Susnata Pramanik

@dartmouth.edu

Postdoctoral Fellow
LMU Munich, Dartmouth College



                 

https://researchid.co/susnata_pramanik

RESEARCH INTERESTS

Supramolecular chemistry. molecular switch, organic synthesis, molecular sensor

26

Scopus Publications

1124

Scholar Citations

15

Scholar h-index

17

Scholar i10-index

Scopus Publications

  • Controlling the Chiroptical Properties of Pyrene-Based Tweezers by Conformation Locking
    Renitta Benny, Nithish Kumar, Anshuman Bera, Rakshantha Srithar, Susnata Pramanik, Sivaranjana Reddy Vennapusa, and Soumen De
    Wiley
    AbstractCircularly polarized excimer emission is highly sought‐after due to its potential in advanced optoelectronic and sensing applications. However, achieving precise control over this phenomenon remains a significant challenge. To address this challenge, we have designed a system where circularly polarized excimer emission could be controlled via conformation locking and aggregation. The structural conformations were extensively examined using circular dichroism spectroscopy, X‐ray crystallography, 1H NMR spectroscopy, and molecular modelling. Self‐assembly was triggered by adding water to THF solutions, with water‐induced aggregation leading to redshifts in absorption bands and excimer emission in T1 (major monomer emission), T2 (minor monomer emission) and T3 at high water content. Additionally, the effects of aggregation on chiroptical properties were studied using circular dichroism and circularly polarized luminescence spectroscopy, revealing a reduction in circular dichroism signal and circularly polarized luminescence quenching with increasing water content. Notably, T3 displayed both excimer and monomer circularly polarized luminescence signals, reflecting two excited‐state geometries. This research underscores the impact of rigidity on the photophysical and chiroptical properties of pyrene and opens avenues for further exploration of BINOL‐pyrene‐based macrocycles and cages.

  • Glucose biosensors
    Rakshantha Srithar, Naveen Kumar M., and Susnata Pramanik
    Elsevier

  • Excitation wavelength-dependent multi-coloured and white-light emissive pyrene-based hydrazones: suppression of Kasha's rule
    Naveen Kumar M, Deikrisha Lyngdoh Lyngkhoi, Sudhakar Gaikwad, Jayanta Samanta, Rafiq Ahamed, Snehadrinarayan Khatua, and Susnata Pramanik
    Royal Society of Chemistry (RSC)
    Multi-coloured and white-light emissions from pyrene-based hydrazones are described.

  • Metal and Proton Relay-Controlled Hierarchical Multistep Switching Cascade
    Heyifei Fu, Susnata Pramanik, and Ivan Aprahamian
    American Chemical Society (ACS)
    Transition metals play an important role in many biological processes including cellular regulation and signal transduction. Emulating such processes on the molecular level, while challenging, can help us learn how to manipulate intermolecular communication, an important requirement for the development of solution-based molecular machines. In this work, we demonstrate a transition metal-based artificial multistep switching cascade that exhibits intrinsic hierarchical level control. The process starts with Zn(II), which initiates a transition metal relay by displacing a macrocycle-encapsulated Pd(II). The latter then binds to a hydrazone switch leading to coordination-coupled deprotonation (CCD). Finally, the proton generated through CCD activates the E/Z isomerization of a second noncoordinating pH-sensitive hydrazone switch. This whole multistep process can be reset to the original state by removing the Pd(II) from the system.

  • The effect of substituents on the aggregation-induced emission of 9,10-phenanthraquinone-hydrazones
    Naveen Kumar M, Deikrisha Lyngdoh Lyngkhoi, Sudhakar Gaikwad, Debabrata Samanta, Snehadrinarayan Khatua, and Susnata Pramanik
    Royal Society of Chemistry (RSC)
    One-step synthesis of six hydrazone derivatives exhibiting red-shifted absorption is reported. The compounds are red-emissive in their solid state with moderate to high quantum efficiency and show AIE properties, supported by DLS and SEM studies.

