyclam as chemical inputs. State II was demonstrated to cis-trans isomerise diazastilbene upon irradiation selectively in the presence of stilbene, and even to operate as a photocatalyst.

  • Spontaneous and catalytic fusion of supramolecules
    Manik Lal Saha, Susnata Pramanik, and Michael Schmittel

    Chemical Communications, ISSN: 13597345, eISSN: 1364548X, Pages: 9459-9461, Published: 28 August 2012 Royal Society of Chemistry (RSC)
    Using principles of completive and integrative self-sorting, a clean supramolecule-to-supramolecule transformation is realised that involves fusion of a 3-component rectangle and a 2-component equilateral triangle into a 5-component scalene triangle. While the spontaneous process takes 15 h at 25 °C, the catalytic transformation is completed within 1 h.

  • Synthesis of azabipyridine and azaterpyridine building blocks for multitopic binding
    Michael Schmittel, Soumen De, and Susnata Pramanik

    Synthesis (Germany), ISSN: 00397881, eISSN: 1437210X, Pages: 2959-2963, Published: 2012 Georg Thieme Verlag KG
    We describe the synthesis of four bromo-substituted azabipyridines­ and two bromo-substituted azaterpyridines through a series of palladium-catalyzed cross-coupling reactions. Both the azabipyridine and azaterpyridine heterocycles contain two orthogonal binding motifs, the value of which has been demonstrated recently in a nanomechanical switch for triggering organocatalysis. The bromo functionality allows heterocyclic ligands to be attached to larger frameworks.

  • Reversible ON/OFF nanoswitch for organocatalysis: Mimicking the locking and unlocking operation of CaMKII
    Michael Schmittel, Soumen De, and Susnata Pramanik

    Angewandte Chemie - International Edition, ISSN: 14337851, eISSN: 15213773, Pages: 3832-3836, Published: 16 April 2012 Wiley
    Flip a switch: a nanoswitch uses chemical inputs to turn an organocatalytic Knoevenagel reaction on and off (see scheme: R=reactant, P=product). To stop catalysis the chemical input (pink and green) wraps around the inhibitory segment of the nanoswitch to effect release or unlocking of the switch. The process can run reversibly over three cycles without loss of activity.

RECENT SCHOLAR PUBLICATIONS

  • Remote control of the reversible assembly/disassembly of supramolecular aggregates
    N Mittal, I Paul, S Pramanik, M Schmittel
    Supramolecular Chemistry 32 (2), 133-138 2020

  • Photochromic hydrazone switches
    I Abrahamian, H Qian, S Pramanik, S Baihao, Q Li
    US Patent App. 16/401,942 2019

  • Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting
    S Gaikwad, MS zer, S Pramanik, M Schmittel
    Organic & biomolecular chemistry 17 (34), 7956-7963 2019

  • Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network
    A Goswami, S Pramanik, M Schmittel
    Chemical Communications 54 (32), 3955-3958 2018

  • A high-speed network of nanoswitches for on/off control of catalysis
    S Gaikwad, S Pramanik, S De, M Schmittel
    Dalton Transactions 47 (6), 1786-1790 2018

  • Photochromic hydrazone switches with extremely long thermal half-lives
    H Qian, S Pramanik, I Aprahamian
    Journal of the American Chemical Society 139 (27), 9140-9143 2017

  • Networking nanoswitches for ON/OFF control of catalysis
    N Mittal, S Pramanik, I Paul, S De, M Schmittel
    Journal of the American Chemical Society 139 (12), 4270-4273 2017

  • Hydrazone switch-based negative feedback loop
    S Pramanik, I Aprahamian
    Journal of the American Chemical Society 138 (46), 15142-15145 2016

  • Redox-dependent self-sorting toggles a rotary nanoswitch
    M Schmittel, S De, S Pramanik
    Organic & Biomolecular Chemistry 13 (33), 8937-8944 2015

  • A toggle nanoswitch alternately controlling two catalytic reactions
    S De, S Pramanik, M Schmittel
    Angewandte Chemie International Edition 53 (51), 14255-14259 2014

  • Bidirectional chemical communication between nanomechanical switches
    S Pramanik, S De, M Schmittel
    Angewandte Chemie International Edition 53 (18), 4709-4713 2014

  • A trio of nanoswitches in redox-potential controlled communication
    S Pramanik, S De, M Schmittel
    Chemical Communications 50 (87), 13254-13257 2014

  • A monomer–dimer nanoswitch that mimics the working principle of the SARS-CoV 3CLpro enzyme controls copper-catalysed cyclopropanation
    S De, S Pramanik, M Schmittel
    Dalton Transactions 43 (28), 10977-10982 2014

  • Dual coordination in ditopic azabipyridines and azaterpyridines as a key for reversible switching
    S De, S Pramanik, M Schmittel
    Dalton Transactions 42 (43), 15391-15398 2013