  • Carbohydrate recognition using metal-ligand assemblies
    Rafiq Ahamed, Jayashree Venkatesh, Rakshantha Srithar, Sudhakar Gaikwad, and Susnata Pramanik
    Royal Society of Chemistry (RSC)
    This review summarises the recognition of carbohydrates using metal-ligand assemblies, including metallosupramolecules, macrocycles, and cages. It also highlights the challenges and future directions in the field.

  • Hydrazone Photoswitches for Structural Modulation of Short Peptides
    Myeongsu Jeong, Jiyoon Park, Yejin Seo, Kwonjung Lee, Susnata Pramanik, Sangdoo Ahn, and Sunbum Kwon
    Wiley
    Molecules that undergo light-driven structural transformations constitute the core components in photoswitchable molecular systems and materials. Among various families of photoswitches, photochromic hydrazones have recently emerged as a novel class of photoswitches with superb properties, such as high photochemical conversion, spectral tunability, thermal stability, and fatigue resistance. Hydrazone photoswitches have been adopted in various adaptive materials at different length scales, however, their utilization for modulating biomolecules still has not been explored. Herein we present new hydrazone switches that can photomodulate the structures of short peptides. Systematic investigation on a set of hydrazone derivatives revealed that installation of the amide group does not significantly alter the photoswitching behaviors. Importantly, a hydrazone switch comprising an upper phenyl ring and a lower quinolinyl ring was effective for structural control of peptides. We anticipate that this work, as a new milestone in the research of hydrazone switches, will open a new avenue for structural and functional control of biomolecules.

  • Light-mediated chiroptical switching of an achiral foldamer host in presence of a carbohydrate guest
    Susnata Pramanik, Brice Kauffmann, Stefan Hecht, Yann Ferrand, and Ivan Huc
    Royal Society of Chemistry (RSC)
    A chiral guest induces opposite helix handedness in the two states of a photoswitchable host.

  • Remote control of the reversible assembly/disassembly of supramolecular aggregates
    Nikita Mittal, Indrajit Paul, Susnata Pramanik, and Michael Schmittel
    Informa UK Limited
    ABSTRACT A multi-component system is presented in which the actuation of a copper-loaded nanoswitch by zinc(II) ions as an external trigger and the thereby prompted release of copper(I) ions allows self-assembly of 11 parts resulting in the formation of a three-component supramolecular prism. Using the same protocol, a three-component rectangle was made from eight parts. Disassembly of the aggregates was accomplished by selective removal of zinc(II) ions using hexacyclen. In sum, the reversible assembly and disassembly of supramolecular aggregates was controlled in a multi-component mixture through intermolecular communication using a second messenger. Graphical_abstract

  • Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting
    Sudhakar Gaikwad, Merve Sinem Özer, Susnata Pramanik, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    Entangled toggling leads to a rare case of a double-pole change-over switching. Since two connections are cleaved in a correlated manner, it represents an intriguing modus operandi of molecular nanoswitching.

  • Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network
    Abir Goswami, Susnata Pramanik, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    As an example of advanced molecular cybernetics eight components work together through chemical signaling reversibly setting up multifunctional nanomachinery.

  • A high-speed network of nanoswitches for on/off control of catalysis
    Sudhakar Gaikwad, Susnata Pramanik, Soumen De, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    Copper(i) ion translocation is the key for fast and reliable communication between networked devices in the catalytic machinery.

  • Photochromic Hydrazone Switches with Extremely Long Thermal Half-Lives
    Hai Qian, Susnata Pramanik, and Ivan Aprahamian
    American Chemical Society (ACS)
    A family of easily accessible light-activated hydrazone switches has been developed having thermal half-lives of up to 2700 years! Structure-property analysis shows that replacing the rotor pyridyl group of our typical hydrazone switch with a phenyl one leads to the long-lived negative photochromic compounds. The switching properties of the hydrazones in both toluene and DMSO were assessed offering insights into the kinetics and thermodynamics of the switching process.

  • Networking Nanoswitches for ON/OFF Control of Catalysis
    Nikita Mittal, Susnata Pramanik, Indrajit Paul, Soumen De, and Michael Schmittel
    American Chemical Society (ACS)
    The nanoswitches 1 and 2 are interdependently linked in so-called network states (NetStates). In NetState I, defined by presence of [Cu(1)]+ and 2, the organocatalyst N-methylpyrrolidine catalyzes a conjugate addition. Addition of iron(II) ions as an external chemical trigger to NetState I discharges Cu+ from [Cu(1)]+. The liberated copper(I) ion acts as a second messenger and changes the toggling state at nanoswitch 2. The resulting nanoswitch [Cu(2)]+ captures the catalytically active species from solution and the conjugate addition is turned OFF. Removal of the original trigger reverses the sequence and turns catalysis ON. The ON/OFF catalytic cycle was run three times in situ.

  • Hydrazone Switch-Based Negative Feedback Loop
    Susnata Pramanik and Ivan Aprahamian
    American Chemical Society (ACS)
    A negative feedback loop that relies on the coordination-coupled deprotonation (CCD) of a hydrazone switch has been developed. Above a particular threshold of zinc(II), CCD releases enough protons to the environment to trigger a cascade of reactions that yield an imine. This imine sequesters the excess of zinc(II) from the hydrazone switch, hence lowering the effective amount of protons, and switching the cascade reactions "OFF", thus establishing the negative feedback loop.

  • Redox-dependent self-sorting toggles a rotary nanoswitch
    Michael Schmittel, Soumen De, and Susnata Pramanik
    Royal Society of Chemistry (RSC)
    The pyridine–pyrimidine (py–pym) arm as the moving part of the two-state nanomechanical rotary switch [Cu(1)]+ is toggled reversibly between two stations using one-electron oxidation/reduction.

  • A toggle nanoswitch alternately controlling two catalytic reactions
    Soumen De, Susnata Pramanik, and Michael Schmittel
    Wiley
    Reversible switching between two states of the triangular nanoswitch [Cu(1)](+) was accomplished by alternate addition of 2-ferrocenyl-1,10-phenanthroline (2) and copper(I) ions. The two switching states regulate the binding and release of two distinct catalysts, piperidine and [Cu(2)](+), in a fully interference-free manner and allow alternating on/off switching of two orthogonal catalytic processes. In switching state I, piperidine is released from the nanoswitch and catalyzes a Knoevenagel addition between 4-nitrobenzaldehyde and diethyl malonate (ON-1 and OFF-2), while in state II the released [Cu(2)](+) catalyzes a click reaction between 4-nitrophenylacetylene and benzylazide (OFF-1 and ON-2). Upon addition of one equivalent of 2 to the (OFF-1 and ON-2)-state, both catalytically active processes are shut down (OFF-1 and OFF-2).

  • A trio of nanoswitches in redox-potential controlled communication
    Susnata Pramanik, Soumen De, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    A potential-controlled two-step bidirectional communication protocol between the nanoswitches [Cu(1)](+), 2 and 3 is set up, in which ligand followed by metal-ion oxidation drives two subsequent metal ion translocations (self-sorting) changing the switching state at each switch. The communication is reset to its starting point by a two-electron reduction.

  • A monomer-dimer nanoswitch that mimics the working principle of the SARS-CoV 3CLpro enzyme controls copper-catalysed cyclopropanation
    Soumen De, Susnata Pramanik, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    A triangular framework with a terpyridine and shielded phenanthroline at its termini constitutes an open/close nanoswitch that is toggled by chemical inputs. In the presence of copper(I) ions, the open triangular framework (OPEN-I) firmly closes to a catalytically inactive heteroleptic [Cu(phen)(terpy)](+) complex (CLOSE). Reversible switching between CLOSE and OPEN-I states was demonstrated by successive addition and removal of Cu(+). In contrast, after addition of iron(II) ions to the CLOSE state a bishomoleptic dimeric [Fe(terpy)2](2+) complex is formed with the copper(I) ions placed in the phenanthroline cavities (OPEN-II). Due to its coordinatively unsaturated [Cu(Phen)](+) sites the dimeric iron complex is able to serve as a catalyst in the cyclopropanation of Z-cyclooctene using ethyl diazoacetate.