  • Orthogonality in discrete self-assembly–survey of current concepts
    ML Saha, S De, S Pramanik, M Schmittel
    Chemical Society Reviews 42 (16), 6860-6909 2013

  • Synthesis of Azabipyridine and Azaterpyridine Building Blocks for Multitopic Binding
    S De, S Pramanik, M Schmittel
    Synthesis 44 (18), 2959-2963 2012

  • Reversible ON/OFF nanoswitch for organocatalysis: mimicking the locking and unlocking operation of CaMKII
    M Schmittel, S De, S Pramanik
    Angewandte Chemie 124 (16), 3898-3902 2012

  • A reversible nanoswitch as an ON–OFF photocatalyst
    M Schmittel, S Pramanik, S De
    Chemical Communications 48 (96), 11730-11732 2012

  • Spontaneous and catalytic fusion of supramolecules
    ML Saha, S Pramanik, M Schmittel
    Chemical Communications 48 (76), 9459-9461 2012

  • SPOTLIGHTS...
    M Schmittel, S De, S Pramanik


MOST CITED SCHOLAR PUBLICATIONS

  • Orthogonality in discrete self-assembly–survey of current concepts
    ML Saha, S De, S Pramanik, M Schmittel
    Chemical Society Reviews 42 (16), 6860-6909 2013
    Citations: 166

  • Reversible ON/OFF nanoswitch for organocatalysis: mimicking the locking and unlocking operation of CaMKII
    M Schmittel, S De, S Pramanik
    Angewandte Chemie 124 (16), 3898-3902 2012
    Citations: 101

  • A toggle nanoswitch alternately controlling two catalytic reactions
    S De, S Pramanik, M Schmittel
    Angewandte Chemie International Edition 53 (51), 14255-14259 2014
    Citations: 62

  • Photochromic hydrazone switches with extremely long thermal half-lives
    H Qian, S Pramanik, I Aprahamian
    Journal of the American Chemical Society 139 (27), 9140-9143 2017
    Citations: 56

  • Hydrazone switch-based negative feedback loop
    S Pramanik, I Aprahamian
    Journal of the American Chemical Society 138 (46), 15142-15145 2016
    Citations: 55

  • A reversible nanoswitch as an ON–OFF photocatalyst
    M Schmittel, S Pramanik, S De
    Chemical Communications 48 (96), 11730-11732 2012
    Citations: 54

  • Spontaneous and catalytic fusion of supramolecules
    ML Saha, S Pramanik, M Schmittel
    Chemical Communications 48 (76), 9459-9461 2012
    Citations: 48

  • Networking nanoswitches for ON/OFF control of catalysis
    N Mittal, S Pramanik, I Paul, S De, M Schmittel
    Journal of the American Chemical Society 139 (12), 4270-4273 2017
    Citations: 47

  • Bidirectional chemical communication between nanomechanical switches
    S Pramanik, S De, M Schmittel
    Angewandte Chemie International Edition 53 (18), 4709-4713 2014
    Citations: 47

  • A trio of nanoswitches in redox-potential controlled communication
    S Pramanik, S De, M Schmittel
    Chemical Communications 50 (87), 13254-13257 2014
    Citations: 27

  • A monomer–dimer nanoswitch that mimics the working principle of the SARS-CoV 3CLpro enzyme controls copper-catalysed cyclopropanation
    S De, S Pramanik, M Schmittel
    Dalton Transactions 43 (28), 10977-10982 2014
    Citations: 23

  • Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network
    A Goswami, S Pramanik, M Schmittel
    Chemical Communications 54 (32), 3955-3958 2018
    Citations: 16

  • A high-speed network of nanoswitches for on/off control of catalysis
    S Gaikwad, S Pramanik, S De, M Schmittel
    Dalton Transactions 47 (6), 1786-1790 2018
    Citations: 11

  • Redox-dependent self-sorting toggles a rotary nanoswitch
    M Schmittel, S De, S Pramanik
    Organic & Biomolecular Chemistry 13 (33), 8937-8944 2015
    Citations: 10

  • Dual coordination in ditopic azabipyridines and azaterpyridines as a key for reversible switching
    S De, S Pramanik, M Schmittel
    Dalton Transactions 42 (43), 15391-15398 2013
    Citations: 10

  • Synthesis of Azabipyridine and Azaterpyridine Building Blocks for Multitopic Binding
    S De, S Pramanik, M Schmittel
    Synthesis 44 (18), 2959-2963 2012
    Citations: 4

  • Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting
    S Gaikwad, MS zer, S Pramanik, M Schmittel
    Organic & biomolecular chemistry 17 (34), 7956-7963 2019
    Citations: 3

  • Remote control of the reversible assembly/disassembly of supramolecular aggregates
    N Mittal, I Paul, S Pramanik, M Schmittel
    Supramolecular Chemistry 32 (2), 133-138 2020
    Citations: 2