  • Bidirectional chemical communication between nanomechanical switches
    Susnata Pramanik, Soumen De, and Michael Schmittel
    Wiley
    The interplay of biological machines depends critically on the bidirectionality of chemical information exchange. The implementation of such a communication procedure for abiological systems is achieved using two nanoswitches that both operate as transmitters and receivers by transfering copper ions in oxidation states +I and +II. Even at micromolar concentrations, communication in both directions is remarkably fast, occurring at t1/2 =2-3 min. Metal ion translocation triggers a 20 Å relocation of the toggle at both nanoswitches, entailing major geometric and electronic changes.

  • Dual coordination in ditopic azabipyridines and azaterpyridines as a key for reversible switching
    Soumen De, Susnata Pramanik, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    Dual coordination at two distinct nitrogen binding sites in various ditopic azabipyridines and azaterpyridines was evaluated by preparing 3- and 4-component complexes. The 4-aza-2,2'-bipyridine unit was implemented into a nanoswitch and used for reversible switching between open and closed forms.

  • Orthogonality in discrete self-assembly – survey of current concepts
    Manik Lal Saha, Soumen De, Susnata Pramanik, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    Over years, mathematicians, biologists and chemists have capitalised on the highly useful concept of orthogonality for developing sophisticated complex systems. The use of orthogonal pairs ensures that any modification made on one pair does not propagate any effect onto the other. While the concept equally pertains to dynamic supramolecular interactions, interference-free self-assembly built on multiple orthogonal interactions is still limited and the underlying notions are not yet firmly established. Herein, we identify, classify and evaluate dynamic interactions in various orthogonal settings in order to distill out general recommendations for reliable dynamic orthogonality. Our classification has to exclude templating, allosteric and/or cooperative effects as the latter are specific for individual cases only.

  • A reversible nanoswitch as an ON–OFF photocatalyst
    Michael Schmittel, Susnata Pramanik, and Soumen De
    Royal Society of Chemistry (RSC)
    The two states of a new nanomechanical switch were quantitatively and reversibly populated in several subsequent switching cycles using either Cu(+) or cyclam as chemical inputs. State II was demonstrated to cis-trans isomerise diazastilbene upon irradiation selectively in the presence of stilbene, and even to operate as a photocatalyst.

  • Spontaneous and catalytic fusion of supramolecules
    Manik Lal Saha, Susnata Pramanik, and Michael Schmittel
    Royal Society of Chemistry (RSC)
    Using principles of completive and integrative self-sorting, a clean supramolecule-to-supramolecule transformation is realised that involves fusion of a 3-component rectangle and a 2-component equilateral triangle into a 5-component scalene triangle. While the spontaneous process takes 15 h at 25 °C, the catalytic transformation is completed within 1 h.

  • Synthesis of azabipyridine and azaterpyridine building blocks for multitopic binding
    Michael Schmittel, Soumen De, and Susnata Pramanik
    Georg Thieme Verlag KG
    We describe the synthesis of four bromo-substituted azabipyridines­ and two bromo-substituted azaterpyridines through a series of palladium-catalyzed cross-coupling reactions. Both the azabipyridine and azaterpyridine heterocycles contain two orthogonal binding motifs, the value of which has been demonstrated recently in a nanomechanical switch for triggering organocatalysis. The bromo functionality allows heterocyclic ligands to be attached to larger frameworks.

RECENT SCHOLAR PUBLICATIONS

  • Controlling the Chiroptical Properties of Pyrene‐Based Tweezers by Conformation Locking
    R Benny, N Kumar, A Bera, R Srithar, S Pramanik, S Reddy Vennapusa, ...
    ChemPhotoChem, e202400396 2025

  • Glucose biosensors
    R Srithar, N Kumar, S Pramanik
    Fundamentals of Biosensors in Healthcare, 405-433 2025

  • Enhanced dual state emission from tri-and tetraphenylethene-substituted pyrene-fused heteroacenes
    R Ahamed, KS Godi, A Bhadke, S Fisher, RK Gamidi, S Pramanik, ...
     2024

  • Metal and Proton Relay-Controlled Hierarchical Multistep Switching Cascade
    H Fu, S Pramanik, I Aprahamian
    Journal of the American Chemical Society 145 (36), 19554-19560 2023

  • Excitation wavelength-dependent multi-coloured and white-light emissive pyrene-based hydrazones: suppression of Kasha's rule
    N Kumar, DL Lyngkhoi, S Gaikwad, J Samanta, R Ahamed, S Khatua, ...
    Chemical Communications 59 (95), 14122-14125 2023

  • The effect of substituents on the aggregation-induced emission of 9, 10-phenanthraquinone-hydrazones
    N Kumar, DL Lyngkhoi, S Gaikwad, D Samanta, S Khatua, S Pramanik
    New Journal of Chemistry 47 (32), 15066-15075 2023

  • Carbohydrate recognition using metal–ligand assemblies
    R Ahamed, J Venkatesh, R Srithar, S Gaikwad, S Pramanik
    Organic & Biomolecular Chemistry 21 (27), 5492-5505 2023

  • Photochromic hydrazone switches
    I Abrahamian, H Qian, S Pramanik, S Baihao, Q Li
    US Patent 11,279,677 2022

  • Hydrazone photoswitches for structural modulation of short peptides
    M Jeong, J Park, Y Seo, K Lee, S Pramanik, S Ahn, S Kwon
    Chemistry–A European Journal 28 (11), e202103972 2022

  • Light-mediated chiroptical switching of an achiral foldamer host in presence of a carbohydrate guest
    S Pramanik, B Kauffmann, S Hecht, Y Ferrand, I Huc
    Chemical Communications 57 (1), 93-96 2021

  • Remote control of the reversible assembly/disassembly of supramolecular aggregates
    N Mittal, I Paul, S Pramanik, M Schmittel
    Supramolecular Chemistry 32 (2), 133-138 2020

  • Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting
    S Gaikwad, MS zer, S Pramanik, M Schmittel
    Organic & Biomolecular Chemistry 17 (34), 7956-7963 2019

  • Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network
    A Goswami, S Pramanik, M Schmittel
    Chemical Communications 54 (32), 3955-3958 2018

  • A high-speed network of nanoswitches for on/off control of catalysis
    S Gaikwad, S Pramanik, S De, M Schmittel
    Dalton Transactions 47 (6), 1786-1790 2018

  • Photochromic hydrazone switches with extremely long thermal half-lives
    H Qian, S Pramanik, I Aprahamian
    Journal of the American Chemical Society 139 (27), 9140-9143 2017

  • Networking nanoswitches for ON/OFF control of catalysis
    N Mittal, S Pramanik, I Paul, S De, M Schmittel
    Journal of the American Chemical Society 139 (12), 4270-4273 2017

  • Hydrazone switch-based negative feedback loop
    S Pramanik, I Aprahamian
    Journal of the American Chemical Society 138 (46), 15142-15145 2016

  • Redox-dependent self-sorting toggles a rotary nanoswitch
    M Schmittel, S De, S Pramanik
    Organic & Biomolecular Chemistry 13 (33), 8937-8944 2015

  • A toggle nanoswitch alternately controlling two catalytic reactions
    S De, S Pramanik, M Schmittel
    Angewandte Chemie International Edition 53 (51), 14255-14259 2014

  • Bidirectional chemical communication between nanomechanical switches
    S Pramanik, S De, M Schmittel
    Angewandte Chemie International Edition 53 (18), 4709-4713 2014

MOST CITED SCHOLAR PUBLICATIONS

  • Orthogonality in discrete self-assembly–survey of current concepts
    ML Saha, S De, S Pramanik, M Schmittel
    Chemical Society Reviews 42 (16), 6860-6909 2013
    Citations: 201

  • Photochromic hydrazone switches with extremely long thermal half-lives
    H Qian, S Pramanik, I Aprahamian
    Journal of the American Chemical Society 139 (27), 9140-9143 2017
    Citations: 173

  • Reversible ON/OFF nanoswitch for organocatalysis: mimicking the locking and unlocking operation of CaMKII
    M Schmittel, S De, S Pramanik
    Angewandte Chemie International Edition 51 (16), 3832-3836 2012
    Citations: 127

  • Hydrazone switch-based negative feedback loop
    S Pramanik, I Aprahamian
    Journal of the American Chemical Society 138 (46), 15142-15145 2016
    Citations: 89

  • A toggle nanoswitch alternately controlling two catalytic reactions
    S De, S Pramanik, M Schmittel
    Angewandte Chemie International Edition 53 (51), 14255-14259 2014
    Citations: 86

  • Networking nanoswitches for ON/OFF control of catalysis
    N Mittal, S Pramanik, I Paul, S De, M Schmittel
    Journal of the American Chemical Society 139 (12), 4270-4273 2017
    Citations: 66

  • A reversible nanoswitch as an ON–OFF photocatalyst
    M Schmittel, S Pramanik, S De
    Chemical Communications 48 (96), 11730-11732 2012
    Citations: 63

  • Bidirectional chemical communication between nanomechanical switches
    S Pramanik, S De, M Schmittel
    Angewandte Chemie International Edition 53 (18), 4709-4713 2014
    Citations: 61

  • Spontaneous and catalytic fusion of supramolecules
    ML Saha, S Pramanik, M Schmittel
    Chemical Communications 48 (76), 9459-9461 2012
    Citations: 54

  • A monomer–dimer nanoswitch that mimics the working principle of the SARS-CoV 3CLpro enzyme controls copper-catalysed cyclopropanation
    S De, S Pramanik, M Schmittel
    Dalton Transactions 43 (28), 10977-10982 2014
    Citations: 37

  • A trio of nanoswitches in redox-potential controlled communication
    S Pramanik, S De, M Schmittel
    Chemical Communications 50 (87), 13254-13257 2014
    Citations: 36

  • Light-mediated chiroptical switching of an achiral foldamer host in presence of a carbohydrate guest
    S Pramanik, B Kauffmann, S Hecht, Y Ferrand, I Huc
    Chemical Communications 57 (1), 93-96 2021
    Citations: 22

  • Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network
    A Goswami, S Pramanik, M Schmittel
    Chemical Communications 54 (32), 3955-3958 2018
    Citations: 22

  • A high-speed network of nanoswitches for on/off control of catalysis
    S Gaikwad, S Pramanik, S De, M Schmittel
    Dalton Transactions 47 (6), 1786-1790 2018
    Citations: 17

  • Hydrazone photoswitches for structural modulation of short peptides
    M Jeong, J Park, Y Seo, K Lee, S Pramanik, S Ahn, S Kwon
    Chemistry–A European Journal 28 (11), e202103972 2022
    Citations: 16

  • Redox-dependent self-sorting toggles a rotary nanoswitch
    M Schmittel, S De, S Pramanik
    Organic & Biomolecular Chemistry 13 (33), 8937-8944 2015
    Citations: 11

  • Dual coordination in ditopic azabipyridines and azaterpyridines as a key for reversible switching
    S De, S Pramanik, M Schmittel
    Dalton Transactions 42 (43), 15391-15398 2013
    Citations: 10

  • Metal and Proton Relay-Controlled Hierarchical Multistep Switching Cascade
    H Fu, S Pramanik, I Aprahamian
    Journal of the American Chemical Society 145 (36), 19554-19560 2023
    Citations: 7

  • Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting
    S Gaikwad, MS zer, S Pramanik, M Schmittel
    Organic & Biomolecular Chemistry 17 (34), 7956-7963 2019
    Citations: 7

  • Remote control of the reversible assembly/disassembly of supramolecular aggregates
    N Mittal, I Paul, S Pramanik, M Schmittel
    Supramolecular Chemistry 32 (2), 133-138 2020
    Citations: 6